Incidental Mutation 'R4593:Vmn1r59'
| ID |
344210 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r59
|
| Ensembl Gene |
ENSMUSG00000074401 |
| Gene Name |
vomeronasal 1 receptor 59 |
| Synonyms |
V1rd10 |
| MMRRC Submission |
041809-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.058)
|
| Stock # |
R4593 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
5456826-5457758 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 5457686 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Isoleucine
at position 25
(F25I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000073768
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000074132]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000074132
AA Change: F25I
PolyPhen 2
Score 0.455 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000073768
Gene: ENSMUSG00000074401
AA Change: F25I
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
289 |
2e-14 |
PFAM |
|
Pfam:7tm_1
|
20 |
279 |
1.9e-6 |
PFAM |
|
Pfam:V1R
|
31 |
287 |
3e-16 |
PFAM |
|
| Meta Mutation Damage Score |
0.1795 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.1%
|
| Validation Efficiency |
96% (45/47) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 42 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2700049A03Rik |
G |
T |
12: 71,211,320 (GRCm39) |
E685* |
probably null |
Het |
| 2700049A03Rik |
A |
T |
12: 71,211,321 (GRCm39) |
E685V |
possibly damaging |
Het |
| Aopep |
T |
C |
13: 63,215,906 (GRCm39) |
S393P |
probably benign |
Het |
| Atm |
G |
T |
9: 53,364,894 (GRCm39) |
A8E |
possibly damaging |
Het |
| Atxn3 |
A |
T |
12: 101,889,436 (GRCm39) |
M333K |
probably benign |
Het |
| Cd86 |
A |
G |
16: 36,426,918 (GRCm39) |
*310R |
probably null |
Het |
| Cyp2s1 |
ACAGCAGCAGCAGCAGCAGCAGCAG |
ACAGCAGCAGCAGCAGCAGCAG |
7: 25,515,867 (GRCm39) |
|
probably benign |
Het |
| Dgat1 |
C |
A |
15: 76,388,889 (GRCm39) |
R111S |
probably damaging |
Het |
| Dner |
T |
C |
1: 84,673,449 (GRCm39) |
M1V |
probably null |
Het |
| Dnhd1 |
G |
A |
7: 105,364,653 (GRCm39) |
D4240N |
probably benign |
Het |
| Emp3 |
A |
G |
7: 45,568,777 (GRCm39) |
L27P |
probably damaging |
Het |
| Glra3 |
G |
T |
8: 56,393,916 (GRCm39) |
G9V |
probably damaging |
Het |
| Gpr149 |
A |
T |
3: 62,510,151 (GRCm39) |
|
probably benign |
Het |
| Ighv1-9 |
T |
C |
12: 114,547,224 (GRCm39) |
T105A |
probably benign |
Het |
| Kcnd3 |
C |
T |
3: 105,566,082 (GRCm39) |
A421V |
probably damaging |
Het |
| Ldhd |
T |
C |
8: 112,355,996 (GRCm39) |
D129G |
probably damaging |
Het |
| Lnpep |
A |
G |
17: 17,799,289 (GRCm39) |
V122A |
probably benign |
Het |
| Lrrc37a |
A |
G |
11: 103,389,795 (GRCm39) |
Y1877H |
possibly damaging |
Het |
| Med13l |
T |
C |
5: 118,880,625 (GRCm39) |
L1239P |
probably damaging |
Het |
| Mib1 |
T |
C |
18: 10,768,191 (GRCm39) |
L480S |
possibly damaging |
Het |
| Mkrn3 |
C |
T |
7: 62,068,552 (GRCm39) |
W413* |
probably null |
Het |
| Myo7b |
A |
G |
18: 32,146,428 (GRCm39) |
V119A |
possibly damaging |
Het |
| Nexn |
T |
A |
3: 151,958,553 (GRCm39) |
R113S |
probably damaging |
Het |
| Npas3 |
A |
T |
12: 54,115,280 (GRCm39) |
Q703L |
probably benign |
Het |
| Npr2 |
A |
G |
4: 43,647,323 (GRCm39) |
|
probably benign |
Het |
| Nub1 |
A |
G |
5: 24,914,119 (GRCm39) |
Y624C |
probably damaging |
Het |
| Obscn |
A |
C |
11: 59,024,075 (GRCm39) |
S532A |
probably damaging |
Het |
| Or1e33 |
T |
A |
11: 73,738,140 (GRCm39) |
K270N |
probably benign |
Het |
| Or9g20 |
A |
G |
2: 85,630,008 (GRCm39) |
L202P |
probably damaging |
Het |
| Panx2 |
T |
C |
15: 88,952,118 (GRCm39) |
I195T |
probably damaging |
Het |
| Parp11 |
T |
C |
6: 127,451,262 (GRCm39) |
I104T |
probably benign |
Het |
| Pkd1l1 |
G |
T |
11: 8,851,253 (GRCm39) |
D726E |
probably damaging |
Het |
| Pom121l2 |
C |
T |
13: 22,168,623 (GRCm39) |
R965W |
probably damaging |
Het |
| Prrc2c |
T |
C |
1: 162,525,101 (GRCm39) |
K502E |
probably damaging |
Het |
| Rasa1 |
T |
C |
13: 85,386,340 (GRCm39) |
|
probably null |
Het |
| Sva |
T |
C |
6: 42,019,592 (GRCm39) |
S151P |
possibly damaging |
Het |
| Svep1 |
T |
C |
4: 58,091,944 (GRCm39) |
N1564D |
possibly damaging |
Het |
| Unk |
T |
C |
11: 115,939,882 (GRCm39) |
I129T |
probably benign |
Het |
| Urb1 |
T |
C |
16: 90,584,332 (GRCm39) |
D550G |
probably damaging |
Het |
| Vmn1r194 |
T |
A |
13: 22,428,461 (GRCm39) |
M26K |
possibly damaging |
Het |
| Vmn1r88 |
A |
G |
7: 12,911,769 (GRCm39) |
K42E |
probably damaging |
Het |
| Zbtb24 |
A |
G |
10: 41,327,953 (GRCm39) |
R280G |
possibly damaging |
Het |
|
| Other mutations in Vmn1r59 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01684:Vmn1r59
|
APN |
7 |
5,457,299 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL02035:Vmn1r59
|
APN |
7 |
5,457,208 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL02039:Vmn1r59
|
APN |
7 |
5,457,380 (GRCm39) |
missense |
probably benign |
0.23 |
|
IGL02812:Vmn1r59
|
APN |
7 |
5,457,176 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0033:Vmn1r59
|
UTSW |
7 |
5,457,433 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0115:Vmn1r59
|
UTSW |
7 |
5,457,115 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1164:Vmn1r59
|
UTSW |
7 |
5,457,410 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1629:Vmn1r59
|
UTSW |
7 |
5,457,466 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1845:Vmn1r59
|
UTSW |
7 |
5,457,553 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1969:Vmn1r59
|
UTSW |
7 |
5,457,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1970:Vmn1r59
|
UTSW |
7 |
5,457,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1971:Vmn1r59
|
UTSW |
7 |
5,457,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2011:Vmn1r59
|
UTSW |
7 |
5,457,283 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3712:Vmn1r59
|
UTSW |
7 |
5,457,637 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4580:Vmn1r59
|
UTSW |
7 |
5,457,136 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4697:Vmn1r59
|
UTSW |
7 |
5,457,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4856:Vmn1r59
|
UTSW |
7 |
5,457,532 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4873:Vmn1r59
|
UTSW |
7 |
5,457,108 (GRCm39) |
missense |
probably benign |
|
|
R4875:Vmn1r59
|
UTSW |
7 |
5,457,108 (GRCm39) |
missense |
probably benign |
|
|
R4925:Vmn1r59
|
UTSW |
7 |
5,457,115 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5319:Vmn1r59
|
UTSW |
7 |
5,457,209 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6239:Vmn1r59
|
UTSW |
7 |
5,457,539 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6533:Vmn1r59
|
UTSW |
7 |
5,457,463 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6912:Vmn1r59
|
UTSW |
7 |
5,457,599 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7023:Vmn1r59
|
UTSW |
7 |
5,457,477 (GRCm39) |
missense |
probably benign |
0.37 |
|
R7205:Vmn1r59
|
UTSW |
7 |
5,457,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7374:Vmn1r59
|
UTSW |
7 |
5,457,160 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7390:Vmn1r59
|
UTSW |
7 |
5,456,986 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R7776:Vmn1r59
|
UTSW |
7 |
5,457,634 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8306:Vmn1r59
|
UTSW |
7 |
5,456,966 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8473:Vmn1r59
|
UTSW |
7 |
5,457,064 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8499:Vmn1r59
|
UTSW |
7 |
5,457,750 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8523:Vmn1r59
|
UTSW |
7 |
5,457,053 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8706:Vmn1r59
|
UTSW |
7 |
5,457,715 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9104:Vmn1r59
|
UTSW |
7 |
5,457,166 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCAAGTTTACATTTGAGGTCAGTTG -3'
(R):5'- AGTGTGTCAAAGCAGTGCCAG -3'
Sequencing Primer
(F):5'- CAGTTGGAGGCTTCCTTGGAAC -3'
(R):5'- GCAGTGCCAGCTTTTCAAACG -3'
|
| Posted On |
2015-09-25 |
Incidental Mutation