Incidental Mutation 'R4584:Slc22a29'
ID 343970
Institutional Source Beutler Lab
Gene Symbol Slc22a29
Ensembl Gene ENSMUSG00000075044
Gene Name solute carrier family 22. member 29
Synonyms D630002G06Rik
MMRRC Submission 041805-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4584 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 8137529-8196264 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 8146655 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 382 (F382L)
Ref Sequence ENSEMBL: ENSMUSP00000152815 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000113298] [ENSMUST00000222533]
AlphaFold Q8BWG6
Predicted Effect probably benign
Transcript: ENSMUST00000113298
AA Change: F382L

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000108923
Gene: ENSMUSG00000075044
AA Change: F382L

DomainStartEndE-ValueType
transmembrane domain 13 35 N/A INTRINSIC
Pfam:Sugar_tr 99 528 1.3e-25 PFAM
Pfam:MFS_1 140 372 7.7e-14 PFAM
Pfam:MFS_1 348 549 6.5e-11 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140910
SMART Domains Protein: ENSMUSP00000117625
Gene: ENSMUSG00000075044

DomainStartEndE-ValueType
transmembrane domain 13 35 N/A INTRINSIC
Pfam:Sugar_tr 98 454 4.6e-20 PFAM
Pfam:MFS_1 137 462 3.6e-15 PFAM
low complexity region 467 481 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142517
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149182
SMART Domains Protein: ENSMUSP00000122262
Gene: ENSMUSG00000075044

DomainStartEndE-ValueType
Pfam:Sugar_tr 62 418 2.2e-20 PFAM
Pfam:MFS_1 101 427 1.9e-15 PFAM
low complexity region 431 445 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000222533
AA Change: F382L

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency 97% (86/89)
Allele List at MGI
Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6430548M08Rik A G 8: 120,886,756 (GRCm39) N343D probably damaging Het
9530002B09Rik T A 4: 122,594,979 (GRCm39) D78E possibly damaging Het
A2m C A 6: 121,634,365 (GRCm39) D632E probably benign Het
Alpk2 A G 18: 65,440,035 (GRCm39) S453P probably damaging Het
Birc2 A T 9: 7,833,675 (GRCm39) F269I probably damaging Het
Ccdc66 G A 14: 27,222,468 (GRCm39) P92S probably benign Het
Cdc34 T A 10: 79,523,869 (GRCm39) D108E possibly damaging Het
Cdk5rap2 A C 4: 70,184,997 (GRCm39) V1151G probably damaging Het
Cemip T C 7: 83,607,747 (GRCm39) K753R probably damaging Het
Cep295 A T 9: 15,246,095 (GRCm39) L787Q possibly damaging Het
Cideb T C 14: 55,995,727 (GRCm39) N8S probably benign Het
Dagla A G 19: 10,248,373 (GRCm39) Y96H probably damaging Het
Dapl1 C A 2: 59,335,086 (GRCm39) T80K possibly damaging Het
Ddx6 T C 9: 44,535,784 (GRCm39) V171A probably damaging Het
Dnah12 C A 14: 26,494,551 (GRCm39) T34K probably damaging Het
Dnhd1 T C 7: 105,327,256 (GRCm39) L735P probably damaging Het
Ep400 T A 5: 110,881,763 (GRCm39) probably benign Het
Erlin1 G T 19: 44,057,758 (GRCm39) Y22* probably null Het
Gmcl1 A G 6: 86,699,605 (GRCm39) S141P probably damaging Het
Gtf2a1 C T 12: 91,529,700 (GRCm39) V338I possibly damaging Het
H2-T15 A T 17: 36,368,559 (GRCm39) M123K probably damaging Het
Ighv1-66 T A 12: 115,557,016 (GRCm39) Q22L possibly damaging Het
Igkv4-80 T C 6: 68,993,720 (GRCm39) Y57C probably damaging Het
Itpk1 G A 12: 102,536,416 (GRCm39) A410V possibly damaging Het
Itsn1 T A 16: 91,617,471 (GRCm39) probably benign Het
Kcnk3 G T 5: 30,745,730 (GRCm39) A24S probably damaging Het
Kif20a A G 18: 34,765,664 (GRCm39) Y887C probably damaging Het
Klf13 T C 7: 63,587,718 (GRCm39) T193A possibly damaging Het
Klhl9 G T 4: 88,640,144 (GRCm39) H32Q probably damaging Het
Kndc1 C G 7: 139,481,159 (GRCm39) P82A probably damaging Het
Llgl1 T A 11: 60,602,908 (GRCm39) L861Q probably damaging Het
Lpcat2 A G 8: 93,615,999 (GRCm39) E305G probably damaging Het
Mib2 C A 4: 155,741,744 (GRCm39) A293S probably damaging Het
Mtfr1 A G 3: 19,269,766 (GRCm39) E138G probably damaging Het
Myoz1 A G 14: 20,700,663 (GRCm39) W185R probably damaging Het
Ninj1 T A 13: 49,347,442 (GRCm39) probably null Het
Nlgn2 A T 11: 69,725,104 (GRCm39) V54E possibly damaging Het
Nlrc5 A C 8: 95,203,903 (GRCm39) I668L probably damaging Het
Npy6r T A 18: 44,409,262 (GRCm39) C228S probably damaging Het
Nufip2 T C 11: 77,632,554 (GRCm39) V690A unknown Het
Nup107 T C 10: 117,602,273 (GRCm39) I513M probably benign Het
Oit3 T C 10: 59,261,284 (GRCm39) D461G probably damaging Het
Or2ab1 T A 11: 58,488,830 (GRCm39) F205I probably benign Het
Paxbp1 T C 16: 90,831,011 (GRCm39) D455G probably damaging Het
Pcdh7 A T 5: 57,878,625 (GRCm39) T727S probably damaging Het
Pex14 G A 4: 149,055,053 (GRCm39) A113V probably damaging Het
Phc3 A G 3: 31,020,031 (GRCm39) V23A possibly damaging Het
Plec T C 15: 76,115,406 (GRCm39) D56G possibly damaging Het
Plekha7 C A 7: 115,836,768 (GRCm39) probably benign Het
Prdm16 T C 4: 154,422,140 (GRCm39) E885G probably damaging Het
Prss1l T C 6: 41,373,701 (GRCm39) L188P probably benign Het
Psd2 A G 18: 36,145,881 (GRCm39) T762A probably benign Het
Psme4 T A 11: 30,784,318 (GRCm39) H964Q probably damaging Het
Rbak C T 5: 143,161,878 (GRCm39) V51I probably benign Het
Rbfa A G 18: 80,243,721 (GRCm39) L15P probably benign Het
Ren1 T C 1: 133,282,546 (GRCm39) Y84H probably damaging Het
Rps6ka5 A T 12: 100,547,577 (GRCm39) I311N probably damaging Het
Samd14 T A 11: 94,912,361 (GRCm39) probably null Het
Scaf4 T C 16: 90,026,403 (GRCm39) probably benign Het
Serpina12 A T 12: 104,004,611 (GRCm39) L7Q unknown Het
Serpinb9d A T 13: 33,384,599 (GRCm39) E192V probably damaging Het
Snta1 T A 2: 154,220,035 (GRCm39) D375V probably benign Het
Stat5b T A 11: 100,678,064 (GRCm39) Y683F probably damaging Het
Strip1 A T 3: 107,531,819 (GRCm39) Y257N probably benign Het
Sugp2 A G 8: 70,704,548 (GRCm39) H695R probably benign Het
Svep1 T A 4: 58,068,526 (GRCm39) R3087* probably null Het
Syngr2 T C 11: 117,703,947 (GRCm39) V138A probably damaging Het
Thra T C 11: 98,655,310 (GRCm39) F397L probably benign Het
Tmem45b T A 9: 31,339,951 (GRCm39) I149F probably damaging Het
Tmprss11f C T 5: 86,687,553 (GRCm39) probably null Het
Ush2a C T 1: 188,183,995 (GRCm39) T1433I probably benign Het
Vmn2r109 A T 17: 20,774,820 (GRCm39) Y178* probably null Het
Vmn2r84 T G 10: 130,226,582 (GRCm39) M419L probably benign Het
Wnk2 C T 13: 49,244,313 (GRCm39) D508N probably damaging Het
Zfp268 T A 4: 145,343,747 (GRCm39) probably null Het
Zfp276 A G 8: 123,995,145 (GRCm39) probably benign Het
Zfp568 T G 7: 29,697,617 (GRCm39) F100V probably benign Het
Zfp667 T A 7: 6,293,624 (GRCm39) D41E possibly damaging Het
Other mutations in Slc22a29
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00230:Slc22a29 APN 19 8,195,177 (GRCm39) missense probably benign 0.44
IGL00562:Slc22a29 APN 19 8,138,993 (GRCm39) missense probably benign 0.03
IGL00563:Slc22a29 APN 19 8,138,993 (GRCm39) missense probably benign 0.03
IGL00952:Slc22a29 APN 19 8,195,221 (GRCm39) missense probably damaging 1.00
IGL01526:Slc22a29 APN 19 8,184,542 (GRCm39) splice site probably benign
IGL01792:Slc22a29 APN 19 8,195,893 (GRCm39) missense probably damaging 1.00
IGL02191:Slc22a29 APN 19 8,196,045 (GRCm39) unclassified probably benign
IGL02391:Slc22a29 APN 19 8,146,717 (GRCm39) missense probably benign 0.13
IGL02408:Slc22a29 APN 19 8,184,649 (GRCm39) missense probably benign 0.00
IGL02957:Slc22a29 APN 19 8,147,354 (GRCm39) missense probably benign 0.01
IGL03059:Slc22a29 APN 19 8,147,354 (GRCm39) missense probably benign 0.01
IGL03299:Slc22a29 APN 19 8,140,012 (GRCm39) critical splice donor site probably null
IGL03368:Slc22a29 APN 19 8,184,626 (GRCm39) critical splice donor site probably null
R0017:Slc22a29 UTSW 19 8,195,630 (GRCm39) splice site probably benign
R0105:Slc22a29 UTSW 19 8,137,991 (GRCm39) unclassified probably benign
R0157:Slc22a29 UTSW 19 8,140,106 (GRCm39) missense possibly damaging 0.61
R0265:Slc22a29 UTSW 19 8,147,334 (GRCm39) missense probably benign 0.18
R1758:Slc22a29 UTSW 19 8,195,126 (GRCm39) critical splice donor site probably null
R1918:Slc22a29 UTSW 19 8,195,123 (GRCm39) splice site probably null
R1927:Slc22a29 UTSW 19 8,184,430 (GRCm39) missense probably benign 0.01
R1959:Slc22a29 UTSW 19 8,146,557 (GRCm39) missense probably benign 0.05
R1960:Slc22a29 UTSW 19 8,146,557 (GRCm39) missense probably benign 0.05
R1961:Slc22a29 UTSW 19 8,146,557 (GRCm39) missense probably benign 0.05
R1966:Slc22a29 UTSW 19 8,195,772 (GRCm39) missense probably damaging 1.00
R1968:Slc22a29 UTSW 19 8,195,707 (GRCm39) missense probably benign 0.27
R1997:Slc22a29 UTSW 19 8,195,162 (GRCm39) missense probably benign 0.00
R3105:Slc22a29 UTSW 19 8,147,337 (GRCm39) missense probably benign 0.25
R3725:Slc22a29 UTSW 19 8,195,973 (GRCm39) missense possibly damaging 0.78
R4118:Slc22a29 UTSW 19 8,137,893 (GRCm39) unclassified probably benign
R4465:Slc22a29 UTSW 19 8,140,088 (GRCm39) nonsense probably null
R4656:Slc22a29 UTSW 19 8,195,664 (GRCm39) missense possibly damaging 0.90
R4679:Slc22a29 UTSW 19 8,138,948 (GRCm39) missense possibly damaging 0.65
R4899:Slc22a29 UTSW 19 8,138,933 (GRCm39) missense probably benign 0.00
R4913:Slc22a29 UTSW 19 8,195,722 (GRCm39) missense probably benign 0.17
R5119:Slc22a29 UTSW 19 8,195,194 (GRCm39) missense probably damaging 0.99
R5470:Slc22a29 UTSW 19 8,138,880 (GRCm39) missense probably benign 0.01
R5474:Slc22a29 UTSW 19 8,195,221 (GRCm39) missense probably damaging 1.00
R6794:Slc22a29 UTSW 19 8,138,887 (GRCm39) missense probably benign 0.06
R6798:Slc22a29 UTSW 19 8,137,968 (GRCm39) missense probably benign 0.16
R7025:Slc22a29 UTSW 19 8,137,944 (GRCm39) missense probably benign
R7240:Slc22a29 UTSW 19 8,138,875 (GRCm39) missense probably damaging 0.98
R7535:Slc22a29 UTSW 19 8,147,342 (GRCm39) missense probably damaging 1.00
R7846:Slc22a29 UTSW 19 8,170,851 (GRCm39) missense probably benign 0.39
R8169:Slc22a29 UTSW 19 8,184,696 (GRCm39) missense probably damaging 1.00
R8275:Slc22a29 UTSW 19 8,146,681 (GRCm39) missense probably benign 0.00
R8403:Slc22a29 UTSW 19 8,139,004 (GRCm39) missense possibly damaging 0.95
R8872:Slc22a29 UTSW 19 8,137,931 (GRCm39) missense probably damaging 0.99
R9129:Slc22a29 UTSW 19 8,146,669 (GRCm39) missense probably benign 0.03
R9381:Slc22a29 UTSW 19 8,195,841 (GRCm39) missense probably benign 0.03
R9550:Slc22a29 UTSW 19 8,195,224 (GRCm39) nonsense probably null
R9645:Slc22a29 UTSW 19 8,184,488 (GRCm39) missense probably benign 0.04
R9673:Slc22a29 UTSW 19 8,140,104 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TCCTGGGGAGATAGCAGAAC -3'
(R):5'- GCCAAGACGCCTTCATAGTC -3'

Sequencing Primer
(F):5'- GGGAGATAGCAGAACTTTCTTTTTC -3'
(R):5'- GACGCCTTCATAGTCAAACTACTAG -3'
Posted On 2015-09-24