Incidental Mutation 'R4519:Dagla'
ID 334151
Institutional Source Beutler Lab
Gene Symbol Dagla
Ensembl Gene ENSMUSG00000035735
Gene Name diacylglycerol lipase, alpha
Synonyms Nsddr
MMRRC Submission 041590-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4519 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 10222629-10282241 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 10247096 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 132 (K132E)
Ref Sequence ENSEMBL: ENSMUSP00000046358 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039327] [ENSMUST00000125567]
AlphaFold Q6WQJ1
Predicted Effect probably damaging
Transcript: ENSMUST00000039327
AA Change: K132E

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000046358
Gene: ENSMUSG00000035735
AA Change: K132E

DomainStartEndE-ValueType
transmembrane domain 21 43 N/A INTRINSIC
transmembrane domain 63 85 N/A INTRINSIC
transmembrane domain 97 119 N/A INTRINSIC
transmembrane domain 134 156 N/A INTRINSIC
Pfam:Lipase_3 394 533 1.3e-12 PFAM
low complexity region 616 625 N/A INTRINSIC
low complexity region 699 717 N/A INTRINSIC
low complexity region 793 810 N/A INTRINSIC
low complexity region 878 896 N/A INTRINSIC
low complexity region 980 1002 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000125567
SMART Domains Protein: ENSMUSP00000138702
Gene: ENSMUSG00000035735

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
transmembrane domain 63 85 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a diacylglycerol lipase. The encoded enzyme is involved in the biosynthesis of the endocannabinoid 2-arachidonoyl-glycerol.[provided by RefSeq, Nov 2010]
PHENOTYPE: Mice homozygous for null mutations have decreased body weight, adult neuronal proliferation, and nervous system endocannaboid levels and abnormal inhibitory postsynaptic currents. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921528I07Rik A G 9: 114,129,092 (GRCm39) noncoding transcript Het
Acadsb A T 7: 131,031,733 (GRCm39) T190S probably damaging Het
Adamts17 G T 7: 66,490,314 (GRCm39) G132V probably damaging Het
Atosa A G 9: 74,930,929 (GRCm39) I957M probably damaging Het
Atp8b3 C T 10: 80,359,681 (GRCm39) M984I probably benign Het
Atp8b4 A T 2: 126,256,379 (GRCm39) probably null Het
Btbd18 T C 2: 84,497,924 (GRCm39) Y521H probably damaging Het
Casd1 A G 6: 4,621,102 (GRCm39) N220S probably benign Het
Ccdc112 T G 18: 46,420,613 (GRCm39) E379A possibly damaging Het
Ccdc88a T C 11: 29,432,651 (GRCm39) I1219T probably benign Het
Cntrl A T 2: 35,063,123 (GRCm39) K1573M probably damaging Het
Col14a1 A T 15: 55,251,975 (GRCm39) I544F unknown Het
Cyp20a1 A T 1: 60,426,306 (GRCm39) Y416F probably damaging Het
Dbn1 A T 13: 55,624,042 (GRCm39) I350N possibly damaging Het
Ddx41 A T 13: 55,680,957 (GRCm39) V329E probably damaging Het
Dhx32 A T 7: 133,335,838 (GRCm39) Y272N probably damaging Het
Fam114a1 C A 5: 65,163,225 (GRCm39) P174Q probably benign Het
Galnt3 C A 2: 65,923,954 (GRCm39) R438L probably damaging Het
Ghr T A 15: 3,362,970 (GRCm39) L167F probably damaging Het
Glod4 T A 11: 76,134,397 (GRCm39) D25V probably damaging Het
Gm9767 T C 10: 25,954,756 (GRCm39) probably benign Het
Golga4 T A 9: 118,388,076 (GRCm39) S1733T probably benign Het
Gsdme A T 6: 50,206,333 (GRCm39) I170N probably damaging Het
H2-M10.3 C T 17: 36,678,722 (GRCm39) probably null Het
Kmt2c T A 5: 25,568,475 (GRCm39) K867M probably damaging Het
Krt35 A G 11: 99,985,453 (GRCm39) V196A possibly damaging Het
Ltbp1 A T 17: 75,671,492 (GRCm39) M1558L probably benign Het
Mcam T G 9: 44,052,640 (GRCm39) M623R possibly damaging Het
Mrps26 A T 2: 130,406,269 (GRCm39) Q134L probably benign Het
Mxra8 T C 4: 155,927,440 (GRCm39) probably null Het
Or13a21 A G 7: 139,999,123 (GRCm39) S188P probably damaging Het
Or52n20 G A 7: 104,320,046 (GRCm39) G46R probably damaging Het
Orc4 G A 2: 48,827,501 (GRCm39) P31S probably benign Het
Pabir3 G A X: 52,382,376 (GRCm39) R94H possibly damaging Het
Parg C A 14: 31,931,592 (GRCm39) T404K probably damaging Het
Parp8 C A 13: 117,032,209 (GRCm39) L321F possibly damaging Het
Piezo2 T C 18: 63,205,951 (GRCm39) E1486G probably damaging Het
Pign A T 1: 105,525,391 (GRCm39) probably null Het
Pik3r4 A G 9: 105,549,924 (GRCm39) H1005R probably damaging Het
Ppp6r1 A C 7: 4,644,045 (GRCm39) probably null Het
Ptdss2 A G 7: 140,734,491 (GRCm39) T309A probably benign Het
Ptprt T C 2: 161,406,609 (GRCm39) M987V probably damaging Het
Rgs17 C A 10: 5,868,192 (GRCm39) L9F probably benign Het
Rock2 A G 12: 17,027,738 (GRCm39) R168G probably damaging Het
Rsph4a T A 10: 33,787,623 (GRCm39) L593* probably null Het
Scaf11 C A 15: 96,322,719 (GRCm39) K108N probably damaging Het
Sec23b T A 2: 144,423,935 (GRCm39) M528K possibly damaging Het
Shank2 G A 7: 143,963,942 (GRCm39) D727N probably damaging Het
Sipa1l2 T C 8: 126,218,965 (GRCm39) D124G probably benign Het
Spatc1 A T 15: 76,176,685 (GRCm39) I479F probably damaging Het
Tmem126b A G 7: 90,118,316 (GRCm39) L188P probably damaging Het
Tnrc6b T G 15: 80,764,448 (GRCm39) L650W probably damaging Het
Vmn2r62 A G 7: 42,413,957 (GRCm39) F829L probably damaging Het
Other mutations in Dagla
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01484:Dagla APN 19 10,225,884 (GRCm39) missense possibly damaging 0.51
IGL01625:Dagla APN 19 10,228,566 (GRCm39) splice site probably benign
IGL01697:Dagla APN 19 10,248,562 (GRCm39) missense probably benign 0.01
IGL01940:Dagla APN 19 10,229,535 (GRCm39) missense probably benign
IGL02330:Dagla APN 19 10,225,386 (GRCm39) missense probably damaging 1.00
blondie UTSW 19 10,248,465 (GRCm39) missense probably damaging 1.00
dagwood UTSW 19 10,247,079 (GRCm39) critical splice donor site probably null
PIT4480001:Dagla UTSW 19 10,238,022 (GRCm39) missense probably benign 0.02
R0541:Dagla UTSW 19 10,232,170 (GRCm39) critical splice donor site probably null
R0610:Dagla UTSW 19 10,248,922 (GRCm39) missense probably damaging 1.00
R0638:Dagla UTSW 19 10,232,247 (GRCm39) missense probably damaging 0.97
R0653:Dagla UTSW 19 10,225,789 (GRCm39) missense probably damaging 1.00
R1675:Dagla UTSW 19 10,246,687 (GRCm39) missense probably benign 0.00
R1822:Dagla UTSW 19 10,240,550 (GRCm39) missense possibly damaging 0.94
R1830:Dagla UTSW 19 10,248,378 (GRCm39) missense probably benign 0.44
R2303:Dagla UTSW 19 10,229,467 (GRCm39) missense probably damaging 1.00
R2568:Dagla UTSW 19 10,225,516 (GRCm39) missense probably benign
R2879:Dagla UTSW 19 10,248,448 (GRCm39) missense possibly damaging 0.93
R2902:Dagla UTSW 19 10,225,467 (GRCm39) missense probably damaging 0.99
R2939:Dagla UTSW 19 10,233,728 (GRCm39) missense probably damaging 1.00
R3771:Dagla UTSW 19 10,225,831 (GRCm39) missense possibly damaging 0.89
R4176:Dagla UTSW 19 10,240,461 (GRCm39) missense probably damaging 1.00
R4255:Dagla UTSW 19 10,234,316 (GRCm39) nonsense probably null
R4584:Dagla UTSW 19 10,248,373 (GRCm39) missense probably damaging 1.00
R4586:Dagla UTSW 19 10,248,373 (GRCm39) missense probably damaging 1.00
R4614:Dagla UTSW 19 10,225,641 (GRCm39) missense probably damaging 1.00
R4751:Dagla UTSW 19 10,227,758 (GRCm39) missense probably benign 0.00
R4933:Dagla UTSW 19 10,247,079 (GRCm39) critical splice donor site probably null
R5844:Dagla UTSW 19 10,248,489 (GRCm39) missense probably damaging 1.00
R5858:Dagla UTSW 19 10,232,332 (GRCm39) intron probably benign
R5958:Dagla UTSW 19 10,225,788 (GRCm39) missense probably damaging 1.00
R6628:Dagla UTSW 19 10,240,591 (GRCm39) missense probably damaging 1.00
R6799:Dagla UTSW 19 10,234,214 (GRCm39) missense probably damaging 1.00
R7072:Dagla UTSW 19 10,233,659 (GRCm39) critical splice donor site probably null
R7253:Dagla UTSW 19 10,239,945 (GRCm39) splice site probably null
R7451:Dagla UTSW 19 10,230,719 (GRCm39) missense probably damaging 1.00
R7654:Dagla UTSW 19 10,225,570 (GRCm39) missense probably benign 0.01
R7941:Dagla UTSW 19 10,248,867 (GRCm39) missense probably damaging 0.99
R7980:Dagla UTSW 19 10,229,406 (GRCm39) missense possibly damaging 0.82
R8293:Dagla UTSW 19 10,229,401 (GRCm39) critical splice donor site probably null
R8327:Dagla UTSW 19 10,228,451 (GRCm39) missense probably benign 0.11
R8442:Dagla UTSW 19 10,248,883 (GRCm39) missense probably damaging 0.99
R8442:Dagla UTSW 19 10,240,456 (GRCm39) critical splice donor site probably null
R8717:Dagla UTSW 19 10,225,587 (GRCm39) missense probably benign 0.03
R8728:Dagla UTSW 19 10,225,771 (GRCm39) missense probably damaging 1.00
R9053:Dagla UTSW 19 10,246,615 (GRCm39) missense probably damaging 1.00
R9179:Dagla UTSW 19 10,228,525 (GRCm39) missense possibly damaging 0.83
R9275:Dagla UTSW 19 10,232,220 (GRCm39) missense probably damaging 1.00
R9387:Dagla UTSW 19 10,248,465 (GRCm39) missense probably damaging 1.00
R9489:Dagla UTSW 19 10,233,053 (GRCm39) missense probably damaging 1.00
R9498:Dagla UTSW 19 10,232,218 (GRCm39) nonsense probably null
R9539:Dagla UTSW 19 10,228,429 (GRCm39) critical splice donor site probably null
R9605:Dagla UTSW 19 10,233,053 (GRCm39) missense probably damaging 1.00
X0021:Dagla UTSW 19 10,248,528 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TGCCTGGACAGTTCTGTGTC -3'
(R):5'- CACAATGCAAGAGATCAGGC -3'

Sequencing Primer
(F):5'- ACAGTTCTGTGTCTGCTGC -3'
(R):5'- CAGCAGAGCCAGGATGAGGTTC -3'
Posted On 2015-08-18