Incidental Mutation 'R4611:Tnik'
ID |
344686 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Tnik
|
Ensembl Gene |
ENSMUSG00000027692 |
Gene Name |
TRAF2 and NCK interacting kinase |
Synonyms |
C530008O15Rik, 4831440I19Rik, 1500031A17Rik, C630040K21Rik |
MMRRC Submission |
041822-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R4611 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
3 |
Chromosomal Location |
28317362-28724734 bp(+) (GRCm39) |
Type of Mutation |
critical splice donor site (2 bp from exon) |
DNA Base Change (assembly) |
T to C
at 28596249 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000124726
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000159236]
[ENSMUST00000159236]
[ENSMUST00000159308]
[ENSMUST00000159308]
[ENSMUST00000159680]
[ENSMUST00000159680]
[ENSMUST00000160307]
[ENSMUST00000160518]
[ENSMUST00000160518]
[ENSMUST00000160934]
[ENSMUST00000161964]
[ENSMUST00000161964]
[ENSMUST00000162485]
[ENSMUST00000162485]
[ENSMUST00000162777]
[ENSMUST00000162777]
|
AlphaFold |
P83510 |
Predicted Effect |
probably null
Transcript: ENSMUST00000159236
|
SMART Domains |
Protein: ENSMUSP00000124681 Gene: ENSMUSG00000027692
Domain | Start | End | E-Value | Type |
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
low complexity region
|
691 |
726 |
N/A |
INTRINSIC |
low complexity region
|
793 |
812 |
N/A |
INTRINSIC |
low complexity region
|
951 |
958 |
N/A |
INTRINSIC |
CNH
|
1005 |
1303 |
1.92e-117 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000159236
|
SMART Domains |
Protein: ENSMUSP00000124681 Gene: ENSMUSG00000027692
Domain | Start | End | E-Value | Type |
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
low complexity region
|
691 |
726 |
N/A |
INTRINSIC |
low complexity region
|
793 |
812 |
N/A |
INTRINSIC |
low complexity region
|
951 |
958 |
N/A |
INTRINSIC |
CNH
|
1005 |
1303 |
1.92e-117 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000159308
|
SMART Domains |
Protein: ENSMUSP00000125466 Gene: ENSMUSG00000027692
Domain | Start | End | E-Value | Type |
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
low complexity region
|
636 |
671 |
N/A |
INTRINSIC |
low complexity region
|
746 |
765 |
N/A |
INTRINSIC |
low complexity region
|
904 |
911 |
N/A |
INTRINSIC |
CNH
|
958 |
1256 |
1.92e-117 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000159308
|
SMART Domains |
Protein: ENSMUSP00000125466 Gene: ENSMUSG00000027692
Domain | Start | End | E-Value | Type |
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
low complexity region
|
636 |
671 |
N/A |
INTRINSIC |
low complexity region
|
746 |
765 |
N/A |
INTRINSIC |
low complexity region
|
904 |
911 |
N/A |
INTRINSIC |
CNH
|
958 |
1256 |
1.92e-117 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000159680
|
SMART Domains |
Protein: ENSMUSP00000124876 Gene: ENSMUSG00000027692
Domain | Start | End | E-Value | Type |
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
low complexity region
|
720 |
755 |
N/A |
INTRINSIC |
low complexity region
|
822 |
841 |
N/A |
INTRINSIC |
low complexity region
|
980 |
987 |
N/A |
INTRINSIC |
CNH
|
1034 |
1332 |
1.92e-117 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000159680
|
SMART Domains |
Protein: ENSMUSP00000124876 Gene: ENSMUSG00000027692
Domain | Start | End | E-Value | Type |
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
low complexity region
|
720 |
755 |
N/A |
INTRINSIC |
low complexity region
|
822 |
841 |
N/A |
INTRINSIC |
low complexity region
|
980 |
987 |
N/A |
INTRINSIC |
CNH
|
1034 |
1332 |
1.92e-117 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000160307
|
SMART Domains |
Protein: ENSMUSP00000125081 Gene: ENSMUSG00000027692
Domain | Start | End | E-Value | Type |
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
low complexity region
|
720 |
755 |
N/A |
INTRINSIC |
low complexity region
|
830 |
849 |
N/A |
INTRINSIC |
low complexity region
|
988 |
995 |
N/A |
INTRINSIC |
CNH
|
1042 |
1340 |
1.92e-117 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000160518
|
SMART Domains |
Protein: ENSMUSP00000124011 Gene: ENSMUSG00000027692
Domain | Start | End | E-Value | Type |
S_TKc
|
25 |
289 |
5.9e-99 |
SMART |
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
low complexity region
|
691 |
726 |
N/A |
INTRINSIC |
low complexity region
|
801 |
820 |
N/A |
INTRINSIC |
low complexity region
|
959 |
966 |
N/A |
INTRINSIC |
CNH
|
1013 |
1311 |
9.3e-120 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000160518
|
SMART Domains |
Protein: ENSMUSP00000124011 Gene: ENSMUSG00000027692
Domain | Start | End | E-Value | Type |
S_TKc
|
25 |
289 |
5.9e-99 |
SMART |
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
low complexity region
|
691 |
726 |
N/A |
INTRINSIC |
low complexity region
|
801 |
820 |
N/A |
INTRINSIC |
low complexity region
|
959 |
966 |
N/A |
INTRINSIC |
CNH
|
1013 |
1311 |
9.3e-120 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000160934
|
SMART Domains |
Protein: ENSMUSP00000123859 Gene: ENSMUSG00000027692
Domain | Start | End | E-Value | Type |
Pfam:Pkinase_Tyr
|
25 |
212 |
2.2e-37 |
PFAM |
Pfam:Pkinase
|
25 |
219 |
5.9e-52 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000161423
|
Predicted Effect |
probably null
Transcript: ENSMUST00000161964
|
SMART Domains |
Protein: ENSMUSP00000125411 Gene: ENSMUSG00000027692
Domain | Start | End | E-Value | Type |
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
low complexity region
|
636 |
671 |
N/A |
INTRINSIC |
low complexity region
|
738 |
757 |
N/A |
INTRINSIC |
low complexity region
|
896 |
903 |
N/A |
INTRINSIC |
CNH
|
950 |
1248 |
1.92e-117 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000161964
|
SMART Domains |
Protein: ENSMUSP00000125411 Gene: ENSMUSG00000027692
Domain | Start | End | E-Value | Type |
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
low complexity region
|
636 |
671 |
N/A |
INTRINSIC |
low complexity region
|
738 |
757 |
N/A |
INTRINSIC |
low complexity region
|
896 |
903 |
N/A |
INTRINSIC |
CNH
|
950 |
1248 |
1.92e-117 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000162485
|
SMART Domains |
Protein: ENSMUSP00000124387 Gene: ENSMUSG00000027692
Domain | Start | End | E-Value | Type |
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
low complexity region
|
665 |
700 |
N/A |
INTRINSIC |
low complexity region
|
775 |
794 |
N/A |
INTRINSIC |
low complexity region
|
933 |
940 |
N/A |
INTRINSIC |
CNH
|
987 |
1285 |
1.92e-117 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000162485
|
SMART Domains |
Protein: ENSMUSP00000124387 Gene: ENSMUSG00000027692
Domain | Start | End | E-Value | Type |
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
low complexity region
|
665 |
700 |
N/A |
INTRINSIC |
low complexity region
|
775 |
794 |
N/A |
INTRINSIC |
low complexity region
|
933 |
940 |
N/A |
INTRINSIC |
CNH
|
987 |
1285 |
1.92e-117 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000162777
|
SMART Domains |
Protein: ENSMUSP00000124726 Gene: ENSMUSG00000027692
Domain | Start | End | E-Value | Type |
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
low complexity region
|
665 |
700 |
N/A |
INTRINSIC |
low complexity region
|
767 |
786 |
N/A |
INTRINSIC |
low complexity region
|
925 |
932 |
N/A |
INTRINSIC |
CNH
|
979 |
1277 |
1.92e-117 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000162777
|
SMART Domains |
Protein: ENSMUSP00000124726 Gene: ENSMUSG00000027692
Domain | Start | End | E-Value | Type |
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
low complexity region
|
665 |
700 |
N/A |
INTRINSIC |
low complexity region
|
767 |
786 |
N/A |
INTRINSIC |
low complexity region
|
925 |
932 |
N/A |
INTRINSIC |
CNH
|
979 |
1277 |
1.92e-117 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000162037
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000193721
|
Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.1%
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008] PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired postsynaptic signaling and cognitive function. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 100 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4930522L14Rik |
G |
A |
5: 109,885,259 (GRCm39) |
R200C |
probably benign |
Het |
Ak7 |
G |
A |
12: 105,679,834 (GRCm39) |
V123M |
probably benign |
Het |
Aoc1l1 |
A |
T |
6: 48,952,090 (GRCm39) |
Q5L |
probably benign |
Het |
Apc |
T |
C |
18: 34,451,618 (GRCm39) |
L2804P |
probably damaging |
Het |
Apob |
C |
A |
12: 8,061,331 (GRCm39) |
A3271E |
probably damaging |
Het |
Asl |
G |
T |
5: 130,047,157 (GRCm39) |
A147E |
probably damaging |
Het |
Atp1a1 |
A |
G |
3: 101,494,259 (GRCm39) |
V447A |
probably benign |
Het |
AY358078 |
T |
A |
14: 52,063,532 (GRCm39) |
C393S |
possibly damaging |
Het |
Bcl11b |
T |
C |
12: 107,882,789 (GRCm39) |
K509E |
probably damaging |
Het |
Btnl1 |
T |
C |
17: 34,598,699 (GRCm39) |
I105T |
probably damaging |
Het |
Btnl10 |
A |
G |
11: 58,811,183 (GRCm39) |
T169A |
probably damaging |
Het |
C8b |
T |
C |
4: 104,647,841 (GRCm39) |
I278T |
probably damaging |
Het |
Ccdc66 |
T |
C |
14: 27,222,377 (GRCm39) |
N122S |
probably damaging |
Het |
Cd8b1 |
T |
C |
6: 71,309,459 (GRCm39) |
V181A |
probably benign |
Het |
Cdan1 |
A |
T |
2: 120,561,201 (GRCm39) |
V189D |
probably damaging |
Het |
Celf2 |
G |
T |
2: 6,590,831 (GRCm39) |
N279K |
possibly damaging |
Het |
Cfap52 |
T |
C |
11: 67,817,247 (GRCm39) |
N549D |
probably damaging |
Het |
Cmklr1 |
C |
T |
5: 113,752,930 (GRCm39) |
V24M |
probably benign |
Het |
Cntnap4 |
G |
T |
8: 113,500,371 (GRCm39) |
|
probably null |
Het |
Col27a1 |
G |
A |
4: 63,211,743 (GRCm39) |
G91R |
probably damaging |
Het |
Col5a3 |
A |
G |
9: 20,726,192 (GRCm39) |
|
probably benign |
Het |
Dcc |
C |
T |
18: 71,682,069 (GRCm39) |
|
probably null |
Het |
Deaf1 |
T |
A |
7: 140,890,884 (GRCm39) |
T433S |
possibly damaging |
Het |
Dnah8 |
T |
A |
17: 30,903,211 (GRCm39) |
L950H |
probably damaging |
Het |
Dnajc7 |
A |
T |
11: 100,481,803 (GRCm39) |
Y228* |
probably null |
Het |
Eno1b |
T |
C |
18: 48,180,770 (GRCm39) |
V316A |
probably damaging |
Het |
Exoc4 |
T |
C |
6: 33,415,340 (GRCm39) |
M404T |
possibly damaging |
Het |
Fignl1 |
A |
T |
11: 11,751,268 (GRCm39) |
C596S |
probably benign |
Het |
Fn1 |
A |
C |
1: 71,663,337 (GRCm39) |
Y1050* |
probably null |
Het |
Frem2 |
A |
G |
3: 53,455,228 (GRCm39) |
L2116S |
possibly damaging |
Het |
Gba2 |
T |
A |
4: 43,568,092 (GRCm39) |
S732C |
probably damaging |
Het |
Gcnt4 |
C |
A |
13: 97,082,990 (GRCm39) |
S95R |
probably benign |
Het |
Gpr37 |
A |
G |
6: 25,669,623 (GRCm39) |
V407A |
probably benign |
Het |
Gria2 |
A |
T |
3: 80,599,799 (GRCm39) |
M695K |
probably damaging |
Het |
Hoxa9 |
T |
C |
6: 52,202,690 (GRCm39) |
K132R |
probably damaging |
Het |
Ifi213 |
T |
A |
1: 173,417,480 (GRCm39) |
T311S |
possibly damaging |
Het |
Itgb2 |
T |
A |
10: 77,385,884 (GRCm39) |
N282K |
probably damaging |
Het |
Kcnh8 |
A |
T |
17: 52,909,864 (GRCm39) |
Q11L |
probably benign |
Het |
Klk14 |
T |
C |
7: 43,343,781 (GRCm39) |
C163R |
probably damaging |
Het |
Klk1b3 |
T |
A |
7: 43,850,689 (GRCm39) |
W74R |
possibly damaging |
Het |
Krtap13-1 |
G |
T |
16: 88,526,142 (GRCm39) |
C122F |
possibly damaging |
Het |
Luzp2 |
T |
C |
7: 54,713,104 (GRCm39) |
|
probably null |
Het |
Mbtps1 |
A |
T |
8: 120,262,086 (GRCm39) |
D354E |
probably damaging |
Het |
Mcpt9 |
C |
T |
14: 56,266,049 (GRCm39) |
V60M |
probably damaging |
Het |
Mical3 |
C |
A |
6: 120,911,799 (GRCm39) |
E1083* |
probably null |
Het |
Mrc2 |
G |
A |
11: 105,239,257 (GRCm39) |
|
probably null |
Het |
Mtor |
T |
A |
4: 148,570,576 (GRCm39) |
V1211E |
probably benign |
Het |
Myb |
T |
A |
10: 21,021,223 (GRCm39) |
D402V |
probably damaging |
Het |
Ncor2 |
G |
A |
5: 125,107,923 (GRCm39) |
T1593I |
probably damaging |
Het |
Ndst3 |
A |
G |
3: 123,465,198 (GRCm39) |
I258T |
probably benign |
Het |
Npy6r |
C |
A |
18: 44,409,468 (GRCm39) |
H296Q |
probably damaging |
Het |
Olfml2b |
T |
A |
1: 170,472,516 (GRCm39) |
L9H |
probably damaging |
Het |
Or10a3n |
A |
G |
7: 108,493,324 (GRCm39) |
C97R |
probably damaging |
Het |
Or1a1b |
A |
T |
11: 74,097,361 (GRCm39) |
V227D |
possibly damaging |
Het |
Or2w2 |
A |
T |
13: 21,757,744 (GRCm39) |
V294D |
probably damaging |
Het |
Or4k15 |
C |
A |
14: 50,364,530 (GRCm39) |
N165K |
probably benign |
Het |
Or5b119 |
C |
T |
19: 13,457,376 (GRCm39) |
C62Y |
probably damaging |
Het |
Or5b94 |
T |
A |
19: 12,652,318 (GRCm39) |
Y250N |
probably damaging |
Het |
Or6c207 |
G |
A |
10: 129,104,274 (GRCm39) |
A306V |
probably benign |
Het |
Or8b8 |
T |
A |
9: 37,809,622 (GRCm39) |
S307R |
probably benign |
Het |
Ovgp1 |
T |
C |
3: 105,893,883 (GRCm39) |
|
probably benign |
Het |
Parg |
G |
A |
14: 31,996,821 (GRCm39) |
R304Q |
probably damaging |
Het |
Pdf |
T |
G |
8: 107,775,167 (GRCm39) |
S22R |
probably benign |
Het |
Phlpp2 |
A |
T |
8: 110,603,515 (GRCm39) |
R60S |
possibly damaging |
Het |
Piwil2 |
C |
T |
14: 70,639,646 (GRCm39) |
E401K |
probably benign |
Het |
Pla2g4e |
T |
G |
2: 120,016,863 (GRCm39) |
H226P |
possibly damaging |
Het |
Polr3a |
T |
C |
14: 24,502,576 (GRCm39) |
|
probably null |
Het |
Ppp3cb |
T |
C |
14: 20,570,714 (GRCm39) |
N339S |
possibly damaging |
Het |
Ptch2 |
G |
A |
4: 116,967,575 (GRCm39) |
D748N |
probably benign |
Het |
Rai14 |
A |
C |
15: 10,592,224 (GRCm39) |
Y224D |
probably damaging |
Het |
Rft1 |
A |
G |
14: 30,411,747 (GRCm39) |
I432V |
probably damaging |
Het |
Rictor |
C |
T |
15: 6,816,625 (GRCm39) |
A1299V |
possibly damaging |
Het |
Sall2 |
A |
G |
14: 52,551,210 (GRCm39) |
C662R |
probably damaging |
Het |
Scn4b |
A |
G |
9: 45,061,737 (GRCm39) |
N208D |
probably damaging |
Het |
Sdhb |
G |
A |
4: 140,700,226 (GRCm39) |
G109R |
probably damaging |
Het |
Sec16a |
A |
G |
2: 26,331,817 (GRCm39) |
V66A |
probably benign |
Het |
Sema4g |
A |
G |
19: 44,990,051 (GRCm39) |
Y710C |
probably damaging |
Het |
Serpinb12 |
T |
A |
1: 106,876,883 (GRCm39) |
D66E |
probably benign |
Het |
Shc4 |
T |
A |
2: 125,497,602 (GRCm39) |
D369V |
probably benign |
Het |
Siglech |
T |
C |
7: 55,421,441 (GRCm39) |
L285P |
probably damaging |
Het |
Skint6 |
A |
G |
4: 112,931,273 (GRCm39) |
M506T |
probably benign |
Het |
Slco1a6 |
C |
A |
6: 142,047,378 (GRCm39) |
C404F |
probably benign |
Het |
Slfn14 |
T |
A |
11: 83,174,140 (GRCm39) |
K284* |
probably null |
Het |
Sox14 |
A |
G |
9: 99,757,715 (GRCm39) |
I8T |
probably damaging |
Het |
Srpk3 |
A |
G |
X: 72,818,547 (GRCm39) |
H79R |
possibly damaging |
Het |
Tdpoz3 |
A |
T |
3: 93,734,330 (GRCm39) |
H335L |
probably damaging |
Het |
Tdrd5 |
T |
A |
1: 156,111,944 (GRCm39) |
T479S |
probably benign |
Het |
Tnpo2 |
T |
C |
8: 85,780,432 (GRCm39) |
S720P |
probably benign |
Het |
Tpst1 |
A |
G |
5: 130,130,547 (GRCm39) |
K6E |
probably damaging |
Het |
Trank1 |
T |
A |
9: 111,191,329 (GRCm39) |
I446N |
probably damaging |
Het |
Trmt44 |
A |
T |
5: 35,732,351 (GRCm39) |
D13E |
probably benign |
Het |
Ubr4 |
T |
A |
4: 139,126,890 (GRCm39) |
V471E |
possibly damaging |
Het |
Ubtd1 |
A |
G |
19: 42,022,030 (GRCm39) |
T101A |
probably benign |
Het |
Ugt3a1 |
A |
T |
15: 9,306,486 (GRCm39) |
K212* |
probably null |
Het |
Zbtb7c |
C |
T |
18: 76,269,918 (GRCm39) |
A2V |
possibly damaging |
Het |
Zfp423 |
C |
T |
8: 88,414,709 (GRCm39) |
G1182D |
possibly damaging |
Het |
Zfp618 |
G |
A |
4: 63,051,216 (GRCm39) |
V666M |
probably damaging |
Het |
Zmat1 |
A |
T |
X: 133,873,694 (GRCm39) |
S566T |
probably damaging |
Homo |
Zscan20 |
T |
C |
4: 128,481,899 (GRCm39) |
T588A |
probably benign |
Het |
Zscan25 |
G |
A |
5: 145,227,926 (GRCm39) |
R530H |
probably damaging |
Het |
|
Other mutations in Tnik |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00516:Tnik
|
APN |
3 |
28,708,367 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL00726:Tnik
|
APN |
3 |
28,587,047 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01022:Tnik
|
APN |
3 |
28,679,377 (GRCm39) |
splice site |
probably null |
|
IGL01145:Tnik
|
APN |
3 |
28,658,316 (GRCm39) |
intron |
probably benign |
|
IGL01664:Tnik
|
APN |
3 |
28,692,628 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01843:Tnik
|
APN |
3 |
28,625,007 (GRCm39) |
splice site |
probably null |
|
IGL02378:Tnik
|
APN |
3 |
28,692,608 (GRCm39) |
nonsense |
probably null |
|
IGL02448:Tnik
|
APN |
3 |
28,675,226 (GRCm39) |
missense |
probably null |
0.01 |
IGL02756:Tnik
|
APN |
3 |
28,596,179 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03332:Tnik
|
APN |
3 |
28,720,304 (GRCm39) |
missense |
probably damaging |
1.00 |
delightful
|
UTSW |
3 |
28,658,334 (GRCm39) |
missense |
probably damaging |
1.00 |
Hottie
|
UTSW |
3 |
28,317,792 (GRCm39) |
start codon destroyed |
probably null |
0.93 |
Knockout
|
UTSW |
3 |
28,715,927 (GRCm39) |
missense |
possibly damaging |
0.91 |
Looker
|
UTSW |
3 |
28,715,853 (GRCm39) |
nonsense |
probably null |
|
Lovely
|
UTSW |
3 |
28,666,119 (GRCm39) |
critical splice donor site |
probably null |
|
Usher
|
UTSW |
3 |
28,618,246 (GRCm39) |
missense |
possibly damaging |
0.61 |
R0135:Tnik
|
UTSW |
3 |
28,661,394 (GRCm39) |
missense |
possibly damaging |
0.67 |
R0418:Tnik
|
UTSW |
3 |
28,625,029 (GRCm39) |
nonsense |
probably null |
|
R0540:Tnik
|
UTSW |
3 |
28,704,308 (GRCm39) |
missense |
probably damaging |
1.00 |
R0549:Tnik
|
UTSW |
3 |
28,625,069 (GRCm39) |
missense |
possibly damaging |
0.87 |
R0556:Tnik
|
UTSW |
3 |
28,679,367 (GRCm39) |
missense |
possibly damaging |
0.95 |
R0586:Tnik
|
UTSW |
3 |
28,631,510 (GRCm39) |
splice site |
probably benign |
|
R0607:Tnik
|
UTSW |
3 |
28,704,308 (GRCm39) |
missense |
probably damaging |
1.00 |
R0842:Tnik
|
UTSW |
3 |
28,648,235 (GRCm39) |
missense |
possibly damaging |
0.72 |
R1068:Tnik
|
UTSW |
3 |
28,587,124 (GRCm39) |
missense |
probably damaging |
1.00 |
R1171:Tnik
|
UTSW |
3 |
28,587,089 (GRCm39) |
missense |
probably damaging |
1.00 |
R1597:Tnik
|
UTSW |
3 |
28,658,418 (GRCm39) |
missense |
probably damaging |
1.00 |
R1638:Tnik
|
UTSW |
3 |
28,719,889 (GRCm39) |
missense |
probably damaging |
0.99 |
R1652:Tnik
|
UTSW |
3 |
28,658,442 (GRCm39) |
missense |
probably benign |
0.22 |
R1996:Tnik
|
UTSW |
3 |
28,719,829 (GRCm39) |
missense |
probably damaging |
1.00 |
R2333:Tnik
|
UTSW |
3 |
28,587,145 (GRCm39) |
missense |
probably damaging |
1.00 |
R2426:Tnik
|
UTSW |
3 |
28,700,830 (GRCm39) |
missense |
probably damaging |
1.00 |
R2509:Tnik
|
UTSW |
3 |
28,722,064 (GRCm39) |
missense |
probably damaging |
1.00 |
R3774:Tnik
|
UTSW |
3 |
28,692,568 (GRCm39) |
missense |
probably damaging |
0.98 |
R3775:Tnik
|
UTSW |
3 |
28,692,568 (GRCm39) |
missense |
probably damaging |
0.98 |
R4007:Tnik
|
UTSW |
3 |
28,658,430 (GRCm39) |
missense |
probably damaging |
1.00 |
R4119:Tnik
|
UTSW |
3 |
28,720,324 (GRCm39) |
missense |
probably damaging |
1.00 |
R4209:Tnik
|
UTSW |
3 |
28,413,214 (GRCm39) |
splice site |
probably benign |
|
R4441:Tnik
|
UTSW |
3 |
28,618,246 (GRCm39) |
missense |
possibly damaging |
0.61 |
R4714:Tnik
|
UTSW |
3 |
28,648,226 (GRCm39) |
missense |
possibly damaging |
0.53 |
R4772:Tnik
|
UTSW |
3 |
28,661,359 (GRCm39) |
missense |
probably benign |
0.09 |
R4829:Tnik
|
UTSW |
3 |
28,593,690 (GRCm39) |
intron |
probably benign |
|
R4839:Tnik
|
UTSW |
3 |
28,650,224 (GRCm39) |
missense |
possibly damaging |
0.86 |
R4898:Tnik
|
UTSW |
3 |
28,704,235 (GRCm39) |
missense |
probably damaging |
1.00 |
R5029:Tnik
|
UTSW |
3 |
28,719,993 (GRCm39) |
splice site |
probably null |
|
R5278:Tnik
|
UTSW |
3 |
28,704,209 (GRCm39) |
missense |
probably damaging |
1.00 |
R5307:Tnik
|
UTSW |
3 |
28,596,121 (GRCm39) |
missense |
probably damaging |
1.00 |
R5330:Tnik
|
UTSW |
3 |
28,596,167 (GRCm39) |
missense |
probably damaging |
1.00 |
R5375:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
R5459:Tnik
|
UTSW |
3 |
28,715,890 (GRCm39) |
missense |
probably damaging |
1.00 |
R5708:Tnik
|
UTSW |
3 |
28,666,120 (GRCm39) |
critical splice donor site |
probably null |
|
R5749:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
R5751:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
R5780:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
R5837:Tnik
|
UTSW |
3 |
28,722,202 (GRCm39) |
unclassified |
probably benign |
|
R5969:Tnik
|
UTSW |
3 |
28,675,097 (GRCm39) |
missense |
probably damaging |
1.00 |
R6244:Tnik
|
UTSW |
3 |
28,704,328 (GRCm39) |
missense |
probably damaging |
1.00 |
R6273:Tnik
|
UTSW |
3 |
28,631,649 (GRCm39) |
missense |
possibly damaging |
0.94 |
R6457:Tnik
|
UTSW |
3 |
28,593,597 (GRCm39) |
missense |
probably damaging |
1.00 |
R6464:Tnik
|
UTSW |
3 |
28,666,119 (GRCm39) |
critical splice donor site |
probably null |
|
R6473:Tnik
|
UTSW |
3 |
28,317,792 (GRCm39) |
start codon destroyed |
probably null |
0.93 |
R6737:Tnik
|
UTSW |
3 |
28,650,235 (GRCm39) |
missense |
possibly damaging |
0.72 |
R7049:Tnik
|
UTSW |
3 |
28,715,853 (GRCm39) |
nonsense |
probably null |
|
R7237:Tnik
|
UTSW |
3 |
28,692,568 (GRCm39) |
missense |
probably damaging |
0.98 |
R7267:Tnik
|
UTSW |
3 |
28,700,776 (GRCm39) |
missense |
probably damaging |
0.99 |
R7445:Tnik
|
UTSW |
3 |
28,718,058 (GRCm39) |
splice site |
probably null |
|
R7499:Tnik
|
UTSW |
3 |
28,684,743 (GRCm39) |
missense |
possibly damaging |
0.47 |
R7629:Tnik
|
UTSW |
3 |
28,715,877 (GRCm39) |
missense |
probably damaging |
0.96 |
R7654:Tnik
|
UTSW |
3 |
28,658,334 (GRCm39) |
missense |
probably damaging |
1.00 |
R7886:Tnik
|
UTSW |
3 |
28,720,288 (GRCm39) |
missense |
probably damaging |
1.00 |
R8096:Tnik
|
UTSW |
3 |
28,715,927 (GRCm39) |
missense |
possibly damaging |
0.91 |
R8210:Tnik
|
UTSW |
3 |
28,658,482 (GRCm39) |
missense |
possibly damaging |
0.95 |
R8233:Tnik
|
UTSW |
3 |
28,609,086 (GRCm39) |
missense |
unknown |
|
R8386:Tnik
|
UTSW |
3 |
28,317,823 (GRCm39) |
missense |
unknown |
|
R8399:Tnik
|
UTSW |
3 |
28,548,159 (GRCm39) |
missense |
unknown |
|
R8490:Tnik
|
UTSW |
3 |
28,650,321 (GRCm39) |
missense |
probably damaging |
0.97 |
R8539:Tnik
|
UTSW |
3 |
28,596,152 (GRCm39) |
missense |
probably damaging |
1.00 |
R8751:Tnik
|
UTSW |
3 |
28,666,057 (GRCm39) |
missense |
probably damaging |
0.98 |
R8804:Tnik
|
UTSW |
3 |
28,648,202 (GRCm39) |
missense |
unknown |
|
R8966:Tnik
|
UTSW |
3 |
28,587,044 (GRCm39) |
missense |
unknown |
|
R8998:Tnik
|
UTSW |
3 |
28,719,920 (GRCm39) |
missense |
probably damaging |
1.00 |
R8999:Tnik
|
UTSW |
3 |
28,719,920 (GRCm39) |
missense |
probably damaging |
1.00 |
R9016:Tnik
|
UTSW |
3 |
28,692,544 (GRCm39) |
missense |
probably damaging |
1.00 |
R9154:Tnik
|
UTSW |
3 |
28,704,235 (GRCm39) |
missense |
probably damaging |
0.99 |
R9284:Tnik
|
UTSW |
3 |
28,593,570 (GRCm39) |
missense |
unknown |
|
R9290:Tnik
|
UTSW |
3 |
28,675,124 (GRCm39) |
missense |
probably benign |
0.00 |
R9411:Tnik
|
UTSW |
3 |
28,684,754 (GRCm39) |
missense |
probably damaging |
1.00 |
R9484:Tnik
|
UTSW |
3 |
28,649,093 (GRCm39) |
missense |
unknown |
|
X0022:Tnik
|
UTSW |
3 |
28,722,100 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1176:Tnik
|
UTSW |
3 |
28,661,477 (GRCm39) |
missense |
probably damaging |
0.96 |
Z1176:Tnik
|
UTSW |
3 |
28,658,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- CCTCACATCCAATCTGAGGTTC -3'
(R):5'- CACAAACCTGCTCTATTTCTCAAG -3'
Sequencing Primer
(F):5'- TTTTGGAGTGAGTGCCCA -3'
(R):5'- ACCTGCTCTATTTCTCAAGAGTAAG -3'
|
Posted On |
2015-09-25 |