Incidental Mutation 'R4572:Zmym1'
ID 342184
Institutional Source Beutler Lab
Gene Symbol Zmym1
Ensembl Gene ENSMUSG00000043872
Gene Name zinc finger, MYM domain containing 1
Synonyms 5830412B09Rik
MMRRC Submission 041796-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.211) question?
Stock # R4572 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 126940887-126954945 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 126944628 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 186 (N186K)
Ref Sequence ENSEMBL: ENSMUSP00000101708 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055013] [ENSMUST00000106099] [ENSMUST00000106102] [ENSMUST00000136186]
AlphaFold Q3TJB1
Predicted Effect probably benign
Transcript: ENSMUST00000055013
AA Change: N186K

PolyPhen 2 Score 0.394 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000050669
Gene: ENSMUSG00000043872
AA Change: N186K

DomainStartEndE-ValueType
Pfam:zf-FCS 6 46 2.4e-8 PFAM
Pfam:zf-FCS 53 96 1.6e-10 PFAM
low complexity region 155 168 N/A INTRINSIC
low complexity region 229 243 N/A INTRINSIC
Pfam:DUF4371 335 569 4.9e-55 PFAM
Pfam:Dimer_Tnp_hAT 870 959 5.1e-18 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000106099
AA Change: N186K
SMART Domains Protein: ENSMUSP00000101705
Gene: ENSMUSG00000043872
AA Change: N186K

DomainStartEndE-ValueType
Pfam:zf-FCS 6 46 3.3e-9 PFAM
Pfam:zf-FCS 53 96 4.6e-10 PFAM
low complexity region 155 168 N/A INTRINSIC
Pfam:DUF4371 237 471 2.8e-52 PFAM
Pfam:Dimer_Tnp_hAT 772 861 5.3e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000106102
AA Change: N186K

PolyPhen 2 Score 0.394 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000101708
Gene: ENSMUSG00000043872
AA Change: N186K

DomainStartEndE-ValueType
Pfam:zf-FCS 6 46 7.8e-9 PFAM
Pfam:zf-FCS 53 96 1.1e-9 PFAM
low complexity region 155 168 N/A INTRINSIC
low complexity region 229 243 N/A INTRINSIC
Pfam:DUF4371 335 569 7.4e-52 PFAM
Pfam:Dimer_Tnp_hAT 870 959 1.7e-17 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000117934
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124429
Predicted Effect probably benign
Transcript: ENSMUST00000136186
SMART Domains Protein: ENSMUSP00000120772
Gene: ENSMUSG00000043872

DomainStartEndE-ValueType
Pfam:zf-FCS 6 46 1.5e-10 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152607
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137236
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140605
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency 100% (71/71)
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca6 A T 11: 110,107,374 (GRCm39) I747N probably benign Het
Adamtsl2 A G 2: 26,973,268 (GRCm39) Y97C probably damaging Het
Alox12e A G 11: 70,212,007 (GRCm39) probably benign Het
Alpk2 A T 18: 65,414,075 (GRCm39) S2014T probably damaging Het
Ankrd36 A T 11: 5,639,340 (GRCm39) probably null Het
Apobec1 T C 6: 122,558,356 (GRCm39) D133G probably damaging Het
Arfgef1 A T 1: 10,283,366 (GRCm39) I181N probably damaging Het
Cilp2 A G 8: 70,335,060 (GRCm39) V646A probably damaging Het
Clasrp A G 7: 19,318,389 (GRCm39) probably null Het
Cnot2 T C 10: 116,330,751 (GRCm39) T423A probably benign Het
Crtap T C 9: 114,213,874 (GRCm39) D227G probably benign Het
Cyp17a1 A G 19: 46,658,990 (GRCm39) F217S probably damaging Het
Ddx60 A G 8: 62,440,455 (GRCm39) M1036V probably damaging Het
Dnah11 A T 12: 117,973,860 (GRCm39) I2818N probably benign Het
Dok6 T A 18: 89,492,071 (GRCm39) I169F possibly damaging Het
Duox2 T A 2: 122,112,207 (GRCm39) R1326S probably benign Het
Epha10 A G 4: 124,796,361 (GRCm39) T357A unknown Het
Ephb2 A C 4: 136,383,251 (GRCm39) F942C probably damaging Het
Fscn3 T A 6: 28,430,634 (GRCm39) probably null Het
Gabrb2 A G 11: 42,484,744 (GRCm39) N267S possibly damaging Het
Gabrr3 A T 16: 59,282,001 (GRCm39) Y452F probably benign Het
Gen1 A G 12: 11,292,419 (GRCm39) S457P probably damaging Het
Gm1993 C T X: 25,515,656 (GRCm39) R77H probably damaging Het
Gm5592 G A 7: 40,865,583 (GRCm39) probably benign Het
Hmbox1 A G 14: 65,140,682 (GRCm39) probably null Het
Hus1 A T 11: 8,957,617 (GRCm39) probably null Het
Ino80 G A 2: 119,232,839 (GRCm39) R1160W probably damaging Het
Kalrn A T 16: 34,212,412 (GRCm39) F27L probably damaging Het
Kri1 A T 9: 21,191,680 (GRCm39) F187L probably damaging Het
Lekr1 A T 3: 65,691,336 (GRCm39) noncoding transcript Het
Mapk15 T C 15: 75,870,599 (GRCm39) probably benign Het
Mrgpre G A 7: 143,334,841 (GRCm39) L221F probably damaging Het
Mrpl50 A T 4: 49,514,399 (GRCm39) S91T possibly damaging Het
Muc4 T C 16: 32,753,802 (GRCm38) I1226T probably benign Het
Mup15 A G 4: 61,356,454 (GRCm39) probably null Het
Ncapd3 A G 9: 27,005,911 (GRCm39) D1469G probably damaging Het
Nlrp9b G A 7: 19,760,606 (GRCm39) probably null Het
Npy6r A T 18: 44,408,984 (GRCm39) Y135F probably benign Het
Or7e170 A C 9: 19,795,275 (GRCm39) C109G probably benign Het
Phf14 G A 6: 12,006,823 (GRCm39) R825Q probably damaging Het
Pigg A G 5: 108,480,751 (GRCm39) M379V probably benign Het
Plppr3 T A 10: 79,701,897 (GRCm39) Q315L probably benign Het
Plxnd1 C A 6: 115,932,717 (GRCm39) C1921F probably damaging Het
Ptger4 A C 15: 5,272,614 (GRCm39) S2A probably benign Het
Qrfprl A T 6: 65,431,975 (GRCm39) M293L probably benign Het
Rab4a A T 8: 124,560,799 (GRCm39) D196V probably benign Het
Rbck1 G A 2: 152,160,653 (GRCm39) Q428* probably null Het
Rgs14 A T 13: 55,527,875 (GRCm39) N266I probably damaging Het
Serpina1c A T 12: 103,864,967 (GRCm39) probably benign Het
Sesn3 G A 9: 14,232,516 (GRCm39) R263H probably benign Het
Slfn1 A T 11: 83,012,289 (GRCm39) D135V probably benign Het
Spata17 T C 1: 186,926,193 (GRCm39) K46E possibly damaging Het
Srcin1 A C 11: 97,425,760 (GRCm39) D432E probably damaging Het
Stxbp5 T C 10: 9,713,888 (GRCm39) E217G probably damaging Het
Terf2ip A G 8: 112,738,649 (GRCm39) D179G probably damaging Het
Tll1 A G 8: 64,509,343 (GRCm39) F556L possibly damaging Het
Tmed4 CTCTTTCT CTCT 11: 6,224,461 (GRCm39) probably null Het
Trappc9 G T 15: 72,808,916 (GRCm39) Q537K possibly damaging Het
Trim30a G T 7: 104,060,395 (GRCm39) C460* probably null Het
Trim35 T C 14: 66,545,322 (GRCm39) Y298H probably damaging Het
Ugt3a1 T A 15: 9,306,479 (GRCm39) H209Q probably benign Het
Ulk4 T C 9: 121,021,830 (GRCm39) K627R probably damaging Het
Wnk1 T C 6: 119,928,872 (GRCm39) T1319A possibly damaging Het
Wnt9b G A 11: 103,622,981 (GRCm39) R141C probably damaging Het
Zfp735 A G 11: 73,580,611 (GRCm39) M37V probably benign Het
Other mutations in Zmym1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01140:Zmym1 APN 4 126,943,435 (GRCm39) missense probably damaging 1.00
IGL02326:Zmym1 APN 4 126,941,553 (GRCm39) missense probably damaging 1.00
IGL02392:Zmym1 APN 4 126,942,256 (GRCm39) missense probably damaging 1.00
IGL02431:Zmym1 APN 4 126,941,557 (GRCm39) nonsense probably null
IGL02512:Zmym1 APN 4 126,942,465 (GRCm39) missense probably damaging 1.00
IGL03303:Zmym1 APN 4 126,942,927 (GRCm39) missense probably damaging 1.00
BB009:Zmym1 UTSW 4 126,944,578 (GRCm39) missense possibly damaging 0.77
BB019:Zmym1 UTSW 4 126,944,578 (GRCm39) missense possibly damaging 0.77
R0195:Zmym1 UTSW 4 126,941,704 (GRCm39) missense possibly damaging 0.85
R0266:Zmym1 UTSW 4 126,941,818 (GRCm39) missense possibly damaging 0.86
R0416:Zmym1 UTSW 4 126,952,613 (GRCm39) missense probably benign 0.00
R1374:Zmym1 UTSW 4 126,943,404 (GRCm39) missense probably damaging 1.00
R1480:Zmym1 UTSW 4 126,942,405 (GRCm39) missense probably damaging 0.99
R1704:Zmym1 UTSW 4 126,942,177 (GRCm39) missense probably damaging 1.00
R1806:Zmym1 UTSW 4 126,941,872 (GRCm39) missense probably damaging 1.00
R1815:Zmym1 UTSW 4 126,942,814 (GRCm39) missense possibly damaging 0.76
R2124:Zmym1 UTSW 4 126,943,363 (GRCm39) missense probably benign 0.05
R2169:Zmym1 UTSW 4 126,947,996 (GRCm39) splice site probably null
R4027:Zmym1 UTSW 4 126,943,672 (GRCm39) missense probably benign 0.08
R4410:Zmym1 UTSW 4 126,941,897 (GRCm39) nonsense probably null
R4788:Zmym1 UTSW 4 126,948,090 (GRCm39) missense probably benign 0.10
R5120:Zmym1 UTSW 4 126,945,230 (GRCm39) splice site probably null
R5130:Zmym1 UTSW 4 126,942,451 (GRCm39) missense probably damaging 1.00
R5615:Zmym1 UTSW 4 126,943,191 (GRCm39) missense probably damaging 1.00
R6190:Zmym1 UTSW 4 126,941,677 (GRCm39) missense probably damaging 0.99
R7426:Zmym1 UTSW 4 126,943,191 (GRCm39) missense possibly damaging 0.81
R7464:Zmym1 UTSW 4 126,952,728 (GRCm39) nonsense probably null
R7540:Zmym1 UTSW 4 126,942,550 (GRCm39) missense probably benign
R7779:Zmym1 UTSW 4 126,948,038 (GRCm39) missense probably benign
R7807:Zmym1 UTSW 4 126,941,667 (GRCm39) missense probably damaging 1.00
R7876:Zmym1 UTSW 4 126,941,496 (GRCm39) missense probably damaging 0.98
R7932:Zmym1 UTSW 4 126,944,578 (GRCm39) missense possibly damaging 0.77
R8183:Zmym1 UTSW 4 126,952,649 (GRCm39) missense probably benign 0.07
R8276:Zmym1 UTSW 4 126,948,051 (GRCm39) missense probably damaging 0.99
R8744:Zmym1 UTSW 4 126,945,165 (GRCm39) missense probably damaging 1.00
R8798:Zmym1 UTSW 4 126,943,664 (GRCm39) missense possibly damaging 0.90
R9199:Zmym1 UTSW 4 126,944,623 (GRCm39) missense possibly damaging 0.80
R9385:Zmym1 UTSW 4 126,952,683 (GRCm39) missense probably damaging 1.00
T0722:Zmym1 UTSW 4 126,943,466 (GRCm39) missense probably benign 0.05
T0722:Zmym1 UTSW 4 126,942,043 (GRCm39) missense probably benign 0.01
T0722:Zmym1 UTSW 4 126,941,740 (GRCm39) missense probably benign 0.00
T0975:Zmym1 UTSW 4 126,943,466 (GRCm39) missense probably benign 0.05
T0975:Zmym1 UTSW 4 126,942,043 (GRCm39) missense probably benign 0.01
T0975:Zmym1 UTSW 4 126,941,740 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CTGTCGAGACAAATGAAAGCAC -3'
(R):5'- ATGCCCACCAGGTGTTATG -3'

Sequencing Primer
(F):5'- CACTTTAATAGCACCATAAGCTCATG -3'
(R):5'- TATGGTGGGCAAGCATTCTCCC -3'
Posted On 2015-09-24