Incidental Mutation 'R0346:Fbxo15'
ID 34309
Institutional Source Beutler Lab
Gene Symbol Fbxo15
Ensembl Gene ENSMUSG00000034391
Gene Name F-box protein 15
Synonyms ecat3, Fbx15
MMRRC Submission 038553-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0346 (G1)
Quality Score 225
Status Validated
Chromosome 18
Chromosomal Location 84952907-84999598 bp(+) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to A at 84978346 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000153473 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037718] [ENSMUST00000224467] [ENSMUST00000225445]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000037718
SMART Domains Protein: ENSMUSP00000045925
Gene: ENSMUSG00000034391

DomainStartEndE-ValueType
low complexity region 35 42 N/A INTRINSIC
FBOX 46 86 3.4e-7 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223789
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224427
Predicted Effect probably null
Transcript: ENSMUST00000224467
Predicted Effect probably benign
Transcript: ENSMUST00000225445
Meta Mutation Damage Score 0.9494 question?
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 98.9%
  • 10x: 97.7%
  • 20x: 96.4%
Validation Efficiency 100% (79/79)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the F-box protein family, such as FBXO15, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Both male and female homozygous null mice develop normally and are fertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A T 11: 9,516,278 (GRCm39) I4406L probably damaging Het
Abca16 T A 7: 120,035,155 (GRCm39) C314S probably damaging Het
Add3 C T 19: 53,205,387 (GRCm39) R46* probably null Het
Alas1 A T 9: 106,120,550 (GRCm39) S82T possibly damaging Het
Alkbh5 C G 11: 60,429,567 (GRCm39) R107G possibly damaging Het
Ap3b1 A T 13: 94,582,479 (GRCm39) R365* probably null Het
Ass1 A T 2: 31,404,831 (GRCm39) N371Y probably damaging Het
AU021092 T C 16: 5,034,718 (GRCm39) D168G possibly damaging Het
Bcl2 G A 1: 106,640,292 (GRCm39) R107C probably damaging Het
Caln1 C A 5: 130,851,762 (GRCm39) H184N possibly damaging Het
Camta1 C A 4: 151,159,597 (GRCm39) R1614L probably damaging Het
Ccdc191 T C 16: 43,759,315 (GRCm39) V372A probably damaging Het
Ccng2 T G 5: 93,418,753 (GRCm39) I126S probably damaging Het
Cep85 A T 4: 133,859,733 (GRCm39) N643K probably damaging Het
Clvs2 G C 10: 33,498,542 (GRCm39) S129R possibly damaging Het
Cntn1 G T 15: 92,129,968 (GRCm39) probably benign Het
Cttn A T 7: 144,006,276 (GRCm39) probably benign Het
Dedd2 T C 7: 24,910,694 (GRCm39) S161G possibly damaging Het
Dnajb13 T C 7: 100,153,132 (GRCm39) D263G probably damaging Het
Dppa4 T A 16: 48,109,687 (GRCm39) probably benign Het
Ear2 A G 14: 44,340,363 (GRCm39) E7G probably damaging Het
Eif2b4 A G 5: 31,345,452 (GRCm39) probably benign Het
Etl4 G T 2: 20,764,463 (GRCm39) probably null Het
Gm9970 A G 5: 31,398,182 (GRCm39) probably benign Het
Hap1 A G 11: 100,246,855 (GRCm39) S17P probably benign Het
Hgd C T 16: 37,409,136 (GRCm39) probably benign Het
Ift56 T C 6: 38,386,370 (GRCm39) C364R probably damaging Het
Inpp5f T A 7: 128,292,392 (GRCm39) L16Q probably damaging Het
Irag1 T C 7: 110,498,183 (GRCm39) D404G probably damaging Het
Islr2 G A 9: 58,105,626 (GRCm39) R545* probably null Het
Itgav G T 2: 83,622,953 (GRCm39) C675F probably damaging Het
Kif13a T A 13: 46,967,695 (GRCm39) I403L possibly damaging Het
Kif14 T A 1: 136,395,898 (GRCm39) I68N probably damaging Het
Kif26a G T 12: 112,145,782 (GRCm39) K1764N probably null Het
Lrrd1 C A 5: 3,900,215 (GRCm39) F173L probably benign Het
Mroh4 G C 15: 74,486,141 (GRCm39) probably benign Het
Msh5 A G 17: 35,248,864 (GRCm39) V723A probably benign Het
Mybph T G 1: 134,125,492 (GRCm39) I279S probably damaging Het
Myh4 A T 11: 67,151,152 (GRCm39) I1936L probably benign Het
Myo1h A T 5: 114,493,270 (GRCm39) T704S probably benign Het
Nav2 C A 7: 49,254,333 (GRCm39) T2377K probably benign Het
Nipbl T G 15: 8,390,440 (GRCm39) Q276H probably damaging Het
Nlrp9b T C 7: 19,758,440 (GRCm39) L559P probably damaging Het
Nup210l T A 3: 90,096,745 (GRCm39) V1318E probably damaging Het
Or1e26 A G 11: 73,480,283 (GRCm39) Y94H probably damaging Het
Or4z4 A T 19: 12,076,803 (GRCm39) S67T probably damaging Het
Or6c8b C A 10: 128,882,342 (GRCm39) V197F possibly damaging Het
Or7e178 A G 9: 20,225,707 (GRCm39) S170P probably benign Het
P2ry13 T C 3: 59,116,987 (GRCm39) T264A possibly damaging Het
Plekhg5 T C 4: 152,198,710 (GRCm39) L966P probably benign Het
Prss35 A G 9: 86,637,404 (GRCm39) K58R probably benign Het
Ptafr T A 4: 132,307,390 (GRCm39) L260* probably null Het
Pum1 A T 4: 130,507,116 (GRCm39) T1157S possibly damaging Het
Rif1 GCCACCA GCCA 2: 52,000,336 (GRCm39) probably benign Het
Rnf145 A G 11: 44,445,991 (GRCm39) Y275C probably damaging Het
Rpl6 A T 5: 121,346,554 (GRCm39) K218N possibly damaging Het
Rps6 T C 4: 86,774,218 (GRCm39) T128A probably benign Het
Ryr1 G T 7: 28,767,013 (GRCm39) probably benign Het
Scel A T 14: 103,767,420 (GRCm39) Q26H probably damaging Het
Sfxn4 A T 19: 60,847,111 (GRCm39) D57E probably benign Het
Slc35d1 A C 4: 103,048,044 (GRCm39) L240R probably damaging Het
Smcr8 A G 11: 60,670,576 (GRCm39) I575V probably benign Het
Spata31e4 T C 13: 50,857,346 (GRCm39) Y995H probably benign Het
Syk G A 13: 52,794,695 (GRCm39) M476I probably damaging Het
Tbcel A T 9: 42,348,539 (GRCm39) probably benign Het
Tob2 C A 15: 81,742,424 (GRCm39) G65W probably damaging Het
Trim16 A G 11: 62,731,520 (GRCm39) N464D probably benign Het
Trim36 T C 18: 46,332,776 (GRCm39) probably benign Het
Trpv4 C A 5: 114,768,590 (GRCm39) probably benign Het
Tsga10 T A 1: 37,879,600 (GRCm39) T64S possibly damaging Het
Vars2 A T 17: 35,975,756 (GRCm39) probably benign Het
Vmn1r72 C A 7: 11,403,621 (GRCm39) V276L probably benign Het
Vps13a T A 19: 16,655,333 (GRCm39) K1898N probably benign Het
Vps18 A G 2: 119,127,645 (GRCm39) M823V probably damaging Het
Washc2 T C 6: 116,197,484 (GRCm39) probably benign Het
Zfp763 A T 17: 33,238,721 (GRCm39) H141Q probably benign Het
Other mutations in Fbxo15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00517:Fbxo15 APN 18 84,977,225 (GRCm39) missense probably damaging 1.00
IGL01375:Fbxo15 APN 18 84,976,404 (GRCm39) missense possibly damaging 0.64
IGL01730:Fbxo15 APN 18 84,982,299 (GRCm39) missense probably benign 0.38
IGL01807:Fbxo15 APN 18 84,999,506 (GRCm39) utr 3 prime probably benign
IGL02220:Fbxo15 APN 18 84,982,317 (GRCm39) critical splice donor site probably null
IGL02255:Fbxo15 APN 18 84,982,321 (GRCm39) splice site probably null
IGL02435:Fbxo15 APN 18 84,977,351 (GRCm39) missense probably damaging 0.97
IGL02546:Fbxo15 APN 18 84,980,847 (GRCm39) critical splice donor site probably null
IGL03099:Fbxo15 APN 18 84,999,338 (GRCm39) missense possibly damaging 0.87
R1606:Fbxo15 UTSW 18 84,980,745 (GRCm39) missense possibly damaging 0.93
R1671:Fbxo15 UTSW 18 84,977,231 (GRCm39) missense possibly damaging 0.73
R2113:Fbxo15 UTSW 18 84,977,230 (GRCm39) missense probably benign 0.00
R3962:Fbxo15 UTSW 18 84,977,372 (GRCm39) missense probably benign 0.02
R4064:Fbxo15 UTSW 18 84,977,243 (GRCm39) missense probably damaging 0.96
R5523:Fbxo15 UTSW 18 84,978,194 (GRCm39) missense probably damaging 1.00
R5931:Fbxo15 UTSW 18 84,999,250 (GRCm39) missense probably damaging 0.96
R6235:Fbxo15 UTSW 18 84,999,029 (GRCm39) intron probably benign
R6349:Fbxo15 UTSW 18 84,982,267 (GRCm39) missense probably benign 0.01
R6607:Fbxo15 UTSW 18 84,977,270 (GRCm39) missense possibly damaging 0.88
R7232:Fbxo15 UTSW 18 84,980,747 (GRCm39) missense probably damaging 1.00
R7325:Fbxo15 UTSW 18 84,977,243 (GRCm39) missense probably damaging 0.96
R7519:Fbxo15 UTSW 18 84,982,359 (GRCm39) unclassified probably benign
R7671:Fbxo15 UTSW 18 84,982,278 (GRCm39) missense probably damaging 1.00
R8094:Fbxo15 UTSW 18 84,983,618 (GRCm39) missense probably benign 0.34
R8365:Fbxo15 UTSW 18 84,980,739 (GRCm39) missense probably damaging 1.00
R8494:Fbxo15 UTSW 18 84,982,252 (GRCm39) missense probably damaging 1.00
R8809:Fbxo15 UTSW 18 84,978,200 (GRCm39) missense possibly damaging 0.94
R9072:Fbxo15 UTSW 18 84,983,645 (GRCm39) missense possibly damaging 0.88
R9073:Fbxo15 UTSW 18 84,983,645 (GRCm39) missense possibly damaging 0.88
R9342:Fbxo15 UTSW 18 84,983,609 (GRCm39) missense unknown
R9386:Fbxo15 UTSW 18 84,977,372 (GRCm39) missense probably benign 0.22
R9409:Fbxo15 UTSW 18 84,977,246 (GRCm39) missense possibly damaging 0.91
R9549:Fbxo15 UTSW 18 84,980,805 (GRCm39) missense possibly damaging 0.56
X0022:Fbxo15 UTSW 18 84,978,244 (GRCm39) missense probably benign 0.00
Z1177:Fbxo15 UTSW 18 84,976,433 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- GCAAAGAACACATCATGCAGCATTCG -3'
(R):5'- tcacctctccagcaccAAGAATATCA -3'

Sequencing Primer
(F):5'- CGAATCTTTCCGTAAATGACAACTC -3'
(R):5'- cccgtgcctctgccttc -3'
Posted On 2013-05-09