Incidental Mutation 'R4611:Gria2'
| ID |
344687 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Gria2
|
| Ensembl Gene |
ENSMUSG00000033981 |
| Gene Name |
glutamate receptor, ionotropic, AMPA2 (alpha 2) |
| Synonyms |
Glur-2, GluA2, GluR2, GluR-B, Glur2 |
| MMRRC Submission |
041822-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.259)
|
| Stock # |
R4611 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
3 |
| Chromosomal Location |
80588757-80710142 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 80599799 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Lysine
at position 695
(M695K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000141447
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000075316]
[ENSMUST00000107745]
[ENSMUST00000192463]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000075316
AA Change: M695K
PolyPhen 2
Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000074787
Gene: ENSMUSG00000033981
AA Change: M695K
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
49 |
379 |
2.7e-58 |
PFAM |
|
PBPe
|
415 |
790 |
3.75e-132 |
SMART |
|
Lig_chan-Glu_bd
|
425 |
490 |
2.96e-31 |
SMART |
|
low complexity region
|
820 |
832 |
N/A |
INTRINSIC |
|
low complexity region
|
853 |
865 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000107745
AA Change: M695K
PolyPhen 2
Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000103374
Gene: ENSMUSG00000033981
AA Change: M695K
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
47 |
379 |
4.8e-53 |
PFAM |
|
PBPe
|
415 |
790 |
8.16e-133 |
SMART |
|
Lig_chan-Glu_bd
|
425 |
490 |
2.96e-31 |
SMART |
|
low complexity region
|
820 |
832 |
N/A |
INTRINSIC |
|
low complexity region
|
853 |
865 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000175485
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000192463
AA Change: M695K
PolyPhen 2
Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000141447
Gene: ENSMUSG00000033981
AA Change: M695K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
47 |
379 |
1.7e-51 |
PFAM |
|
PBPe
|
415 |
770 |
1.2e-105 |
SMART |
|
Lig_chan-Glu_bd
|
425 |
490 |
2.2e-35 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000194383
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for targeted null mutations exhibit epilepsy, deficient dendritic architecture, altered exploratory behavior, impaired motor and learning performance, and increased mortality. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 100 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930522L14Rik |
G |
A |
5: 109,885,259 (GRCm39) |
R200C |
probably benign |
Het |
| Ak7 |
G |
A |
12: 105,679,834 (GRCm39) |
V123M |
probably benign |
Het |
| Aoc1l1 |
A |
T |
6: 48,952,090 (GRCm39) |
Q5L |
probably benign |
Het |
| Apc |
T |
C |
18: 34,451,618 (GRCm39) |
L2804P |
probably damaging |
Het |
| Apob |
C |
A |
12: 8,061,331 (GRCm39) |
A3271E |
probably damaging |
Het |
| Asl |
G |
T |
5: 130,047,157 (GRCm39) |
A147E |
probably damaging |
Het |
| Atp1a1 |
A |
G |
3: 101,494,259 (GRCm39) |
V447A |
probably benign |
Het |
| AY358078 |
T |
A |
14: 52,063,532 (GRCm39) |
C393S |
possibly damaging |
Het |
| Bcl11b |
T |
C |
12: 107,882,789 (GRCm39) |
K509E |
probably damaging |
Het |
| Btnl1 |
T |
C |
17: 34,598,699 (GRCm39) |
I105T |
probably damaging |
Het |
| Btnl10 |
A |
G |
11: 58,811,183 (GRCm39) |
T169A |
probably damaging |
Het |
| C8b |
T |
C |
4: 104,647,841 (GRCm39) |
I278T |
probably damaging |
Het |
| Ccdc66 |
T |
C |
14: 27,222,377 (GRCm39) |
N122S |
probably damaging |
Het |
| Cd8b1 |
T |
C |
6: 71,309,459 (GRCm39) |
V181A |
probably benign |
Het |
| Cdan1 |
A |
T |
2: 120,561,201 (GRCm39) |
V189D |
probably damaging |
Het |
| Celf2 |
G |
T |
2: 6,590,831 (GRCm39) |
N279K |
possibly damaging |
Het |
| Cfap52 |
T |
C |
11: 67,817,247 (GRCm39) |
N549D |
probably damaging |
Het |
| Cmklr1 |
C |
T |
5: 113,752,930 (GRCm39) |
V24M |
probably benign |
Het |
| Cntnap4 |
G |
T |
8: 113,500,371 (GRCm39) |
|
probably null |
Het |
| Col27a1 |
G |
A |
4: 63,211,743 (GRCm39) |
G91R |
probably damaging |
Het |
| Col5a3 |
A |
G |
9: 20,726,192 (GRCm39) |
|
probably benign |
Het |
| Dcc |
C |
T |
18: 71,682,069 (GRCm39) |
|
probably null |
Het |
| Deaf1 |
T |
A |
7: 140,890,884 (GRCm39) |
T433S |
possibly damaging |
Het |
| Dnah8 |
T |
A |
17: 30,903,211 (GRCm39) |
L950H |
probably damaging |
Het |
| Dnajc7 |
A |
T |
11: 100,481,803 (GRCm39) |
Y228* |
probably null |
Het |
| Eno1b |
T |
C |
18: 48,180,770 (GRCm39) |
V316A |
probably damaging |
Het |
| Exoc4 |
T |
C |
6: 33,415,340 (GRCm39) |
M404T |
possibly damaging |
Het |
| Fignl1 |
A |
T |
11: 11,751,268 (GRCm39) |
C596S |
probably benign |
Het |
| Fn1 |
A |
C |
1: 71,663,337 (GRCm39) |
Y1050* |
probably null |
Het |
| Frem2 |
A |
G |
3: 53,455,228 (GRCm39) |
L2116S |
possibly damaging |
Het |
| Gba2 |
T |
A |
4: 43,568,092 (GRCm39) |
S732C |
probably damaging |
Het |
| Gcnt4 |
C |
A |
13: 97,082,990 (GRCm39) |
S95R |
probably benign |
Het |
| Gpr37 |
A |
G |
6: 25,669,623 (GRCm39) |
V407A |
probably benign |
Het |
| Hoxa9 |
T |
C |
6: 52,202,690 (GRCm39) |
K132R |
probably damaging |
Het |
| Ifi213 |
T |
A |
1: 173,417,480 (GRCm39) |
T311S |
possibly damaging |
Het |
| Itgb2 |
T |
A |
10: 77,385,884 (GRCm39) |
N282K |
probably damaging |
Het |
| Kcnh8 |
A |
T |
17: 52,909,864 (GRCm39) |
Q11L |
probably benign |
Het |
| Klk14 |
T |
C |
7: 43,343,781 (GRCm39) |
C163R |
probably damaging |
Het |
| Klk1b3 |
T |
A |
7: 43,850,689 (GRCm39) |
W74R |
possibly damaging |
Het |
| Krtap13-1 |
G |
T |
16: 88,526,142 (GRCm39) |
C122F |
possibly damaging |
Het |
| Luzp2 |
T |
C |
7: 54,713,104 (GRCm39) |
|
probably null |
Het |
| Mbtps1 |
A |
T |
8: 120,262,086 (GRCm39) |
D354E |
probably damaging |
Het |
| Mcpt9 |
C |
T |
14: 56,266,049 (GRCm39) |
V60M |
probably damaging |
Het |
| Mical3 |
C |
A |
6: 120,911,799 (GRCm39) |
E1083* |
probably null |
Het |
| Mrc2 |
G |
A |
11: 105,239,257 (GRCm39) |
|
probably null |
Het |
| Mtor |
T |
A |
4: 148,570,576 (GRCm39) |
V1211E |
probably benign |
Het |
| Myb |
T |
A |
10: 21,021,223 (GRCm39) |
D402V |
probably damaging |
Het |
| Ncor2 |
G |
A |
5: 125,107,923 (GRCm39) |
T1593I |
probably damaging |
Het |
| Ndst3 |
A |
G |
3: 123,465,198 (GRCm39) |
I258T |
probably benign |
Het |
| Npy6r |
C |
A |
18: 44,409,468 (GRCm39) |
H296Q |
probably damaging |
Het |
| Olfml2b |
T |
A |
1: 170,472,516 (GRCm39) |
L9H |
probably damaging |
Het |
| Or10a3n |
A |
G |
7: 108,493,324 (GRCm39) |
C97R |
probably damaging |
Het |
| Or1a1b |
A |
T |
11: 74,097,361 (GRCm39) |
V227D |
possibly damaging |
Het |
| Or2w2 |
A |
T |
13: 21,757,744 (GRCm39) |
V294D |
probably damaging |
Het |
| Or4k15 |
C |
A |
14: 50,364,530 (GRCm39) |
N165K |
probably benign |
Het |
| Or5b119 |
C |
T |
19: 13,457,376 (GRCm39) |
C62Y |
probably damaging |
Het |
| Or5b94 |
T |
A |
19: 12,652,318 (GRCm39) |
Y250N |
probably damaging |
Het |
| Or6c207 |
G |
A |
10: 129,104,274 (GRCm39) |
A306V |
probably benign |
Het |
| Or8b8 |
T |
A |
9: 37,809,622 (GRCm39) |
S307R |
probably benign |
Het |
| Ovgp1 |
T |
C |
3: 105,893,883 (GRCm39) |
|
probably benign |
Het |
| Parg |
G |
A |
14: 31,996,821 (GRCm39) |
R304Q |
probably damaging |
Het |
| Pdf |
T |
G |
8: 107,775,167 (GRCm39) |
S22R |
probably benign |
Het |
| Phlpp2 |
A |
T |
8: 110,603,515 (GRCm39) |
R60S |
possibly damaging |
Het |
| Piwil2 |
C |
T |
14: 70,639,646 (GRCm39) |
E401K |
probably benign |
Het |
| Pla2g4e |
T |
G |
2: 120,016,863 (GRCm39) |
H226P |
possibly damaging |
Het |
| Polr3a |
T |
C |
14: 24,502,576 (GRCm39) |
|
probably null |
Het |
| Ppp3cb |
T |
C |
14: 20,570,714 (GRCm39) |
N339S |
possibly damaging |
Het |
| Ptch2 |
G |
A |
4: 116,967,575 (GRCm39) |
D748N |
probably benign |
Het |
| Rai14 |
A |
C |
15: 10,592,224 (GRCm39) |
Y224D |
probably damaging |
Het |
| Rft1 |
A |
G |
14: 30,411,747 (GRCm39) |
I432V |
probably damaging |
Het |
| Rictor |
C |
T |
15: 6,816,625 (GRCm39) |
A1299V |
possibly damaging |
Het |
| Sall2 |
A |
G |
14: 52,551,210 (GRCm39) |
C662R |
probably damaging |
Het |
| Scn4b |
A |
G |
9: 45,061,737 (GRCm39) |
N208D |
probably damaging |
Het |
| Sdhb |
G |
A |
4: 140,700,226 (GRCm39) |
G109R |
probably damaging |
Het |
| Sec16a |
A |
G |
2: 26,331,817 (GRCm39) |
V66A |
probably benign |
Het |
| Sema4g |
A |
G |
19: 44,990,051 (GRCm39) |
Y710C |
probably damaging |
Het |
| Serpinb12 |
T |
A |
1: 106,876,883 (GRCm39) |
D66E |
probably benign |
Het |
| Shc4 |
T |
A |
2: 125,497,602 (GRCm39) |
D369V |
probably benign |
Het |
| Siglech |
T |
C |
7: 55,421,441 (GRCm39) |
L285P |
probably damaging |
Het |
| Skint6 |
A |
G |
4: 112,931,273 (GRCm39) |
M506T |
probably benign |
Het |
| Slco1a6 |
C |
A |
6: 142,047,378 (GRCm39) |
C404F |
probably benign |
Het |
| Slfn14 |
T |
A |
11: 83,174,140 (GRCm39) |
K284* |
probably null |
Het |
| Sox14 |
A |
G |
9: 99,757,715 (GRCm39) |
I8T |
probably damaging |
Het |
| Srpk3 |
A |
G |
X: 72,818,547 (GRCm39) |
H79R |
possibly damaging |
Het |
| Tdpoz3 |
A |
T |
3: 93,734,330 (GRCm39) |
H335L |
probably damaging |
Het |
| Tdrd5 |
T |
A |
1: 156,111,944 (GRCm39) |
T479S |
probably benign |
Het |
| Tnik |
T |
C |
3: 28,596,249 (GRCm39) |
|
probably null |
Het |
| Tnpo2 |
T |
C |
8: 85,780,432 (GRCm39) |
S720P |
probably benign |
Het |
| Tpst1 |
A |
G |
5: 130,130,547 (GRCm39) |
K6E |
probably damaging |
Het |
| Trank1 |
T |
A |
9: 111,191,329 (GRCm39) |
I446N |
probably damaging |
Het |
| Trmt44 |
A |
T |
5: 35,732,351 (GRCm39) |
D13E |
probably benign |
Het |
| Ubr4 |
T |
A |
4: 139,126,890 (GRCm39) |
V471E |
possibly damaging |
Het |
| Ubtd1 |
A |
G |
19: 42,022,030 (GRCm39) |
T101A |
probably benign |
Het |
| Ugt3a1 |
A |
T |
15: 9,306,486 (GRCm39) |
K212* |
probably null |
Het |
| Zbtb7c |
C |
T |
18: 76,269,918 (GRCm39) |
A2V |
possibly damaging |
Het |
| Zfp423 |
C |
T |
8: 88,414,709 (GRCm39) |
G1182D |
possibly damaging |
Het |
| Zfp618 |
G |
A |
4: 63,051,216 (GRCm39) |
V666M |
probably damaging |
Het |
| Zmat1 |
A |
T |
X: 133,873,694 (GRCm39) |
S566T |
probably damaging |
Homo |
| Zscan20 |
T |
C |
4: 128,481,899 (GRCm39) |
T588A |
probably benign |
Het |
| Zscan25 |
G |
A |
5: 145,227,926 (GRCm39) |
R530H |
probably damaging |
Het |
|
| Other mutations in Gria2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00796:Gria2
|
APN |
3 |
80,618,097 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL00832:Gria2
|
APN |
3 |
80,614,558 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01086:Gria2
|
APN |
3 |
80,599,688 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01409:Gria2
|
APN |
3 |
80,615,004 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01924:Gria2
|
APN |
3 |
80,617,638 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL01999:Gria2
|
APN |
3 |
80,639,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02355:Gria2
|
APN |
3 |
80,614,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02362:Gria2
|
APN |
3 |
80,614,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02389:Gria2
|
APN |
3 |
80,616,729 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL02444:Gria2
|
APN |
3 |
80,609,860 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL02532:Gria2
|
APN |
3 |
80,614,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02991:Gria2
|
UTSW |
3 |
80,615,116 (GRCm39) |
nonsense |
probably null |
|
|
R0015:Gria2
|
UTSW |
3 |
80,615,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0148:Gria2
|
UTSW |
3 |
80,615,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0201:Gria2
|
UTSW |
3 |
80,615,145 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0411:Gria2
|
UTSW |
3 |
80,618,165 (GRCm39) |
splice site |
probably benign |
|
|
R0551:Gria2
|
UTSW |
3 |
80,639,333 (GRCm39) |
splice site |
probably benign |
|
|
R0655:Gria2
|
UTSW |
3 |
80,639,377 (GRCm39) |
nonsense |
probably null |
|
|
R0866:Gria2
|
UTSW |
3 |
80,629,331 (GRCm39) |
splice site |
probably benign |
|
|
R1393:Gria2
|
UTSW |
3 |
80,614,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1458:Gria2
|
UTSW |
3 |
80,639,352 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1563:Gria2
|
UTSW |
3 |
80,598,704 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1771:Gria2
|
UTSW |
3 |
80,599,608 (GRCm39) |
nonsense |
probably null |
|
|
R1775:Gria2
|
UTSW |
3 |
80,598,645 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1902:Gria2
|
UTSW |
3 |
80,629,415 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1993:Gria2
|
UTSW |
3 |
80,709,664 (GRCm39) |
missense |
probably benign |
|
|
R1994:Gria2
|
UTSW |
3 |
80,709,664 (GRCm39) |
missense |
probably benign |
|
|
R1995:Gria2
|
UTSW |
3 |
80,709,664 (GRCm39) |
missense |
probably benign |
|
|
R2001:Gria2
|
UTSW |
3 |
80,618,112 (GRCm39) |
missense |
probably benign |
0.28 |
|
R2389:Gria2
|
UTSW |
3 |
80,609,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2520:Gria2
|
UTSW |
3 |
80,614,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2679:Gria2
|
UTSW |
3 |
80,648,260 (GRCm39) |
splice site |
probably benign |
|
|
R2865:Gria2
|
UTSW |
3 |
80,639,392 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2869:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2869:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2870:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2870:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2871:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2871:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2872:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2872:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3716:Gria2
|
UTSW |
3 |
80,648,311 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R3967:Gria2
|
UTSW |
3 |
80,618,084 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4285:Gria2
|
UTSW |
3 |
80,614,969 (GRCm39) |
intron |
probably benign |
|
|
R4612:Gria2
|
UTSW |
3 |
80,639,358 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4616:Gria2
|
UTSW |
3 |
80,614,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4706:Gria2
|
UTSW |
3 |
80,648,297 (GRCm39) |
missense |
probably benign |
|
|
R4996:Gria2
|
UTSW |
3 |
80,614,448 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5502:Gria2
|
UTSW |
3 |
80,614,252 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5930:Gria2
|
UTSW |
3 |
80,614,556 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6142:Gria2
|
UTSW |
3 |
80,709,024 (GRCm39) |
missense |
probably benign |
0.13 |
|
R6233:Gria2
|
UTSW |
3 |
80,614,510 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6317:Gria2
|
UTSW |
3 |
80,648,311 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R6453:Gria2
|
UTSW |
3 |
80,648,281 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6526:Gria2
|
UTSW |
3 |
80,599,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6545:Gria2
|
UTSW |
3 |
80,648,451 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6574:Gria2
|
UTSW |
3 |
80,596,603 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6720:Gria2
|
UTSW |
3 |
80,709,611 (GRCm39) |
missense |
probably benign |
0.37 |
|
R7009:Gria2
|
UTSW |
3 |
80,614,279 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7049:Gria2
|
UTSW |
3 |
80,596,634 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7191:Gria2
|
UTSW |
3 |
80,639,392 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7225:Gria2
|
UTSW |
3 |
80,709,938 (GRCm39) |
unclassified |
probably benign |
|
|
R7374:Gria2
|
UTSW |
3 |
80,648,383 (GRCm39) |
missense |
probably benign |
|
|
R7837:Gria2
|
UTSW |
3 |
80,618,095 (GRCm39) |
missense |
probably benign |
0.18 |
|
R8034:Gria2
|
UTSW |
3 |
80,709,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8125:Gria2
|
UTSW |
3 |
80,614,550 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8189:Gria2
|
UTSW |
3 |
80,629,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8209:Gria2
|
UTSW |
3 |
80,616,764 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8362:Gria2
|
UTSW |
3 |
80,615,197 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8481:Gria2
|
UTSW |
3 |
80,708,998 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8500:Gria2
|
UTSW |
3 |
80,599,774 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8516:Gria2
|
UTSW |
3 |
80,614,294 (GRCm39) |
missense |
probably benign |
0.27 |
|
R8918:Gria2
|
UTSW |
3 |
80,599,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8939:Gria2
|
UTSW |
3 |
80,618,170 (GRCm39) |
intron |
probably benign |
|
|
R8971:Gria2
|
UTSW |
3 |
80,615,200 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9229:Gria2
|
UTSW |
3 |
80,709,689 (GRCm39) |
start codon destroyed |
probably null |
0.60 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGTGGGATACTATAACAACATTGAGC -3'
(R):5'- TGAAAGCTTTTCCGCGTCC -3'
Sequencing Primer
(F):5'- GATGCCGTAGCCTTTGGAATCC -3'
(R):5'- CTGGGCACTACTGTGTAAGCAC -3'
|
| Posted On |
2015-09-25 |
Incidental Mutation