Incidental Mutation 'R4546:Vmn2r9'
| ID |
333766 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r9
|
| Ensembl Gene |
ENSMUSG00000091624 |
| Gene Name |
vomeronasal 2, receptor 9 |
| Synonyms |
EG435864 |
| MMRRC Submission |
041780-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.113)
|
| Stock # |
R4546 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
108990813-109000376 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 108995551 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Leucine
at position 366
(M366L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129520
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170419]
|
| AlphaFold |
K7N6Z8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170419
AA Change: M366L
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000129520
Gene: ENSMUSG00000091624
AA Change: M366L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
412 |
8.1e-29 |
PFAM |
|
Pfam:NCD3G
|
507 |
561 |
2.3e-16 |
PFAM |
|
Pfam:7tm_3
|
592 |
829 |
3.4e-54 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000176157
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 94.0%
|
| Validation Efficiency |
97% (65/67) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 56 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9930012K11Rik |
G |
A |
14: 70,393,927 (GRCm39) |
S236L |
probably benign |
Het |
| Ahcyl |
C |
T |
16: 45,974,330 (GRCm39) |
C349Y |
possibly damaging |
Het |
| Alg9 |
C |
T |
9: 50,716,654 (GRCm39) |
T409M |
possibly damaging |
Het |
| Alpi |
T |
A |
1: 87,026,839 (GRCm39) |
Y413F |
probably damaging |
Het |
| Asmt |
T |
C |
X: 169,110,230 (GRCm39) |
|
probably null |
Het |
| Atf7 |
A |
G |
15: 102,442,762 (GRCm39) |
V449A |
probably benign |
Het |
| Bnc2 |
A |
G |
4: 84,210,213 (GRCm39) |
F744L |
probably benign |
Het |
| Ccnyl1 |
G |
T |
1: 64,762,735 (GRCm39) |
M347I |
probably benign |
Het |
| Cdk13 |
T |
C |
13: 17,941,159 (GRCm39) |
K21R |
probably damaging |
Het |
| Cenpf |
A |
C |
1: 189,386,847 (GRCm39) |
L1811R |
probably damaging |
Het |
| Cfap91 |
C |
T |
16: 38,155,885 (GRCm39) |
V113I |
probably benign |
Het |
| Cr2 |
A |
G |
1: 194,853,349 (GRCm39) |
I43T |
possibly damaging |
Het |
| Cspg4 |
T |
A |
9: 56,795,913 (GRCm39) |
L1216Q |
possibly damaging |
Het |
| Cylc2 |
A |
T |
4: 51,229,840 (GRCm39) |
D394V |
unknown |
Het |
| Cylc2 |
C |
G |
4: 51,229,651 (GRCm39) |
T331R |
unknown |
Het |
| Dcaf8 |
T |
C |
1: 172,007,460 (GRCm39) |
|
probably benign |
Het |
| Dlec1 |
A |
T |
9: 118,957,146 (GRCm39) |
I796F |
probably damaging |
Het |
| Dnah12 |
A |
T |
14: 26,494,971 (GRCm39) |
Q1343L |
probably damaging |
Het |
| Dnajc21 |
T |
C |
15: 10,447,183 (GRCm39) |
R522G |
probably benign |
Het |
| F2rl3 |
C |
T |
8: 73,489,211 (GRCm39) |
A146V |
probably benign |
Het |
| Fastkd1 |
C |
T |
2: 69,542,655 (GRCm39) |
E51K |
probably damaging |
Het |
| Glrb |
T |
C |
3: 80,786,993 (GRCm39) |
S57G |
probably damaging |
Het |
| Gm5507 |
T |
A |
18: 54,117,409 (GRCm39) |
|
noncoding transcript |
Het |
| Golga4 |
A |
G |
9: 118,385,913 (GRCm39) |
K22E |
probably damaging |
Het |
| Hdac1-ps |
A |
T |
17: 78,800,388 (GRCm39) |
T460S |
probably benign |
Het |
| Ift122 |
T |
A |
6: 115,867,549 (GRCm39) |
L433Q |
probably damaging |
Het |
| Il21r |
A |
G |
7: 125,228,071 (GRCm39) |
R181G |
probably damaging |
Het |
| Il5ra |
G |
T |
6: 106,715,459 (GRCm39) |
S125* |
probably null |
Het |
| Kdm7a |
T |
C |
6: 39,152,406 (GRCm39) |
R97G |
probably benign |
Het |
| Lepr |
T |
A |
4: 101,671,838 (GRCm39) |
I954N |
probably benign |
Het |
| Lims1 |
T |
C |
10: 58,254,612 (GRCm39) |
|
probably benign |
Het |
| Mest |
T |
C |
6: 30,740,679 (GRCm39) |
W13R |
probably damaging |
Het |
| Mfn2 |
A |
G |
4: 147,971,909 (GRCm39) |
V224A |
probably benign |
Het |
| Muc15 |
T |
C |
2: 110,567,844 (GRCm39) |
S330P |
probably damaging |
Het |
| Ncapg |
T |
C |
5: 45,828,554 (GRCm39) |
F102L |
probably damaging |
Het |
| Nkd2 |
T |
C |
13: 73,971,475 (GRCm39) |
D187G |
probably benign |
Het |
| Nphp1 |
C |
T |
2: 127,607,939 (GRCm39) |
|
probably null |
Het |
| Or10ag59 |
T |
C |
2: 87,405,530 (GRCm39) |
F34S |
probably benign |
Het |
| Or1e19 |
T |
C |
11: 73,316,012 (GRCm39) |
N266D |
probably benign |
Het |
| Or2a12 |
C |
T |
6: 42,904,348 (GRCm39) |
S61L |
probably damaging |
Het |
| Osbpl6 |
T |
C |
2: 76,414,836 (GRCm39) |
V409A |
possibly damaging |
Het |
| Pdhx |
A |
T |
2: 102,903,742 (GRCm39) |
L18Q |
probably null |
Het |
| Pear1 |
C |
T |
3: 87,661,968 (GRCm39) |
G469D |
probably damaging |
Het |
| Plec |
T |
C |
15: 76,065,757 (GRCm39) |
T1506A |
probably benign |
Het |
| Plod3 |
T |
A |
5: 137,017,801 (GRCm39) |
D192E |
possibly damaging |
Het |
| Rbks |
T |
C |
5: 31,781,912 (GRCm39) |
N296S |
probably benign |
Het |
| Sema3c |
G |
A |
5: 17,899,770 (GRCm39) |
V421I |
probably benign |
Het |
| Slc15a4 |
A |
G |
5: 127,681,600 (GRCm39) |
|
probably null |
Het |
| Slc7a8 |
C |
G |
14: 54,973,247 (GRCm39) |
G240A |
possibly damaging |
Het |
| Tmem200c |
A |
G |
17: 69,149,166 (GRCm39) |
D583G |
probably benign |
Het |
| Trpm6 |
A |
G |
19: 18,809,841 (GRCm39) |
Y1079C |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,652,932 (GRCm39) |
|
probably null |
Het |
| Vcp |
T |
C |
4: 42,988,813 (GRCm39) |
|
probably benign |
Het |
| Vmn2r78 |
T |
C |
7: 86,603,811 (GRCm39) |
V663A |
probably damaging |
Het |
| Wdr11 |
A |
G |
7: 129,230,729 (GRCm39) |
E878G |
probably damaging |
Het |
| Zan |
C |
G |
5: 137,382,096 (GRCm39) |
M5150I |
unknown |
Het |
|
| Other mutations in Vmn2r9 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00920:Vmn2r9
|
APN |
5 |
108,995,890 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL00972:Vmn2r9
|
APN |
5 |
108,996,903 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01102:Vmn2r9
|
APN |
5 |
108,990,811 (GRCm39) |
splice site |
probably null |
|
|
IGL01892:Vmn2r9
|
APN |
5 |
108,995,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02086:Vmn2r9
|
APN |
5 |
108,995,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02118:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02119:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02120:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02121:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02123:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02131:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02132:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02171:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02185:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02186:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02346:Vmn2r9
|
APN |
5 |
108,990,850 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL02508:Vmn2r9
|
APN |
5 |
108,996,067 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
IGL02815:Vmn2r9
|
APN |
5 |
108,990,856 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL03077:Vmn2r9
|
APN |
5 |
108,996,173 (GRCm39) |
splice site |
probably benign |
|
|
IGL03269:Vmn2r9
|
APN |
5 |
108,995,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03293:Vmn2r9
|
APN |
5 |
108,995,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0112:Vmn2r9
|
UTSW |
5 |
108,990,991 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0328:Vmn2r9
|
UTSW |
5 |
108,995,405 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0382:Vmn2r9
|
UTSW |
5 |
108,995,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0521:Vmn2r9
|
UTSW |
5 |
108,996,154 (GRCm39) |
nonsense |
probably null |
|
|
R0975:Vmn2r9
|
UTSW |
5 |
108,991,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1216:Vmn2r9
|
UTSW |
5 |
108,995,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1458:Vmn2r9
|
UTSW |
5 |
108,996,850 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1469:Vmn2r9
|
UTSW |
5 |
108,991,694 (GRCm39) |
missense |
probably benign |
|
|
R1469:Vmn2r9
|
UTSW |
5 |
108,991,694 (GRCm39) |
missense |
probably benign |
|
|
R1704:Vmn2r9
|
UTSW |
5 |
108,994,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1967:Vmn2r9
|
UTSW |
5 |
108,995,388 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1991:Vmn2r9
|
UTSW |
5 |
108,994,305 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2410:Vmn2r9
|
UTSW |
5 |
108,996,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3419:Vmn2r9
|
UTSW |
5 |
108,994,299 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3852:Vmn2r9
|
UTSW |
5 |
108,995,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3873:Vmn2r9
|
UTSW |
5 |
108,995,701 (GRCm39) |
missense |
probably benign |
0.14 |
|
R3905:Vmn2r9
|
UTSW |
5 |
108,995,785 (GRCm39) |
missense |
probably benign |
0.37 |
|
R3908:Vmn2r9
|
UTSW |
5 |
108,995,785 (GRCm39) |
missense |
probably benign |
0.37 |
|
R3921:Vmn2r9
|
UTSW |
5 |
108,996,921 (GRCm39) |
missense |
probably benign |
|
|
R4156:Vmn2r9
|
UTSW |
5 |
108,995,743 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R4477:Vmn2r9
|
UTSW |
5 |
108,994,143 (GRCm39) |
missense |
probably benign |
|
|
R4478:Vmn2r9
|
UTSW |
5 |
108,994,143 (GRCm39) |
missense |
probably benign |
|
|
R4544:Vmn2r9
|
UTSW |
5 |
108,995,551 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4627:Vmn2r9
|
UTSW |
5 |
108,995,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5215:Vmn2r9
|
UTSW |
5 |
108,994,351 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5361:Vmn2r9
|
UTSW |
5 |
108,995,929 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5587:Vmn2r9
|
UTSW |
5 |
108,995,427 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6054:Vmn2r9
|
UTSW |
5 |
108,996,126 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6106:Vmn2r9
|
UTSW |
5 |
108,992,902 (GRCm39) |
missense |
probably benign |
|
|
R6125:Vmn2r9
|
UTSW |
5 |
108,990,836 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6137:Vmn2r9
|
UTSW |
5 |
108,996,882 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6920:Vmn2r9
|
UTSW |
5 |
108,996,912 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7579:Vmn2r9
|
UTSW |
5 |
108,992,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8683:Vmn2r9
|
UTSW |
5 |
108,996,873 (GRCm39) |
missense |
probably benign |
|
|
R8964:Vmn2r9
|
UTSW |
5 |
108,996,031 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9022:Vmn2r9
|
UTSW |
5 |
108,992,923 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9118:Vmn2r9
|
UTSW |
5 |
108,990,937 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9125:Vmn2r9
|
UTSW |
5 |
108,996,047 (GRCm39) |
missense |
|
|
|
R9240:Vmn2r9
|
UTSW |
5 |
108,996,099 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R9327:Vmn2r9
|
UTSW |
5 |
108,996,841 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9412:Vmn2r9
|
UTSW |
5 |
108,991,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9499:Vmn2r9
|
UTSW |
5 |
108,995,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9757:Vmn2r9
|
UTSW |
5 |
108,995,908 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R9790:Vmn2r9
|
UTSW |
5 |
108,995,409 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9791:Vmn2r9
|
UTSW |
5 |
108,995,409 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCGTACTTCCGTTTGCTGAG -3'
(R):5'- GCAAGGAGAATCTGGATCACAACC -3'
Sequencing Primer
(F):5'- CCGTTTGCTGAGATTCTACTTG -3'
(R):5'- ACCTCACAATGGGACGTTATC -3'
|
| Posted On |
2015-08-18 |
Incidental Mutation