Incidental Mutation 'R4556:Lxn'
ID 341859
Institutional Source Beutler Lab
Gene Symbol Lxn
Ensembl Gene ENSMUSG00000047557
Gene Name latexin
Synonyms
MMRRC Submission 041597-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.217) question?
Stock # R4556 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 67365332-67371240 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 67365953 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 182 (I182F)
Ref Sequence ENSEMBL: ENSMUSP00000060732 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058981] [ENSMUST00000077271]
AlphaFold P70202
PDB Structure Crystal structure of mouse Latexin (tissue carboxypeptidase inhibitor) [X-RAY DIFFRACTION]
Predicted Effect possibly damaging
Transcript: ENSMUST00000058981
AA Change: I182F

PolyPhen 2 Score 0.950 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000060732
Gene: ENSMUSG00000047557
AA Change: I182F

DomainStartEndE-ValueType
Pfam:Latexin 3 219 8.7e-99 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000077271
SMART Domains Protein: ENSMUSP00000076503
Gene: ENSMUSG00000027774

DomainStartEndE-ValueType
Pfam:GTP_EFTU 45 320 3.5e-65 PFAM
Pfam:GTP_EFTU_D2 366 432 6e-18 PFAM
Pfam:EFG_II 446 520 1.9e-31 PFAM
EFG_IV 522 642 1.64e-47 SMART
EFG_C 644 731 2.16e-24 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160202
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160529
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160827
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161009
SMART Domains Protein: ENSMUSP00000125161
Gene: ENSMUSG00000027774

DomainStartEndE-ValueType
Pfam:GTP_EFTU 45 320 3.4e-63 PFAM
Pfam:GTP_EFTU_D2 366 432 4.1e-18 PFAM
Pfam:EFG_II 446 520 4.4e-33 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases. [provided by RefSeq, Oct 2008]
PHENOTYPE: Mice homozygous for a targeted null mutation display reduced sensitivity to acute thermal pain, which can be reversed by exogenous carboxypeptidase inhibitor. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A830005F24Rik T C 13: 48,667,937 (GRCm39) probably benign Het
Adamts16 G A 13: 70,927,637 (GRCm39) probably benign Het
Adamts17 A T 7: 66,677,641 (GRCm39) E518D probably damaging Het
Cdk5rap2 A G 4: 70,157,549 (GRCm39) S1601P probably damaging Het
Erc2 A C 14: 28,024,861 (GRCm39) D580A probably damaging Het
Fbxo4 A G 15: 3,995,187 (GRCm39) *386R probably null Het
Fbxo42 T A 4: 140,926,321 (GRCm39) H334Q probably damaging Het
Gdf5 A G 2: 155,783,782 (GRCm39) R24G probably benign Het
Lama3 G T 18: 12,612,816 (GRCm39) R1200L possibly damaging Het
Mbd5 G A 2: 49,169,406 (GRCm39) G1526R probably damaging Het
Mcub G A 3: 129,709,384 (GRCm39) Q310* probably null Het
Ndufaf7 T C 17: 79,249,516 (GRCm39) S138P probably benign Het
Nktr A G 9: 121,570,189 (GRCm39) T90A probably damaging Het
Nr1h5 G A 3: 102,853,457 (GRCm39) A350V probably benign Het
Or1e29 G A 11: 73,667,307 (GRCm39) T282I possibly damaging Het
Or7e174 T C 9: 20,012,619 (GRCm39) L188P possibly damaging Het
Pros1 A G 16: 62,721,036 (GRCm39) K197R possibly damaging Het
Rmnd5b G T 11: 51,517,732 (GRCm39) probably null Het
Rnf25 A T 1: 74,638,264 (GRCm39) I26N probably damaging Het
Scn4a T C 11: 106,211,272 (GRCm39) I1582V probably benign Het
Sh2d3c A G 2: 32,643,021 (GRCm39) T583A possibly damaging Het
Sh3tc1 T C 5: 35,864,426 (GRCm39) Y587C probably damaging Het
Slc6a11 A G 6: 114,221,773 (GRCm39) S488G probably benign Het
Smim22 T A 16: 4,825,730 (GRCm39) F38L possibly damaging Het
Stab2 T G 10: 86,803,543 (GRCm39) E335D possibly damaging Het
Tas2r102 T C 6: 132,739,878 (GRCm39) F262S probably damaging Het
Thap12 A G 7: 98,365,052 (GRCm39) N407D probably benign Het
Tmem225 T C 9: 40,060,762 (GRCm39) F107S probably damaging Het
Vmn1r229 T A 17: 21,034,953 (GRCm39) V66E possibly damaging Het
Vmn1r27 A G 6: 58,192,804 (GRCm39) S67P possibly damaging Het
Xrcc4 A T 13: 90,140,623 (GRCm39) H195Q probably benign Het
Other mutations in Lxn
AlleleSourceChrCoordTypePredicted EffectPPH Score
PIT4791001:Lxn UTSW 3 67,365,979 (GRCm39) missense probably damaging 1.00
R0568:Lxn UTSW 3 67,368,335 (GRCm39) missense probably damaging 1.00
R7000:Lxn UTSW 3 67,369,704 (GRCm39) missense probably benign 0.00
R9090:Lxn UTSW 3 67,368,651 (GRCm39) missense probably damaging 1.00
R9271:Lxn UTSW 3 67,368,651 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGGATGATACACTTCGACTTGG -3'
(R):5'- TGCCATTACTGACACTAGGGTTC -3'

Sequencing Primer
(F):5'- GGTGCCTGTCTTAACTGTCAGTAAC -3'
(R):5'- CAGTAATGCTTTTAAATAGCTGCCAC -3'
Posted On 2015-09-24