Incidental Mutation 'R4576:Pde4dip'
| ID |
342448 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pde4dip
|
| Ensembl Gene |
ENSMUSG00000038170 |
| Gene Name |
phosphodiesterase 4D interacting protein (myomegalin) |
| Synonyms |
Usmg4, D3Bwg1078e, D130016K21Rik, 9430063L05Rik, 4732458A06Rik |
| MMRRC Submission |
041799-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R4576 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
97597144-97796023 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 97661565 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Aspartic acid
at position 657
(E657D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000040905
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000045243]
[ENSMUST00000090750]
[ENSMUST00000107038]
[ENSMUST00000168438]
[ENSMUST00000175751]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000045243
AA Change: E657D
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000040905
Gene: ENSMUSG00000038170
AA Change: E657D
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
72 |
90 |
N/A |
INTRINSIC |
|
low complexity region
|
159 |
170 |
N/A |
INTRINSIC |
|
coiled coil region
|
399 |
451 |
N/A |
INTRINSIC |
|
SCOP:d1gw5a_
|
613 |
839 |
3e-3 |
SMART |
|
coiled coil region
|
909 |
985 |
N/A |
INTRINSIC |
|
low complexity region
|
1081 |
1099 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000090750
AA Change: E614D
PolyPhen 2
Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000088254
Gene: ENSMUSG00000038170
AA Change: E614D
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
10 |
40 |
N/A |
INTRINSIC |
|
low complexity region
|
45 |
57 |
N/A |
INTRINSIC |
|
Pfam:Cnn_1N
|
124 |
196 |
3.2e-26 |
PFAM |
|
low complexity region
|
204 |
219 |
N/A |
INTRINSIC |
|
coiled coil region
|
282 |
325 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
397 |
438 |
4.03e-5 |
PROSPERO |
|
low complexity region
|
567 |
578 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
617 |
667 |
6.59e-5 |
PROSPERO |
|
internal_repeat_1
|
620 |
661 |
4.03e-5 |
PROSPERO |
|
coiled coil region
|
866 |
942 |
N/A |
INTRINSIC |
|
low complexity region
|
1038 |
1056 |
N/A |
INTRINSIC |
|
low complexity region
|
1067 |
1082 |
N/A |
INTRINSIC |
|
coiled coil region
|
1118 |
1163 |
N/A |
INTRINSIC |
|
coiled coil region
|
1336 |
1363 |
N/A |
INTRINSIC |
|
low complexity region
|
1403 |
1420 |
N/A |
INTRINSIC |
|
coiled coil region
|
1470 |
1508 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
1597 |
1644 |
6.59e-5 |
PROSPERO |
|
DUF1220
|
1680 |
1747 |
1.17e-17 |
SMART |
|
low complexity region
|
1758 |
1780 |
N/A |
INTRINSIC |
|
low complexity region
|
1836 |
1851 |
N/A |
INTRINSIC |
|
low complexity region
|
1860 |
1874 |
N/A |
INTRINSIC |
|
low complexity region
|
1940 |
1951 |
N/A |
INTRINSIC |
|
coiled coil region
|
1962 |
2138 |
N/A |
INTRINSIC |
|
coiled coil region
|
2162 |
2197 |
N/A |
INTRINSIC |
|
coiled coil region
|
2387 |
2431 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000107038
AA Change: E560D
PolyPhen 2
Score 0.083 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000102653
Gene: ENSMUSG00000038170
AA Change: E560D
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Microtub_assoc
|
70 |
144 |
7.8e-32 |
PFAM |
|
low complexity region
|
150 |
165 |
N/A |
INTRINSIC |
|
coiled coil region
|
228 |
271 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
343 |
384 |
5.54e-5 |
PROSPERO |
|
low complexity region
|
513 |
524 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
566 |
607 |
5.54e-5 |
PROSPERO |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000168438
AA Change: E614D
PolyPhen 2
Score 0.613 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000131170
Gene: ENSMUSG00000038170
AA Change: E614D
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
10 |
40 |
N/A |
INTRINSIC |
|
low complexity region
|
45 |
57 |
N/A |
INTRINSIC |
|
Pfam:Microtub_assoc
|
124 |
198 |
1.4e-31 |
PFAM |
|
low complexity region
|
204 |
219 |
N/A |
INTRINSIC |
|
coiled coil region
|
282 |
325 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
397 |
438 |
3.56e-5 |
PROSPERO |
|
low complexity region
|
567 |
578 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
617 |
667 |
5.83e-5 |
PROSPERO |
|
internal_repeat_1
|
620 |
661 |
3.56e-5 |
PROSPERO |
|
coiled coil region
|
866 |
942 |
N/A |
INTRINSIC |
|
low complexity region
|
1038 |
1056 |
N/A |
INTRINSIC |
|
low complexity region
|
1067 |
1082 |
N/A |
INTRINSIC |
|
coiled coil region
|
1118 |
1163 |
N/A |
INTRINSIC |
|
coiled coil region
|
1336 |
1363 |
N/A |
INTRINSIC |
|
low complexity region
|
1403 |
1420 |
N/A |
INTRINSIC |
|
coiled coil region
|
1470 |
1508 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
1597 |
1644 |
5.83e-5 |
PROSPERO |
|
DUF1220
|
1680 |
1747 |
1.17e-17 |
SMART |
|
low complexity region
|
1758 |
1769 |
N/A |
INTRINSIC |
|
low complexity region
|
1785 |
1800 |
N/A |
INTRINSIC |
|
low complexity region
|
1809 |
1823 |
N/A |
INTRINSIC |
|
low complexity region
|
1889 |
1900 |
N/A |
INTRINSIC |
|
coiled coil region
|
1911 |
2087 |
N/A |
INTRINSIC |
|
coiled coil region
|
2111 |
2146 |
N/A |
INTRINSIC |
|
coiled coil region
|
2336 |
2380 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000175751
|
| SMART Domains |
Protein: ENSMUSP00000134832
Gene: ENSMUSG00000038170
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:zf-AD
|
4 |
78 |
4.3e-8 |
PFAM |
|
low complexity region
|
159 |
170 |
N/A |
INTRINSIC |
|
coiled coil region
|
399 |
451 |
N/A |
INTRINSIC |
|
coiled coil region
|
513 |
538 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.2%
|
| Validation Efficiency |
98% (84/86) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene serves to anchor phosphodiesterase 4D to the Golgi/centrosome region of the cell. Defects in this gene may be a cause of myeloproliferative disorder (MBD) associated with eosinophilia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]
PHENOTYPE: Mice homozygous for a null allele exhibit partial (in utero or perinatal) lethality, hyperactivity, and increased vertical activity. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 78 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adhfe1 |
A |
T |
1: 9,623,979 (GRCm39) |
D160V |
probably damaging |
Het |
| Ano9 |
T |
C |
7: 140,684,051 (GRCm39) |
Q538R |
probably damaging |
Het |
| Atp4a |
A |
G |
7: 30,417,147 (GRCm39) |
D510G |
probably benign |
Het |
| Atp8a1 |
T |
C |
5: 67,973,158 (GRCm39) |
|
probably benign |
Het |
| Auts2 |
C |
T |
5: 132,287,773 (GRCm39) |
G70E |
probably benign |
Het |
| C7 |
A |
G |
15: 5,032,238 (GRCm39) |
S658P |
probably damaging |
Het |
| Cdh9 |
T |
C |
15: 16,832,325 (GRCm39) |
V404A |
possibly damaging |
Het |
| Cfap54 |
C |
T |
10: 92,879,090 (GRCm39) |
|
probably null |
Het |
| Chml |
G |
T |
1: 175,514,506 (GRCm39) |
Q129K |
probably damaging |
Het |
| Chst2 |
T |
C |
9: 95,287,224 (GRCm39) |
H374R |
probably damaging |
Het |
| Cimip2a |
T |
C |
2: 25,110,300 (GRCm39) |
S71P |
probably benign |
Het |
| Cirbp |
A |
G |
10: 80,006,075 (GRCm39) |
K84E |
probably damaging |
Het |
| Cln6 |
G |
T |
9: 62,746,231 (GRCm39) |
Q23H |
probably benign |
Het |
| Cntn5 |
A |
G |
9: 9,673,297 (GRCm39) |
M801T |
probably benign |
Het |
| Dapk1 |
A |
T |
13: 60,869,636 (GRCm39) |
M293L |
probably benign |
Het |
| Ddx11 |
A |
G |
17: 66,457,721 (GRCm39) |
K869E |
probably damaging |
Het |
| Ddx17 |
A |
T |
15: 79,425,347 (GRCm39) |
M108K |
probably benign |
Het |
| Dnaaf5 |
C |
A |
5: 139,171,394 (GRCm39) |
A557D |
probably damaging |
Het |
| Ecpas |
A |
T |
4: 58,834,708 (GRCm39) |
|
probably benign |
Het |
| Edil3 |
T |
C |
13: 89,467,850 (GRCm39) |
Y452H |
probably damaging |
Het |
| Elfn1 |
T |
C |
5: 139,957,808 (GRCm39) |
S271P |
probably benign |
Het |
| Enah |
G |
A |
1: 181,747,128 (GRCm39) |
S298L |
possibly damaging |
Het |
| Exoc7 |
T |
C |
11: 116,180,009 (GRCm39) |
*685W |
probably null |
Het |
| Fgfbp1 |
C |
T |
5: 44,136,806 (GRCm39) |
R162H |
probably benign |
Het |
| Foxj3 |
A |
G |
4: 119,478,860 (GRCm39) |
S439G |
unknown |
Het |
| Fzd9 |
A |
G |
5: 135,279,166 (GRCm39) |
S240P |
probably damaging |
Het |
| Gin1 |
A |
G |
1: 97,720,064 (GRCm39) |
D442G |
probably damaging |
Het |
| Gm10804 |
C |
T |
2: 93,299,014 (GRCm39) |
|
noncoding transcript |
Het |
| Grhl3 |
G |
T |
4: 135,288,562 (GRCm39) |
T41K |
probably damaging |
Het |
| H6pd |
A |
T |
4: 150,078,933 (GRCm39) |
D243E |
probably damaging |
Het |
| Heatr6 |
T |
A |
11: 83,655,826 (GRCm39) |
S306T |
probably benign |
Het |
| Hkdc1 |
T |
C |
10: 62,221,622 (GRCm39) |
D812G |
possibly damaging |
Het |
| Hmcn1 |
G |
T |
1: 150,610,238 (GRCm39) |
T1477K |
probably benign |
Het |
| Ift80 |
A |
G |
3: 68,857,863 (GRCm39) |
S261P |
possibly damaging |
Het |
| Kcnu1 |
A |
T |
8: 26,380,048 (GRCm39) |
D424V |
probably benign |
Het |
| Kctd1 |
A |
G |
18: 15,140,757 (GRCm39) |
S658P |
probably damaging |
Het |
| Klk12 |
A |
G |
7: 43,422,667 (GRCm39) |
D198G |
probably damaging |
Het |
| Kntc1 |
T |
G |
5: 123,904,018 (GRCm39) |
L345R |
probably damaging |
Het |
| Llph-ps2 |
A |
G |
X: 13,084,690 (GRCm39) |
|
noncoding transcript |
Het |
| Lpxn |
T |
C |
19: 12,810,654 (GRCm39) |
I366T |
probably benign |
Het |
| Lrp1 |
ACAGGCGC |
AC |
10: 127,376,057 (GRCm39) |
|
probably benign |
Het |
| Maml3 |
G |
A |
3: 51,763,927 (GRCm39) |
Q346* |
probably null |
Het |
| Mef2a |
T |
C |
7: 66,890,187 (GRCm39) |
N131S |
probably benign |
Het |
| Mlc1 |
G |
A |
15: 88,858,740 (GRCm39) |
T136M |
probably damaging |
Het |
| Mplkipl1 |
C |
T |
19: 61,164,364 (GRCm39) |
G24R |
unknown |
Het |
| Pcdhga9 |
A |
C |
18: 37,870,881 (GRCm39) |
N237H |
probably damaging |
Het |
| Pknox2 |
A |
G |
9: 36,834,844 (GRCm39) |
|
probably benign |
Het |
| Plcb3 |
C |
T |
19: 6,936,415 (GRCm39) |
|
probably benign |
Het |
| Plxnd1 |
G |
A |
6: 115,945,005 (GRCm39) |
A99V |
probably benign |
Het |
| Pnpla2 |
T |
C |
7: 141,037,257 (GRCm39) |
S87P |
probably damaging |
Het |
| Ppp1r14c |
G |
T |
10: 3,316,912 (GRCm39) |
K82N |
probably damaging |
Het |
| Pum3 |
G |
A |
19: 27,393,308 (GRCm39) |
T389M |
probably benign |
Het |
| Pxdn |
A |
T |
12: 30,061,922 (GRCm39) |
T1165S |
probably benign |
Het |
| Rasgrf2 |
T |
C |
13: 92,044,529 (GRCm39) |
D925G |
possibly damaging |
Het |
| Samhd1 |
A |
T |
2: 156,943,670 (GRCm39) |
C615S |
probably damaging |
Het |
| Sec16a |
A |
T |
2: 26,321,131 (GRCm39) |
Y1320* |
probably null |
Het |
| Slco6b1 |
T |
A |
1: 96,916,422 (GRCm39) |
|
noncoding transcript |
Het |
| Slitrk6 |
C |
A |
14: 110,987,602 (GRCm39) |
V702F |
probably benign |
Het |
| Spata31d1b |
C |
A |
13: 59,864,675 (GRCm39) |
H608N |
probably damaging |
Het |
| Spef1l |
A |
G |
7: 139,558,043 (GRCm39) |
I51T |
probably damaging |
Het |
| Srpra |
T |
C |
9: 35,125,904 (GRCm39) |
I394T |
possibly damaging |
Het |
| Svop |
C |
T |
5: 114,203,743 (GRCm39) |
V13M |
probably damaging |
Het |
| Tacc3 |
T |
A |
5: 33,818,841 (GRCm39) |
|
probably benign |
Het |
| Tango2 |
A |
T |
16: 18,119,392 (GRCm39) |
D146E |
probably damaging |
Het |
| Thbs1 |
G |
A |
2: 117,949,897 (GRCm39) |
R624Q |
probably damaging |
Het |
| Tmem161a |
T |
C |
8: 70,634,713 (GRCm39) |
|
probably null |
Het |
| Tmem175 |
A |
G |
5: 108,792,468 (GRCm39) |
D248G |
possibly damaging |
Het |
| Traf3ip2 |
A |
G |
10: 39,510,650 (GRCm39) |
N308D |
probably damaging |
Het |
| Trim30b |
T |
C |
7: 104,006,538 (GRCm39) |
Y106C |
possibly damaging |
Het |
| Trip11 |
G |
A |
12: 101,852,499 (GRCm39) |
Q521* |
probably null |
Het |
| Tssk5 |
C |
T |
15: 76,256,668 (GRCm39) |
R280Q |
probably benign |
Het |
| Ttc16 |
A |
T |
2: 32,660,071 (GRCm39) |
F246I |
probably benign |
Het |
| Unc79 |
T |
C |
12: 102,968,062 (GRCm39) |
|
probably benign |
Het |
| Vmn1r74 |
A |
G |
7: 11,580,696 (GRCm39) |
|
probably null |
Het |
| Vmn2r16 |
A |
T |
5: 109,511,665 (GRCm39) |
Y624F |
possibly damaging |
Het |
| Zc3h4 |
G |
A |
7: 16,168,579 (GRCm39) |
R896H |
unknown |
Het |
| Zfp941 |
T |
A |
7: 140,391,503 (GRCm39) |
K619* |
probably null |
Het |
| Zfp970 |
A |
T |
2: 177,167,473 (GRCm39) |
H349L |
probably damaging |
Het |
|
| Other mutations in Pde4dip |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00332:Pde4dip
|
APN |
3 |
97,674,593 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00543:Pde4dip
|
APN |
3 |
97,664,940 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL00979:Pde4dip
|
APN |
3 |
97,655,074 (GRCm39) |
splice site |
probably benign |
|
|
IGL01483:Pde4dip
|
APN |
3 |
97,661,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02122:Pde4dip
|
APN |
3 |
97,674,737 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02398:Pde4dip
|
APN |
3 |
97,674,097 (GRCm39) |
missense |
probably benign |
|
|
IGL02814:Pde4dip
|
APN |
3 |
97,674,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02826:Pde4dip
|
APN |
3 |
97,674,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
D3080:Pde4dip
|
UTSW |
3 |
97,674,146 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0077:Pde4dip
|
UTSW |
3 |
97,660,442 (GRCm39) |
nonsense |
probably null |
|
|
R0096:Pde4dip
|
UTSW |
3 |
97,674,783 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0277:Pde4dip
|
UTSW |
3 |
97,751,028 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0304:Pde4dip
|
UTSW |
3 |
97,751,028 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0616:Pde4dip
|
UTSW |
3 |
97,654,849 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0676:Pde4dip
|
UTSW |
3 |
97,624,413 (GRCm39) |
splice site |
probably benign |
|
|
R1166:Pde4dip
|
UTSW |
3 |
97,620,512 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1376:Pde4dip
|
UTSW |
3 |
97,650,533 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1376:Pde4dip
|
UTSW |
3 |
97,650,533 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1452:Pde4dip
|
UTSW |
3 |
97,631,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1550:Pde4dip
|
UTSW |
3 |
97,627,020 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1700:Pde4dip
|
UTSW |
3 |
97,610,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1704:Pde4dip
|
UTSW |
3 |
97,661,576 (GRCm39) |
missense |
probably benign |
0.28 |
|
R1769:Pde4dip
|
UTSW |
3 |
97,603,246 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1934:Pde4dip
|
UTSW |
3 |
97,600,007 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R1980:Pde4dip
|
UTSW |
3 |
97,664,312 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R2088:Pde4dip
|
UTSW |
3 |
97,661,749 (GRCm39) |
missense |
probably null |
1.00 |
|
R2143:Pde4dip
|
UTSW |
3 |
97,795,835 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R2149:Pde4dip
|
UTSW |
3 |
97,700,152 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R2156:Pde4dip
|
UTSW |
3 |
97,631,534 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2158:Pde4dip
|
UTSW |
3 |
97,664,937 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2240:Pde4dip
|
UTSW |
3 |
97,631,480 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2249:Pde4dip
|
UTSW |
3 |
97,700,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2256:Pde4dip
|
UTSW |
3 |
97,625,500 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2680:Pde4dip
|
UTSW |
3 |
97,608,933 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R2921:Pde4dip
|
UTSW |
3 |
97,626,885 (GRCm39) |
missense |
probably benign |
|
|
R3407:Pde4dip
|
UTSW |
3 |
97,661,784 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3736:Pde4dip
|
UTSW |
3 |
97,631,427 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3787:Pde4dip
|
UTSW |
3 |
97,622,868 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3883:Pde4dip
|
UTSW |
3 |
97,620,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4437:Pde4dip
|
UTSW |
3 |
97,673,885 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R4528:Pde4dip
|
UTSW |
3 |
97,624,338 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4600:Pde4dip
|
UTSW |
3 |
97,603,260 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4653:Pde4dip
|
UTSW |
3 |
97,674,654 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4678:Pde4dip
|
UTSW |
3 |
97,602,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4679:Pde4dip
|
UTSW |
3 |
97,602,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4688:Pde4dip
|
UTSW |
3 |
97,750,993 (GRCm39) |
nonsense |
probably null |
|
|
R4770:Pde4dip
|
UTSW |
3 |
97,674,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4841:Pde4dip
|
UTSW |
3 |
97,700,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4842:Pde4dip
|
UTSW |
3 |
97,700,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4899:Pde4dip
|
UTSW |
3 |
97,616,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4914:Pde4dip
|
UTSW |
3 |
97,622,644 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4943:Pde4dip
|
UTSW |
3 |
97,662,827 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5131:Pde4dip
|
UTSW |
3 |
97,616,830 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5408:Pde4dip
|
UTSW |
3 |
97,704,052 (GRCm39) |
missense |
probably benign |
0.35 |
|
R5583:Pde4dip
|
UTSW |
3 |
97,654,892 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R5677:Pde4dip
|
UTSW |
3 |
97,748,964 (GRCm39) |
nonsense |
probably null |
|
|
R5689:Pde4dip
|
UTSW |
3 |
97,599,683 (GRCm39) |
nonsense |
probably null |
|
|
R5696:Pde4dip
|
UTSW |
3 |
97,616,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5860:Pde4dip
|
UTSW |
3 |
97,631,504 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R6279:Pde4dip
|
UTSW |
3 |
97,606,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6341:Pde4dip
|
UTSW |
3 |
97,602,227 (GRCm39) |
missense |
probably benign |
|
|
R6440:Pde4dip
|
UTSW |
3 |
97,674,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6464:Pde4dip
|
UTSW |
3 |
97,617,660 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6489:Pde4dip
|
UTSW |
3 |
97,662,907 (GRCm39) |
nonsense |
probably null |
|
|
R6706:Pde4dip
|
UTSW |
3 |
97,648,709 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6722:Pde4dip
|
UTSW |
3 |
97,625,555 (GRCm39) |
nonsense |
probably null |
|
|
R6798:Pde4dip
|
UTSW |
3 |
97,795,850 (GRCm39) |
missense |
probably benign |
|
|
R6804:Pde4dip
|
UTSW |
3 |
97,700,564 (GRCm39) |
nonsense |
probably null |
|
|
R6862:Pde4dip
|
UTSW |
3 |
97,674,340 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R6957:Pde4dip
|
UTSW |
3 |
97,731,649 (GRCm39) |
splice site |
probably null |
|
|
R6983:Pde4dip
|
UTSW |
3 |
97,625,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7014:Pde4dip
|
UTSW |
3 |
97,622,738 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7025:Pde4dip
|
UTSW |
3 |
97,631,499 (GRCm39) |
nonsense |
probably null |
|
|
R7136:Pde4dip
|
UTSW |
3 |
97,601,379 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7178:Pde4dip
|
UTSW |
3 |
97,622,946 (GRCm39) |
missense |
probably benign |
0.26 |
|
R7269:Pde4dip
|
UTSW |
3 |
97,674,275 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7283:Pde4dip
|
UTSW |
3 |
97,666,198 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7354:Pde4dip
|
UTSW |
3 |
97,626,646 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7357:Pde4dip
|
UTSW |
3 |
97,622,857 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7360:Pde4dip
|
UTSW |
3 |
97,625,632 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7371:Pde4dip
|
UTSW |
3 |
97,664,587 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7432:Pde4dip
|
UTSW |
3 |
97,602,408 (GRCm39) |
missense |
probably benign |
|
|
R7536:Pde4dip
|
UTSW |
3 |
97,664,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7542:Pde4dip
|
UTSW |
3 |
97,673,971 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R7609:Pde4dip
|
UTSW |
3 |
97,622,881 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7650:Pde4dip
|
UTSW |
3 |
97,606,423 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7800:Pde4dip
|
UTSW |
3 |
97,622,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7846:Pde4dip
|
UTSW |
3 |
97,622,490 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7918:Pde4dip
|
UTSW |
3 |
97,622,539 (GRCm39) |
nonsense |
probably null |
|
|
R8120:Pde4dip
|
UTSW |
3 |
97,614,254 (GRCm39) |
missense |
probably null |
0.94 |
|
R8139:Pde4dip
|
UTSW |
3 |
97,604,309 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8144:Pde4dip
|
UTSW |
3 |
97,622,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8177:Pde4dip
|
UTSW |
3 |
97,674,848 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8294:Pde4dip
|
UTSW |
3 |
97,674,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8406:Pde4dip
|
UTSW |
3 |
97,606,428 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8911:Pde4dip
|
UTSW |
3 |
97,650,917 (GRCm39) |
missense |
probably benign |
0.22 |
|
R8912:Pde4dip
|
UTSW |
3 |
97,617,633 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8960:Pde4dip
|
UTSW |
3 |
97,700,464 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8993:Pde4dip
|
UTSW |
3 |
97,673,810 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9031:Pde4dip
|
UTSW |
3 |
97,599,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9032:Pde4dip
|
UTSW |
3 |
97,601,385 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9085:Pde4dip
|
UTSW |
3 |
97,601,385 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9103:Pde4dip
|
UTSW |
3 |
97,749,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9163:Pde4dip
|
UTSW |
3 |
97,659,123 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9182:Pde4dip
|
UTSW |
3 |
97,602,314 (GRCm39) |
missense |
probably benign |
0.13 |
|
R9185:Pde4dip
|
UTSW |
3 |
97,666,132 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9286:Pde4dip
|
UTSW |
3 |
97,607,183 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9357:Pde4dip
|
UTSW |
3 |
97,625,645 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9415:Pde4dip
|
UTSW |
3 |
97,660,468 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R9500:Pde4dip
|
UTSW |
3 |
97,795,896 (GRCm39) |
missense |
unknown |
|
|
R9595:Pde4dip
|
UTSW |
3 |
97,602,207 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9689:Pde4dip
|
UTSW |
3 |
97,649,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9720:Pde4dip
|
UTSW |
3 |
97,603,287 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTGAAGGCTTCAGGAGTGAG -3'
(R):5'- TTCTTGAGAAATTGCGGCAAC -3'
Sequencing Primer
(F):5'- CTTCAGGAGTGAGGAGAGTAGGC -3'
(R):5'- TACAAGACCGAGCTGTTGC -3'
|
| Posted On |
2015-09-24 |
Incidental Mutation