Incidental Mutation 'R4545:Zfp810'
ID 333722
Institutional Source Beutler Lab
Gene Symbol Zfp810
Ensembl Gene ENSMUSG00000066829
Gene Name zinc finger protein 810
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.104) question?
Stock # R4545 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 22188044-22218944 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 22190041 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 289 (T289I)
Ref Sequence ENSEMBL: ENSMUSP00000083459 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086278] [ENSMUST00000215202]
AlphaFold Q99K45
Predicted Effect probably damaging
Transcript: ENSMUST00000086278
AA Change: T289I

PolyPhen 2 Score 0.965 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000083459
Gene: ENSMUSG00000066829
AA Change: T289I

DomainStartEndE-ValueType
KRAB 4 64 1.09e-33 SMART
ZnF_C2H2 126 148 2.44e2 SMART
ZnF_C2H2 182 204 3.07e-1 SMART
ZnF_C2H2 210 232 8.47e-4 SMART
ZnF_C2H2 238 260 6.78e-3 SMART
ZnF_C2H2 266 288 6.13e-1 SMART
ZnF_C2H2 294 316 5.06e-2 SMART
ZnF_C2H2 322 344 4.79e-3 SMART
ZnF_C2H2 350 372 2.99e-4 SMART
ZnF_C2H2 378 400 1.33e-1 SMART
ZnF_C2H2 406 428 2.75e-3 SMART
ZnF_C2H2 434 456 1.58e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214499
Predicted Effect probably benign
Transcript: ENSMUST00000215202
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.7%
Validation Efficiency 98% (41/42)
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akr1c20 A C 13: 4,557,843 (GRCm39) V201G probably damaging Het
Atf7 A G 15: 102,442,762 (GRCm39) V449A probably benign Het
Ccr1 G A 9: 123,764,437 (GRCm39) A31V probably benign Het
Chrna6 A T 8: 27,896,711 (GRCm39) S389T probably benign Het
Clic6 C T 16: 92,289,045 (GRCm39) probably benign Het
Cmya5 G A 13: 93,228,426 (GRCm39) R2221* probably null Het
Coq8b G T 7: 26,932,930 (GRCm39) C13F probably benign Het
Cspg4 T A 9: 56,795,913 (GRCm39) L1216Q possibly damaging Het
Decr1 C A 4: 15,930,979 (GRCm39) V118F probably damaging Het
Dlec1 A T 9: 118,957,146 (GRCm39) I796F probably damaging Het
Dnajc11 T A 4: 152,064,398 (GRCm39) D516E probably damaging Het
Dock8 G A 19: 25,165,722 (GRCm39) V1869M probably damaging Het
Dst A G 1: 34,227,819 (GRCm39) D1982G probably damaging Het
Gnptab G A 10: 88,250,457 (GRCm39) D190N probably benign Het
Golga4 A G 9: 118,385,913 (GRCm39) K22E probably damaging Het
Hecw2 T C 1: 53,852,381 (GRCm39) *1579W probably null Het
Ica1l A G 1: 60,052,977 (GRCm39) probably null Het
Ift122 T A 6: 115,867,549 (GRCm39) L433Q probably damaging Het
Iqgap1 T C 7: 80,412,315 (GRCm39) probably null Het
Klra13-ps T C 6: 130,268,232 (GRCm39) noncoding transcript Het
Mndal A T 1: 173,703,230 (GRCm39) Y58* probably null Het
Mvb12b G C 2: 33,717,712 (GRCm39) P172R possibly damaging Het
Ncapg T C 5: 45,828,554 (GRCm39) F102L probably damaging Het
Or1e30 T C 11: 73,677,992 (GRCm39) V76A probably damaging Het
Or5an11 T C 19: 12,246,188 (GRCm39) V198A possibly damaging Het
Or5b97 T A 19: 12,878,632 (GRCm39) K171* probably null Het
Pde8a A T 7: 80,977,847 (GRCm39) R713S probably damaging Het
Rbks T C 5: 31,781,912 (GRCm39) N296S probably benign Het
Sema3c G A 5: 17,899,770 (GRCm39) V421I probably benign Het
Tm9sf1 A G 14: 55,875,565 (GRCm39) V393A possibly damaging Het
Tubgcp2 G A 7: 139,575,984 (GRCm39) P893L possibly damaging Het
Uba52rt C T 4: 3,973,244 (GRCm39) R106H probably benign Het
Vnn3 G A 10: 23,732,224 (GRCm39) R158H probably benign Het
Zfa-ps G T 10: 52,421,032 (GRCm39) noncoding transcript Het
Zfp414 T C 17: 33,850,622 (GRCm39) probably benign Het
Zfp819 G T 7: 43,267,209 (GRCm39) R488L probably damaging Het
Zfp942 C T 17: 22,147,285 (GRCm39) G448D probably benign Het
Zscan12 A G 13: 21,550,875 (GRCm39) K165E possibly damaging Het
Other mutations in Zfp810
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00484:Zfp810 APN 9 22,189,605 (GRCm39) nonsense probably null
IGL03079:Zfp810 APN 9 22,195,423 (GRCm39) missense probably damaging 1.00
IGL03402:Zfp810 APN 9 22,190,441 (GRCm39) splice site probably null
H8562:Zfp810 UTSW 9 22,190,387 (GRCm39) missense probably benign 0.42
R1116:Zfp810 UTSW 9 22,190,381 (GRCm39) missense probably benign 0.11
R1160:Zfp810 UTSW 9 22,189,828 (GRCm39) missense possibly damaging 0.64
R1171:Zfp810 UTSW 9 22,190,122 (GRCm39) missense possibly damaging 0.95
R1393:Zfp810 UTSW 9 22,191,810 (GRCm39) missense probably benign
R1608:Zfp810 UTSW 9 22,190,216 (GRCm39) missense probably benign 0.00
R1644:Zfp810 UTSW 9 22,190,324 (GRCm39) missense possibly damaging 0.67
R1766:Zfp810 UTSW 9 22,189,828 (GRCm39) missense possibly damaging 0.64
R2568:Zfp810 UTSW 9 22,190,534 (GRCm39) missense probably benign 0.01
R3684:Zfp810 UTSW 9 22,189,531 (GRCm39) missense probably benign 0.01
R4002:Zfp810 UTSW 9 22,190,188 (GRCm39) missense probably damaging 1.00
R4134:Zfp810 UTSW 9 22,190,369 (GRCm39) missense probably damaging 0.97
R4135:Zfp810 UTSW 9 22,190,369 (GRCm39) missense probably damaging 0.97
R4334:Zfp810 UTSW 9 22,190,080 (GRCm39) missense probably benign 0.00
R5399:Zfp810 UTSW 9 22,190,125 (GRCm39) missense possibly damaging 0.91
R5622:Zfp810 UTSW 9 22,190,392 (GRCm39) missense probably benign 0.00
R5643:Zfp810 UTSW 9 22,194,467 (GRCm39) missense probably benign 0.26
R7375:Zfp810 UTSW 9 22,201,833 (GRCm39) critical splice donor site probably null
R7441:Zfp810 UTSW 9 22,190,568 (GRCm39) nonsense probably null
R7809:Zfp810 UTSW 9 22,190,278 (GRCm39) missense possibly damaging 0.51
R8422:Zfp810 UTSW 9 22,194,518 (GRCm39) nonsense probably null
R8526:Zfp810 UTSW 9 22,189,586 (GRCm39) missense probably damaging 1.00
R8719:Zfp810 UTSW 9 22,190,571 (GRCm39) missense probably benign 0.00
R9177:Zfp810 UTSW 9 22,189,936 (GRCm39) missense probably damaging 1.00
R9479:Zfp810 UTSW 9 22,194,497 (GRCm39) missense possibly damaging 0.68
R9521:Zfp810 UTSW 9 22,190,227 (GRCm39) missense possibly damaging 0.81
R9683:Zfp810 UTSW 9 22,189,799 (GRCm39) missense possibly damaging 0.90
Predicted Primers PCR Primer
(F):5'- AACGGACTTATTAAGTATTACCCTGCT -3'
(R):5'- TGCAAGTCTCACCTCACTGT -3'

Sequencing Primer
(F):5'- ACTCGGGACATTCATATGGC -3'
(R):5'- TCTGAGAATTCACACCGGTG -3'
Posted On 2015-08-18