Incidental Mutation 'R4552:Tipin'
ID 334020
Institutional Source Beutler Lab
Gene Symbol Tipin
Ensembl Gene ENSMUSG00000032397
Gene Name timeless interacting protein
Synonyms 1110005A05Rik, 1110018P21Rik
MMRRC Submission 041783-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.528) question?
Stock # R4552 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 64188863-64212706 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 64195385 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000149833 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034964] [ENSMUST00000213165] [ENSMUST00000213165] [ENSMUST00000213289] [ENSMUST00000215031] [ENSMUST00000216594] [ENSMUST00000216594]
AlphaFold Q91WA1
Predicted Effect probably null
Transcript: ENSMUST00000034964
SMART Domains Protein: ENSMUSP00000034964
Gene: ENSMUSG00000032397

DomainStartEndE-ValueType
low complexity region 19 43 N/A INTRINSIC
Pfam:Swi3 63 143 2.8e-36 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000213165
Predicted Effect probably null
Transcript: ENSMUST00000213165
Predicted Effect probably null
Transcript: ENSMUST00000213289
Predicted Effect probably null
Transcript: ENSMUST00000215031
Predicted Effect probably null
Transcript: ENSMUST00000216594
Predicted Effect probably null
Transcript: ENSMUST00000216594
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.4%
Validation Efficiency 97% (62/64)
MGI Phenotype FUNCTION: The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM and aids in protecting cells against DNA damage and stress. [provided by RefSeq, Feb 2014]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts16 G A 13: 70,927,637 (GRCm39) probably benign Het
Arhgap33 A T 7: 30,218,533 (GRCm39) probably benign Het
Arid1a A C 4: 133,423,010 (GRCm39) probably benign Het
C4bp A G 1: 130,564,464 (GRCm39) Y407H possibly damaging Het
Camta1 T C 4: 151,876,959 (GRCm39) R79G probably damaging Het
Caskin1 G A 17: 24,725,602 (GRCm39) S1296N probably benign Het
Cep128 T C 12: 91,260,936 (GRCm39) E309G probably damaging Het
Chit1 A G 1: 134,071,789 (GRCm39) T100A probably benign Het
Dalrd3 A G 9: 108,449,429 (GRCm39) D454G possibly damaging Het
Ddx19a G A 8: 111,705,198 (GRCm39) Q308* probably null Het
Dmxl2 T C 9: 54,359,047 (GRCm39) N395S probably damaging Het
Dnah17 T C 11: 117,943,769 (GRCm39) D3125G possibly damaging Het
Dnah5 T C 15: 28,397,300 (GRCm39) V3331A probably benign Het
Dnah9 T C 11: 65,732,192 (GRCm39) E4238G probably damaging Het
Dner T C 1: 84,361,578 (GRCm39) Y677C probably damaging Het
Epgn A T 5: 91,175,421 (GRCm39) K14* probably null Het
Hid1 G A 11: 115,249,505 (GRCm39) T240M possibly damaging Het
Igbp1b T A 6: 138,635,112 (GRCm39) M111L probably benign Het
Kif26b T A 1: 178,711,600 (GRCm39) I740N probably damaging Het
Klk4 C A 7: 43,533,443 (GRCm39) H101N probably benign Het
Mrgpra2b C A 7: 47,113,754 (GRCm39) S300I probably benign Het
Mtss2 A G 8: 111,465,137 (GRCm39) T464A probably damaging Het
Nbas T C 12: 13,385,938 (GRCm39) probably null Het
Nif3l1 C T 1: 58,488,483 (GRCm39) probably benign Het
Noct T A 3: 51,157,589 (GRCm39) I309N probably benign Het
Obscn T C 11: 59,022,472 (GRCm39) R758G possibly damaging Het
Odf2l A T 3: 144,856,844 (GRCm39) T600S probably benign Het
Odf4 C T 11: 68,812,866 (GRCm39) S264N probably benign Het
Or13a17 A T 7: 140,271,655 (GRCm39) Y279F probably damaging Het
Or1m1 A G 9: 18,666,430 (GRCm39) V167A possibly damaging Het
Or2y1e A T 11: 49,218,777 (GRCm39) M180L probably benign Het
Or6c217 T C 10: 129,737,992 (GRCm39) M196V probably benign Het
Papolb T C 5: 142,514,933 (GRCm39) I237V probably benign Het
Parpbp T A 10: 87,929,564 (GRCm39) Q428L possibly damaging Het
Pclo T C 5: 14,719,285 (GRCm39) S1141P unknown Het
Plcb1 T C 2: 135,177,413 (GRCm39) S582P probably benign Het
Ppargc1a C T 5: 51,620,557 (GRCm39) probably benign Het
Ptchd4 A T 17: 42,813,346 (GRCm39) I416L probably benign Het
Rhpn1 G A 15: 75,585,968 (GRCm39) R627H probably benign Het
Ric8a G A 7: 140,441,250 (GRCm39) G182S probably damaging Het
Rims1 T C 1: 22,443,718 (GRCm39) D895G probably damaging Het
Rrp1b G A 17: 32,274,984 (GRCm39) probably benign Het
Rtf1 T A 2: 119,561,210 (GRCm39) D636E probably benign Het
Scn3a T C 2: 65,354,523 (GRCm39) D333G probably benign Het
Sema6a A G 18: 47,424,990 (GRCm39) L207P probably damaging Het
Shcbp1 A T 8: 4,799,779 (GRCm39) Y160* probably null Het
Slc27a1 A T 8: 72,032,710 (GRCm39) probably null Het
Ston2 C T 12: 91,608,646 (GRCm39) R818Q probably damaging Het
Tjap1 A T 17: 46,570,953 (GRCm39) probably null Het
Vmn1r117 A T 7: 20,617,517 (GRCm39) F177Y probably damaging Het
Vmn1r57 A G 7: 5,223,667 (GRCm39) D64G possibly damaging Het
Vmn2r73 T A 7: 85,525,055 (GRCm39) D31V probably benign Het
Vmn2r-ps41 A T 7: 9,180,063 (GRCm39) noncoding transcript Het
Other mutations in Tipin
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01457:Tipin APN 9 64,211,690 (GRCm39) missense probably benign
IGL02164:Tipin APN 9 64,201,631 (GRCm39) missense probably damaging 0.99
IGL02431:Tipin APN 9 64,208,467 (GRCm39) missense probably benign 0.42
IGL03355:Tipin APN 9 64,195,406 (GRCm39) missense probably benign 0.29
R0410:Tipin UTSW 9 64,195,397 (GRCm39) start codon destroyed probably null 1.00
R2080:Tipin UTSW 9 64,197,658 (GRCm39) nonsense probably null
R2870:Tipin UTSW 9 64,211,609 (GRCm39) missense probably benign 0.01
R2870:Tipin UTSW 9 64,211,609 (GRCm39) missense probably benign 0.01
R4553:Tipin UTSW 9 64,195,385 (GRCm39) splice site probably null
R4812:Tipin UTSW 9 64,211,694 (GRCm39) missense probably benign
R7330:Tipin UTSW 9 64,195,508 (GRCm39) missense probably benign
R8985:Tipin UTSW 9 64,195,385 (GRCm39) splice site probably null
R9224:Tipin UTSW 9 64,195,430 (GRCm39) missense probably benign 0.28
Predicted Primers PCR Primer
(F):5'- AAATCCACCTGCCTCTGCC -3'
(R):5'- AGACAGCTACAGTGCACTCATAA -3'

Sequencing Primer
(F):5'- CCCAGCACAACTCAGTTCTGATG -3'
(R):5'- ACAACTAAGCTTGGTGGCTC -3'
Posted On 2015-08-18