Incidental Mutation 'R4523:Vmn2r97'
ID 334330
Institutional Source Beutler Lab
Gene Symbol Vmn2r97
Ensembl Gene ENSMUSG00000091491
Gene Name vomeronasal 2, receptor 97
Synonyms EG627367
MMRRC Submission 042004-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.071) question?
Stock # R4523 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 19134584-19168333 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 19149333 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 240 (N240K)
Ref Sequence ENSEMBL: ENSMUSP00000156141 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168710] [ENSMUST00000232219]
AlphaFold K7N6Z2
Predicted Effect probably benign
Transcript: ENSMUST00000168710
AA Change: N240K

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000129313
Gene: ENSMUSG00000091491
AA Change: N240K

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:ANF_receptor 82 442 2.9e-36 PFAM
Pfam:NCD3G 513 566 4.9e-21 PFAM
Pfam:7tm_3 599 834 1.7e-52 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000232219
AA Change: N240K

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000232325
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency 100% (61/61)
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp8a1 G T 5: 67,824,943 (GRCm39) T796K probably benign Het
Atr T C 9: 95,744,916 (GRCm39) S78P probably damaging Het
Calb2 C T 8: 110,875,141 (GRCm39) probably null Het
Ccdc88c G T 12: 100,879,591 (GRCm39) S1843R possibly damaging Het
Cdca7 A G 2: 72,310,042 (GRCm39) S77G probably damaging Het
Cfap47 A T X: 78,553,601 (GRCm39) N291K possibly damaging Het
Cnot2 C T 10: 116,417,379 (GRCm39) probably benign Het
Cstf2t T A 19: 31,060,482 (GRCm39) V6D possibly damaging Het
Cybc1 A G 11: 121,114,934 (GRCm39) probably benign Het
Dido1 T C 2: 180,314,085 (GRCm39) I852V probably damaging Het
Dmgdh C T 13: 93,825,138 (GRCm39) Q154* probably null Het
Dnah12 T C 14: 26,491,979 (GRCm39) F1138S probably damaging Het
Dnah12 G A 14: 26,598,915 (GRCm39) A998T possibly damaging Het
Dusp5 T G 19: 53,526,032 (GRCm39) Y225D probably damaging Het
Fam193a G A 5: 34,600,715 (GRCm39) D601N probably benign Het
Fbxo41 A G 6: 85,461,024 (GRCm39) I228T probably damaging Het
Fmo2 T C 1: 162,715,277 (GRCm39) K115R probably benign Het
Gak G T 5: 108,724,432 (GRCm39) Q1093K probably benign Het
Gm5277 G T 3: 78,799,493 (GRCm39) noncoding transcript Het
Hgsnat A G 8: 26,458,389 (GRCm39) probably null Het
Hycc1 T C 5: 24,170,120 (GRCm39) T410A probably benign Het
Irag1 T C 7: 110,523,048 (GRCm39) M338V probably benign Het
Map3k3 G A 11: 106,039,694 (GRCm39) R278H probably damaging Het
Muc4 T C 16: 32,555,154 (GRCm39) probably benign Het
Nectin3 C A 16: 46,268,953 (GRCm39) R483L probably benign Het
Nop2 G T 6: 125,110,515 (GRCm39) R47L probably damaging Het
Ntng1 A G 3: 109,842,312 (GRCm39) S154P probably damaging Het
Olfml2b T C 1: 170,496,791 (GRCm39) I474T probably benign Het
Optc G T 1: 133,831,492 (GRCm39) T138K possibly damaging Het
Or7g25 T C 9: 19,160,525 (GRCm39) T57A probably damaging Het
Or8k22 C G 2: 86,163,644 (GRCm39) D19H probably benign Het
Orc4 G A 2: 48,827,501 (GRCm39) P31S probably benign Het
Pabir3 G A X: 52,382,376 (GRCm39) R94H possibly damaging Het
Pard3 C T 8: 128,125,108 (GRCm39) P421S probably benign Het
Pcdhb22 G T 18: 37,653,474 (GRCm39) E647D probably benign Het
Pclo A G 5: 14,730,006 (GRCm39) probably benign Het
Prkce G T 17: 86,798,178 (GRCm39) probably null Het
Prr12 T C 7: 44,697,947 (GRCm39) D656G unknown Het
Ptprk A T 10: 28,342,048 (GRCm39) D485V probably damaging Het
Ptprn2 T C 12: 116,839,620 (GRCm39) L381P probably damaging Het
Rnf144b T C 13: 47,361,013 (GRCm39) I51T probably benign Het
Rpl10l T C 12: 66,330,512 (GRCm39) D207G probably benign Het
Sh3glb2 A T 2: 30,240,711 (GRCm39) V118E probably damaging Het
Sipa1l2 C T 8: 126,219,163 (GRCm39) G58D probably damaging Het
Slc5a4a C T 10: 75,984,196 (GRCm39) A46V probably damaging Het
Spmip8 T A 8: 96,039,638 (GRCm39) Y18* probably null Het
Tgm7 C A 2: 120,929,069 (GRCm39) probably null Het
Tjap1 A G 17: 46,569,718 (GRCm39) V424A probably benign Het
Trpm6 A T 19: 18,773,864 (GRCm39) I414F probably damaging Het
Tsr3 C G 17: 25,460,723 (GRCm39) D196E probably benign Het
Ubqlnl C T 7: 103,798,925 (GRCm39) V191M probably benign Het
Vmn2r72 T A 7: 85,401,134 (GRCm39) H95L probably benign Het
Xdh C A 17: 74,205,339 (GRCm39) G1042V probably damaging Het
Zcchc4 A G 5: 52,941,409 (GRCm39) D68G probably damaging Het
Other mutations in Vmn2r97
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00897:Vmn2r97 APN 17 19,167,921 (GRCm39) missense probably benign 0.37
IGL00962:Vmn2r97 APN 17 19,149,490 (GRCm39) missense probably damaging 1.00
IGL01704:Vmn2r97 APN 17 19,168,073 (GRCm39) missense probably damaging 0.99
IGL01888:Vmn2r97 APN 17 19,149,286 (GRCm39) nonsense probably null
IGL02429:Vmn2r97 APN 17 19,150,596 (GRCm39) missense possibly damaging 0.94
IGL02742:Vmn2r97 APN 17 19,149,432 (GRCm39) missense probably damaging 0.97
IGL02934:Vmn2r97 APN 17 19,149,947 (GRCm39) missense probably benign 0.00
IGL02978:Vmn2r97 APN 17 19,168,298 (GRCm39) missense probably benign 0.01
IGL03230:Vmn2r97 APN 17 19,149,668 (GRCm39) missense probably benign 0.10
IGL03241:Vmn2r97 APN 17 19,148,438 (GRCm39) missense probably benign 0.11
IGL03050:Vmn2r97 UTSW 17 19,167,900 (GRCm39) missense possibly damaging 0.84
PIT4469001:Vmn2r97 UTSW 17 19,149,878 (GRCm39) missense probably benign 0.00
R0482:Vmn2r97 UTSW 17 19,167,930 (GRCm39) missense probably damaging 1.00
R0514:Vmn2r97 UTSW 17 19,134,734 (GRCm39) missense probably benign 0.25
R0944:Vmn2r97 UTSW 17 19,167,665 (GRCm39) missense probably benign 0.13
R1061:Vmn2r97 UTSW 17 19,148,440 (GRCm39) nonsense probably null
R1546:Vmn2r97 UTSW 17 19,168,110 (GRCm39) missense probably damaging 1.00
R1725:Vmn2r97 UTSW 17 19,149,397 (GRCm39) missense probably benign 0.43
R1860:Vmn2r97 UTSW 17 19,167,648 (GRCm39) missense probably benign 0.01
R1938:Vmn2r97 UTSW 17 19,149,593 (GRCm39) missense probably benign 0.01
R1944:Vmn2r97 UTSW 17 19,160,500 (GRCm39) missense probably benign 0.00
R2027:Vmn2r97 UTSW 17 19,149,944 (GRCm39) missense unknown
R2106:Vmn2r97 UTSW 17 19,168,100 (GRCm39) missense probably damaging 1.00
R2151:Vmn2r97 UTSW 17 19,167,584 (GRCm39) nonsense probably null
R2153:Vmn2r97 UTSW 17 19,167,584 (GRCm39) nonsense probably null
R2154:Vmn2r97 UTSW 17 19,167,584 (GRCm39) nonsense probably null
R2516:Vmn2r97 UTSW 17 19,167,814 (GRCm39) missense probably benign
R3739:Vmn2r97 UTSW 17 19,148,413 (GRCm39) missense probably damaging 1.00
R3744:Vmn2r97 UTSW 17 19,149,890 (GRCm39) missense probably benign
R3885:Vmn2r97 UTSW 17 19,148,596 (GRCm39) missense possibly damaging 0.90
R3899:Vmn2r97 UTSW 17 19,167,873 (GRCm39) missense probably damaging 0.96
R4115:Vmn2r97 UTSW 17 19,148,332 (GRCm39) missense probably benign 0.01
R4247:Vmn2r97 UTSW 17 19,167,542 (GRCm39) missense possibly damaging 0.83
R4287:Vmn2r97 UTSW 17 19,168,337 (GRCm39) intron probably benign
R4439:Vmn2r97 UTSW 17 19,150,616 (GRCm39) missense probably benign 0.00
R4783:Vmn2r97 UTSW 17 19,149,550 (GRCm39) missense probably benign
R4948:Vmn2r97 UTSW 17 19,167,561 (GRCm39) missense possibly damaging 0.95
R4981:Vmn2r97 UTSW 17 19,160,436 (GRCm39) nonsense probably null
R5029:Vmn2r97 UTSW 17 19,168,173 (GRCm39) missense probably damaging 1.00
R5200:Vmn2r97 UTSW 17 19,148,615 (GRCm39) missense probably damaging 1.00
R5541:Vmn2r97 UTSW 17 19,148,617 (GRCm39) nonsense probably null
R5637:Vmn2r97 UTSW 17 19,167,628 (GRCm39) nonsense probably null
R5765:Vmn2r97 UTSW 17 19,167,442 (GRCm39) nonsense probably null
R5885:Vmn2r97 UTSW 17 19,168,035 (GRCm39) missense possibly damaging 0.50
R6272:Vmn2r97 UTSW 17 19,167,861 (GRCm39) missense possibly damaging 0.70
R6553:Vmn2r97 UTSW 17 19,150,566 (GRCm39) nonsense probably null
R6818:Vmn2r97 UTSW 17 19,168,193 (GRCm39) missense possibly damaging 0.95
R6880:Vmn2r97 UTSW 17 19,134,770 (GRCm39) missense probably benign 0.00
R7012:Vmn2r97 UTSW 17 19,167,756 (GRCm39) missense probably damaging 0.99
R7023:Vmn2r97 UTSW 17 19,134,663 (GRCm39) missense probably damaging 1.00
R7044:Vmn2r97 UTSW 17 19,134,629 (GRCm39) missense probably benign 0.05
R7191:Vmn2r97 UTSW 17 19,150,548 (GRCm39) missense probably damaging 1.00
R7503:Vmn2r97 UTSW 17 19,148,470 (GRCm39) missense probably benign
R7862:Vmn2r97 UTSW 17 19,167,416 (GRCm39) missense probably damaging 1.00
R7876:Vmn2r97 UTSW 17 19,149,326 (GRCm39) missense probably damaging 0.97
R7890:Vmn2r97 UTSW 17 19,149,802 (GRCm39) missense probably benign 0.00
R7936:Vmn2r97 UTSW 17 19,150,662 (GRCm39) missense probably damaging 1.00
R7978:Vmn2r97 UTSW 17 19,167,854 (GRCm39) missense probably damaging 1.00
R8405:Vmn2r97 UTSW 17 19,134,802 (GRCm39) critical splice donor site probably null
R8755:Vmn2r97 UTSW 17 19,168,104 (GRCm39) missense probably damaging 1.00
R8790:Vmn2r97 UTSW 17 19,160,472 (GRCm39) missense probably damaging 1.00
R8850:Vmn2r97 UTSW 17 19,149,607 (GRCm39) missense probably benign 0.00
R9060:Vmn2r97 UTSW 17 19,134,585 (GRCm39) start codon destroyed probably null 0.94
R9079:Vmn2r97 UTSW 17 19,149,640 (GRCm39) missense probably benign
R9252:Vmn2r97 UTSW 17 19,167,849 (GRCm39) missense probably benign 0.00
R9278:Vmn2r97 UTSW 17 19,134,762 (GRCm39) missense probably benign 0.00
R9342:Vmn2r97 UTSW 17 19,149,368 (GRCm39) missense probably benign
R9422:Vmn2r97 UTSW 17 19,149,333 (GRCm39) missense probably benign 0.03
R9496:Vmn2r97 UTSW 17 19,149,227 (GRCm39) missense probably damaging 1.00
R9571:Vmn2r97 UTSW 17 19,149,919 (GRCm39) missense probably benign
R9601:Vmn2r97 UTSW 17 19,134,770 (GRCm39) missense probably benign
R9672:Vmn2r97 UTSW 17 19,149,442 (GRCm39) missense probably benign 0.00
R9773:Vmn2r97 UTSW 17 19,168,221 (GRCm39) missense probably benign 0.01
R9795:Vmn2r97 UTSW 17 19,167,561 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GACCGTGGTCAATATCCTTATCTC -3'
(R):5'- GCTCCCATGGAATGAGTCTAAC -3'

Sequencing Primer
(F):5'- AATATCCTTATCTCTACCAGATGGC -3'
(R):5'- TGTTCATGATCCAGACATTCCATG -3'
Posted On 2015-08-18