Incidental Mutation 'R4583:Frem3'
| ID |
343838 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Frem3
|
| Ensembl Gene |
ENSMUSG00000042353 |
| Gene Name |
Fras1 related extracellular matrix protein 3 |
| Synonyms |
LOC333315 |
| MMRRC Submission |
041804-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.133)
|
| Stock # |
R4583 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
8 |
| Chromosomal Location |
81337709-81421985 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 81340143 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 812
(V812A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000038015
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000039695]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000039695
AA Change: V812A
PolyPhen 2
Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000038015
Gene: ENSMUSG00000042353
AA Change: V812A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
27 |
N/A |
INTRINSIC |
|
Pfam:Cadherin_3
|
369 |
515 |
9.5e-31 |
PFAM |
|
Pfam:Cadherin_3
|
495 |
596 |
9.4e-20 |
PFAM |
|
Pfam:Cadherin_3
|
637 |
786 |
4.2e-20 |
PFAM |
|
Pfam:Cadherin_3
|
788 |
913 |
5.5e-23 |
PFAM |
|
Pfam:Cadherin_3
|
998 |
1163 |
1.8e-20 |
PFAM |
|
Pfam:Cadherin_3
|
1129 |
1254 |
1.3e-19 |
PFAM |
|
Pfam:Cadherin_3
|
1250 |
1395 |
9.5e-34 |
PFAM |
|
Pfam:Cadherin_3
|
1397 |
1508 |
2.7e-21 |
PFAM |
|
Pfam:Cadherin_3
|
1493 |
1617 |
1.2e-27 |
PFAM |
|
Pfam:Cadherin_3
|
1622 |
1748 |
4.8e-17 |
PFAM |
|
Calx_beta
|
1754 |
1853 |
1.45e-7 |
SMART |
|
Calx_beta
|
1866 |
1977 |
3.35e-12 |
SMART |
|
Calx_beta
|
1991 |
2098 |
1.61e-5 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an integral membrane protein containing numerous CSPG (chondroitin sulfate proteoglycan element) repeats and Calx-beta domains. The protein belongs to the family of FRAS1/FREM extracellular matrix proteins and may play a role cell adhesion. [provided by RefSeq, Feb 2017]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 119 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310022A10Rik |
T |
C |
7: 27,274,017 (GRCm39) |
L86P |
unknown |
Het |
| Aimp1 |
C |
T |
3: 132,382,808 (GRCm39) |
E23K |
probably damaging |
Het |
| Ap2b1 |
A |
T |
11: 83,288,605 (GRCm39) |
N884I |
probably benign |
Het |
| Apoe |
G |
T |
7: 19,431,423 (GRCm39) |
Q65K |
possibly damaging |
Het |
| Arhgef1 |
T |
A |
7: 24,611,996 (GRCm39) |
D93E |
probably benign |
Het |
| Arhgef12 |
G |
T |
9: 42,888,958 (GRCm39) |
T1085K |
probably damaging |
Het |
| Arid5a |
T |
C |
1: 36,356,745 (GRCm39) |
|
probably null |
Het |
| Atp9a |
A |
T |
2: 168,531,280 (GRCm39) |
|
probably null |
Het |
| Baz1a |
T |
C |
12: 54,969,325 (GRCm39) |
I635V |
probably damaging |
Het |
| Bbs10 |
A |
G |
10: 111,136,995 (GRCm39) |
K703E |
probably benign |
Het |
| Cckar |
T |
A |
5: 53,857,124 (GRCm39) |
M429L |
probably benign |
Het |
| Ccl3 |
A |
T |
11: 83,539,164 (GRCm39) |
L65Q |
probably benign |
Het |
| Ccr3 |
A |
G |
9: 123,829,477 (GRCm39) |
T271A |
probably benign |
Het |
| Cd8b1 |
T |
A |
6: 71,303,081 (GRCm39) |
I52N |
probably damaging |
Het |
| Cdh15 |
G |
A |
8: 123,591,767 (GRCm39) |
E551K |
probably damaging |
Het |
| Cdh17 |
A |
G |
4: 11,810,466 (GRCm39) |
K719R |
probably benign |
Het |
| Cfap43 |
T |
C |
19: 47,825,655 (GRCm39) |
R38G |
probably null |
Het |
| Chd6 |
T |
C |
2: 160,856,114 (GRCm39) |
E715G |
probably damaging |
Het |
| Cldn34b2 |
T |
A |
X: 153,908,625 (GRCm39) |
R68* |
probably null |
Het |
| Col19a1 |
T |
G |
1: 24,600,410 (GRCm39) |
D44A |
unknown |
Het |
| Colgalt2 |
C |
T |
1: 152,382,627 (GRCm39) |
S493F |
probably damaging |
Het |
| Cr1l |
T |
C |
1: 194,812,139 (GRCm39) |
I99M |
probably damaging |
Het |
| Crybg1 |
T |
C |
10: 43,873,616 (GRCm39) |
E1164G |
probably damaging |
Het |
| Cym |
G |
T |
3: 107,118,718 (GRCm39) |
D367E |
probably damaging |
Het |
| Dennd2a |
G |
T |
6: 39,499,776 (GRCm39) |
T263K |
probably damaging |
Het |
| Dhx9 |
T |
A |
1: 153,336,049 (GRCm39) |
M869L |
probably damaging |
Het |
| Dnm2 |
A |
G |
9: 21,415,742 (GRCm39) |
H692R |
probably damaging |
Het |
| Ern1 |
A |
T |
11: 106,298,031 (GRCm39) |
S697T |
probably damaging |
Het |
| F12 |
G |
A |
13: 55,568,943 (GRCm39) |
T273I |
probably benign |
Het |
| Fam151b |
A |
T |
13: 92,604,617 (GRCm39) |
L124Q |
probably damaging |
Het |
| Fancg |
A |
G |
4: 43,002,991 (GRCm39) |
V622A |
probably benign |
Het |
| Fbxo2 |
T |
A |
4: 148,249,356 (GRCm39) |
N159K |
possibly damaging |
Het |
| Fgd2 |
C |
A |
17: 29,586,052 (GRCm39) |
T212K |
possibly damaging |
Het |
| Fhl3 |
T |
A |
4: 124,601,342 (GRCm39) |
D178E |
probably benign |
Het |
| Filip1 |
G |
T |
9: 79,723,091 (GRCm39) |
A1176D |
possibly damaging |
Het |
| Fndc1 |
T |
C |
17: 7,958,081 (GRCm39) |
Y1722C |
probably damaging |
Het |
| Fsip2 |
A |
G |
2: 82,809,017 (GRCm39) |
I1779V |
probably benign |
Het |
| Gli2 |
C |
T |
1: 118,769,798 (GRCm39) |
V585I |
probably benign |
Het |
| Gm15056 |
C |
G |
8: 21,390,697 (GRCm39) |
S80T |
probably benign |
Het |
| Gm5145 |
A |
G |
17: 20,790,715 (GRCm39) |
E31G |
probably benign |
Het |
| Gmfg |
A |
G |
7: 28,145,369 (GRCm39) |
Y71C |
probably damaging |
Het |
| Grk1 |
A |
G |
8: 13,459,322 (GRCm39) |
E291G |
probably damaging |
Het |
| Gtpbp1 |
A |
G |
15: 79,600,152 (GRCm39) |
E393G |
possibly damaging |
Het |
| Gtpbp2 |
A |
G |
17: 46,472,071 (GRCm39) |
D2G |
probably damaging |
Het |
| Hc |
A |
T |
2: 34,918,189 (GRCm39) |
V698E |
probably benign |
Het |
| Helz |
G |
A |
11: 107,536,895 (GRCm39) |
R249H |
probably damaging |
Het |
| Hmcn2 |
A |
G |
2: 31,303,277 (GRCm39) |
I2973V |
possibly damaging |
Het |
| Hnrnpa3 |
A |
G |
2: 75,493,950 (GRCm39) |
R286G |
probably benign |
Het |
| Hus1b |
A |
T |
13: 31,131,501 (GRCm39) |
W53R |
probably damaging |
Het |
| Hydin |
C |
T |
8: 111,321,857 (GRCm39) |
T4503I |
probably benign |
Het |
| Ighmbp2 |
G |
C |
19: 3,315,324 (GRCm39) |
P699A |
probably benign |
Het |
| Igkv1-122 |
A |
T |
6: 67,994,442 (GRCm39) |
Y110F |
probably benign |
Het |
| Igkv8-28 |
T |
C |
6: 70,120,604 (GRCm39) |
Y113C |
probably damaging |
Het |
| Iigp1c |
T |
C |
18: 60,379,152 (GRCm39) |
I229T |
possibly damaging |
Het |
| Il16 |
A |
G |
7: 83,332,107 (GRCm39) |
S158P |
probably damaging |
Het |
| Kalrn |
T |
A |
16: 34,055,637 (GRCm39) |
H876L |
probably damaging |
Het |
| Kdm5d |
T |
A |
Y: 914,134 (GRCm39) |
L357H |
probably damaging |
Het |
| Krt78 |
T |
C |
15: 101,855,055 (GRCm39) |
T919A |
possibly damaging |
Het |
| L3mbtl2 |
T |
C |
15: 81,569,107 (GRCm39) |
C594R |
probably damaging |
Het |
| Lcorl |
A |
T |
5: 45,890,931 (GRCm39) |
L474* |
probably null |
Het |
| Lgals3 |
A |
T |
14: 47,619,144 (GRCm39) |
|
probably null |
Het |
| Lnx1 |
C |
T |
5: 74,771,457 (GRCm39) |
V350I |
probably benign |
Het |
| Lpcat3 |
T |
G |
6: 124,680,286 (GRCm39) |
W429G |
possibly damaging |
Het |
| Lrp1 |
T |
C |
10: 127,377,241 (GRCm39) |
T4149A |
probably benign |
Het |
| Memo1 |
G |
A |
17: 74,565,456 (GRCm39) |
Q36* |
probably null |
Het |
| Mical2 |
A |
G |
7: 112,012,154 (GRCm39) |
N668S |
probably benign |
Het |
| Ms4a10 |
A |
T |
19: 10,945,553 (GRCm39) |
I76N |
possibly damaging |
Het |
| Mthfr |
T |
G |
4: 148,136,329 (GRCm39) |
L362V |
possibly damaging |
Het |
| Myh3 |
T |
A |
11: 66,987,279 (GRCm39) |
Y1376* |
probably null |
Het |
| Mymk |
C |
A |
2: 26,952,292 (GRCm39) |
V192F |
probably benign |
Het |
| Myo1c |
A |
G |
11: 75,562,688 (GRCm39) |
D966G |
possibly damaging |
Het |
| Ncam2 |
A |
G |
16: 81,314,445 (GRCm39) |
N474D |
probably damaging |
Het |
| Nmnat1 |
T |
C |
4: 149,553,608 (GRCm39) |
N168S |
possibly damaging |
Het |
| Nmur1 |
C |
T |
1: 86,314,367 (GRCm39) |
V323M |
possibly damaging |
Het |
| Npr2 |
C |
A |
4: 43,633,522 (GRCm39) |
|
probably null |
Het |
| Nsd3 |
T |
A |
8: 26,200,703 (GRCm39) |
M1265K |
probably benign |
Het |
| Or13c7 |
A |
G |
4: 43,855,262 (GRCm39) |
T318A |
probably benign |
Het |
| Or1e34 |
T |
C |
11: 73,778,629 (GRCm39) |
T190A |
probably damaging |
Het |
| Or1j16 |
A |
C |
2: 36,530,626 (GRCm39) |
T192P |
probably damaging |
Het |
| Or4c107 |
T |
A |
2: 88,789,556 (GRCm39) |
F249I |
probably damaging |
Het |
| Or4c11 |
G |
T |
2: 88,695,838 (GRCm39) |
M296I |
probably benign |
Het |
| Or5b108 |
T |
A |
19: 13,168,062 (GRCm39) |
F10L |
probably damaging |
Het |
| Or5i1 |
T |
C |
2: 87,613,565 (GRCm39) |
V227A |
possibly damaging |
Het |
| Or6c216 |
T |
C |
10: 129,678,344 (GRCm39) |
D189G |
probably damaging |
Het |
| Otub1 |
G |
A |
19: 7,181,801 (GRCm39) |
A25V |
possibly damaging |
Het |
| Paqr3 |
T |
A |
5: 97,256,069 (GRCm39) |
R102* |
probably null |
Het |
| Patl2 |
A |
G |
2: 121,957,226 (GRCm39) |
S103P |
probably benign |
Het |
| Pcdhb15 |
A |
T |
18: 37,608,628 (GRCm39) |
H620L |
possibly damaging |
Het |
| Pdgfc |
A |
T |
3: 81,048,835 (GRCm39) |
D81V |
possibly damaging |
Het |
| Pdia2 |
T |
C |
17: 26,415,476 (GRCm39) |
D447G |
probably damaging |
Het |
| Pold1 |
C |
A |
7: 44,188,337 (GRCm39) |
A514S |
probably damaging |
Het |
| Pomgnt1 |
C |
T |
4: 116,015,691 (GRCm39) |
T552I |
probably benign |
Het |
| Ppl |
T |
C |
16: 4,922,400 (GRCm39) |
E294G |
probably benign |
Het |
| Pramel12 |
A |
G |
4: 143,143,324 (GRCm39) |
Y30C |
probably damaging |
Het |
| Prkcb |
A |
G |
7: 122,056,447 (GRCm39) |
S100G |
probably benign |
Het |
| Psg16 |
T |
G |
7: 16,829,097 (GRCm39) |
I227S |
probably benign |
Het |
| Rbbp6 |
AAAGAAGAAGAAGAAGAAG |
AAAGAAGAAGAAGAAG |
7: 122,601,175 (GRCm39) |
|
probably benign |
Het |
| Reck |
T |
C |
4: 43,931,062 (GRCm39) |
|
probably null |
Het |
| Rrbp1 |
C |
T |
2: 143,830,671 (GRCm39) |
G499S |
probably benign |
Het |
| Sema6d |
G |
T |
2: 124,506,082 (GRCm39) |
R630L |
probably damaging |
Het |
| Slc29a1 |
A |
G |
17: 45,900,882 (GRCm39) |
V94A |
possibly damaging |
Het |
| Slc35a1 |
T |
A |
4: 34,664,146 (GRCm39) |
Q324L |
probably benign |
Het |
| Slc35c1 |
A |
T |
2: 92,289,266 (GRCm39) |
L80Q |
probably damaging |
Het |
| Slc7a10 |
G |
T |
7: 34,897,377 (GRCm39) |
|
probably null |
Het |
| Srrm2 |
C |
T |
17: 24,038,593 (GRCm39) |
|
probably benign |
Het |
| Stk38 |
T |
G |
17: 29,201,130 (GRCm39) |
D182A |
probably damaging |
Het |
| Tas2r104 |
C |
T |
6: 131,662,398 (GRCm39) |
G104S |
probably benign |
Het |
| Tmem121b |
T |
C |
6: 120,469,055 (GRCm39) |
E554G |
probably damaging |
Het |
| Tor1aip2 |
A |
G |
1: 155,940,888 (GRCm39) |
H398R |
probably benign |
Het |
| Tram2 |
C |
T |
1: 21,083,673 (GRCm39) |
V83I |
probably benign |
Het |
| Ube3a |
C |
T |
7: 58,935,811 (GRCm39) |
T565I |
probably damaging |
Het |
| Ubr4 |
T |
C |
4: 139,108,164 (GRCm39) |
V56A |
possibly damaging |
Het |
| Vmn1r128 |
T |
C |
7: 21,083,644 (GRCm39) |
V116A |
possibly damaging |
Het |
| Vmn1r170 |
C |
T |
7: 23,306,087 (GRCm39) |
T163I |
probably benign |
Het |
| Vmn2r75 |
T |
A |
7: 85,813,290 (GRCm39) |
D504V |
possibly damaging |
Het |
| Vps36 |
G |
A |
8: 22,708,436 (GRCm39) |
M363I |
probably benign |
Het |
| Wdsub1 |
A |
G |
2: 59,708,661 (GRCm39) |
S71P |
probably damaging |
Het |
| Zdhhc12 |
A |
G |
2: 29,981,496 (GRCm39) |
F189L |
probably benign |
Het |
| Zfp521 |
T |
C |
18: 13,977,387 (GRCm39) |
M1009V |
probably benign |
Het |
|
| Other mutations in Frem3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00481:Frem3
|
APN |
8 |
81,395,439 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL01019:Frem3
|
APN |
8 |
81,341,763 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01470:Frem3
|
APN |
8 |
81,340,944 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01609:Frem3
|
APN |
8 |
81,339,333 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01622:Frem3
|
APN |
8 |
81,340,544 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01623:Frem3
|
APN |
8 |
81,340,544 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01751:Frem3
|
APN |
8 |
81,342,372 (GRCm39) |
missense |
probably benign |
0.33 |
|
IGL02037:Frem3
|
APN |
8 |
81,338,118 (GRCm39) |
missense |
probably benign |
0.31 |
|
IGL02039:Frem3
|
APN |
8 |
81,339,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02084:Frem3
|
APN |
8 |
81,339,072 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02124:Frem3
|
APN |
8 |
81,339,723 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02140:Frem3
|
APN |
8 |
81,340,736 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL02836:Frem3
|
APN |
8 |
81,341,010 (GRCm39) |
missense |
probably benign |
|
|
IGL03090:Frem3
|
APN |
8 |
81,344,858 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03102:Frem3
|
APN |
8 |
81,339,661 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL03116:Frem3
|
APN |
8 |
81,339,435 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL03165:Frem3
|
APN |
8 |
81,339,158 (GRCm39) |
missense |
probably benign |
0.26 |
|
IGL03224:Frem3
|
APN |
8 |
81,340,092 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03401:Frem3
|
APN |
8 |
81,341,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03403:Frem3
|
APN |
8 |
81,337,719 (GRCm39) |
missense |
probably benign |
0.04 |
|
FR4340:Frem3
|
UTSW |
8 |
81,341,870 (GRCm39) |
small insertion |
probably benign |
|
|
FR4976:Frem3
|
UTSW |
8 |
81,341,870 (GRCm39) |
small insertion |
probably benign |
|
|
IGL02991:Frem3
|
UTSW |
8 |
81,395,511 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03052:Frem3
|
UTSW |
8 |
81,341,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0089:Frem3
|
UTSW |
8 |
81,342,507 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0647:Frem3
|
UTSW |
8 |
81,341,814 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0690:Frem3
|
UTSW |
8 |
81,340,581 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R0766:Frem3
|
UTSW |
8 |
81,341,951 (GRCm39) |
missense |
probably benign |
|
|
R0834:Frem3
|
UTSW |
8 |
81,413,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0909:Frem3
|
UTSW |
8 |
81,390,035 (GRCm39) |
missense |
probably benign |
0.45 |
|
R1033:Frem3
|
UTSW |
8 |
81,421,786 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1144:Frem3
|
UTSW |
8 |
81,338,513 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1312:Frem3
|
UTSW |
8 |
81,341,951 (GRCm39) |
missense |
probably benign |
|
|
R1330:Frem3
|
UTSW |
8 |
81,395,468 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1355:Frem3
|
UTSW |
8 |
81,417,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1390:Frem3
|
UTSW |
8 |
81,417,402 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1413:Frem3
|
UTSW |
8 |
81,395,430 (GRCm39) |
missense |
probably benign |
|
|
R1470:Frem3
|
UTSW |
8 |
81,337,820 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1470:Frem3
|
UTSW |
8 |
81,337,820 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1503:Frem3
|
UTSW |
8 |
81,413,647 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1538:Frem3
|
UTSW |
8 |
81,339,764 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1538:Frem3
|
UTSW |
8 |
81,339,339 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1612:Frem3
|
UTSW |
8 |
81,341,490 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1793:Frem3
|
UTSW |
8 |
81,339,741 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1872:Frem3
|
UTSW |
8 |
81,339,205 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1879:Frem3
|
UTSW |
8 |
81,338,567 (GRCm39) |
nonsense |
probably null |
|
|
R1886:Frem3
|
UTSW |
8 |
81,340,514 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1933:Frem3
|
UTSW |
8 |
81,339,519 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2027:Frem3
|
UTSW |
8 |
81,421,966 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R2040:Frem3
|
UTSW |
8 |
81,342,455 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R2050:Frem3
|
UTSW |
8 |
81,341,520 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2079:Frem3
|
UTSW |
8 |
81,341,732 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2099:Frem3
|
UTSW |
8 |
81,342,488 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2120:Frem3
|
UTSW |
8 |
81,342,086 (GRCm39) |
missense |
probably benign |
0.20 |
|
R2842:Frem3
|
UTSW |
8 |
81,395,978 (GRCm39) |
splice site |
probably null |
|
|
R2845:Frem3
|
UTSW |
8 |
81,339,849 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3015:Frem3
|
UTSW |
8 |
81,417,402 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3442:Frem3
|
UTSW |
8 |
81,339,669 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3724:Frem3
|
UTSW |
8 |
81,341,900 (GRCm39) |
missense |
probably benign |
0.06 |
|
R3730:Frem3
|
UTSW |
8 |
81,342,545 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3939:Frem3
|
UTSW |
8 |
81,341,649 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R3940:Frem3
|
UTSW |
8 |
81,341,649 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R3941:Frem3
|
UTSW |
8 |
81,341,649 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R4089:Frem3
|
UTSW |
8 |
81,341,802 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4282:Frem3
|
UTSW |
8 |
81,340,770 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4437:Frem3
|
UTSW |
8 |
81,339,236 (GRCm39) |
missense |
probably benign |
0.30 |
|
R4480:Frem3
|
UTSW |
8 |
81,337,986 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4575:Frem3
|
UTSW |
8 |
81,342,704 (GRCm39) |
missense |
probably benign |
0.17 |
|
R4620:Frem3
|
UTSW |
8 |
81,395,586 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4621:Frem3
|
UTSW |
8 |
81,395,820 (GRCm39) |
splice site |
probably null |
|
|
R4644:Frem3
|
UTSW |
8 |
81,340,356 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4667:Frem3
|
UTSW |
8 |
81,390,049 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4748:Frem3
|
UTSW |
8 |
81,338,088 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4823:Frem3
|
UTSW |
8 |
81,340,587 (GRCm39) |
missense |
probably benign |
0.25 |
|
R4836:Frem3
|
UTSW |
8 |
81,390,026 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4867:Frem3
|
UTSW |
8 |
81,339,912 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4921:Frem3
|
UTSW |
8 |
81,339,765 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R5030:Frem3
|
UTSW |
8 |
81,339,876 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5035:Frem3
|
UTSW |
8 |
81,342,543 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5172:Frem3
|
UTSW |
8 |
81,339,195 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5289:Frem3
|
UTSW |
8 |
81,338,948 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5492:Frem3
|
UTSW |
8 |
81,339,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5655:Frem3
|
UTSW |
8 |
81,339,323 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5685:Frem3
|
UTSW |
8 |
81,421,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5723:Frem3
|
UTSW |
8 |
81,340,026 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5743:Frem3
|
UTSW |
8 |
81,342,407 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5889:Frem3
|
UTSW |
8 |
81,340,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6048:Frem3
|
UTSW |
8 |
81,340,062 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6057:Frem3
|
UTSW |
8 |
81,342,216 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6137:Frem3
|
UTSW |
8 |
81,341,676 (GRCm39) |
missense |
probably benign |
|
|
R6264:Frem3
|
UTSW |
8 |
81,341,832 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6339:Frem3
|
UTSW |
8 |
81,339,644 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6418:Frem3
|
UTSW |
8 |
81,337,781 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6680:Frem3
|
UTSW |
8 |
81,395,949 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6773:Frem3
|
UTSW |
8 |
81,338,444 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6838:Frem3
|
UTSW |
8 |
81,338,660 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6928:Frem3
|
UTSW |
8 |
81,337,911 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R6939:Frem3
|
UTSW |
8 |
81,341,774 (GRCm39) |
missense |
probably benign |
0.23 |
|
R6995:Frem3
|
UTSW |
8 |
81,339,208 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7112:Frem3
|
UTSW |
8 |
81,338,660 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7155:Frem3
|
UTSW |
8 |
81,342,668 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7235:Frem3
|
UTSW |
8 |
81,417,354 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7282:Frem3
|
UTSW |
8 |
81,338,660 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7403:Frem3
|
UTSW |
8 |
81,342,774 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7422:Frem3
|
UTSW |
8 |
81,342,392 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7485:Frem3
|
UTSW |
8 |
81,339,965 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7516:Frem3
|
UTSW |
8 |
81,338,712 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7858:Frem3
|
UTSW |
8 |
81,338,350 (GRCm39) |
nonsense |
probably null |
|
|
R7976:Frem3
|
UTSW |
8 |
81,338,231 (GRCm39) |
nonsense |
probably null |
|
|
R8171:Frem3
|
UTSW |
8 |
81,341,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8185:Frem3
|
UTSW |
8 |
81,338,933 (GRCm39) |
nonsense |
probably null |
|
|
R8306:Frem3
|
UTSW |
8 |
81,338,840 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8478:Frem3
|
UTSW |
8 |
81,338,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8518:Frem3
|
UTSW |
8 |
81,339,224 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8794:Frem3
|
UTSW |
8 |
81,342,851 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8794:Frem3
|
UTSW |
8 |
81,338,907 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8806:Frem3
|
UTSW |
8 |
81,390,064 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8833:Frem3
|
UTSW |
8 |
81,339,401 (GRCm39) |
missense |
probably benign |
0.29 |
|
R8879:Frem3
|
UTSW |
8 |
81,339,777 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8897:Frem3
|
UTSW |
8 |
81,339,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8983:Frem3
|
UTSW |
8 |
81,395,875 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9207:Frem3
|
UTSW |
8 |
81,340,071 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R9277:Frem3
|
UTSW |
8 |
81,417,402 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9536:Frem3
|
UTSW |
8 |
81,342,048 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9596:Frem3
|
UTSW |
8 |
81,341,951 (GRCm39) |
missense |
probably benign |
|
|
R9649:Frem3
|
UTSW |
8 |
81,341,145 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9671:Frem3
|
UTSW |
8 |
81,339,134 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9723:Frem3
|
UTSW |
8 |
81,341,352 (GRCm39) |
missense |
probably benign |
|
|
R9790:Frem3
|
UTSW |
8 |
81,339,890 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9791:Frem3
|
UTSW |
8 |
81,339,890 (GRCm39) |
missense |
probably benign |
0.01 |
|
RF030:Frem3
|
UTSW |
8 |
81,341,867 (GRCm39) |
small insertion |
probably benign |
|
|
RF034:Frem3
|
UTSW |
8 |
81,341,867 (GRCm39) |
small insertion |
probably benign |
|
|
RF042:Frem3
|
UTSW |
8 |
81,341,867 (GRCm39) |
small insertion |
probably benign |
|
|
X0024:Frem3
|
UTSW |
8 |
81,339,710 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
X0027:Frem3
|
UTSW |
8 |
81,339,017 (GRCm39) |
nonsense |
probably null |
|
|
Z1088:Frem3
|
UTSW |
8 |
81,342,055 (GRCm39) |
missense |
probably benign |
0.04 |
|
Z1176:Frem3
|
UTSW |
8 |
81,342,060 (GRCm39) |
missense |
probably benign |
0.03 |
|
Z1176:Frem3
|
UTSW |
8 |
81,338,132 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Frem3
|
UTSW |
8 |
81,342,758 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACTGATTCACCAGGTAGACCC -3'
(R):5'- ATGCTCCCATTGATAACATCAGC -3'
Sequencing Primer
(F):5'- GATTCACCAGGTAGACCCATCGTTC -3'
(R):5'- AAAGTACTGCAAGTGTCCATGCTG -3'
|
| Posted On |
2015-09-24 |
Incidental Mutation