Incidental Mutation 'R4597:Qrfprl'
ID 344439
Institutional Source Beutler Lab
Gene Symbol Qrfprl
Ensembl Gene ENSMUSG00000029917
Gene Name pyroglutamylated RFamide peptide receptor like
Synonyms C130060K24Rik
MMRRC Submission 041813-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # R4597 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 65358278-65435134 bp(+) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to C at 65424408 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000130225 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000133352] [ENSMUST00000170608]
AlphaFold G3UWA8
Predicted Effect probably null
Transcript: ENSMUST00000133352
SMART Domains Protein: ENSMUSP00000122416
Gene: ENSMUSG00000029917

DomainStartEndE-ValueType
low complexity region 39 49 N/A INTRINSIC
Pfam:7TM_GPCR_Srsx 55 113 1.2e-7 PFAM
Pfam:7tm_1 61 122 1.3e-14 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000136016
SMART Domains Protein: ENSMUSP00000121875
Gene: ENSMUSG00000029917

DomainStartEndE-ValueType
transmembrane domain 45 67 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000170608
SMART Domains Protein: ENSMUSP00000130225
Gene: ENSMUSG00000029917

DomainStartEndE-ValueType
low complexity region 39 49 N/A INTRINSIC
Pfam:7TM_GPCR_Srsx 55 346 2.5e-5 PFAM
Pfam:7tm_1 61 331 7.2e-56 PFAM
Meta Mutation Damage Score 0.9494 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.8%
Validation Efficiency 96% (67/70)
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931422A03Rik T A 2: 103,856,500 (GRCm39) probably benign Het
Aadacl2fm3 T A 3: 59,784,214 (GRCm39) M229K possibly damaging Het
Adh5 T C 3: 138,151,118 (GRCm39) V27A probably damaging Het
Ank2 A T 3: 126,781,800 (GRCm39) D843E probably damaging Het
Aopep T C 13: 63,215,906 (GRCm39) S393P probably benign Het
Arid2 A G 15: 96,268,737 (GRCm39) N950S probably damaging Het
Arl1 A T 10: 88,566,608 (GRCm39) probably benign Het
Bcl3 T G 7: 19,546,428 (GRCm39) I136L probably damaging Het
Car9 T A 4: 43,509,138 (GRCm39) S235R probably damaging Het
Carnmt1 G T 19: 18,648,451 (GRCm39) G30W probably damaging Het
Casp12 C T 9: 5,348,941 (GRCm39) T101I possibly damaging Het
Cdh23 A G 10: 60,244,823 (GRCm39) L1026P probably damaging Het
Clec10a A T 11: 70,060,806 (GRCm39) Y186F probably damaging Het
Col22a1 G T 15: 71,836,511 (GRCm39) A508E possibly damaging Het
Crocc G C 4: 140,747,088 (GRCm39) S1573R probably damaging Het
Cttnbp2nl G T 3: 104,913,191 (GRCm39) T231K possibly damaging Het
Drd4 T C 7: 140,874,392 (GRCm39) V319A probably damaging Het
Ehbp1l1 T C 19: 5,767,955 (GRCm39) E1116G possibly damaging Het
Fam83d T C 2: 158,627,142 (GRCm39) V277A possibly damaging Het
Fga G T 3: 82,938,542 (GRCm39) G306* probably null Het
Fkbp9 A G 6: 56,809,367 (GRCm39) Y59C probably damaging Het
Frmpd1 A G 4: 45,274,441 (GRCm39) T450A probably benign Het
Gabbr1 A G 17: 37,367,791 (GRCm39) M414V possibly damaging Het
Gm16506 A G 14: 43,962,572 (GRCm39) F112L unknown Het
Gm27047 T C 6: 130,607,299 (GRCm39) noncoding transcript Het
Gm4353 T A 7: 115,682,847 (GRCm39) K245* probably null Het
Gm4950 A T 18: 51,998,865 (GRCm39) I30N probably benign Het
H1f5 A T 13: 21,964,681 (GRCm39) V15E probably damaging Het
H2-M10.2 T C 17: 36,596,285 (GRCm39) T187A probably benign Het
H60c A T 10: 3,209,968 (GRCm39) N106K possibly damaging Het
Hoxa6 T C 6: 52,185,387 (GRCm39) probably null Het
Ighv1-74 A G 12: 115,766,276 (GRCm39) C115R probably damaging Het
Il17a G A 1: 20,801,217 (GRCm39) probably null Het
Itga9 T C 9: 118,672,582 (GRCm39) Y199H probably damaging Het
Itpr3 C T 17: 27,312,257 (GRCm39) R554C probably damaging Het
Kcnc3 T A 7: 44,245,240 (GRCm39) M510K probably damaging Het
Kif15 A G 9: 122,822,914 (GRCm39) T432A probably benign Het
Kif26b A T 1: 178,744,358 (GRCm39) S1485C probably damaging Het
Klhl2 C A 8: 65,207,421 (GRCm39) G313W probably damaging Het
Klhl32 C T 4: 24,629,339 (GRCm39) S476N probably benign Het
Krt1 C T 15: 101,756,063 (GRCm39) E386K possibly damaging Het
Lats1 T C 10: 7,567,510 (GRCm39) S94P probably benign Het
Ltf G A 9: 110,852,001 (GRCm39) C146Y probably damaging Het
Mars1 A G 10: 127,136,322 (GRCm39) L501P probably damaging Het
Myh2 A C 11: 67,080,244 (GRCm39) I1153L probably benign Het
Ncstn A T 1: 171,895,823 (GRCm39) Y522* probably null Het
Nipal4 A G 11: 46,042,156 (GRCm39) V175A probably damaging Het
Or7e169 T C 9: 19,756,987 (GRCm39) I309M probably benign Het
Pcdha1 C G 18: 37,064,959 (GRCm39) A541G possibly damaging Het
Pex11g A G 8: 3,514,043 (GRCm39) Y40H probably damaging Het
Pira13 T A 7: 3,825,154 (GRCm39) Y496F possibly damaging Het
Rin2 G T 2: 145,702,825 (GRCm39) R507L probably benign Het
Sh2b2 T C 5: 136,260,616 (GRCm39) D200G probably damaging Het
Smg7 C A 1: 152,716,052 (GRCm39) probably null Het
Snx17 T C 5: 31,355,857 (GRCm39) probably benign Het
Sos1 T C 17: 80,741,255 (GRCm39) Y510C probably benign Het
Spata31d1c T A 13: 65,183,427 (GRCm39) L323* probably null Het
Supt16 C T 14: 52,411,046 (GRCm39) G686D probably damaging Het
Szt2 C T 4: 118,229,878 (GRCm39) R2751H unknown Het
Tnfsf8 A G 4: 63,755,337 (GRCm39) L95P probably damaging Het
Vmn2r17 A G 5: 109,577,428 (GRCm39) H493R probably benign Het
Zfp770 C T 2: 114,027,251 (GRCm39) A273T possibly damaging Het
Other mutations in Qrfprl
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02084:Qrfprl APN 6 65,358,594 (GRCm39) missense probably benign 0.36
IGL03335:Qrfprl APN 6 65,430,101 (GRCm39) critical splice donor site probably null
R1291:Qrfprl UTSW 6 65,429,884 (GRCm39) nonsense probably null
R1689:Qrfprl UTSW 6 65,358,591 (GRCm39) missense possibly damaging 0.84
R1705:Qrfprl UTSW 6 65,433,290 (GRCm39) missense probably benign 0.01
R2188:Qrfprl UTSW 6 65,418,260 (GRCm39) missense probably damaging 0.97
R3955:Qrfprl UTSW 6 65,430,092 (GRCm39) missense possibly damaging 0.73
R4058:Qrfprl UTSW 6 65,358,525 (GRCm39) missense probably damaging 1.00
R4572:Qrfprl UTSW 6 65,431,975 (GRCm39) missense probably benign 0.06
R4756:Qrfprl UTSW 6 65,429,898 (GRCm39) missense probably benign 0.02
R5139:Qrfprl UTSW 6 65,433,203 (GRCm39) missense probably damaging 0.98
R5872:Qrfprl UTSW 6 65,418,369 (GRCm39) intron probably benign
R6193:Qrfprl UTSW 6 65,433,142 (GRCm39) missense probably damaging 1.00
R6305:Qrfprl UTSW 6 65,431,975 (GRCm39) missense probably benign 0.06
R6423:Qrfprl UTSW 6 65,433,077 (GRCm39) missense probably benign 0.01
R6453:Qrfprl UTSW 6 65,430,014 (GRCm39) missense possibly damaging 0.71
R6677:Qrfprl UTSW 6 65,433,229 (GRCm39) missense probably benign
R6744:Qrfprl UTSW 6 65,418,324 (GRCm39) missense possibly damaging 0.88
R6793:Qrfprl UTSW 6 65,358,405 (GRCm39) missense probably benign 0.20
R6875:Qrfprl UTSW 6 65,433,320 (GRCm39) missense probably benign 0.21
R6941:Qrfprl UTSW 6 65,424,385 (GRCm39) missense probably damaging 1.00
R6995:Qrfprl UTSW 6 65,418,285 (GRCm39) missense probably damaging 1.00
R7063:Qrfprl UTSW 6 65,418,387 (GRCm39) intron probably benign
R7564:Qrfprl UTSW 6 65,429,891 (GRCm39) nonsense probably null
R7699:Qrfprl UTSW 6 65,429,940 (GRCm39) missense probably benign 0.30
R7700:Qrfprl UTSW 6 65,429,940 (GRCm39) missense probably benign 0.30
R7711:Qrfprl UTSW 6 65,418,357 (GRCm39) missense
R7799:Qrfprl UTSW 6 65,433,121 (GRCm39) missense possibly damaging 0.78
R7801:Qrfprl UTSW 6 65,418,201 (GRCm39) missense probably damaging 1.00
R8737:Qrfprl UTSW 6 65,433,260 (GRCm39) missense probably benign
R8762:Qrfprl UTSW 6 65,424,393 (GRCm39) missense probably benign 0.12
R8927:Qrfprl UTSW 6 65,358,597 (GRCm39) nonsense probably null
R8928:Qrfprl UTSW 6 65,358,597 (GRCm39) nonsense probably null
R9317:Qrfprl UTSW 6 65,424,368 (GRCm39) missense probably benign 0.10
R9405:Qrfprl UTSW 6 65,433,078 (GRCm39) missense probably benign 0.16
R9712:Qrfprl UTSW 6 65,433,124 (GRCm39) missense probably benign 0.00
RF018:Qrfprl UTSW 6 65,433,174 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CCAGAGGTAAGTGTTCTACTCC -3'
(R):5'- TGGAGAAACCCAAGAATTGTACATG -3'

Sequencing Primer
(F):5'- GGTAAGTGTTCTACTCCATGACAGAG -3'
(R):5'- GCTAAGAAAATGGTGAAGGTTATTTG -3'
Posted On 2015-09-25