Incidental Mutation 'R4566:Rasl2-9'
| ID |
343319 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rasl2-9
|
| Ensembl Gene |
ENSMUSG00000083649 |
| Gene Name |
RAS-like, family 2, locus 9 |
| Synonyms |
Rasl2-9-ps, Ran/M2 |
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.898)
|
| Stock # |
R4566 (G1)
|
| Quality Score |
217 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
5127941-5128949 bp(-) (GRCm39) |
| Type of Mutation |
frame shift |
| DNA Base Change (assembly) |
AGG to A
at 5128374 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129559
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000147835]
|
| AlphaFold |
Q61820 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000147835
|
| SMART Domains |
Protein: ENSMUSP00000129559
Gene: ENSMUSG00000083649
| Domain | Start | End | E-Value | Type |
|---|
|
RAN
|
16 |
216 |
1.25e-161 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000175212
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000207732
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.0%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 21 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrv1 |
T |
C |
13: 81,567,927 (GRCm39) |
E5082G |
probably damaging |
Het |
| Apol7a |
A |
T |
15: 77,273,951 (GRCm39) |
Y170* |
probably null |
Het |
| Cfhr1 |
T |
A |
1: 139,481,386 (GRCm39) |
I165F |
possibly damaging |
Het |
| Dnah8 |
G |
A |
17: 30,967,542 (GRCm39) |
D2585N |
probably benign |
Het |
| Espnl |
C |
A |
1: 91,272,301 (GRCm39) |
P510T |
possibly damaging |
Het |
| Fbxw4 |
A |
G |
19: 45,580,225 (GRCm39) |
V258A |
probably benign |
Het |
| Foxq1 |
T |
C |
13: 31,743,471 (GRCm39) |
M191T |
probably benign |
Het |
| Gabrg1 |
A |
T |
5: 70,999,484 (GRCm39) |
L22I |
probably benign |
Het |
| Limk1 |
A |
G |
5: 134,715,537 (GRCm39) |
L38P |
probably benign |
Het |
| Mfhas1 |
C |
T |
8: 36,058,203 (GRCm39) |
R893C |
probably damaging |
Het |
| Mug2 |
G |
A |
6: 122,056,597 (GRCm39) |
V1181I |
probably benign |
Het |
| Or52ac1 |
A |
T |
7: 104,245,823 (GRCm39) |
C188* |
probably null |
Het |
| Pithd1 |
A |
G |
4: 135,704,548 (GRCm39) |
V56A |
probably damaging |
Het |
| Plxna4 |
T |
C |
6: 32,494,338 (GRCm39) |
K93E |
probably benign |
Het |
| Ppp2cb |
T |
C |
8: 34,100,723 (GRCm39) |
V48A |
possibly damaging |
Het |
| Rrs1 |
T |
C |
1: 9,616,452 (GRCm39) |
F235S |
probably damaging |
Het |
| Rtl1 |
G |
A |
12: 109,559,293 (GRCm39) |
L849F |
probably damaging |
Het |
| Slc5a9 |
C |
A |
4: 111,748,941 (GRCm39) |
|
probably null |
Het |
| Trps1 |
A |
G |
15: 50,695,074 (GRCm39) |
V116A |
probably damaging |
Het |
| Vmn2r51 |
C |
T |
7: 9,836,341 (GRCm39) |
E147K |
probably benign |
Het |
| Yy1 |
T |
A |
12: 108,778,889 (GRCm39) |
I296K |
probably damaging |
Het |
|
| Other mutations in Rasl2-9 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02110:Rasl2-9
|
APN |
7 |
5,128,346 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1500:Rasl2-9
|
UTSW |
7 |
5,128,441 (GRCm39) |
nonsense |
probably null |
|
|
R4567:Rasl2-9
|
UTSW |
7 |
5,128,374 (GRCm39) |
frame shift |
probably null |
|
|
R4568:Rasl2-9
|
UTSW |
7 |
5,128,374 (GRCm39) |
frame shift |
probably null |
|
|
R4745:Rasl2-9
|
UTSW |
7 |
5,128,702 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7301:Rasl2-9
|
UTSW |
7 |
5,128,739 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8025:Rasl2-9
|
UTSW |
7 |
5,128,481 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8281:Rasl2-9
|
UTSW |
7 |
5,128,351 (GRCm39) |
nonsense |
probably null |
|
|
R9272:Rasl2-9
|
UTSW |
7 |
5,128,448 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGAATTGCACGATCTCCTTTAGC -3'
(R):5'- TCCCCATTGTATTGTGTGGC -3'
Sequencing Primer
(F):5'- CTCCTTTAGCTAAATAAGGTGGCAC -3'
(R):5'- GGCAACAAAGTGGATGTTAAAGAC -3'
|
| Posted On |
2015-09-24 |
Incidental Mutation