Incidental Mutation 'R4520:Trmt13'
ID 334163
Institutional Source Beutler Lab
Gene Symbol Trmt13
Ensembl Gene ENSMUSG00000033439
Gene Name tRNA methyltransferase 13
Synonyms A930028L21Rik, Ccdc76, 4631408H19Rik
MMRRC Submission 041763-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.151) question?
Stock # R4520 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 116374742-116408236 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 116375262 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000047320 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029573] [ENSMUST00000041524] [ENSMUST00000183638] [ENSMUST00000184963] [ENSMUST00000197190]
AlphaFold Q8BYH3
Predicted Effect probably benign
Transcript: ENSMUST00000029573
SMART Domains Protein: ENSMUSP00000029573
Gene: ENSMUSG00000027961

DomainStartEndE-ValueType
LRR 105 127 1.15e1 SMART
LRR_TYP 128 151 7.26e-3 SMART
LRR 175 197 6.58e0 SMART
LRR 198 220 1e1 SMART
LRR 221 243 7.16e0 SMART
LRR 244 267 6.58e0 SMART
Predicted Effect probably null
Transcript: ENSMUST00000041524
SMART Domains Protein: ENSMUSP00000047320
Gene: ENSMUSG00000033439

DomainStartEndE-ValueType
Pfam:zf-TRM13_CCCH 17 45 7.2e-17 PFAM
Pfam:zf-U11-48K 56 80 3.4e-12 PFAM
Pfam:TRM13 165 469 7e-96 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156161
Predicted Effect probably benign
Transcript: ENSMUST00000183638
SMART Domains Protein: ENSMUSP00000139223
Gene: ENSMUSG00000033439

DomainStartEndE-ValueType
Pfam:zf-TRM13_CCCH 16 46 1.4e-17 PFAM
Pfam:zf-U11-48K 55 81 1.2e-12 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000184963
SMART Domains Protein: ENSMUSP00000138868
Gene: ENSMUSG00000033439

DomainStartEndE-ValueType
Pfam:zf-TRM13_CCCH 16 46 2.9e-17 PFAM
Pfam:zf-U11-48K 55 81 2.3e-12 PFAM
Pfam:TRM13 165 285 3.4e-42 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000197190
SMART Domains Protein: ENSMUSP00000143637
Gene: ENSMUSG00000033439

DomainStartEndE-ValueType
Pfam:TRM13 116 179 5.2e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199439
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik A G 3: 137,776,027 (GRCm39) T1739A probably damaging Het
Ascc3 A G 10: 50,536,766 (GRCm39) N700D probably benign Het
Ccdc88c G T 12: 100,879,591 (GRCm39) S1843R possibly damaging Het
Cel C T 2: 28,447,980 (GRCm39) V349M probably benign Het
Cspp1 A G 1: 10,204,452 (GRCm39) T1127A probably benign Het
Cyp2b10 T C 7: 25,610,982 (GRCm39) V113A probably benign Het
Cyp2c50 A G 19: 40,079,133 (GRCm39) T159A probably benign Het
Degs1 T C 1: 182,104,373 (GRCm39) D304G possibly damaging Het
Esr2 G A 12: 76,214,323 (GRCm39) P43S possibly damaging Het
Fbxo41 A G 6: 85,461,024 (GRCm39) I228T probably damaging Het
Gm5444 A G 13: 4,884,225 (GRCm39) noncoding transcript Het
Golga3 T A 5: 110,351,617 (GRCm39) L790* probably null Het
Gtpbp6 T C 5: 110,255,725 (GRCm39) T105A probably benign Het
Ido2 T C 8: 25,066,194 (GRCm39) E24G probably damaging Het
Ihh T A 1: 74,990,109 (GRCm39) I89F probably damaging Het
Krt13 A G 11: 100,010,174 (GRCm39) M269T probably damaging Het
Marf1 T C 16: 13,950,530 (GRCm39) H952R probably damaging Het
Mga T A 2: 119,778,579 (GRCm39) F2041L possibly damaging Het
Msmo1 A C 8: 65,173,557 (GRCm39) probably benign Het
Mterf1a A G 5: 3,940,992 (GRCm39) V292A probably damaging Het
Naxe A G 3: 87,965,289 (GRCm39) probably null Het
Ntng1 A G 3: 109,842,312 (GRCm39) S154P probably damaging Het
Or51h5 A T 7: 102,577,764 (GRCm39) I310F probably benign Het
Or56b1 T A 7: 104,285,376 (GRCm39) V165E probably damaging Het
Or8h7 T C 2: 86,721,363 (GRCm39) D52G probably benign Het
Otog T A 7: 45,890,477 (GRCm39) probably benign Het
Pigo A T 4: 43,020,301 (GRCm39) H880Q probably benign Het
Plce1 T C 19: 38,512,763 (GRCm39) S21P possibly damaging Het
Pole T A 5: 110,445,790 (GRCm39) D555E probably damaging Het
Prkag2 A G 5: 25,071,169 (GRCm39) V403A probably damaging Het
Psg28 T A 7: 18,156,826 (GRCm39) M470L probably benign Het
Rpgrip1 A G 14: 52,389,746 (GRCm39) T1138A probably benign Het
Rpl10l T C 12: 66,330,512 (GRCm39) D207G probably benign Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Serpinb9c T C 13: 33,335,840 (GRCm39) probably null Het
Sh2d6 T C 6: 72,495,936 (GRCm39) N101D possibly damaging Het
Shisa8 C G 15: 82,096,163 (GRCm39) V151L possibly damaging Het
Slc13a1 T C 6: 24,134,512 (GRCm39) T124A probably benign Het
Slc6a3 G A 13: 73,688,975 (GRCm39) V100M possibly damaging Het
Sspn A G 6: 145,907,033 (GRCm39) T79A probably benign Het
Tlr8 C T X: 166,026,171 (GRCm39) R893H probably damaging Het
Tnrc18 T C 5: 142,717,905 (GRCm39) K2183R unknown Het
Trim15 T C 17: 37,177,242 (GRCm39) I139M probably benign Het
Vmn2r84 T A 10: 130,222,391 (GRCm39) T610S probably damaging Het
Zcchc14 A T 8: 122,335,834 (GRCm39) probably benign Het
Other mutations in Trmt13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00926:Trmt13 APN 3 116,383,884 (GRCm39) nonsense probably null
IGL01516:Trmt13 APN 3 116,383,459 (GRCm39) unclassified probably benign
IGL01732:Trmt13 APN 3 116,375,113 (GRCm39) missense probably damaging 1.00
IGL01783:Trmt13 APN 3 116,376,561 (GRCm39) nonsense probably null
IGL02470:Trmt13 APN 3 116,383,877 (GRCm39) critical splice donor site probably null
IGL02492:Trmt13 APN 3 116,376,192 (GRCm39) missense possibly damaging 0.53
IGL02531:Trmt13 APN 3 116,385,840 (GRCm39) critical splice donor site probably null
IGL03156:Trmt13 APN 3 116,379,451 (GRCm39) missense probably benign 0.00
R0394:Trmt13 UTSW 3 116,376,299 (GRCm39) missense probably damaging 1.00
R0446:Trmt13 UTSW 3 116,376,275 (GRCm39) missense probably damaging 1.00
R2211:Trmt13 UTSW 3 116,388,403 (GRCm39) missense probably benign 0.00
R2942:Trmt13 UTSW 3 116,379,421 (GRCm39) missense probably damaging 1.00
R3124:Trmt13 UTSW 3 116,383,893 (GRCm39) missense probably benign 0.00
R3945:Trmt13 UTSW 3 116,375,167 (GRCm39) missense probably damaging 1.00
R3946:Trmt13 UTSW 3 116,375,167 (GRCm39) missense probably damaging 1.00
R4255:Trmt13 UTSW 3 116,376,337 (GRCm39) nonsense probably null
R4609:Trmt13 UTSW 3 116,388,476 (GRCm39) utr 5 prime probably benign
R4678:Trmt13 UTSW 3 116,383,404 (GRCm39) missense probably damaging 1.00
R4679:Trmt13 UTSW 3 116,383,404 (GRCm39) missense probably damaging 1.00
R4703:Trmt13 UTSW 3 116,388,247 (GRCm39) missense probably benign 0.00
R6526:Trmt13 UTSW 3 116,385,864 (GRCm39) missense probably damaging 1.00
R7064:Trmt13 UTSW 3 116,376,346 (GRCm39) missense probably damaging 1.00
R7079:Trmt13 UTSW 3 116,376,480 (GRCm39) missense probably benign 0.00
R7308:Trmt13 UTSW 3 116,388,388 (GRCm39) missense probably benign 0.09
R8347:Trmt13 UTSW 3 116,376,417 (GRCm39) missense probably benign 0.00
R8491:Trmt13 UTSW 3 116,376,228 (GRCm39) missense probably benign
R8544:Trmt13 UTSW 3 116,386,094 (GRCm39) splice site probably null
R9108:Trmt13 UTSW 3 116,375,129 (GRCm39) missense probably damaging 1.00
R9208:Trmt13 UTSW 3 116,376,356 (GRCm39) missense possibly damaging 0.95
R9492:Trmt13 UTSW 3 116,388,281 (GRCm39) missense probably benign 0.10
Predicted Primers PCR Primer
(F):5'- TTTCCTGCGATGACGGATGAG -3'
(R):5'- GTCTTTTGGCTGAGATCAAGTATAC -3'

Sequencing Primer
(F):5'- CGATGACGGATGAGCTGGTAC -3'
(R):5'- GGTGGCTCACAACCATCTGTAATG -3'
Posted On 2015-08-18