Incidental Mutation 'R4546:Alg9'
ID |
333779 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Alg9
|
Ensembl Gene |
ENSMUSG00000032059 |
Gene Name |
ALG9 alpha-1,2-mannosyltransferase |
Synonyms |
B430313H07Rik, 8230402H15Rik, Dibd1 |
MMRRC Submission |
041780-MU
|
Accession Numbers |
|
Essential gene? |
Essential
(E-score: 1.000)
|
Stock # |
R4546 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
9 |
Chromosomal Location |
50686570-50754939 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
C to T
at 50716654 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Threonine to Methionine
at position 409
(T409M)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000034561
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000034561]
[ENSMUST00000162073]
[ENSMUST00000177320]
|
AlphaFold |
Q8VDI9 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000034561
AA Change: T409M
PolyPhen 2
Score 0.901 (Sensitivity: 0.82; Specificity: 0.94)
|
SMART Domains |
Protein: ENSMUSP00000034561 Gene: ENSMUSG00000032059 AA Change: T409M
Domain | Start | End | E-Value | Type |
Pfam:Glyco_transf_22
|
60 |
482 |
3.5e-127 |
PFAM |
low complexity region
|
598 |
611 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000162073
|
SMART Domains |
Protein: ENSMUSP00000125425 Gene: ENSMUSG00000032059
Domain | Start | End | E-Value | Type |
Pfam:Glyco_transf_22
|
60 |
167 |
7.5e-31 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000175728
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000177320
AA Change: T26M
PolyPhen 2
Score 0.548 (Sensitivity: 0.88; Specificity: 0.91)
|
SMART Domains |
Protein: ENSMUSP00000134818 Gene: ENSMUSG00000032059 AA Change: T26M
Domain | Start | End | E-Value | Type |
Pfam:Glyco_transf_22
|
2 |
99 |
4.3e-15 |
PFAM |
|
Meta Mutation Damage Score |
0.1795 |
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 94.0%
|
Validation Efficiency |
97% (65/67) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an alpha-1,2-mannosyltransferase enzyme that functions in lipid-linked oligosaccharide assembly. Mutations in this gene result in congenital disorder of glycosylation type Il. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 56 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
9930012K11Rik |
G |
A |
14: 70,393,927 (GRCm39) |
S236L |
probably benign |
Het |
Ahcyl |
C |
T |
16: 45,974,330 (GRCm39) |
C349Y |
possibly damaging |
Het |
Alpi |
T |
A |
1: 87,026,839 (GRCm39) |
Y413F |
probably damaging |
Het |
Asmt |
T |
C |
X: 169,110,230 (GRCm39) |
|
probably null |
Het |
Atf7 |
A |
G |
15: 102,442,762 (GRCm39) |
V449A |
probably benign |
Het |
Bnc2 |
A |
G |
4: 84,210,213 (GRCm39) |
F744L |
probably benign |
Het |
Ccnyl1 |
G |
T |
1: 64,762,735 (GRCm39) |
M347I |
probably benign |
Het |
Cdk13 |
T |
C |
13: 17,941,159 (GRCm39) |
K21R |
probably damaging |
Het |
Cenpf |
A |
C |
1: 189,386,847 (GRCm39) |
L1811R |
probably damaging |
Het |
Cfap91 |
C |
T |
16: 38,155,885 (GRCm39) |
V113I |
probably benign |
Het |
Cr2 |
A |
G |
1: 194,853,349 (GRCm39) |
I43T |
possibly damaging |
Het |
Cspg4 |
T |
A |
9: 56,795,913 (GRCm39) |
L1216Q |
possibly damaging |
Het |
Cylc2 |
A |
T |
4: 51,229,840 (GRCm39) |
D394V |
unknown |
Het |
Cylc2 |
C |
G |
4: 51,229,651 (GRCm39) |
T331R |
unknown |
Het |
Dcaf8 |
T |
C |
1: 172,007,460 (GRCm39) |
|
probably benign |
Het |
Dlec1 |
A |
T |
9: 118,957,146 (GRCm39) |
I796F |
probably damaging |
Het |
Dnah12 |
A |
T |
14: 26,494,971 (GRCm39) |
Q1343L |
probably damaging |
Het |
Dnajc21 |
T |
C |
15: 10,447,183 (GRCm39) |
R522G |
probably benign |
Het |
F2rl3 |
C |
T |
8: 73,489,211 (GRCm39) |
A146V |
probably benign |
Het |
Fastkd1 |
C |
T |
2: 69,542,655 (GRCm39) |
E51K |
probably damaging |
Het |
Glrb |
T |
C |
3: 80,786,993 (GRCm39) |
S57G |
probably damaging |
Het |
Gm5507 |
T |
A |
18: 54,117,409 (GRCm39) |
|
noncoding transcript |
Het |
Golga4 |
A |
G |
9: 118,385,913 (GRCm39) |
K22E |
probably damaging |
Het |
Hdac1-ps |
A |
T |
17: 78,800,388 (GRCm39) |
T460S |
probably benign |
Het |
Ift122 |
T |
A |
6: 115,867,549 (GRCm39) |
L433Q |
probably damaging |
Het |
Il21r |
A |
G |
7: 125,228,071 (GRCm39) |
R181G |
probably damaging |
Het |
Il5ra |
G |
T |
6: 106,715,459 (GRCm39) |
S125* |
probably null |
Het |
Kdm7a |
T |
C |
6: 39,152,406 (GRCm39) |
R97G |
probably benign |
Het |
Lepr |
T |
A |
4: 101,671,838 (GRCm39) |
I954N |
probably benign |
Het |
Lims1 |
T |
C |
10: 58,254,612 (GRCm39) |
|
probably benign |
Het |
Mest |
T |
C |
6: 30,740,679 (GRCm39) |
W13R |
probably damaging |
Het |
Mfn2 |
A |
G |
4: 147,971,909 (GRCm39) |
V224A |
probably benign |
Het |
Muc15 |
T |
C |
2: 110,567,844 (GRCm39) |
S330P |
probably damaging |
Het |
Ncapg |
T |
C |
5: 45,828,554 (GRCm39) |
F102L |
probably damaging |
Het |
Nkd2 |
T |
C |
13: 73,971,475 (GRCm39) |
D187G |
probably benign |
Het |
Nphp1 |
C |
T |
2: 127,607,939 (GRCm39) |
|
probably null |
Het |
Or10ag59 |
T |
C |
2: 87,405,530 (GRCm39) |
F34S |
probably benign |
Het |
Or1e19 |
T |
C |
11: 73,316,012 (GRCm39) |
N266D |
probably benign |
Het |
Or2a12 |
C |
T |
6: 42,904,348 (GRCm39) |
S61L |
probably damaging |
Het |
Osbpl6 |
T |
C |
2: 76,414,836 (GRCm39) |
V409A |
possibly damaging |
Het |
Pdhx |
A |
T |
2: 102,903,742 (GRCm39) |
L18Q |
probably null |
Het |
Pear1 |
C |
T |
3: 87,661,968 (GRCm39) |
G469D |
probably damaging |
Het |
Plec |
T |
C |
15: 76,065,757 (GRCm39) |
T1506A |
probably benign |
Het |
Plod3 |
T |
A |
5: 137,017,801 (GRCm39) |
D192E |
possibly damaging |
Het |
Rbks |
T |
C |
5: 31,781,912 (GRCm39) |
N296S |
probably benign |
Het |
Sema3c |
G |
A |
5: 17,899,770 (GRCm39) |
V421I |
probably benign |
Het |
Slc15a4 |
A |
G |
5: 127,681,600 (GRCm39) |
|
probably null |
Het |
Slc7a8 |
C |
G |
14: 54,973,247 (GRCm39) |
G240A |
possibly damaging |
Het |
Tmem200c |
A |
G |
17: 69,149,166 (GRCm39) |
D583G |
probably benign |
Het |
Trpm6 |
A |
G |
19: 18,809,841 (GRCm39) |
Y1079C |
probably damaging |
Het |
Ttn |
T |
C |
2: 76,652,932 (GRCm39) |
|
probably null |
Het |
Vcp |
T |
C |
4: 42,988,813 (GRCm39) |
|
probably benign |
Het |
Vmn2r78 |
T |
C |
7: 86,603,811 (GRCm39) |
V663A |
probably damaging |
Het |
Vmn2r9 |
T |
G |
5: 108,995,551 (GRCm39) |
M366L |
probably benign |
Het |
Wdr11 |
A |
G |
7: 129,230,729 (GRCm39) |
E878G |
probably damaging |
Het |
Zan |
C |
G |
5: 137,382,096 (GRCm39) |
M5150I |
unknown |
Het |
|
Other mutations in Alg9 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01634:Alg9
|
APN |
9 |
50,686,677 (GRCm39) |
splice site |
probably null |
|
IGL02792:Alg9
|
APN |
9 |
50,754,048 (GRCm39) |
missense |
possibly damaging |
0.90 |
gum_drop
|
UTSW |
9 |
50,716,654 (GRCm39) |
missense |
possibly damaging |
0.90 |
FR4976:Alg9
|
UTSW |
9 |
50,686,731 (GRCm39) |
unclassified |
probably benign |
|
R1183:Alg9
|
UTSW |
9 |
50,700,833 (GRCm39) |
missense |
possibly damaging |
0.82 |
R1270:Alg9
|
UTSW |
9 |
50,698,872 (GRCm39) |
intron |
probably benign |
|
R1575:Alg9
|
UTSW |
9 |
50,686,802 (GRCm39) |
missense |
possibly damaging |
0.65 |
R1773:Alg9
|
UTSW |
9 |
50,690,396 (GRCm39) |
missense |
probably benign |
0.30 |
R1837:Alg9
|
UTSW |
9 |
50,717,615 (GRCm39) |
missense |
probably damaging |
1.00 |
R2011:Alg9
|
UTSW |
9 |
50,699,500 (GRCm39) |
missense |
probably damaging |
1.00 |
R4324:Alg9
|
UTSW |
9 |
50,716,643 (GRCm39) |
missense |
probably damaging |
1.00 |
R4514:Alg9
|
UTSW |
9 |
50,716,654 (GRCm39) |
missense |
possibly damaging |
0.90 |
R4544:Alg9
|
UTSW |
9 |
50,716,654 (GRCm39) |
missense |
possibly damaging |
0.90 |
R4996:Alg9
|
UTSW |
9 |
50,720,005 (GRCm39) |
missense |
probably damaging |
1.00 |
R5007:Alg9
|
UTSW |
9 |
50,699,524 (GRCm39) |
missense |
probably damaging |
1.00 |
R5053:Alg9
|
UTSW |
9 |
50,699,472 (GRCm39) |
missense |
probably damaging |
1.00 |
R5308:Alg9
|
UTSW |
9 |
50,734,011 (GRCm39) |
missense |
possibly damaging |
0.95 |
R6803:Alg9
|
UTSW |
9 |
50,700,860 (GRCm39) |
missense |
probably benign |
0.37 |
R6994:Alg9
|
UTSW |
9 |
50,703,422 (GRCm39) |
nonsense |
probably null |
|
R6998:Alg9
|
UTSW |
9 |
50,700,921 (GRCm39) |
missense |
possibly damaging |
0.95 |
R7298:Alg9
|
UTSW |
9 |
50,690,361 (GRCm39) |
missense |
probably damaging |
0.97 |
R7480:Alg9
|
UTSW |
9 |
50,733,928 (GRCm39) |
missense |
probably benign |
0.06 |
R7561:Alg9
|
UTSW |
9 |
50,754,074 (GRCm39) |
missense |
possibly damaging |
0.95 |
R7578:Alg9
|
UTSW |
9 |
50,700,835 (GRCm39) |
missense |
probably benign |
|
R7721:Alg9
|
UTSW |
9 |
50,687,942 (GRCm39) |
missense |
probably damaging |
0.99 |
R7829:Alg9
|
UTSW |
9 |
50,699,471 (GRCm39) |
missense |
probably damaging |
1.00 |
R7847:Alg9
|
UTSW |
9 |
50,700,905 (GRCm39) |
missense |
possibly damaging |
0.62 |
R7878:Alg9
|
UTSW |
9 |
50,754,083 (GRCm39) |
missense |
probably benign |
0.00 |
R8113:Alg9
|
UTSW |
9 |
50,720,080 (GRCm39) |
nonsense |
probably null |
|
R8257:Alg9
|
UTSW |
9 |
50,690,387 (GRCm39) |
missense |
possibly damaging |
0.62 |
R9214:Alg9
|
UTSW |
9 |
50,717,545 (GRCm39) |
missense |
probably damaging |
1.00 |
R9497:Alg9
|
UTSW |
9 |
50,711,436 (GRCm39) |
missense |
probably damaging |
0.97 |
R9511:Alg9
|
UTSW |
9 |
50,717,525 (GRCm39) |
missense |
probably damaging |
1.00 |
RF003:Alg9
|
UTSW |
9 |
50,686,727 (GRCm39) |
unclassified |
probably benign |
|
RF006:Alg9
|
UTSW |
9 |
50,686,717 (GRCm39) |
unclassified |
probably benign |
|
RF058:Alg9
|
UTSW |
9 |
50,686,727 (GRCm39) |
unclassified |
probably benign |
|
Z1177:Alg9
|
UTSW |
9 |
50,699,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- TCAGACCCTTGTCACACCTG -3'
(R):5'- AGGTACAGAGGTCACATCCCAC -3'
Sequencing Primer
(F):5'- ACACCTGCTGTTCTGCGTG -3'
(R):5'- ACATGACTTCCCTTTGAGAGCAG -3'
|
Posted On |
2015-08-18 |