Incidental Mutation 'R4561:Zfp760'
ID 343112
Institutional Source Beutler Lab
Gene Symbol Zfp760
Ensembl Gene ENSMUSG00000067928
Gene Name zinc finger protein 760
Synonyms
MMRRC Submission 041786-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.135) question?
Stock # R4561 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 21926723-21944617 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 21942648 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 608 (S608T)
Ref Sequence ENSEMBL: ENSMUSP00000073038 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073312]
AlphaFold E9QAF5
Predicted Effect probably benign
Transcript: ENSMUST00000073312
AA Change: S608T

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000073038
Gene: ENSMUSG00000067928
AA Change: S608T

DomainStartEndE-ValueType
KRAB 8 69 3.62e-21 SMART
ZnF_C2H2 183 202 1.78e2 SMART
ZnF_C2H2 208 230 1.69e-3 SMART
ZnF_C2H2 236 258 4.54e-4 SMART
ZnF_C2H2 264 286 2.79e-4 SMART
ZnF_C2H2 292 314 1.1e-2 SMART
ZnF_C2H2 320 342 2.71e-2 SMART
ZnF_C2H2 348 370 7.9e-4 SMART
ZnF_C2H2 376 398 1.72e-4 SMART
ZnF_C2H2 404 426 1.14e0 SMART
ZnF_C2H2 432 454 4.05e-1 SMART
ZnF_C2H2 460 482 5.14e-3 SMART
ZnF_C2H2 488 510 1.18e-2 SMART
ZnF_C2H2 516 538 1.95e-3 SMART
ZnF_C2H2 544 566 1.82e-3 SMART
ZnF_C2H2 572 594 4.17e-3 SMART
ZnF_C2H2 600 622 1.04e-3 SMART
ZnF_C2H2 628 650 1.28e-3 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ank3 T C 10: 69,837,848 (GRCm39) S1601P probably damaging Het
Arnt A G 3: 95,359,924 (GRCm39) N56D probably damaging Het
Atad5 A G 11: 79,986,715 (GRCm39) T601A probably benign Het
Calr4 A G 4: 109,103,379 (GRCm39) N163S probably damaging Het
Cenpc1 C A 5: 86,195,491 (GRCm39) A93S probably damaging Het
Cep135 C T 5: 76,786,040 (GRCm39) H1048Y possibly damaging Het
Ctnna2 A G 6: 77,613,696 (GRCm39) probably null Het
Ddx60 T C 8: 62,395,495 (GRCm39) L144P probably damaging Het
Dera A T 6: 137,757,736 (GRCm39) T96S possibly damaging Het
Dock9 T A 14: 121,796,419 (GRCm39) M1853L probably benign Het
Erbb4 G A 1: 68,383,080 (GRCm39) R306* probably null Het
Glyat G T 19: 12,628,644 (GRCm39) L146F possibly damaging Het
Grk4 C A 5: 34,852,157 (GRCm39) Q134K probably benign Het
Hkdc1 T C 10: 62,245,618 (GRCm39) Q181R probably benign Het
Huwe1 A T X: 150,646,955 (GRCm39) I682F probably damaging Het
Ipo4 C T 14: 55,867,546 (GRCm39) probably benign Het
Ivl CCTGCTGCTGCT CCTGCTGCTGCTGCT 3: 92,479,262 (GRCm39) probably benign Het
Kcnd2 A G 6: 21,216,395 (GRCm39) Q33R probably benign Het
Kdm7a C T 6: 39,129,757 (GRCm39) R473Q probably damaging Het
Klhl30 A T 1: 91,288,753 (GRCm39) H504L probably damaging Het
Map4 A G 9: 109,881,439 (GRCm39) Y101C possibly damaging Het
Mfn2 C A 4: 147,961,492 (GRCm39) R707L probably damaging Het
Mslnl G A 17: 25,961,908 (GRCm39) V128M probably damaging Het
Myof T C 19: 37,911,438 (GRCm39) N1511D probably benign Het
Neb A T 2: 52,176,167 (GRCm39) Y1431N probably damaging Het
Nlrc5 A G 8: 95,203,774 (GRCm39) T625A probably damaging Het
Or5g27 G T 2: 85,409,964 (GRCm39) C127F probably damaging Het
Pax2 A G 19: 44,824,402 (GRCm39) Y374C unknown Het
Pde8a T A 7: 80,958,568 (GRCm39) Y315* probably null Het
Pkhd1 A T 1: 20,604,943 (GRCm39) L1124Q possibly damaging Het
Ppp1r3a A G 6: 14,754,681 (GRCm39) F189L probably damaging Het
Prex2 G A 1: 11,254,769 (GRCm39) probably null Het
Robo4 CGG CG 9: 37,322,786 (GRCm39) probably null Het
Slc22a22 T A 15: 57,126,781 (GRCm39) Q77L probably damaging Het
Slc24a2 A T 4: 87,145,634 (GRCm39) V140D probably damaging Het
Slc35g2 C A 9: 100,435,287 (GRCm39) R128L probably damaging Het
Slco1b2 A G 6: 141,616,893 (GRCm39) T409A probably benign Het
Spag7 T C 11: 70,555,816 (GRCm39) I80M probably damaging Het
Srgap3 A G 6: 112,758,015 (GRCm39) M164T probably damaging Het
Sspo A T 6: 48,452,468 (GRCm39) probably null Het
Tcte2 T C 17: 13,942,864 (GRCm39) probably benign Het
Tmem117 A T 15: 94,992,677 (GRCm39) M446L probably benign Het
Tmtc4 T C 14: 123,200,710 (GRCm39) T194A probably benign Het
Ttc21b T C 2: 66,016,562 (GRCm39) Y1269C probably damaging Het
Zfp236 A T 18: 82,638,531 (GRCm39) I1363N probably damaging Het
Zfp947 G T 17: 22,365,124 (GRCm39) Y183* probably null Het
Other mutations in Zfp760
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00472:Zfp760 APN 17 21,942,457 (GRCm39) missense possibly damaging 0.75
IGL00862:Zfp760 APN 17 21,941,265 (GRCm39) missense probably benign 0.00
IGL02198:Zfp760 APN 17 21,941,193 (GRCm39) missense probably benign 0.00
R0478:Zfp760 UTSW 17 21,940,995 (GRCm39) nonsense probably null
R0835:Zfp760 UTSW 17 21,942,559 (GRCm39) missense possibly damaging 0.63
R1191:Zfp760 UTSW 17 21,942,286 (GRCm39) missense probably damaging 1.00
R1760:Zfp760 UTSW 17 21,941,311 (GRCm39) missense probably damaging 1.00
R2698:Zfp760 UTSW 17 21,939,935 (GRCm39) missense probably damaging 0.99
R3722:Zfp760 UTSW 17 21,941,143 (GRCm39) missense probably damaging 1.00
R4700:Zfp760 UTSW 17 21,941,388 (GRCm39) missense probably benign 0.01
R4859:Zfp760 UTSW 17 21,942,516 (GRCm39) nonsense probably null
R4859:Zfp760 UTSW 17 21,942,511 (GRCm39) missense probably damaging 0.97
R4897:Zfp760 UTSW 17 21,942,229 (GRCm39) missense probably benign 0.02
R6675:Zfp760 UTSW 17 21,941,991 (GRCm39) missense possibly damaging 0.92
R7286:Zfp760 UTSW 17 21,941,760 (GRCm39) missense probably benign 0.04
R7336:Zfp760 UTSW 17 21,942,814 (GRCm39) missense unknown
R7356:Zfp760 UTSW 17 21,941,601 (GRCm39) missense probably benign
R7369:Zfp760 UTSW 17 21,942,214 (GRCm39) missense probably benign 0.00
R7504:Zfp760 UTSW 17 21,941,655 (GRCm39) missense probably damaging 0.97
R7553:Zfp760 UTSW 17 21,941,872 (GRCm39) missense possibly damaging 0.82
R7577:Zfp760 UTSW 17 21,941,242 (GRCm39) nonsense probably null
R7579:Zfp760 UTSW 17 21,941,907 (GRCm39) missense possibly damaging 0.93
R7608:Zfp760 UTSW 17 21,941,797 (GRCm39) missense probably benign 0.00
R7973:Zfp760 UTSW 17 21,941,084 (GRCm39) missense probably benign 0.00
R8078:Zfp760 UTSW 17 21,942,436 (GRCm39) missense probably benign 0.27
R8332:Zfp760 UTSW 17 21,942,301 (GRCm39) missense probably damaging 0.99
R8750:Zfp760 UTSW 17 21,941,356 (GRCm39) missense possibly damaging 0.56
R9094:Zfp760 UTSW 17 21,941,932 (GRCm39) missense possibly damaging 0.86
R9264:Zfp760 UTSW 17 21,942,663 (GRCm39) missense possibly damaging 0.80
R9372:Zfp760 UTSW 17 21,941,035 (GRCm39) missense probably benign 0.00
R9520:Zfp760 UTSW 17 21,941,036 (GRCm39) missense probably benign 0.00
R9564:Zfp760 UTSW 17 21,942,272 (GRCm39) missense possibly damaging 0.94
R9743:Zfp760 UTSW 17 21,942,338 (GRCm39) missense probably benign
X0057:Zfp760 UTSW 17 21,942,663 (GRCm39) missense possibly damaging 0.80
Predicted Primers PCR Primer
(F):5'- CTGGAGAGAAACCGTACAATTG -3'
(R):5'- ACGACAGTGAACATTCTTCTGG -3'

Sequencing Primer
(F):5'- AAGGAATGTGGTAAGTTCTTCCATTG -3'
(R):5'- CGACAGTGAACATTCTTCTGGTTTAG -3'
Posted On 2015-09-24