Incidental Mutation 'R4572:Clasrp'
ID 343400
Institutional Source Beutler Lab
Gene Symbol Clasrp
Ensembl Gene ENSMUSG00000061028
Gene Name CLK4-associating serine/arginine rich protein
Synonyms SWAP2, Sfrs16, Srsf16
MMRRC Submission 041796-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R4572 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 19314960-19338411 bp(-) (GRCm39)
Type of Mutation splice site (6 bp from exon)
DNA Base Change (assembly) A to G at 19318389 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000083205 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086041] [ENSMUST00000086041] [ENSMUST00000108453] [ENSMUST00000207524] [ENSMUST00000207524] [ENSMUST00000208068] [ENSMUST00000208068] [ENSMUST00000207907] [ENSMUST00000207907] [ENSMUST00000207663] [ENSMUST00000207663]
AlphaFold Q8CFC7
Predicted Effect probably null
Transcript: ENSMUST00000086041
SMART Domains Protein: ENSMUSP00000083205
Gene: ENSMUSG00000061028

DomainStartEndE-ValueType
low complexity region 19 35 N/A INTRINSIC
DRY_EERY 39 171 1.28e-64 SMART
low complexity region 172 212 N/A INTRINSIC
low complexity region 241 260 N/A INTRINSIC
low complexity region 263 283 N/A INTRINSIC
low complexity region 302 324 N/A INTRINSIC
low complexity region 339 368 N/A INTRINSIC
low complexity region 372 446 N/A INTRINSIC
low complexity region 453 476 N/A INTRINSIC
low complexity region 480 532 N/A INTRINSIC
coiled coil region 574 630 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000086041
SMART Domains Protein: ENSMUSP00000083205
Gene: ENSMUSG00000061028

DomainStartEndE-ValueType
low complexity region 19 35 N/A INTRINSIC
DRY_EERY 39 171 1.28e-64 SMART
low complexity region 172 212 N/A INTRINSIC
low complexity region 241 260 N/A INTRINSIC
low complexity region 263 283 N/A INTRINSIC
low complexity region 302 324 N/A INTRINSIC
low complexity region 339 368 N/A INTRINSIC
low complexity region 372 446 N/A INTRINSIC
low complexity region 453 476 N/A INTRINSIC
low complexity region 480 532 N/A INTRINSIC
coiled coil region 574 630 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000108453
SMART Domains Protein: ENSMUSP00000104093
Gene: ENSMUSG00000011267

DomainStartEndE-ValueType
ZnF_C2H2 138 161 5.07e0 SMART
ZnF_C2H2 212 234 2.05e-2 SMART
ZnF_C2H2 240 262 1.1e-2 SMART
low complexity region 281 295 N/A INTRINSIC
low complexity region 317 329 N/A INTRINSIC
ZnF_C2H2 360 382 1.95e-3 SMART
ZnF_C2H2 388 410 3.39e-3 SMART
ZnF_C2H2 418 441 1.14e0 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207253
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207264
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207447
Predicted Effect probably benign
Transcript: ENSMUST00000207524
Predicted Effect probably benign
Transcript: ENSMUST00000207524
Predicted Effect probably benign
Transcript: ENSMUST00000208068
Predicted Effect probably benign
Transcript: ENSMUST00000208068
Predicted Effect probably benign
Transcript: ENSMUST00000207907
Predicted Effect probably benign
Transcript: ENSMUST00000207907
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208464
Predicted Effect probably benign
Transcript: ENSMUST00000207663
Predicted Effect probably benign
Transcript: ENSMUST00000207663
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209059
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208427
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208716
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency 100% (71/71)
MGI Phenotype FUNCTION: The protein encoded by this gene contains serine/arginine (SR) dipeptide repeat domains, and is thought to be involved in the regulation of alternative splicing. This protein is thought to interact with, and be phosphorylated by, Clk4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca6 A T 11: 110,107,374 (GRCm39) I747N probably benign Het
Adamtsl2 A G 2: 26,973,268 (GRCm39) Y97C probably damaging Het
Alox12e A G 11: 70,212,007 (GRCm39) probably benign Het
Alpk2 A T 18: 65,414,075 (GRCm39) S2014T probably damaging Het
Ankrd36 A T 11: 5,639,340 (GRCm39) probably null Het
Apobec1 T C 6: 122,558,356 (GRCm39) D133G probably damaging Het
Arfgef1 A T 1: 10,283,366 (GRCm39) I181N probably damaging Het
Cilp2 A G 8: 70,335,060 (GRCm39) V646A probably damaging Het
Cnot2 T C 10: 116,330,751 (GRCm39) T423A probably benign Het
Crtap T C 9: 114,213,874 (GRCm39) D227G probably benign Het
Cyp17a1 A G 19: 46,658,990 (GRCm39) F217S probably damaging Het
Ddx60 A G 8: 62,440,455 (GRCm39) M1036V probably damaging Het
Dnah11 A T 12: 117,973,860 (GRCm39) I2818N probably benign Het
Dok6 T A 18: 89,492,071 (GRCm39) I169F possibly damaging Het
Duox2 T A 2: 122,112,207 (GRCm39) R1326S probably benign Het
Epha10 A G 4: 124,796,361 (GRCm39) T357A unknown Het
Ephb2 A C 4: 136,383,251 (GRCm39) F942C probably damaging Het
Fscn3 T A 6: 28,430,634 (GRCm39) probably null Het
Gabrb2 A G 11: 42,484,744 (GRCm39) N267S possibly damaging Het
Gabrr3 A T 16: 59,282,001 (GRCm39) Y452F probably benign Het
Gen1 A G 12: 11,292,419 (GRCm39) S457P probably damaging Het
Gm1993 C T X: 25,515,656 (GRCm39) R77H probably damaging Het
Gm5592 G A 7: 40,865,583 (GRCm39) probably benign Het
Hmbox1 A G 14: 65,140,682 (GRCm39) probably null Het
Hus1 A T 11: 8,957,617 (GRCm39) probably null Het
Ino80 G A 2: 119,232,839 (GRCm39) R1160W probably damaging Het
Kalrn A T 16: 34,212,412 (GRCm39) F27L probably damaging Het
Kri1 A T 9: 21,191,680 (GRCm39) F187L probably damaging Het
Lekr1 A T 3: 65,691,336 (GRCm39) noncoding transcript Het
Mapk15 T C 15: 75,870,599 (GRCm39) probably benign Het
Mrgpre G A 7: 143,334,841 (GRCm39) L221F probably damaging Het
Mrpl50 A T 4: 49,514,399 (GRCm39) S91T possibly damaging Het
Muc4 T C 16: 32,753,802 (GRCm38) I1226T probably benign Het
Mup15 A G 4: 61,356,454 (GRCm39) probably null Het
Ncapd3 A G 9: 27,005,911 (GRCm39) D1469G probably damaging Het
Nlrp9b G A 7: 19,760,606 (GRCm39) probably null Het
Npy6r A T 18: 44,408,984 (GRCm39) Y135F probably benign Het
Or7e170 A C 9: 19,795,275 (GRCm39) C109G probably benign Het
Phf14 G A 6: 12,006,823 (GRCm39) R825Q probably damaging Het
Pigg A G 5: 108,480,751 (GRCm39) M379V probably benign Het
Plppr3 T A 10: 79,701,897 (GRCm39) Q315L probably benign Het
Plxnd1 C A 6: 115,932,717 (GRCm39) C1921F probably damaging Het
Ptger4 A C 15: 5,272,614 (GRCm39) S2A probably benign Het
Qrfprl A T 6: 65,431,975 (GRCm39) M293L probably benign Het
Rab4a A T 8: 124,560,799 (GRCm39) D196V probably benign Het
Rbck1 G A 2: 152,160,653 (GRCm39) Q428* probably null Het
Rgs14 A T 13: 55,527,875 (GRCm39) N266I probably damaging Het
Serpina1c A T 12: 103,864,967 (GRCm39) probably benign Het
Sesn3 G A 9: 14,232,516 (GRCm39) R263H probably benign Het
Slfn1 A T 11: 83,012,289 (GRCm39) D135V probably benign Het
Spata17 T C 1: 186,926,193 (GRCm39) K46E possibly damaging Het
Srcin1 A C 11: 97,425,760 (GRCm39) D432E probably damaging Het
Stxbp5 T C 10: 9,713,888 (GRCm39) E217G probably damaging Het
Terf2ip A G 8: 112,738,649 (GRCm39) D179G probably damaging Het
Tll1 A G 8: 64,509,343 (GRCm39) F556L possibly damaging Het
Tmed4 CTCTTTCT CTCT 11: 6,224,461 (GRCm39) probably null Het
Trappc9 G T 15: 72,808,916 (GRCm39) Q537K possibly damaging Het
Trim30a G T 7: 104,060,395 (GRCm39) C460* probably null Het
Trim35 T C 14: 66,545,322 (GRCm39) Y298H probably damaging Het
Ugt3a1 T A 15: 9,306,479 (GRCm39) H209Q probably benign Het
Ulk4 T C 9: 121,021,830 (GRCm39) K627R probably damaging Het
Wnk1 T C 6: 119,928,872 (GRCm39) T1319A possibly damaging Het
Wnt9b G A 11: 103,622,981 (GRCm39) R141C probably damaging Het
Zfp735 A G 11: 73,580,611 (GRCm39) M37V probably benign Het
Zmym1 A T 4: 126,944,628 (GRCm39) N186K probably benign Het
Other mutations in Clasrp
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02394:Clasrp APN 7 19,337,179 (GRCm39) missense probably damaging 1.00
clarissa UTSW 7 19,324,173 (GRCm39) missense possibly damaging 0.82
suet UTSW 7 19,320,393 (GRCm39) utr 3 prime probably benign
R0518:Clasrp UTSW 7 19,322,528 (GRCm39) missense probably benign 0.32
R0519:Clasrp UTSW 7 19,318,089 (GRCm39) utr 3 prime probably benign
R0521:Clasrp UTSW 7 19,322,528 (GRCm39) missense probably benign 0.32
R0626:Clasrp UTSW 7 19,318,418 (GRCm39) utr 3 prime probably benign
R0826:Clasrp UTSW 7 19,318,226 (GRCm39) utr 3 prime probably benign
R1918:Clasrp UTSW 7 19,319,188 (GRCm39) nonsense probably null
R2044:Clasrp UTSW 7 19,320,640 (GRCm39) utr 3 prime probably benign
R2256:Clasrp UTSW 7 19,320,510 (GRCm39) utr 3 prime probably benign
R2257:Clasrp UTSW 7 19,320,510 (GRCm39) utr 3 prime probably benign
R2870:Clasrp UTSW 7 19,319,165 (GRCm39) utr 3 prime probably benign
R2870:Clasrp UTSW 7 19,319,165 (GRCm39) utr 3 prime probably benign
R2871:Clasrp UTSW 7 19,319,165 (GRCm39) utr 3 prime probably benign
R2871:Clasrp UTSW 7 19,319,165 (GRCm39) utr 3 prime probably benign
R2940:Clasrp UTSW 7 19,319,165 (GRCm39) utr 3 prime probably benign
R3408:Clasrp UTSW 7 19,319,165 (GRCm39) utr 3 prime probably benign
R3691:Clasrp UTSW 7 19,319,165 (GRCm39) utr 3 prime probably benign
R4168:Clasrp UTSW 7 19,315,079 (GRCm39) unclassified probably benign
R4496:Clasrp UTSW 7 19,319,165 (GRCm39) utr 3 prime probably benign
R4505:Clasrp UTSW 7 19,319,165 (GRCm39) utr 3 prime probably benign
R4507:Clasrp UTSW 7 19,319,165 (GRCm39) utr 3 prime probably benign
R4753:Clasrp UTSW 7 19,328,865 (GRCm39) missense probably damaging 1.00
R4871:Clasrp UTSW 7 19,324,173 (GRCm39) missense possibly damaging 0.82
R4938:Clasrp UTSW 7 19,318,703 (GRCm39) splice site probably null
R5538:Clasrp UTSW 7 19,318,707 (GRCm39) utr 3 prime probably benign
R5582:Clasrp UTSW 7 19,320,781 (GRCm39) missense probably damaging 0.97
R5615:Clasrp UTSW 7 19,320,372 (GRCm39) utr 3 prime probably benign
R5794:Clasrp UTSW 7 19,325,034 (GRCm39) missense probably damaging 0.99
R5944:Clasrp UTSW 7 19,328,431 (GRCm39) missense probably damaging 1.00
R6102:Clasrp UTSW 7 19,320,393 (GRCm39) utr 3 prime probably benign
R6171:Clasrp UTSW 7 19,318,747 (GRCm39) splice site probably benign
R6485:Clasrp UTSW 7 19,320,294 (GRCm39) utr 3 prime probably benign
R6600:Clasrp UTSW 7 19,324,207 (GRCm39) nonsense probably null
R7383:Clasrp UTSW 7 19,319,198 (GRCm39) missense unknown
R7719:Clasrp UTSW 7 19,321,769 (GRCm39) missense probably damaging 0.99
R7750:Clasrp UTSW 7 19,318,516 (GRCm39) makesense probably null
R7808:Clasrp UTSW 7 19,322,671 (GRCm39) splice site probably null
R8192:Clasrp UTSW 7 19,329,387 (GRCm39) missense possibly damaging 0.83
R8820:Clasrp UTSW 7 19,320,362 (GRCm39) missense unknown
R8821:Clasrp UTSW 7 19,320,362 (GRCm39) missense unknown
R8924:Clasrp UTSW 7 19,318,232 (GRCm39) missense unknown
R9471:Clasrp UTSW 7 19,319,172 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CATGCTCCTGCTGGATCATC -3'
(R):5'- AGAATTTGGAACTCGCCCGTC -3'

Sequencing Primer
(F):5'- GGATCATCTTCTCCTGAGCTG -3'
(R):5'- TAACTCCCGTCAGCAGCAGTG -3'
Posted On 2015-09-24