Incidental Mutation 'R4593:Gpr149'
ID |
344201 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Gpr149
|
Ensembl Gene |
ENSMUSG00000043441 |
Gene Name |
G protein-coupled receptor 149 |
Synonyms |
PGR10, 9630018L10Rik, R35, Ieda |
MMRRC Submission |
041809-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.074)
|
Stock # |
R4593 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
3 |
Chromosomal Location |
62436851-62512861 bp(-) (GRCm39) |
Type of Mutation |
intron |
DNA Base Change (assembly) |
A to T
at 62510151 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000060893
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000058535]
|
AlphaFold |
Q3UVY1 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000058535
|
SMART Domains |
Protein: ENSMUSP00000060893 Gene: ENSMUSG00000043441
Domain | Start | End | E-Value | Type |
Pfam:7tm_1
|
52 |
363 |
7.2e-7 |
PFAM |
coiled coil region
|
694 |
730 |
N/A |
INTRINSIC |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000149007
|
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.1%
|
Validation Efficiency |
96% (45/47) |
MGI Phenotype |
PHENOTYPE: Female mice homozygous for a knock-out allele exhibit increased fertility with increased litter size and frequency. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 42 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
2700049A03Rik |
G |
T |
12: 71,211,320 (GRCm39) |
E685* |
probably null |
Het |
2700049A03Rik |
A |
T |
12: 71,211,321 (GRCm39) |
E685V |
possibly damaging |
Het |
Aopep |
T |
C |
13: 63,215,906 (GRCm39) |
S393P |
probably benign |
Het |
Atm |
G |
T |
9: 53,364,894 (GRCm39) |
A8E |
possibly damaging |
Het |
Atxn3 |
A |
T |
12: 101,889,436 (GRCm39) |
M333K |
probably benign |
Het |
Cd86 |
A |
G |
16: 36,426,918 (GRCm39) |
*310R |
probably null |
Het |
Cyp2s1 |
ACAGCAGCAGCAGCAGCAGCAGCAG |
ACAGCAGCAGCAGCAGCAGCAG |
7: 25,515,867 (GRCm39) |
|
probably benign |
Het |
Dgat1 |
C |
A |
15: 76,388,889 (GRCm39) |
R111S |
probably damaging |
Het |
Dner |
T |
C |
1: 84,673,449 (GRCm39) |
M1V |
probably null |
Het |
Dnhd1 |
G |
A |
7: 105,364,653 (GRCm39) |
D4240N |
probably benign |
Het |
Emp3 |
A |
G |
7: 45,568,777 (GRCm39) |
L27P |
probably damaging |
Het |
Glra3 |
G |
T |
8: 56,393,916 (GRCm39) |
G9V |
probably damaging |
Het |
Ighv1-9 |
T |
C |
12: 114,547,224 (GRCm39) |
T105A |
probably benign |
Het |
Kcnd3 |
C |
T |
3: 105,566,082 (GRCm39) |
A421V |
probably damaging |
Het |
Ldhd |
T |
C |
8: 112,355,996 (GRCm39) |
D129G |
probably damaging |
Het |
Lnpep |
A |
G |
17: 17,799,289 (GRCm39) |
V122A |
probably benign |
Het |
Lrrc37a |
A |
G |
11: 103,389,795 (GRCm39) |
Y1877H |
possibly damaging |
Het |
Med13l |
T |
C |
5: 118,880,625 (GRCm39) |
L1239P |
probably damaging |
Het |
Mib1 |
T |
C |
18: 10,768,191 (GRCm39) |
L480S |
possibly damaging |
Het |
Mkrn3 |
C |
T |
7: 62,068,552 (GRCm39) |
W413* |
probably null |
Het |
Myo7b |
A |
G |
18: 32,146,428 (GRCm39) |
V119A |
possibly damaging |
Het |
Nexn |
T |
A |
3: 151,958,553 (GRCm39) |
R113S |
probably damaging |
Het |
Npas3 |
A |
T |
12: 54,115,280 (GRCm39) |
Q703L |
probably benign |
Het |
Npr2 |
A |
G |
4: 43,647,323 (GRCm39) |
|
probably benign |
Het |
Nub1 |
A |
G |
5: 24,914,119 (GRCm39) |
Y624C |
probably damaging |
Het |
Obscn |
A |
C |
11: 59,024,075 (GRCm39) |
S532A |
probably damaging |
Het |
Or1e33 |
T |
A |
11: 73,738,140 (GRCm39) |
K270N |
probably benign |
Het |
Or9g20 |
A |
G |
2: 85,630,008 (GRCm39) |
L202P |
probably damaging |
Het |
Panx2 |
T |
C |
15: 88,952,118 (GRCm39) |
I195T |
probably damaging |
Het |
Parp11 |
T |
C |
6: 127,451,262 (GRCm39) |
I104T |
probably benign |
Het |
Pkd1l1 |
G |
T |
11: 8,851,253 (GRCm39) |
D726E |
probably damaging |
Het |
Pom121l2 |
C |
T |
13: 22,168,623 (GRCm39) |
R965W |
probably damaging |
Het |
Prrc2c |
T |
C |
1: 162,525,101 (GRCm39) |
K502E |
probably damaging |
Het |
Rasa1 |
T |
C |
13: 85,386,340 (GRCm39) |
|
probably null |
Het |
Sva |
T |
C |
6: 42,019,592 (GRCm39) |
S151P |
possibly damaging |
Het |
Svep1 |
T |
C |
4: 58,091,944 (GRCm39) |
N1564D |
possibly damaging |
Het |
Unk |
T |
C |
11: 115,939,882 (GRCm39) |
I129T |
probably benign |
Het |
Urb1 |
T |
C |
16: 90,584,332 (GRCm39) |
D550G |
probably damaging |
Het |
Vmn1r194 |
T |
A |
13: 22,428,461 (GRCm39) |
M26K |
possibly damaging |
Het |
Vmn1r59 |
A |
T |
7: 5,457,686 (GRCm39) |
F25I |
possibly damaging |
Het |
Vmn1r88 |
A |
G |
7: 12,911,769 (GRCm39) |
K42E |
probably damaging |
Het |
Zbtb24 |
A |
G |
10: 41,327,953 (GRCm39) |
R280G |
possibly damaging |
Het |
|
Other mutations in Gpr149 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00330:Gpr149
|
APN |
3 |
62,438,094 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01339:Gpr149
|
APN |
3 |
62,511,718 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01399:Gpr149
|
APN |
3 |
62,511,852 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01954:Gpr149
|
APN |
3 |
62,438,348 (GRCm39) |
missense |
probably benign |
0.36 |
IGL02115:Gpr149
|
APN |
3 |
62,502,336 (GRCm39) |
missense |
probably benign |
0.02 |
IGL02218:Gpr149
|
APN |
3 |
62,437,952 (GRCm39) |
utr 3 prime |
probably benign |
|
IGL02592:Gpr149
|
APN |
3 |
62,511,231 (GRCm39) |
missense |
possibly damaging |
0.75 |
IGL03393:Gpr149
|
APN |
3 |
62,511,366 (GRCm39) |
missense |
probably benign |
0.15 |
R0578:Gpr149
|
UTSW |
3 |
62,510,110 (GRCm39) |
missense |
possibly damaging |
0.81 |
R1173:Gpr149
|
UTSW |
3 |
62,511,888 (GRCm39) |
missense |
probably damaging |
1.00 |
R1174:Gpr149
|
UTSW |
3 |
62,511,888 (GRCm39) |
missense |
probably damaging |
1.00 |
R1175:Gpr149
|
UTSW |
3 |
62,511,888 (GRCm39) |
missense |
probably damaging |
1.00 |
R1432:Gpr149
|
UTSW |
3 |
62,438,439 (GRCm39) |
missense |
probably damaging |
1.00 |
R1484:Gpr149
|
UTSW |
3 |
62,502,592 (GRCm39) |
missense |
probably benign |
0.00 |
R1972:Gpr149
|
UTSW |
3 |
62,438,216 (GRCm39) |
missense |
probably benign |
0.39 |
R1973:Gpr149
|
UTSW |
3 |
62,438,216 (GRCm39) |
missense |
probably benign |
0.39 |
R2180:Gpr149
|
UTSW |
3 |
62,511,489 (GRCm39) |
missense |
probably damaging |
1.00 |
R2241:Gpr149
|
UTSW |
3 |
62,511,474 (GRCm39) |
missense |
probably benign |
0.00 |
R3118:Gpr149
|
UTSW |
3 |
62,502,443 (GRCm39) |
missense |
probably benign |
0.00 |
R3547:Gpr149
|
UTSW |
3 |
62,502,549 (GRCm39) |
missense |
probably benign |
0.01 |
R3548:Gpr149
|
UTSW |
3 |
62,502,549 (GRCm39) |
missense |
probably benign |
0.01 |
R4206:Gpr149
|
UTSW |
3 |
62,511,924 (GRCm39) |
missense |
possibly damaging |
0.92 |
R4332:Gpr149
|
UTSW |
3 |
62,511,794 (GRCm39) |
missense |
possibly damaging |
0.93 |
R4531:Gpr149
|
UTSW |
3 |
62,510,099 (GRCm39) |
missense |
probably benign |
0.00 |
R4557:Gpr149
|
UTSW |
3 |
62,511,918 (GRCm39) |
missense |
probably benign |
0.02 |
R4557:Gpr149
|
UTSW |
3 |
62,438,291 (GRCm39) |
missense |
probably damaging |
1.00 |
R5397:Gpr149
|
UTSW |
3 |
62,438,226 (GRCm39) |
missense |
probably damaging |
1.00 |
R6592:Gpr149
|
UTSW |
3 |
62,437,961 (GRCm39) |
missense |
probably benign |
0.02 |
R6642:Gpr149
|
UTSW |
3 |
62,437,995 (GRCm39) |
missense |
probably damaging |
1.00 |
R6845:Gpr149
|
UTSW |
3 |
62,511,942 (GRCm39) |
missense |
possibly damaging |
0.58 |
R7303:Gpr149
|
UTSW |
3 |
62,502,491 (GRCm39) |
missense |
possibly damaging |
0.59 |
R7659:Gpr149
|
UTSW |
3 |
62,511,256 (GRCm39) |
missense |
probably benign |
0.01 |
R7682:Gpr149
|
UTSW |
3 |
62,438,160 (GRCm39) |
missense |
probably damaging |
1.00 |
R7803:Gpr149
|
UTSW |
3 |
62,438,136 (GRCm39) |
missense |
probably damaging |
1.00 |
R7904:Gpr149
|
UTSW |
3 |
62,502,356 (GRCm39) |
missense |
probably benign |
0.00 |
R7943:Gpr149
|
UTSW |
3 |
62,438,132 (GRCm39) |
missense |
probably damaging |
1.00 |
R8844:Gpr149
|
UTSW |
3 |
62,502,572 (GRCm39) |
missense |
probably benign |
0.05 |
R8919:Gpr149
|
UTSW |
3 |
62,438,478 (GRCm39) |
missense |
probably damaging |
1.00 |
R9043:Gpr149
|
UTSW |
3 |
62,511,360 (GRCm39) |
missense |
probably damaging |
1.00 |
R9209:Gpr149
|
UTSW |
3 |
62,511,093 (GRCm39) |
missense |
probably benign |
0.40 |
Z1177:Gpr149
|
UTSW |
3 |
62,511,380 (GRCm39) |
frame shift |
probably null |
|
Z1190:Gpr149
|
UTSW |
3 |
62,511,972 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
Predicted Primers |
PCR Primer
(F):5'- TGGCAGTTGATGATGCAGCC -3'
(R):5'- AGGAATTTCAAATCGTAGCAGGTG -3'
Sequencing Primer
(F):5'- CAGTTGATGATGCAGCCACAAG -3'
(R):5'- GGAAACTAAACTCTGCTCTAGTGC -3'
|
Posted On |
2015-09-25 |