Incidental Mutation 'R4518:Or7d9'
ID 334074
Institutional Source Beutler Lab
Gene Symbol Or7d9
Ensembl Gene ENSMUSG00000059623
Gene Name olfactory receptor family 7 subfamily D member 9
Synonyms Olfr39, MOR144-1, GA_x6K02T2PVTD-14025733-14026668
MMRRC Submission 041762-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.085) question?
Stock # R4518 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 20193647-20197944 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 20197546 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 184 (I184V)
Ref Sequence ENSEMBL: ENSMUSP00000148572 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071725] [ENSMUST00000212983]
AlphaFold E9PVX1
Predicted Effect probably benign
Transcript: ENSMUST00000071725
AA Change: I192V

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000071641
Gene: ENSMUSG00000059623
AA Change: I192V

DomainStartEndE-ValueType
Pfam:7tm_4 39 315 1.3e-51 PFAM
Pfam:7TM_GPCR_Srsx 43 307 1e-6 PFAM
Pfam:7tm_1 49 298 3.1e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000212983
AA Change: I184V

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.9%
Validation Efficiency 98% (60/61)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110082J24Rik T A 5: 30,311,006 (GRCm39) probably null Het
Abr A G 11: 76,363,344 (GRCm39) S167P possibly damaging Het
Adamtsl2 T C 2: 26,985,559 (GRCm39) L481P probably benign Het
Atp8b3 C T 10: 80,359,681 (GRCm39) M984I probably benign Het
Brip1 G A 11: 85,968,704 (GRCm39) A827V possibly damaging Het
Carns1 T G 19: 4,220,069 (GRCm39) T389P probably benign Het
Ccdc88a T C 11: 29,432,651 (GRCm39) I1219T probably benign Het
Cckar T C 5: 53,857,264 (GRCm39) N311S probably damaging Het
Cenpc1 A G 5: 86,195,446 (GRCm39) S108P possibly damaging Het
Chpf G T 1: 75,451,689 (GRCm39) S588R probably damaging Het
Clca3a2 T A 3: 144,514,466 (GRCm39) T414S probably damaging Het
Cntrl A G 2: 35,038,986 (GRCm39) E1092G probably damaging Het
Crb2 C A 2: 37,680,401 (GRCm39) T443K probably damaging Het
Crppa G A 12: 36,523,179 (GRCm39) V203I possibly damaging Het
Cwf19l1 A G 19: 44,121,473 (GRCm39) V25A probably damaging Het
Cyb561d1 T C 3: 108,106,887 (GRCm39) I111V possibly damaging Het
Dbn1 A T 13: 55,624,042 (GRCm39) I350N possibly damaging Het
Dnajb4 T C 3: 151,890,813 (GRCm39) I329V probably benign Het
Dnmt1 G T 9: 20,823,274 (GRCm39) D1055E probably benign Het
Fam168a C T 7: 100,483,247 (GRCm39) A176V probably damaging Het
Farp2 A G 1: 93,548,363 (GRCm39) E1016G probably benign Het
Fibcd1 A T 2: 31,707,207 (GRCm39) V350E probably damaging Het
Galnt3 C A 2: 65,923,954 (GRCm39) R438L probably damaging Het
Golga4 T A 9: 118,388,076 (GRCm39) S1733T probably benign Het
Golgb1 G A 16: 36,749,625 (GRCm39) E3076K probably damaging Het
Grm7 A G 6: 110,891,507 (GRCm39) probably null Het
Hcn2 T C 10: 79,560,536 (GRCm39) V289A probably benign Het
Hipk1 G T 3: 103,657,688 (GRCm39) H799N probably damaging Het
Klf14 A G 6: 30,934,867 (GRCm39) S256P possibly damaging Het
Muc6 T A 7: 141,230,489 (GRCm39) T1214S probably benign Het
Nlrp2 T A 7: 5,328,055 (GRCm39) D666V possibly damaging Het
Ntng1 A G 3: 109,842,329 (GRCm39) I148T probably damaging Het
Or4k35 T C 2: 111,100,263 (GRCm39) M150V probably benign Het
Or7g27 T A 9: 19,250,556 (GRCm39) S267T possibly damaging Het
Orc4 G A 2: 48,827,501 (GRCm39) P31S probably benign Het
Pabir3 G A X: 52,382,376 (GRCm39) R94H possibly damaging Het
Pacs2 A G 12: 113,024,289 (GRCm39) D360G probably benign Het
Parp8 C A 13: 117,032,209 (GRCm39) L321F possibly damaging Het
Pdss2 T A 10: 43,248,146 (GRCm39) S217T probably damaging Het
Plekhn1 T C 4: 156,309,988 (GRCm39) S109G probably damaging Het
Prlr C A 15: 10,329,085 (GRCm39) T520K possibly damaging Het
Prokr2 T A 2: 132,216,012 (GRCm39) probably null Het
Rab3gap2 G A 1: 184,999,265 (GRCm39) V991I probably benign Het
Reln T C 5: 22,106,741 (GRCm39) I3210V probably benign Het
Rims2 T C 15: 39,300,922 (GRCm39) Y218H probably damaging Het
Slc41a1 T C 1: 131,766,863 (GRCm39) V127A probably damaging Het
St8sia6 T A 2: 13,797,562 (GRCm39) probably null Het
Tlr6 A G 5: 65,112,247 (GRCm39) F220S possibly damaging Het
Trmt1l C T 1: 151,324,094 (GRCm39) Q314* probably null Het
Ubqlnl C T 7: 103,798,925 (GRCm39) V191M probably benign Het
Vnn3 G A 10: 23,743,124 (GRCm39) V445M possibly damaging Het
Ypel1 A T 16: 16,913,905 (GRCm39) F173I possibly damaging Het
Zfhx4 T C 3: 5,477,578 (GRCm39) C3398R probably damaging Het
Zfyve16 T C 13: 92,657,820 (GRCm39) E697G possibly damaging Het
Other mutations in Or7d9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02173:Or7d9 APN 9 20,197,691 (GRCm39) missense probably benign 0.00
IGL02219:Or7d9 APN 9 20,197,756 (GRCm39) missense probably benign 0.45
IGL02468:Or7d9 APN 9 20,197,574 (GRCm39) missense probably damaging 1.00
IGL03024:Or7d9 APN 9 20,197,280 (GRCm39) missense probably benign 0.00
R0329:Or7d9 UTSW 9 20,197,153 (GRCm39) missense possibly damaging 0.95
R1656:Or7d9 UTSW 9 20,197,873 (GRCm39) missense probably damaging 1.00
R3116:Or7d9 UTSW 9 20,197,523 (GRCm39) missense probably benign 0.19
R7204:Or7d9 UTSW 9 20,197,100 (GRCm39) missense probably benign 0.19
R7395:Or7d9 UTSW 9 20,197,826 (GRCm39) missense probably damaging 0.99
R7775:Or7d9 UTSW 9 20,193,708 (GRCm39) start gained probably benign
R7778:Or7d9 UTSW 9 20,193,708 (GRCm39) start gained probably benign
R8439:Or7d9 UTSW 9 20,197,337 (GRCm39) nonsense probably null
R8878:Or7d9 UTSW 9 20,197,358 (GRCm39) missense probably damaging 1.00
R9669:Or7d9 UTSW 9 20,197,160 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACTGTAATGGCCTTTGACCGC -3'
(R):5'- GCTGAACTGAGGTAAACCCC -3'

Sequencing Primer
(F):5'- AATGGCCTTTGACCGCTTTGTG -3'
(R):5'- TGAACTGAGGTAAACCCCCAGTG -3'
Posted On 2015-08-18