Incidental Mutation 'R4591:Naa15'
ID 342804
Institutional Source Beutler Lab
Gene Symbol Naa15
Ensembl Gene ENSMUSG00000063273
Gene Name N(alpha)-acetyltransferase 15, NatA auxiliary subunit
Synonyms Narg1, 5730450D16Rik, ASTBDN, Tbdn-1, tubedown, mNAT1
Accession Numbers
Essential gene? Probably essential (E-score: 0.964) question?
Stock # R4591 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 51323437-51383406 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 51349345 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 38 (L38P)
Ref Sequence ENSEMBL: ENSMUSP00000141433 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029303] [ENSMUST00000192419] [ENSMUST00000193266]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000029303
AA Change: L88P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000029303
Gene: ENSMUSG00000063273
AA Change: L88P

DomainStartEndE-ValueType
TPR 46 79 6.24e1 SMART
TPR 80 113 1.01e0 SMART
Blast:TPR 224 257 3e-12 BLAST
TPR 374 407 1.87e1 SMART
TPR 408 441 5.06e1 SMART
low complexity region 603 641 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000192197
AA Change: L6P
Predicted Effect probably damaging
Transcript: ENSMUST00000192419
AA Change: L38P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000141965
Gene: ENSMUSG00000063273
AA Change: L38P

DomainStartEndE-ValueType
Blast:TPR 1 29 8e-12 BLAST
Pfam:TPR_2 30 63 3.4e-5 PFAM
Pfam:TPR_8 30 63 2.6e-4 PFAM
Pfam:TPR_11 31 95 4.8e-7 PFAM
Pfam:TPR_7 32 65 1.5e-2 PFAM
Pfam:TPR_1 37 63 1.6e-4 PFAM
Pfam:TPR_9 38 85 1e-2 PFAM
Pfam:TPR_9 88 126 1.2e0 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000192523
Predicted Effect probably damaging
Transcript: ENSMUST00000193266
AA Change: L38P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000141433
Gene: ENSMUSG00000063273
AA Change: L38P

DomainStartEndE-ValueType
Blast:TPR 1 29 3e-10 BLAST
TPR 30 63 4.9e-3 SMART
Blast:TPR 174 207 3e-12 BLAST
TPR 324 357 8.9e-2 SMART
TPR 358 391 2.4e-1 SMART
coiled coil region 533 585 N/A INTRINSIC
Blast:TPR 622 655 7e-10 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000195430
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes the auxillary subunit of the N-terminal acetyltransferase A (NatA) complex. [provided by RefSeq, Jan 2017]
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110032F04Rik T C 3: 68,777,599 (GRCm39) S187P possibly damaging Het
4932438H23Rik T C 16: 90,852,959 (GRCm39) N59S probably damaging Het
Abca15 A T 7: 119,981,636 (GRCm39) D1030V probably damaging Het
Acmsd A T 1: 127,676,934 (GRCm39) N153I probably damaging Het
Adprh C A 16: 38,266,345 (GRCm39) V266L probably benign Het
Aldh5a1 G A 13: 25,107,991 (GRCm39) P217S probably damaging Het
Alpk2 A T 18: 65,438,894 (GRCm39) L1300Q probably benign Het
Alyref C T 11: 120,486,799 (GRCm39) R154Q probably benign Het
Ano6 T A 15: 95,841,308 (GRCm39) C468* probably null Het
Aox3 A T 1: 58,191,815 (GRCm39) I456F probably damaging Het
Art4 A G 6: 136,831,755 (GRCm39) Y129H probably damaging Het
Asb16 C A 11: 102,167,551 (GRCm39) H306N probably damaging Het
Atp8a2 C A 14: 59,892,078 (GRCm39) R1090L probably benign Het
Brap G T 5: 121,800,113 (GRCm39) V1F probably null Het
C1qb C A 4: 136,609,528 (GRCm39) G31W probably damaging Het
Cacna2d4 T C 6: 119,275,425 (GRCm39) Y666H probably benign Het
Casr T C 16: 36,320,732 (GRCm39) N472S probably benign Het
Ccdc91 T G 6: 147,491,963 (GRCm39) S282A unknown Het
Cd300lg A G 11: 101,937,006 (GRCm39) T164A probably benign Het
Cd79b A T 11: 106,202,872 (GRCm39) D243E probably damaging Het
Cdh6 C A 15: 13,051,572 (GRCm39) V354F possibly damaging Het
Cdhr2 A G 13: 54,863,497 (GRCm39) N126S probably benign Het
Cep192 A T 18: 67,968,039 (GRCm39) N841I probably damaging Het
Cngb1 T C 8: 95,980,012 (GRCm39) T963A probably damaging Het
Col16a1 A G 4: 129,955,592 (GRCm39) probably null Het
Coro1a A G 7: 126,302,164 (GRCm39) V61A probably damaging Het
Crocc T A 4: 140,745,983 (GRCm39) D1712V probably damaging Het
Ddn T C 15: 98,705,687 (GRCm39) D3G possibly damaging Het
Dnal1 T C 12: 84,180,627 (GRCm39) F89S probably benign Het
Dusp3 T A 11: 101,864,446 (GRCm39) probably benign Het
Dyrk3 C A 1: 131,057,895 (GRCm39) G58C probably damaging Het
Fat1 T C 8: 45,479,279 (GRCm39) F2775S probably benign Het
Frk A G 10: 34,481,829 (GRCm39) N373S probably benign Het
Glmn A G 5: 107,708,917 (GRCm39) probably null Het
Gm11565 A T 11: 99,805,769 (GRCm39) T54S possibly damaging Het
Gm14410 A G 2: 176,885,820 (GRCm39) I148T possibly damaging Het
Gm21834 T A 17: 58,048,880 (GRCm39) H112L possibly damaging Het
Gm5862 A G 5: 26,224,486 (GRCm39) I161T possibly damaging Het
Grid2 G T 6: 64,297,086 (GRCm39) G483V probably damaging Het
Hfm1 A T 5: 106,995,533 (GRCm39) S1293T probably benign Het
Il1a G A 2: 129,148,447 (GRCm39) R88W probably damaging Het
Il20rb A T 9: 100,357,043 (GRCm39) V29D possibly damaging Het
Ilvbl C T 10: 78,419,139 (GRCm39) L463F probably benign Het
Kif17 A G 4: 138,005,110 (GRCm39) E225G probably benign Het
Lrp2 A G 2: 69,366,419 (GRCm39) F227L probably damaging Het
Lrrc43 A G 5: 123,639,227 (GRCm39) M419V probably benign Het
Magel2 A G 7: 62,030,837 (GRCm39) Q1247R unknown Het
Mamdc4 T A 2: 25,454,609 (GRCm39) M1068L possibly damaging Het
Mdn1 T G 4: 32,707,636 (GRCm39) S1642A probably damaging Het
Mtarc1 T C 1: 184,539,365 (GRCm39) E102G probably benign Het
Mtcl1 T C 17: 66,655,506 (GRCm39) E819G probably benign Het
Nlrp3 A G 11: 59,440,048 (GRCm39) R542G probably benign Het
Or10c1 C T 17: 37,522,010 (GRCm39) V245I probably benign Het
Or4d2b A G 11: 87,780,375 (GRCm39) S116P probably benign Het
Or5ac19 A C 16: 59,089,776 (GRCm39) F85V possibly damaging Het
Or5b125-ps1 ACAC ACACGCAC 19: 13,056,266 (GRCm39) noncoding transcript Het
Pbxip1 T A 3: 89,353,467 (GRCm39) L249Q probably benign Het
Pla2g7 T C 17: 43,911,450 (GRCm39) S201P probably damaging Het
Psmd1 G T 1: 86,055,926 (GRCm39) V763F probably benign Het
Ptp4a2 A G 4: 129,740,308 (GRCm39) E124G probably benign Het
Rab6b T C 9: 103,044,373 (GRCm39) probably null Het
Rbks T A 5: 31,817,352 (GRCm39) K139M possibly damaging Het
Rgs22 T A 15: 36,100,282 (GRCm39) E268D probably benign Het
Slc16a9 T G 10: 70,118,710 (GRCm39) L343R probably damaging Het
Smagp T C 15: 100,519,860 (GRCm39) I55V probably damaging Het
Sox13 T C 1: 133,311,421 (GRCm39) S604G probably damaging Het
St6gal1 G T 16: 23,140,044 (GRCm39) V72F probably benign Het
Stxbp4 A G 11: 90,485,606 (GRCm39) V247A probably benign Het
Susd3 A T 13: 49,384,736 (GRCm39) M217K possibly damaging Het
Tas2r129 T A 6: 132,928,574 (GRCm39) N170K probably benign Het
Tmem245 C A 4: 56,910,204 (GRCm39) A515S probably damaging Het
Tpte T C 8: 22,817,791 (GRCm39) V259A probably benign Het
Trpa1 T C 1: 14,952,332 (GRCm39) probably null Het
Ttc28 G A 5: 111,371,147 (GRCm39) R532H probably damaging Het
Vwa5a A T 9: 38,646,916 (GRCm39) N529I possibly damaging Het
Zfp574 T C 7: 24,778,969 (GRCm39) probably benign Het
Other mutations in Naa15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Naa15 APN 3 51,345,826 (GRCm39) missense probably damaging 1.00
IGL01753:Naa15 APN 3 51,350,274 (GRCm39) missense probably damaging 1.00
IGL01837:Naa15 APN 3 51,351,369 (GRCm39) nonsense probably null
IGL02619:Naa15 APN 3 51,367,552 (GRCm39) missense probably benign 0.03
IGL02691:Naa15 APN 3 51,358,747 (GRCm39) missense probably damaging 0.97
IGL02974:Naa15 APN 3 51,368,628 (GRCm39) missense possibly damaging 0.95
R0009:Naa15 UTSW 3 51,377,640 (GRCm39) missense probably damaging 1.00
R0010:Naa15 UTSW 3 51,343,634 (GRCm39) critical splice acceptor site probably null
R0114:Naa15 UTSW 3 51,355,859 (GRCm39) critical splice donor site probably null
R0411:Naa15 UTSW 3 51,373,060 (GRCm39) missense possibly damaging 0.81
R1348:Naa15 UTSW 3 51,373,091 (GRCm39) missense probably damaging 1.00
R1941:Naa15 UTSW 3 51,363,355 (GRCm39) nonsense probably null
R3082:Naa15 UTSW 3 51,367,471 (GRCm39) missense probably damaging 1.00
R4377:Naa15 UTSW 3 51,355,786 (GRCm39) missense possibly damaging 0.91
R4980:Naa15 UTSW 3 51,366,173 (GRCm39) critical splice donor site probably null
R5087:Naa15 UTSW 3 51,364,706 (GRCm39) splice site probably null
R5139:Naa15 UTSW 3 51,351,261 (GRCm39) missense probably damaging 1.00
R5289:Naa15 UTSW 3 51,363,315 (GRCm39) missense probably damaging 1.00
R5527:Naa15 UTSW 3 51,349,368 (GRCm39) missense probably damaging 1.00
R5776:Naa15 UTSW 3 51,367,447 (GRCm39) missense probably damaging 0.96
R5909:Naa15 UTSW 3 51,367,485 (GRCm39) missense probably damaging 1.00
R6034:Naa15 UTSW 3 51,350,242 (GRCm39) missense probably damaging 0.98
R6034:Naa15 UTSW 3 51,350,242 (GRCm39) missense probably damaging 0.98
R6194:Naa15 UTSW 3 51,370,721 (GRCm39) missense probably benign 0.00
R6291:Naa15 UTSW 3 51,350,212 (GRCm39) missense probably damaging 1.00
R6522:Naa15 UTSW 3 51,378,935 (GRCm39) missense probably damaging 1.00
R6731:Naa15 UTSW 3 51,363,294 (GRCm39) missense probably damaging 1.00
R6984:Naa15 UTSW 3 51,380,021 (GRCm39) missense probably benign 0.10
R7040:Naa15 UTSW 3 51,380,205 (GRCm39) missense possibly damaging 0.89
R7091:Naa15 UTSW 3 51,366,177 (GRCm39) splice site probably null
R7380:Naa15 UTSW 3 51,367,268 (GRCm39) splice site probably null
R7685:Naa15 UTSW 3 51,377,395 (GRCm39) splice site probably null
R7781:Naa15 UTSW 3 51,378,904 (GRCm39) critical splice acceptor site probably null
R7797:Naa15 UTSW 3 51,356,031 (GRCm39) missense probably damaging 0.99
R7836:Naa15 UTSW 3 51,370,688 (GRCm39) nonsense probably null
R7981:Naa15 UTSW 3 51,366,092 (GRCm39) missense probably damaging 0.96
R8513:Naa15 UTSW 3 51,367,444 (GRCm39) missense probably damaging 0.99
R8923:Naa15 UTSW 3 51,367,443 (GRCm39) missense probably damaging 1.00
R9159:Naa15 UTSW 3 51,358,802 (GRCm39) missense probably benign 0.01
R9701:Naa15 UTSW 3 51,349,370 (GRCm39) nonsense probably null
R9802:Naa15 UTSW 3 51,349,370 (GRCm39) nonsense probably null
X0020:Naa15 UTSW 3 51,377,553 (GRCm39) missense probably benign 0.00
X0061:Naa15 UTSW 3 51,356,022 (GRCm39) missense probably benign 0.11
X0061:Naa15 UTSW 3 51,356,021 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GACCTAAGGCTATCTGTCTCTGC -3'
(R):5'- TGTAATCACTAAGGGGCAGTC -3'

Sequencing Primer
(F):5'- AAGGCTATCTGTCTCTGCTTTCTAAG -3'
(R):5'- ACCCTATAGCCCTCAAGATC -3'
Posted On 2015-09-24