Incidental Mutation 'R4546:Wdr11'
ID 333777
Institutional Source Beutler Lab
Gene Symbol Wdr11
Ensembl Gene ENSMUSG00000042055
Gene Name WD repeat domain 11
Synonyms Wdr11, Brwd2, 2900055P10Rik
MMRRC Submission 041780-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.245) question?
Stock # R4546 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 129193587-129237462 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 129230729 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 878 (E878G)
Ref Sequence ENSEMBL: ENSMUSP00000081567 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084519]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000084519
AA Change: E878G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000081567
Gene: ENSMUSG00000042055
AA Change: E878G

DomainStartEndE-ValueType
WD40 50 99 2e-1 SMART
WD40 102 145 2.84e2 SMART
low complexity region 189 200 N/A INTRINSIC
low complexity region 213 227 N/A INTRINSIC
low complexity region 454 465 N/A INTRINSIC
WD40 552 595 4.42e1 SMART
WD40 696 735 1.66e0 SMART
WD40 737 777 1.43e1 SMART
WD40 780 821 1.38e1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000136560
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140877
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143422
Predicted Effect probably benign
Transcript: ENSMUST00000148752
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149541
Meta Mutation Damage Score 0.1359 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.0%
Validation Efficiency 97% (65/67)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9930012K11Rik G A 14: 70,393,927 (GRCm39) S236L probably benign Het
Ahcyl C T 16: 45,974,330 (GRCm39) C349Y possibly damaging Het
Alg9 C T 9: 50,716,654 (GRCm39) T409M possibly damaging Het
Alpi T A 1: 87,026,839 (GRCm39) Y413F probably damaging Het
Asmt T C X: 169,110,230 (GRCm39) probably null Het
Atf7 A G 15: 102,442,762 (GRCm39) V449A probably benign Het
Bnc2 A G 4: 84,210,213 (GRCm39) F744L probably benign Het
Ccnyl1 G T 1: 64,762,735 (GRCm39) M347I probably benign Het
Cdk13 T C 13: 17,941,159 (GRCm39) K21R probably damaging Het
Cenpf A C 1: 189,386,847 (GRCm39) L1811R probably damaging Het
Cfap91 C T 16: 38,155,885 (GRCm39) V113I probably benign Het
Cr2 A G 1: 194,853,349 (GRCm39) I43T possibly damaging Het
Cspg4 T A 9: 56,795,913 (GRCm39) L1216Q possibly damaging Het
Cylc2 A T 4: 51,229,840 (GRCm39) D394V unknown Het
Cylc2 C G 4: 51,229,651 (GRCm39) T331R unknown Het
Dcaf8 T C 1: 172,007,460 (GRCm39) probably benign Het
Dlec1 A T 9: 118,957,146 (GRCm39) I796F probably damaging Het
Dnah12 A T 14: 26,494,971 (GRCm39) Q1343L probably damaging Het
Dnajc21 T C 15: 10,447,183 (GRCm39) R522G probably benign Het
F2rl3 C T 8: 73,489,211 (GRCm39) A146V probably benign Het
Fastkd1 C T 2: 69,542,655 (GRCm39) E51K probably damaging Het
Glrb T C 3: 80,786,993 (GRCm39) S57G probably damaging Het
Gm5507 T A 18: 54,117,409 (GRCm39) noncoding transcript Het
Golga4 A G 9: 118,385,913 (GRCm39) K22E probably damaging Het
Hdac1-ps A T 17: 78,800,388 (GRCm39) T460S probably benign Het
Ift122 T A 6: 115,867,549 (GRCm39) L433Q probably damaging Het
Il21r A G 7: 125,228,071 (GRCm39) R181G probably damaging Het
Il5ra G T 6: 106,715,459 (GRCm39) S125* probably null Het
Kdm7a T C 6: 39,152,406 (GRCm39) R97G probably benign Het
Lepr T A 4: 101,671,838 (GRCm39) I954N probably benign Het
Lims1 T C 10: 58,254,612 (GRCm39) probably benign Het
Mest T C 6: 30,740,679 (GRCm39) W13R probably damaging Het
Mfn2 A G 4: 147,971,909 (GRCm39) V224A probably benign Het
Muc15 T C 2: 110,567,844 (GRCm39) S330P probably damaging Het
Ncapg T C 5: 45,828,554 (GRCm39) F102L probably damaging Het
Nkd2 T C 13: 73,971,475 (GRCm39) D187G probably benign Het
Nphp1 C T 2: 127,607,939 (GRCm39) probably null Het
Or10ag59 T C 2: 87,405,530 (GRCm39) F34S probably benign Het
Or1e19 T C 11: 73,316,012 (GRCm39) N266D probably benign Het
Or2a12 C T 6: 42,904,348 (GRCm39) S61L probably damaging Het
Osbpl6 T C 2: 76,414,836 (GRCm39) V409A possibly damaging Het
Pdhx A T 2: 102,903,742 (GRCm39) L18Q probably null Het
Pear1 C T 3: 87,661,968 (GRCm39) G469D probably damaging Het
Plec T C 15: 76,065,757 (GRCm39) T1506A probably benign Het
Plod3 T A 5: 137,017,801 (GRCm39) D192E possibly damaging Het
Rbks T C 5: 31,781,912 (GRCm39) N296S probably benign Het
Sema3c G A 5: 17,899,770 (GRCm39) V421I probably benign Het
Slc15a4 A G 5: 127,681,600 (GRCm39) probably null Het
Slc7a8 C G 14: 54,973,247 (GRCm39) G240A possibly damaging Het
Tmem200c A G 17: 69,149,166 (GRCm39) D583G probably benign Het
Trpm6 A G 19: 18,809,841 (GRCm39) Y1079C probably damaging Het
Ttn T C 2: 76,652,932 (GRCm39) probably null Het
Vcp T C 4: 42,988,813 (GRCm39) probably benign Het
Vmn2r78 T C 7: 86,603,811 (GRCm39) V663A probably damaging Het
Vmn2r9 T G 5: 108,995,551 (GRCm39) M366L probably benign Het
Zan C G 5: 137,382,096 (GRCm39) M5150I unknown Het
Other mutations in Wdr11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00834:Wdr11 APN 7 129,194,817 (GRCm39) splice site probably null
IGL01121:Wdr11 APN 7 129,229,746 (GRCm39) missense probably benign 0.02
IGL01385:Wdr11 APN 7 129,209,637 (GRCm39) missense probably benign
IGL01923:Wdr11 APN 7 129,234,046 (GRCm39) critical splice acceptor site probably null
IGL02274:Wdr11 APN 7 129,232,896 (GRCm39) critical splice acceptor site probably null
IGL02894:Wdr11 APN 7 129,232,890 (GRCm39) splice site probably benign
IGL02927:Wdr11 APN 7 129,208,822 (GRCm39) critical splice donor site probably null
IGL03008:Wdr11 APN 7 129,208,715 (GRCm39) unclassified probably benign
IGL03026:Wdr11 APN 7 129,226,060 (GRCm39) missense probably damaging 1.00
IGL03354:Wdr11 APN 7 129,227,026 (GRCm39) missense probably benign 0.01
IGL03379:Wdr11 APN 7 129,200,847 (GRCm39) missense probably damaging 1.00
beeline UTSW 7 129,207,437 (GRCm39) nonsense probably null
bekummernis UTSW 7 129,226,451 (GRCm39) missense probably damaging 0.97
hort UTSW 7 129,232,523 (GRCm39) critical splice donor site probably null
Knees UTSW 7 129,236,560 (GRCm39) missense probably benign 0.02
Propeller UTSW 7 129,208,399 (GRCm39) missense possibly damaging 0.91
Zuversicht UTSW 7 129,208,264 (GRCm39) missense probably benign 0.13
R0003:Wdr11 UTSW 7 129,200,785 (GRCm39) missense probably damaging 1.00
R0928:Wdr11 UTSW 7 129,208,377 (GRCm39) missense probably damaging 1.00
R1170:Wdr11 UTSW 7 129,208,831 (GRCm39) unclassified probably benign
R1645:Wdr11 UTSW 7 129,215,613 (GRCm39) missense probably benign 0.29
R1908:Wdr11 UTSW 7 129,206,954 (GRCm39) missense possibly damaging 0.60
R1938:Wdr11 UTSW 7 129,208,331 (GRCm39) missense probably benign 0.08
R2122:Wdr11 UTSW 7 129,233,490 (GRCm39) missense probably damaging 1.00
R2148:Wdr11 UTSW 7 129,230,807 (GRCm39) splice site probably null
R2240:Wdr11 UTSW 7 129,207,418 (GRCm39) critical splice acceptor site probably null
R2362:Wdr11 UTSW 7 129,236,560 (GRCm39) missense probably benign 0.05
R3774:Wdr11 UTSW 7 129,233,417 (GRCm39) splice site probably null
R4297:Wdr11 UTSW 7 129,226,910 (GRCm39) missense probably benign 0.18
R4787:Wdr11 UTSW 7 129,210,658 (GRCm39) splice site probably benign
R4789:Wdr11 UTSW 7 129,220,394 (GRCm39) nonsense probably null
R4807:Wdr11 UTSW 7 129,229,746 (GRCm39) missense probably benign 0.02
R4855:Wdr11 UTSW 7 129,202,158 (GRCm39) splice site probably null
R4898:Wdr11 UTSW 7 129,235,445 (GRCm39) missense probably benign
R5022:Wdr11 UTSW 7 129,226,435 (GRCm39) missense probably benign 0.10
R5326:Wdr11 UTSW 7 129,226,973 (GRCm39) missense probably damaging 1.00
R5398:Wdr11 UTSW 7 129,232,956 (GRCm39) missense probably damaging 1.00
R6120:Wdr11 UTSW 7 129,226,515 (GRCm39) missense probably damaging 0.99
R6136:Wdr11 UTSW 7 129,220,427 (GRCm39) missense possibly damaging 0.86
R6280:Wdr11 UTSW 7 129,200,830 (GRCm39) nonsense probably null
R6352:Wdr11 UTSW 7 129,208,399 (GRCm39) missense possibly damaging 0.91
R6432:Wdr11 UTSW 7 129,208,242 (GRCm39) missense possibly damaging 0.83
R6766:Wdr11 UTSW 7 129,226,036 (GRCm39) missense probably benign 0.02
R6911:Wdr11 UTSW 7 129,208,819 (GRCm39) missense probably benign 0.28
R7135:Wdr11 UTSW 7 129,229,830 (GRCm39) missense possibly damaging 0.76
R7151:Wdr11 UTSW 7 129,208,376 (GRCm39) missense probably damaging 1.00
R7463:Wdr11 UTSW 7 129,208,810 (GRCm39) missense probably damaging 0.99
R7503:Wdr11 UTSW 7 129,204,834 (GRCm39) missense probably benign
R8097:Wdr11 UTSW 7 129,209,611 (GRCm39) missense probably damaging 1.00
R8254:Wdr11 UTSW 7 129,236,560 (GRCm39) missense probably benign 0.02
R8354:Wdr11 UTSW 7 129,204,723 (GRCm39) missense probably damaging 0.99
R8377:Wdr11 UTSW 7 129,208,412 (GRCm39) missense possibly damaging 0.56
R8416:Wdr11 UTSW 7 129,232,403 (GRCm39) missense possibly damaging 0.62
R8708:Wdr11 UTSW 7 129,200,780 (GRCm39) missense probably benign 0.07
R8896:Wdr11 UTSW 7 129,207,437 (GRCm39) nonsense probably null
R9092:Wdr11 UTSW 7 129,226,451 (GRCm39) missense probably damaging 0.97
R9136:Wdr11 UTSW 7 129,204,816 (GRCm39) missense
R9315:Wdr11 UTSW 7 129,208,264 (GRCm39) missense probably benign 0.13
R9343:Wdr11 UTSW 7 129,232,523 (GRCm39) critical splice donor site probably null
R9663:Wdr11 UTSW 7 129,210,647 (GRCm39) missense probably damaging 1.00
R9771:Wdr11 UTSW 7 129,206,851 (GRCm39) missense probably damaging 1.00
Z1177:Wdr11 UTSW 7 129,209,602 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAGTGAGTCTCAGGCACATTG -3'
(R):5'- TGATTATTAAGATGGCCCTTCTGG -3'

Sequencing Primer
(F):5'- GTGAGTCTCAGGCACATTGTTACTAC -3'
(R):5'- CTTCTGGCAAACAAGGCTAC -3'
Posted On 2015-08-18