Incidental Mutation 'R0218:Mrgprx3-ps'
ID 33658
Institutional Source Beutler Lab
Gene Symbol Mrgprx3-ps
Ensembl Gene ENSMUSG00000099560
Gene Name MAS-related GPR, member X3, pseudogene
Synonyms LOC269919, Gm660, Gm19419
MMRRC Submission 038467-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.189) question?
Stock # R0218 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 46959126-46960043 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 46959154 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 279 (E279G)
Ref Sequence ENSEMBL: ENSMUSP00000136396 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000179005]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000179005
AA Change: E279G

PolyPhen 2 Score 0.873 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000136396
Gene: ENSMUSG00000074111
AA Change: E279G

DomainStartEndE-ValueType
Pfam:7tm_1 12 178 3.4e-9 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000187741
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.2%
  • 10x: 96.0%
  • 20x: 91.7%
Validation Efficiency 98% (53/54)
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam34l T G 8: 44,079,477 (GRCm39) Q249P probably benign Het
Adgrv1 C T 13: 81,255,017 (GRCm39) probably null Het
Ccdc110 A G 8: 46,387,761 (GRCm39) probably benign Het
Cd200r1 T A 16: 44,609,106 (GRCm39) probably benign Het
Cdkl1 A T 12: 69,836,809 (GRCm39) D40E probably benign Het
Cdx1 A G 18: 61,153,436 (GRCm39) probably benign Het
Cenpp T A 13: 49,801,108 (GRCm39) K103N possibly damaging Het
Cep162 A G 9: 87,093,862 (GRCm39) Y839H possibly damaging Het
Chac1 T A 2: 119,183,941 (GRCm39) L181* probably null Het
Ciapin1 G T 8: 95,554,938 (GRCm39) Q173K probably damaging Het
Cmklr2 T A 1: 63,222,690 (GRCm39) N182Y probably benign Het
Dgcr2 A G 16: 17,667,650 (GRCm39) C270R probably damaging Het
Dlc1 A G 8: 37,317,383 (GRCm39) S431P probably benign Het
Efcab12 T C 6: 115,791,611 (GRCm39) probably benign Het
Ehbp1 A T 11: 22,181,992 (GRCm39) probably benign Het
Enpp3 A T 10: 24,652,767 (GRCm39) V730D possibly damaging Het
Fam174b A G 7: 73,390,512 (GRCm39) T88A probably benign Het
Fancl A G 11: 26,421,337 (GRCm39) K364E probably benign Het
Fbp2 A T 13: 63,001,862 (GRCm39) F118I probably damaging Het
Galc A G 12: 98,188,906 (GRCm39) Y402H probably damaging Het
Gga2 T C 7: 121,598,123 (GRCm39) N324D possibly damaging Het
Hc G T 2: 34,918,086 (GRCm39) F732L probably damaging Het
Heca T C 10: 17,791,463 (GRCm39) M198V probably benign Het
Herc6 C A 6: 57,596,586 (GRCm39) H509N probably benign Het
Irf2bpl A T 12: 86,929,398 (GRCm39) M425K probably benign Het
Mael C T 1: 166,066,159 (GRCm39) G26D probably damaging Het
Map1a A G 2: 121,135,906 (GRCm39) T2241A probably benign Het
Mcc C G 18: 44,652,583 (GRCm39) probably benign Het
Mdga2 A G 12: 66,701,894 (GRCm39) S505P probably damaging Het
Mdm1 A G 10: 117,992,783 (GRCm39) probably benign Het
Mex3b A T 7: 82,518,312 (GRCm39) E209V probably damaging Het
Ms4a20 A T 19: 11,093,801 (GRCm39) Y10* probably null Het
Nfe2l1 A T 11: 96,718,439 (GRCm39) L32Q probably damaging Het
Npas1 C T 7: 16,195,818 (GRCm39) V285I probably benign Het
Or5e1 T A 7: 108,354,781 (GRCm39) C239* probably null Het
Or5h19 C T 16: 58,856,456 (GRCm39) V215I probably benign Het
Or9i14 T C 19: 13,792,342 (GRCm39) N204S probably benign Het
Osr1 A G 12: 9,629,639 (GRCm39) T171A probably benign Het
Ppp3cb A T 14: 20,574,044 (GRCm39) C265S probably damaging Het
Pramel27 A G 4: 143,578,401 (GRCm39) I220M probably damaging Het
Sephs1 A G 2: 4,904,371 (GRCm39) T250A probably benign Het
Simc1 T C 13: 54,674,417 (GRCm39) Y922H probably damaging Het
Slc25a39 A G 11: 102,297,056 (GRCm39) F56L probably benign Het
Smg8 A G 11: 86,976,948 (GRCm39) L211P probably damaging Het
Sncaip A G 18: 53,040,400 (GRCm39) S805G probably benign Het
Sra1 T C 18: 36,809,662 (GRCm39) probably benign Het
Tas2r104 T G 6: 131,662,055 (GRCm39) D218A probably damaging Het
Unc45b A G 11: 82,802,686 (GRCm39) probably benign Het
Unc79 A G 12: 103,075,040 (GRCm39) probably null Het
Washc2 T A 6: 116,225,007 (GRCm39) L785* probably null Het
Zfp30 A G 7: 29,493,063 (GRCm39) E439G probably damaging Het
Zfp518a A G 19: 40,901,072 (GRCm39) T334A probably benign Het
Other mutations in Mrgprx3-ps
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01629:Mrgprx3-ps APN 7 46,959,353 (GRCm39) nonsense probably null 0.00
IGL01919:Mrgprx3-ps APN 7 46,959,959 (GRCm39) missense probably benign 0.00
IGL02455:Mrgprx3-ps APN 7 46,959,263 (GRCm39) exon noncoding transcript
R0308:Mrgprx3-ps UTSW 7 46,959,766 (GRCm39) missense probably benign 0.25
R4003:Mrgprx3-ps UTSW 7 46,959,959 (GRCm39) missense probably benign 0.00
R4274:Mrgprx3-ps UTSW 7 46,959,574 (GRCm39) exon noncoding transcript
R4411:Mrgprx3-ps UTSW 7 46,959,746 (GRCm39) exon noncoding transcript
R4413:Mrgprx3-ps UTSW 7 46,959,746 (GRCm39) exon noncoding transcript
R5254:Mrgprx3-ps UTSW 7 46,959,184 (GRCm39) exon noncoding transcript
Predicted Primers PCR Primer
(F):5'- AAGGTGTTGGTAGACCACTGAGGC -3'
(R):5'- CGTGACCATCATGCTGACCATTTTG -3'

Sequencing Primer
(F):5'- ACCTCTGAAATCCAGGCAGA -3'
(R):5'- CTGGTTCCTGTTATCCAAGATTAAG -3'
Posted On 2013-05-09