Incidental Mutation 'R4589:Lzic'
ID 342664
Institutional Source Beutler Lab
Gene Symbol Lzic
Ensembl Gene ENSMUSG00000028990
Gene Name leucine zipper and CTNNBIP1 domain containing
Synonyms 1810030J04Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.185) question?
Stock # R4589 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 149569686-149581125 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 149572561 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Phenylalanine at position 50 (L50F)
Ref Sequence ENSEMBL: ENSMUSP00000116150 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030842] [ENSMUST00000030845] [ENSMUST00000105693] [ENSMUST00000119921] [ENSMUST00000124413] [ENSMUST00000126896] [ENSMUST00000141293] [ENSMUST00000210722] [ENSMUST00000229840]
AlphaFold Q8K3C3
Predicted Effect possibly damaging
Transcript: ENSMUST00000030842
AA Change: L50F

PolyPhen 2 Score 0.937 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000030842
Gene: ENSMUSG00000028990
AA Change: L50F

DomainStartEndE-ValueType
coiled coil region 2 63 N/A INTRINSIC
Pfam:ICAT 113 188 5.7e-36 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000030845
SMART Domains Protein: ENSMUSP00000030845
Gene: ENSMUSG00000028992

DomainStartEndE-ValueType
Pfam:CTP_transf_2 12 230 2.5e-34 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000105693
SMART Domains Protein: ENSMUSP00000101318
Gene: ENSMUSG00000028992

DomainStartEndE-ValueType
Pfam:CTP_transf_like 12 230 9.5e-32 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000119921
SMART Domains Protein: ENSMUSP00000113156
Gene: ENSMUSG00000028992

DomainStartEndE-ValueType
Pfam:CTP_transf_2 12 140 9.8e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000122947
Predicted Effect probably damaging
Transcript: ENSMUST00000124413
AA Change: L50F

PolyPhen 2 Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000116150
Gene: ENSMUSG00000028990
AA Change: L50F

DomainStartEndE-ValueType
SCOP:d1lxa__ 11 56 7e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000126896
Predicted Effect possibly damaging
Transcript: ENSMUST00000141293
AA Change: L50F

PolyPhen 2 Score 0.917 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000119294
Gene: ENSMUSG00000028990
AA Change: L50F

DomainStartEndE-ValueType
SCOP:d1lxa__ 11 61 1e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138464
Predicted Effect noncoding transcript
Transcript: ENSMUST00000146427
Predicted Effect probably benign
Transcript: ENSMUST00000210722
Predicted Effect probably benign
Transcript: ENSMUST00000229840
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc1 G T 16: 14,211,895 (GRCm39) V157L probably benign Het
Actn1 G A 12: 80,218,573 (GRCm39) T737I possibly damaging Het
Ada T C 2: 163,574,868 (GRCm39) K90E possibly damaging Het
Ap2b1 T A 11: 83,223,837 (GRCm39) L184* probably null Het
Arfgef3 T C 10: 18,521,947 (GRCm39) D693G probably damaging Het
Arid4a A T 12: 71,116,738 (GRCm39) I277F probably damaging Het
Armh4 A G 14: 50,011,039 (GRCm39) S223P probably damaging Het
Ccdc171 A G 4: 83,467,855 (GRCm39) S67G probably benign Het
Ccr5 T A 9: 123,924,539 (GRCm39) F47L probably benign Het
Clip4 T A 17: 72,117,862 (GRCm39) C302* probably null Het
Cyth1 C T 11: 118,075,811 (GRCm39) V142I possibly damaging Het
Ddx59 T A 1: 136,367,480 (GRCm39) probably null Het
Def6 G T 17: 28,447,121 (GRCm39) R584L probably benign Het
Dnah7c C A 1: 46,553,743 (GRCm39) Y340* probably null Het
Eif2ak4 T G 2: 118,247,819 (GRCm39) C173W probably damaging Het
Gm14403 C T 2: 177,200,428 (GRCm39) H125Y probably benign Het
Grk3 T C 5: 113,089,584 (GRCm39) I323V possibly damaging Het
Homez G T 14: 55,094,487 (GRCm39) T407K probably damaging Het
Igdcc4 A G 9: 65,037,910 (GRCm39) T763A probably damaging Het
Ighg2b A T 12: 113,270,104 (GRCm39) W305R unknown Het
Il27ra G T 8: 84,763,038 (GRCm39) N296K probably damaging Het
Mbtd1 T C 11: 93,812,245 (GRCm39) V183A probably damaging Het
Mme T A 3: 63,287,693 (GRCm39) D731E probably benign Het
Mocos T C 18: 24,787,095 (GRCm39) L38P probably damaging Het
Mrps18a T C 17: 46,428,899 (GRCm39) probably null Het
Msh2 T A 17: 87,987,460 (GRCm39) V200D possibly damaging Het
Mug1 A T 6: 121,834,310 (GRCm39) I364F probably benign Het
Mycbp2 G T 14: 103,414,749 (GRCm39) S2554R probably benign Het
Nat10 A G 2: 103,584,415 (GRCm39) C121R probably damaging Het
Nfatc3 T A 8: 106,805,705 (GRCm39) D183E probably damaging Het
Odr4 C T 1: 150,260,238 (GRCm39) V127I probably benign Het
Or4d10c T C 19: 12,065,305 (GRCm39) I284V possibly damaging Het
Or51ac3 A T 7: 103,213,639 (GRCm39) F282L probably damaging Het
Or52h1 C A 7: 103,828,636 (GRCm39) probably null Het
Or5d14 T C 2: 87,880,823 (GRCm39) I48M probably benign Het
Pak6 T A 2: 118,527,021 (GRCm39) I672K probably damaging Het
Pan3 A T 5: 147,479,983 (GRCm39) I830F probably damaging Het
Pcdh9 A T 14: 94,125,628 (GRCm39) L181I probably damaging Het
Pigg G A 5: 108,480,556 (GRCm39) A447T probably benign Het
Pitpnb T A 5: 111,519,214 (GRCm39) S165T probably damaging Het
Pla2g2a A G 4: 138,560,590 (GRCm39) Y67C probably damaging Het
Plch1 A G 3: 63,688,928 (GRCm39) I80T probably damaging Het
Pnma1 A G 12: 84,194,235 (GRCm39) I156T probably benign Het
Prss21 G T 17: 24,091,796 (GRCm39) D255Y possibly damaging Het
Prune1 T A 3: 95,169,642 (GRCm39) I187F possibly damaging Het
Rab7b T C 1: 131,633,385 (GRCm39) F78L probably benign Het
Riok3 T A 18: 12,269,844 (GRCm39) Y92N probably benign Het
Rpap2 T C 5: 107,768,361 (GRCm39) S400P probably benign Het
Ryr3 C A 2: 112,705,478 (GRCm39) G792V probably damaging Het
Septin3 A G 15: 82,170,092 (GRCm39) E206G probably damaging Het
Stkld1 T C 2: 26,840,679 (GRCm39) S454P probably damaging Het
Tdh A T 14: 63,733,326 (GRCm39) L140Q probably damaging Het
Tex15 T A 8: 34,047,401 (GRCm39) H159Q probably damaging Het
Tmed6 C T 8: 107,790,793 (GRCm39) V85I probably benign Het
Vmn1r174 T A 7: 23,454,204 (GRCm39) L290* probably null Het
Vmn1r31 A G 6: 58,449,596 (GRCm39) S90P probably damaging Het
Vmn2r55 T C 7: 12,404,822 (GRCm39) T194A probably damaging Het
Vmn2r82 A T 10: 79,192,548 (GRCm39) I42F probably damaging Het
Vps35 G A 8: 86,014,331 (GRCm39) P106L probably damaging Het
Xrcc6 T A 15: 81,906,661 (GRCm39) Y69N probably damaging Het
Zbtb14 C T 17: 69,695,465 (GRCm39) P388S probably damaging Het
Zfp541 C T 7: 15,817,261 (GRCm39) A902V probably benign Het
Other mutations in Lzic
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00886:Lzic APN 4 149,577,753 (GRCm39) critical splice donor site probably null
IGL01433:Lzic APN 4 149,572,604 (GRCm39) missense probably benign 0.00
IGL02480:Lzic APN 4 149,571,260 (GRCm39) missense probably damaging 1.00
R0097:Lzic UTSW 4 149,572,533 (GRCm39) missense probably damaging 1.00
R0097:Lzic UTSW 4 149,572,533 (GRCm39) missense probably damaging 1.00
R1345:Lzic UTSW 4 149,571,308 (GRCm39) missense probably damaging 1.00
R2162:Lzic UTSW 4 149,573,185 (GRCm39) missense probably null 0.01
R3831:Lzic UTSW 4 149,573,185 (GRCm39) missense probably null 0.01
R4929:Lzic UTSW 4 149,572,585 (GRCm39) splice site probably null
R5837:Lzic UTSW 4 149,570,457 (GRCm39) critical splice donor site probably null
R7126:Lzic UTSW 4 149,573,132 (GRCm39) missense probably damaging 0.99
R8154:Lzic UTSW 4 149,573,141 (GRCm39) missense probably damaging 1.00
R8316:Lzic UTSW 4 149,572,527 (GRCm39) missense probably benign 0.03
R9632:Lzic UTSW 4 149,573,141 (GRCm39) missense probably damaging 1.00
R9710:Lzic UTSW 4 149,573,141 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGCCAGAAGTGTAACTCGGG -3'
(R):5'- ATGTTACTGGAGCCGAGCAG -3'

Sequencing Primer
(F):5'- TAACTCGGGGGACATGTGCAC -3'
(R):5'- GTCTTGTCCATGCTAAGCAAG -3'
Posted On 2015-09-24