Incidental Mutation 'R4561:Glyat'
ID 343116
Institutional Source Beutler Lab
Gene Symbol Glyat
Ensembl Gene ENSMUSG00000063683
Gene Name glycine-N-acyltransferase
Synonyms A330009E03Rik
MMRRC Submission 041786-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4561 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 12610672-12629101 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 12628644 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Phenylalanine at position 146 (L146F)
Ref Sequence ENSEMBL: ENSMUSP00000114002 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044976] [ENSMUST00000119960]
AlphaFold Q91XE0
Predicted Effect possibly damaging
Transcript: ENSMUST00000044976
AA Change: L180F

PolyPhen 2 Score 0.881 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000043308
Gene: ENSMUSG00000063683
AA Change: L180F

DomainStartEndE-ValueType
Pfam:Gly_acyl_tr_N 1 206 1.9e-90 PFAM
Pfam:Gly_acyl_tr_C 207 295 2.8e-46 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000119960
AA Change: L146F

PolyPhen 2 Score 0.881 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000114002
Gene: ENSMUSG00000063683
AA Change: L146F

DomainStartEndE-ValueType
Pfam:Gly_acyl_tr_N 1 172 1.2e-91 PFAM
Pfam:Gly_acyl_tr_C 173 261 3.6e-46 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123173
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157069
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The glycine-N-acyltransferase protein conjugates glycine with acyl-CoA substrates in the mitochondria. The protein is thought to be important in the detoxification of endogenous and xenobiotic acyl-CoA's. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ank3 T C 10: 69,837,848 (GRCm39) S1601P probably damaging Het
Arnt A G 3: 95,359,924 (GRCm39) N56D probably damaging Het
Atad5 A G 11: 79,986,715 (GRCm39) T601A probably benign Het
Calr4 A G 4: 109,103,379 (GRCm39) N163S probably damaging Het
Cenpc1 C A 5: 86,195,491 (GRCm39) A93S probably damaging Het
Cep135 C T 5: 76,786,040 (GRCm39) H1048Y possibly damaging Het
Ctnna2 A G 6: 77,613,696 (GRCm39) probably null Het
Ddx60 T C 8: 62,395,495 (GRCm39) L144P probably damaging Het
Dera A T 6: 137,757,736 (GRCm39) T96S possibly damaging Het
Dock9 T A 14: 121,796,419 (GRCm39) M1853L probably benign Het
Erbb4 G A 1: 68,383,080 (GRCm39) R306* probably null Het
Grk4 C A 5: 34,852,157 (GRCm39) Q134K probably benign Het
Hkdc1 T C 10: 62,245,618 (GRCm39) Q181R probably benign Het
Huwe1 A T X: 150,646,955 (GRCm39) I682F probably damaging Het
Ipo4 C T 14: 55,867,546 (GRCm39) probably benign Het
Ivl CCTGCTGCTGCT CCTGCTGCTGCTGCT 3: 92,479,262 (GRCm39) probably benign Het
Kcnd2 A G 6: 21,216,395 (GRCm39) Q33R probably benign Het
Kdm7a C T 6: 39,129,757 (GRCm39) R473Q probably damaging Het
Klhl30 A T 1: 91,288,753 (GRCm39) H504L probably damaging Het
Map4 A G 9: 109,881,439 (GRCm39) Y101C possibly damaging Het
Mfn2 C A 4: 147,961,492 (GRCm39) R707L probably damaging Het
Mslnl G A 17: 25,961,908 (GRCm39) V128M probably damaging Het
Myof T C 19: 37,911,438 (GRCm39) N1511D probably benign Het
Neb A T 2: 52,176,167 (GRCm39) Y1431N probably damaging Het
Nlrc5 A G 8: 95,203,774 (GRCm39) T625A probably damaging Het
Or5g27 G T 2: 85,409,964 (GRCm39) C127F probably damaging Het
Pax2 A G 19: 44,824,402 (GRCm39) Y374C unknown Het
Pde8a T A 7: 80,958,568 (GRCm39) Y315* probably null Het
Pkhd1 A T 1: 20,604,943 (GRCm39) L1124Q possibly damaging Het
Ppp1r3a A G 6: 14,754,681 (GRCm39) F189L probably damaging Het
Prex2 G A 1: 11,254,769 (GRCm39) probably null Het
Robo4 CGG CG 9: 37,322,786 (GRCm39) probably null Het
Slc22a22 T A 15: 57,126,781 (GRCm39) Q77L probably damaging Het
Slc24a2 A T 4: 87,145,634 (GRCm39) V140D probably damaging Het
Slc35g2 C A 9: 100,435,287 (GRCm39) R128L probably damaging Het
Slco1b2 A G 6: 141,616,893 (GRCm39) T409A probably benign Het
Spag7 T C 11: 70,555,816 (GRCm39) I80M probably damaging Het
Srgap3 A G 6: 112,758,015 (GRCm39) M164T probably damaging Het
Sspo A T 6: 48,452,468 (GRCm39) probably null Het
Tcte2 T C 17: 13,942,864 (GRCm39) probably benign Het
Tmem117 A T 15: 94,992,677 (GRCm39) M446L probably benign Het
Tmtc4 T C 14: 123,200,710 (GRCm39) T194A probably benign Het
Ttc21b T C 2: 66,016,562 (GRCm39) Y1269C probably damaging Het
Zfp236 A T 18: 82,638,531 (GRCm39) I1363N probably damaging Het
Zfp760 T A 17: 21,942,648 (GRCm39) S608T probably benign Het
Zfp947 G T 17: 22,365,124 (GRCm39) Y183* probably null Het
Other mutations in Glyat
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00478:Glyat APN 19 12,625,497 (GRCm39) splice site probably benign
IGL00766:Glyat APN 19 12,628,626 (GRCm39) missense probably benign 0.19
IGL01288:Glyat APN 19 12,627,719 (GRCm39) missense possibly damaging 0.56
IGL02296:Glyat APN 19 12,628,625 (GRCm39) missense probably damaging 0.99
PIT4458001:Glyat UTSW 19 12,625,373 (GRCm39) missense probably benign 0.34
R0416:Glyat UTSW 19 12,628,817 (GRCm39) missense possibly damaging 0.87
R1463:Glyat UTSW 19 12,625,467 (GRCm39) missense probably damaging 1.00
R1750:Glyat UTSW 19 12,623,679 (GRCm39) missense probably benign 0.01
R2416:Glyat UTSW 19 12,628,618 (GRCm39) missense possibly damaging 0.50
R2504:Glyat UTSW 19 12,628,762 (GRCm39) missense possibly damaging 0.82
R2960:Glyat UTSW 19 12,617,214 (GRCm39) missense probably damaging 1.00
R3958:Glyat UTSW 19 12,617,197 (GRCm39) missense probably benign 0.05
R4126:Glyat UTSW 19 12,628,843 (GRCm39) missense probably benign 0.03
R4705:Glyat UTSW 19 12,628,661 (GRCm39) missense possibly damaging 0.68
R5062:Glyat UTSW 19 12,627,627 (GRCm39) missense probably damaging 1.00
R5490:Glyat UTSW 19 12,627,645 (GRCm39) missense probably benign 0.35
R7028:Glyat UTSW 19 12,627,723 (GRCm39) missense probably benign 0.00
R7044:Glyat UTSW 19 12,627,629 (GRCm39) missense probably benign 0.05
R7599:Glyat UTSW 19 12,617,172 (GRCm39) missense probably damaging 0.99
R9595:Glyat UTSW 19 12,623,728 (GRCm39) missense probably damaging 1.00
R9784:Glyat UTSW 19 12,628,844 (GRCm39) missense probably benign 0.00
Z1088:Glyat UTSW 19 12,625,373 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CCAACAACACTGGCCTTTCTG -3'
(R):5'- TGGTCTTGTGAATGGACAACAAAG -3'

Sequencing Primer
(F):5'- CTAGCATAAGCCTATCTATTCCAGG -3'
(R):5'- AAGACCTTGGAGCCGGTACTC -3'
Posted On 2015-09-24