Incidental Mutation 'R4559:Map10'
ID 342995
Institutional Source Beutler Lab
Gene Symbol Map10
Ensembl Gene ENSMUSG00000050930
Gene Name microtubule-associated protein 10
Synonyms 4933403G14Rik
MMRRC Submission 041785-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # R4559 (G1)
Quality Score 225
Status Validated
Chromosome 8
Chromosomal Location 126396557-126400098 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 126398553 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 649 (T649A)
Ref Sequence ENSEMBL: ENSMUSP00000061679 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053078]
AlphaFold Q8BJS7
Predicted Effect probably benign
Transcript: ENSMUST00000053078
AA Change: T649A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000061679
Gene: ENSMUSG00000050930
AA Change: T649A

DomainStartEndE-ValueType
low complexity region 38 54 N/A INTRINSIC
low complexity region 68 91 N/A INTRINSIC
Pfam:HPHLAWLY 243 535 1.4e-130 PFAM
Pfam:HPHLAWLY 527 890 9.1e-133 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency 100% (56/56)
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017G19Rik A G 3: 40,567,240 (GRCm39) noncoding transcript Het
1700066M21Rik T C 1: 57,422,083 (GRCm39) F153S possibly damaging Het
Acss1 A G 2: 150,480,405 (GRCm39) V222A probably benign Het
Atad2b A G 12: 4,993,223 (GRCm39) I247M probably benign Het
Atxn10 A G 15: 85,322,321 (GRCm39) I398V possibly damaging Het
Cep192 T A 18: 68,004,584 (GRCm39) C2312S probably damaging Het
Cidea C T 18: 67,493,298 (GRCm39) Q106* probably null Het
Cnga4 A G 7: 105,054,892 (GRCm39) T159A probably damaging Het
Cyp2j12 G T 4: 96,001,194 (GRCm39) S304R probably damaging Het
Dennd2b A G 7: 109,124,785 (GRCm39) F665L probably damaging Het
Dsg4 T A 18: 20,603,978 (GRCm39) V815E probably damaging Het
Entrep1 G A 19: 24,007,913 (GRCm39) S130L probably damaging Het
Farp1 T C 14: 121,510,213 (GRCm39) M737T probably damaging Het
Fbn1 T A 2: 125,193,634 (GRCm39) D1395V possibly damaging Het
Fbn2 C T 18: 58,209,146 (GRCm39) M1076I probably benign Het
Fitm2 T A 2: 163,314,593 (GRCm39) probably benign Het
Fras1 A G 5: 96,929,148 (GRCm39) R3851G probably damaging Het
Frem2 C T 3: 53,561,742 (GRCm39) V922I probably benign Het
Gm10719 A T 9: 3,018,945 (GRCm39) T200S probably benign Het
Grin3a T C 4: 49,844,555 (GRCm39) D176G probably damaging Het
Hdac5 T C 11: 102,089,928 (GRCm39) probably benign Het
Ift140 C A 17: 25,309,741 (GRCm39) H1090Q probably damaging Het
Il20ra A G 10: 19,625,032 (GRCm39) T104A probably damaging Het
Il22ra2 A G 10: 19,502,460 (GRCm39) D93G possibly damaging Het
Ing1 A G 8: 11,612,090 (GRCm39) K176R probably benign Het
Jph1 A T 1: 17,074,735 (GRCm39) C428S probably benign Het
Kif13b G T 14: 65,043,581 (GRCm39) G1794W probably damaging Het
Med12l T C 3: 58,914,523 (GRCm39) probably null Het
Nat8f1 A G 6: 85,887,567 (GRCm39) I131T probably benign Het
Oas1d C A 5: 121,054,958 (GRCm39) Q177K probably benign Het
Or4a74 C A 2: 89,440,043 (GRCm39) M134I probably damaging Het
Or51q1 G A 7: 103,628,767 (GRCm39) D123N probably damaging Het
P2ry2 A G 7: 100,647,363 (GRCm39) V314A possibly damaging Het
Pabir2 G A X: 52,349,554 (GRCm39) probably benign Het
Pfkl G T 10: 77,824,717 (GRCm39) R691S probably benign Het
Plb1 T A 5: 32,490,175 (GRCm39) I1005N probably damaging Het
Prkacb A G 3: 146,451,147 (GRCm39) probably benign Het
Ptprm A T 17: 66,990,403 (GRCm39) Y1412N possibly damaging Het
Rab22a A G 2: 173,503,226 (GRCm39) D13G probably damaging Het
Rab29 G A 1: 131,800,305 (GRCm39) W201* probably null Het
Rasa3 T C 8: 13,648,259 (GRCm39) E135G probably damaging Het
Rassf10 A G 7: 112,554,338 (GRCm39) E313G probably benign Het
Sf1 GGCAGCAGCAGCAGCAGCAGC GGCAGCAGCAGCAGCAGC 19: 6,424,845 (GRCm39) probably benign Het
Sipa1l3 A T 7: 29,031,678 (GRCm39) L468Q probably damaging Het
Slc17a1 A T 13: 24,062,695 (GRCm39) K254* probably null Het
Slc6a12 G A 6: 121,340,820 (GRCm39) probably null Het
Slfn8 A G 11: 82,895,570 (GRCm39) L412P probably damaging Het
Taf4b T C 18: 14,946,583 (GRCm39) S469P probably damaging Het
Tgoln1 T C 6: 72,592,664 (GRCm39) E272G probably damaging Het
Tlr12 C A 4: 128,509,563 (GRCm39) G896W probably damaging Het
Tnfrsf1a A G 6: 125,337,729 (GRCm39) I229V probably benign Het
Ttn G A 2: 76,749,890 (GRCm39) H3720Y probably benign Het
Other mutations in Map10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00813:Map10 APN 8 126,398,671 (GRCm39) missense probably benign 0.00
IGL01567:Map10 APN 8 126,398,232 (GRCm39) missense probably benign 0.32
IGL02566:Map10 APN 8 126,398,494 (GRCm39) missense probably benign
IGL03088:Map10 APN 8 126,397,809 (GRCm39) missense probably benign 0.14
debauched UTSW 8 126,397,984 (GRCm39) missense probably damaging 1.00
R1083:Map10 UTSW 8 126,397,178 (GRCm39) nonsense probably null
R1543:Map10 UTSW 8 126,397,611 (GRCm39) missense probably benign 0.00
R3155:Map10 UTSW 8 126,398,313 (GRCm39) missense possibly damaging 0.79
R4076:Map10 UTSW 8 126,398,584 (GRCm39) missense probably benign 0.23
R4856:Map10 UTSW 8 126,397,431 (GRCm39) missense probably damaging 1.00
R4886:Map10 UTSW 8 126,397,431 (GRCm39) missense probably damaging 1.00
R5412:Map10 UTSW 8 126,397,724 (GRCm39) missense probably damaging 1.00
R6034:Map10 UTSW 8 126,399,205 (GRCm39) missense probably damaging 1.00
R6034:Map10 UTSW 8 126,399,205 (GRCm39) missense probably damaging 1.00
R6150:Map10 UTSW 8 126,398,328 (GRCm39) missense probably damaging 0.96
R6351:Map10 UTSW 8 126,397,984 (GRCm39) missense probably damaging 1.00
R6466:Map10 UTSW 8 126,399,123 (GRCm39) nonsense probably null
R6544:Map10 UTSW 8 126,398,113 (GRCm39) missense probably benign 0.00
R6557:Map10 UTSW 8 126,396,991 (GRCm39) missense probably damaging 0.98
R6821:Map10 UTSW 8 126,397,138 (GRCm39) missense probably benign 0.01
R7096:Map10 UTSW 8 126,398,662 (GRCm39) missense probably damaging 0.99
R7128:Map10 UTSW 8 126,398,592 (GRCm39) missense probably benign
R7177:Map10 UTSW 8 126,398,584 (GRCm39) missense probably benign 0.23
R7237:Map10 UTSW 8 126,397,963 (GRCm39) missense probably benign 0.03
R7814:Map10 UTSW 8 126,398,350 (GRCm39) missense probably benign 0.14
R7819:Map10 UTSW 8 126,397,260 (GRCm39) frame shift probably null
R8202:Map10 UTSW 8 126,397,647 (GRCm39) missense possibly damaging 0.95
R8812:Map10 UTSW 8 126,396,664 (GRCm39) missense probably damaging 0.99
R8859:Map10 UTSW 8 126,397,291 (GRCm39) missense probably benign 0.04
R8947:Map10 UTSW 8 126,397,839 (GRCm39) missense probably benign 0.06
R9178:Map10 UTSW 8 126,397,649 (GRCm39) missense probably damaging 0.98
R9698:Map10 UTSW 8 126,398,723 (GRCm39) missense probably benign 0.16
Z1088:Map10 UTSW 8 126,398,670 (GRCm39) frame shift probably null
Z1177:Map10 UTSW 8 126,396,809 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTGAAACAGAGCCATGCCATG -3'
(R):5'- CGTGAACCCTTTTGCACATG -3'

Sequencing Primer
(F):5'- CCATGCCATGAAACAAGAAATGGTTG -3'
(R):5'- AGACTTCTGCTGTTATTCTCAGTTG -3'
Posted On 2015-09-24