Incidental Mutation 'R4545:Clic6'
ID 333736
Institutional Source Beutler Lab
Gene Symbol Clic6
Ensembl Gene ENSMUSG00000022949
Gene Name chloride intracellular channel 6
Synonyms CLIC1L, 5730466J16Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.147) question?
Stock # R4545 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 92295035-92338129 bp(+) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) C to T at 92289045 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000124498 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000162181]
AlphaFold Q8BHB9
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160494
SMART Domains Protein: ENSMUSP00000123968
Gene: ENSMUSG00000051297

DomainStartEndE-ValueType
low complexity region 4 22 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000162181
SMART Domains Protein: ENSMUSP00000124498
Gene: ENSMUSG00000022949

DomainStartEndE-ValueType
Pfam:GST_N_3 34 100 2.8e-10 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.7%
Validation Efficiency 98% (41/42)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2015]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akr1c20 A C 13: 4,557,843 (GRCm39) V201G probably damaging Het
Atf7 A G 15: 102,442,762 (GRCm39) V449A probably benign Het
Ccr1 G A 9: 123,764,437 (GRCm39) A31V probably benign Het
Chrna6 A T 8: 27,896,711 (GRCm39) S389T probably benign Het
Cmya5 G A 13: 93,228,426 (GRCm39) R2221* probably null Het
Coq8b G T 7: 26,932,930 (GRCm39) C13F probably benign Het
Cspg4 T A 9: 56,795,913 (GRCm39) L1216Q possibly damaging Het
Decr1 C A 4: 15,930,979 (GRCm39) V118F probably damaging Het
Dlec1 A T 9: 118,957,146 (GRCm39) I796F probably damaging Het
Dnajc11 T A 4: 152,064,398 (GRCm39) D516E probably damaging Het
Dock8 G A 19: 25,165,722 (GRCm39) V1869M probably damaging Het
Dst A G 1: 34,227,819 (GRCm39) D1982G probably damaging Het
Gnptab G A 10: 88,250,457 (GRCm39) D190N probably benign Het
Golga4 A G 9: 118,385,913 (GRCm39) K22E probably damaging Het
Hecw2 T C 1: 53,852,381 (GRCm39) *1579W probably null Het
Ica1l A G 1: 60,052,977 (GRCm39) probably null Het
Ift122 T A 6: 115,867,549 (GRCm39) L433Q probably damaging Het
Iqgap1 T C 7: 80,412,315 (GRCm39) probably null Het
Klra13-ps T C 6: 130,268,232 (GRCm39) noncoding transcript Het
Mndal A T 1: 173,703,230 (GRCm39) Y58* probably null Het
Mvb12b G C 2: 33,717,712 (GRCm39) P172R possibly damaging Het
Ncapg T C 5: 45,828,554 (GRCm39) F102L probably damaging Het
Or1e30 T C 11: 73,677,992 (GRCm39) V76A probably damaging Het
Or5an11 T C 19: 12,246,188 (GRCm39) V198A possibly damaging Het
Or5b97 T A 19: 12,878,632 (GRCm39) K171* probably null Het
Pde8a A T 7: 80,977,847 (GRCm39) R713S probably damaging Het
Rbks T C 5: 31,781,912 (GRCm39) N296S probably benign Het
Sema3c G A 5: 17,899,770 (GRCm39) V421I probably benign Het
Tm9sf1 A G 14: 55,875,565 (GRCm39) V393A possibly damaging Het
Tubgcp2 G A 7: 139,575,984 (GRCm39) P893L possibly damaging Het
Uba52rt C T 4: 3,973,244 (GRCm39) R106H probably benign Het
Vnn3 G A 10: 23,732,224 (GRCm39) R158H probably benign Het
Zfa-ps G T 10: 52,421,032 (GRCm39) noncoding transcript Het
Zfp414 T C 17: 33,850,622 (GRCm39) probably benign Het
Zfp810 G A 9: 22,190,041 (GRCm39) T289I probably damaging Het
Zfp819 G T 7: 43,267,209 (GRCm39) R488L probably damaging Het
Zfp942 C T 17: 22,147,285 (GRCm39) G448D probably benign Het
Zscan12 A G 13: 21,550,875 (GRCm39) K165E possibly damaging Het
Other mutations in Clic6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00421:Clic6 APN 16 92,296,196 (GRCm39) missense probably damaging 0.99
IGL02104:Clic6 APN 16 92,295,367 (GRCm39) missense possibly damaging 0.72
IGL02387:Clic6 APN 16 92,326,807 (GRCm39) missense probably damaging 1.00
IGL02437:Clic6 APN 16 92,327,817 (GRCm39) missense probably damaging 1.00
IGL02617:Clic6 APN 16 92,296,206 (GRCm39) missense probably benign 0.00
unsweetened UTSW 16 92,327,697 (GRCm39) missense possibly damaging 0.79
R1544:Clic6 UTSW 16 92,288,961 (GRCm39) intron probably benign
R1677:Clic6 UTSW 16 92,324,972 (GRCm39) missense probably damaging 1.00
R2149:Clic6 UTSW 16 92,296,095 (GRCm39) missense probably benign 0.00
R3965:Clic6 UTSW 16 92,295,732 (GRCm39) missense probably benign 0.00
R4171:Clic6 UTSW 16 92,293,949 (GRCm39) intron probably benign
R4637:Clic6 UTSW 16 92,293,949 (GRCm39) intron probably benign
R4649:Clic6 UTSW 16 92,327,827 (GRCm39) critical splice donor site probably null
R5159:Clic6 UTSW 16 92,324,954 (GRCm39) missense probably benign 0.13
R5249:Clic6 UTSW 16 92,336,339 (GRCm39) missense probably damaging 1.00
R5486:Clic6 UTSW 16 92,326,740 (GRCm39) splice site probably null
R5582:Clic6 UTSW 16 92,296,342 (GRCm39) missense possibly damaging 0.93
R6140:Clic6 UTSW 16 92,336,380 (GRCm39) missense probably damaging 1.00
R6234:Clic6 UTSW 16 92,296,110 (GRCm39) missense probably benign
R6379:Clic6 UTSW 16 92,336,423 (GRCm39) missense probably damaging 1.00
R6593:Clic6 UTSW 16 92,325,005 (GRCm39) missense possibly damaging 0.82
R7890:Clic6 UTSW 16 92,296,275 (GRCm39) missense probably benign 0.41
R8794:Clic6 UTSW 16 92,324,987 (GRCm39) missense possibly damaging 0.91
R8937:Clic6 UTSW 16 92,296,245 (GRCm39) missense probably damaging 0.98
R9450:Clic6 UTSW 16 92,327,644 (GRCm39) missense possibly damaging 0.95
R9502:Clic6 UTSW 16 92,295,588 (GRCm39) missense probably damaging 1.00
RF012:Clic6 UTSW 16 92,327,697 (GRCm39) missense possibly damaging 0.79
X0058:Clic6 UTSW 16 92,295,595 (GRCm39) missense probably benign
Z1176:Clic6 UTSW 16 92,295,783 (GRCm39) missense probably benign 0.26
Z1177:Clic6 UTSW 16 92,296,027 (GRCm39) missense probably benign 0.08
Predicted Primers PCR Primer
(F):5'- CAAAATATTCACAGGTGGAGGC -3'
(R):5'- GGTGATCTTGGACTCCTGTC -3'

Sequencing Primer
(F):5'- AGGCAGAAGGTTTACATCGAGTTTC -3'
(R):5'- GTGATCTTGGACTCCTGTCAAATCAG -3'
Posted On 2015-08-18