Incidental Mutation 'R4587:Zfp977'
ID 344167
Institutional Source Beutler Lab
Gene Symbol Zfp977
Ensembl Gene ENSMUSG00000092335
Gene Name zinc finger protein 977
Synonyms Gm7221
MMRRC Submission 042006-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.242) question?
Stock # R4587 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 42229207-42241971 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 42229614 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 304 (C304S)
Ref Sequence ENSEMBL: ENSMUSP00000134517 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000173283] [ENSMUST00000179470]
AlphaFold L7N2E7
Predicted Effect probably damaging
Transcript: ENSMUST00000173283
AA Change: C304S

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000134517
Gene: ENSMUSG00000092335
AA Change: C304S

DomainStartEndE-ValueType
KRAB 4 66 3.82e-20 SMART
ZnF_C2H2 131 153 1.92e-2 SMART
ZnF_C2H2 159 181 6.32e-3 SMART
ZnF_C2H2 187 209 5.99e-4 SMART
ZnF_C2H2 215 237 2.4e-3 SMART
ZnF_C2H2 243 265 7.15e-2 SMART
ZnF_C2H2 271 293 5.21e-4 SMART
ZnF_C2H2 299 321 5.5e-3 SMART
ZnF_C2H2 327 349 2.75e-3 SMART
ZnF_C2H2 355 377 3.11e-2 SMART
ZnF_C2H2 383 405 4.87e-4 SMART
ZnF_C2H2 411 433 1.82e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000179470
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205775
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205970
Meta Mutation Damage Score 0.3224 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.8%
  • 20x: 93.8%
Validation Efficiency 100% (47/47)
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd16a T C 17: 35,320,063 (GRCm39) probably null Het
Adsl T C 15: 80,851,968 (GRCm39) probably null Het
Arhgap32 T C 9: 32,172,241 (GRCm39) S1674P probably benign Het
Cd244a T G 1: 171,405,447 (GRCm39) D277E probably benign Het
Ceacam23 C T 7: 17,620,149 (GRCm39) L18F possibly damaging Het
Ces1a A G 8: 93,751,932 (GRCm39) Y401H probably damaging Het
Chd9 G T 8: 91,763,134 (GRCm39) V2320F possibly damaging Het
Chrd A G 16: 20,557,325 (GRCm39) E670G possibly damaging Het
Ckap2 A G 8: 22,666,992 (GRCm39) S290P probably benign Het
Cluap1 T A 16: 3,751,680 (GRCm39) probably null Het
Col15a1 C T 4: 47,257,184 (GRCm39) T325M probably damaging Het
Cplane1 T C 15: 8,230,636 (GRCm39) I971T possibly damaging Het
Dnah5 T C 15: 28,304,745 (GRCm39) F1652S probably damaging Het
Dok6 T C 18: 89,319,320 (GRCm39) Q312R probably benign Het
Glis1 C A 4: 107,484,740 (GRCm39) H600N possibly damaging Het
Hivep1 A G 13: 42,309,704 (GRCm39) D648G probably benign Het
Kif22 A T 7: 126,632,052 (GRCm39) probably null Het
Lmtk3 A G 7: 45,443,504 (GRCm39) D729G possibly damaging Het
Mapk8ip3 G A 17: 25,123,761 (GRCm39) P587L probably damaging Het
Muc4 G C 16: 32,753,919 (GRCm38) R1265P probably benign Het
Myt1l A G 12: 29,960,800 (GRCm39) K1038E unknown Het
Nf1 T A 11: 79,426,863 (GRCm39) probably null Het
Nom1 T C 5: 29,656,163 (GRCm39) S843P possibly damaging Het
Or1e33 A G 11: 73,738,045 (GRCm39) I302T probably benign Het
Pex14 A G 4: 149,048,021 (GRCm39) probably benign Het
Ptcd1 T C 5: 145,091,531 (GRCm39) T523A possibly damaging Het
Rasip1 T C 7: 45,282,159 (GRCm39) V554A possibly damaging Het
Ric3 A T 7: 108,653,570 (GRCm39) probably null Het
Skint4 G A 4: 111,944,221 (GRCm39) C11Y probably damaging Het
Smr2 G A 5: 88,256,631 (GRCm39) R103H probably benign Het
Sobp T C 10: 43,034,020 (GRCm39) Y102C probably damaging Het
Taar7f T A 10: 23,926,473 (GRCm39) F356I probably damaging Het
Tbcd T C 11: 121,496,097 (GRCm39) V1044A possibly damaging Het
Tecpr1 C G 5: 144,149,408 (GRCm39) V340L probably damaging Het
Tle3 A G 9: 61,281,295 (GRCm39) I22V probably damaging Het
Trim30a G A 7: 104,084,851 (GRCm39) R120* probably null Het
Trim72 A G 7: 127,607,164 (GRCm39) D231G probably benign Het
Vmn2r59 T A 7: 41,695,648 (GRCm39) N255Y probably benign Het
Vps13a T C 19: 16,617,403 (GRCm39) T3002A probably damaging Het
Wnt7a A T 6: 91,343,324 (GRCm39) probably null Het
Zfp51 C T 17: 21,685,178 (GRCm39) Q598* probably null Het
Zfp617 A T 8: 72,683,003 (GRCm39) N51I probably damaging Het
Zic1 A G 9: 91,246,875 (GRCm39) S66P probably damaging Het
Other mutations in Zfp977
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01350:Zfp977 APN 7 42,230,090 (GRCm39) missense probably damaging 1.00
IGL01541:Zfp977 APN 7 42,230,156 (GRCm39) missense probably benign 0.01
IGL02034:Zfp977 APN 7 42,230,136 (GRCm39) missense probably damaging 1.00
IGL02678:Zfp977 APN 7 42,232,419 (GRCm39) missense probably damaging 1.00
IGL02684:Zfp977 APN 7 42,232,439 (GRCm39) missense probably damaging 0.98
IGL03178:Zfp977 APN 7 42,232,072 (GRCm39) missense probably damaging 0.99
R0707:Zfp977 UTSW 7 42,229,958 (GRCm39) missense probably damaging 1.00
R1640:Zfp977 UTSW 7 42,229,530 (GRCm39) missense probably damaging 0.99
R1668:Zfp977 UTSW 7 42,230,070 (GRCm39) missense probably benign 0.03
R1993:Zfp977 UTSW 7 42,229,409 (GRCm39) missense probably benign 0.00
R3151:Zfp977 UTSW 7 42,229,870 (GRCm39) missense probably benign 0.00
R4678:Zfp977 UTSW 7 42,229,437 (GRCm39) missense probably benign 0.04
R6073:Zfp977 UTSW 7 42,230,165 (GRCm39) missense probably benign 0.34
R7054:Zfp977 UTSW 7 42,229,786 (GRCm39) missense possibly damaging 0.82
R7436:Zfp977 UTSW 7 42,229,884 (GRCm39) missense probably benign
R7500:Zfp977 UTSW 7 42,229,629 (GRCm39) missense probably damaging 1.00
R8294:Zfp977 UTSW 7 42,229,689 (GRCm39) missense probably benign
R8418:Zfp977 UTSW 7 42,229,410 (GRCm39) missense probably benign
R8439:Zfp977 UTSW 7 42,230,102 (GRCm39) missense probably benign 0.03
R8995:Zfp977 UTSW 7 42,232,072 (GRCm39) missense probably damaging 1.00
R9005:Zfp977 UTSW 7 42,230,082 (GRCm39) missense probably benign 0.04
R9369:Zfp977 UTSW 7 42,229,518 (GRCm39) missense probably damaging 0.99
X0023:Zfp977 UTSW 7 42,229,543 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TTTGTGTAAAGGCCTTACCACAT -3'
(R):5'- CCTATCCACACCAGAGTTATCTCC -3'

Sequencing Primer
(F):5'- TACTTGACCTGTGCAAAGGC -3'
(R):5'- CCAGAGTTATCTCCGAAAACATG -3'
Posted On 2015-09-24