Incidental Mutation 'R4611:Btnl10'
ID 344742
Institutional Source Beutler Lab
Gene Symbol Btnl10
Ensembl Gene ENSMUSG00000020490
Gene Name butyrophilin-like 10
Synonyms BUTR-1, Butr1
MMRRC Submission 041822-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R4611 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 58808703-58817791 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 58811183 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 169 (T169A)
Ref Sequence ENSEMBL: ENSMUSP00000124234 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020792] [ENSMUST00000069941] [ENSMUST00000108818] [ENSMUST00000142499]
AlphaFold Q9JK39
Predicted Effect probably damaging
Transcript: ENSMUST00000020792
AA Change: T169A

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000020792
Gene: ENSMUSG00000020490
AA Change: T169A

DomainStartEndE-ValueType
IGv 49 130 2.62e-7 SMART
Pfam:C2-set_2 150 233 3.6e-9 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000069941
AA Change: T169A

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000063279
Gene: ENSMUSG00000020490
AA Change: T169A

DomainStartEndE-ValueType
IGv 49 130 2.62e-7 SMART
Pfam:C2-set_2 150 233 5.5e-7 PFAM
PRY 300 352 1.11e-11 SMART
SPRY 353 474 6.55e-24 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000108818
AA Change: T169A

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000104446
Gene: ENSMUSG00000020490
AA Change: T169A

DomainStartEndE-ValueType
IGv 49 130 2.62e-7 SMART
Pfam:C2-set_2 150 233 3.6e-9 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000142499
AA Change: T169A

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000124234
Gene: ENSMUSG00000020490
AA Change: T169A

DomainStartEndE-ValueType
IGv 49 130 2.62e-7 SMART
Pfam:C2-set_2 151 233 1e-8 PFAM
PRY 300 352 1.11e-11 SMART
SPRY 353 474 6.55e-24 SMART
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 100 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930522L14Rik G A 5: 109,885,259 (GRCm39) R200C probably benign Het
Ak7 G A 12: 105,679,834 (GRCm39) V123M probably benign Het
Aoc1l1 A T 6: 48,952,090 (GRCm39) Q5L probably benign Het
Apc T C 18: 34,451,618 (GRCm39) L2804P probably damaging Het
Apob C A 12: 8,061,331 (GRCm39) A3271E probably damaging Het
Asl G T 5: 130,047,157 (GRCm39) A147E probably damaging Het
Atp1a1 A G 3: 101,494,259 (GRCm39) V447A probably benign Het
AY358078 T A 14: 52,063,532 (GRCm39) C393S possibly damaging Het
Bcl11b T C 12: 107,882,789 (GRCm39) K509E probably damaging Het
Btnl1 T C 17: 34,598,699 (GRCm39) I105T probably damaging Het
C8b T C 4: 104,647,841 (GRCm39) I278T probably damaging Het
Ccdc66 T C 14: 27,222,377 (GRCm39) N122S probably damaging Het
Cd8b1 T C 6: 71,309,459 (GRCm39) V181A probably benign Het
Cdan1 A T 2: 120,561,201 (GRCm39) V189D probably damaging Het
Celf2 G T 2: 6,590,831 (GRCm39) N279K possibly damaging Het
Cfap52 T C 11: 67,817,247 (GRCm39) N549D probably damaging Het
Cmklr1 C T 5: 113,752,930 (GRCm39) V24M probably benign Het
Cntnap4 G T 8: 113,500,371 (GRCm39) probably null Het
Col27a1 G A 4: 63,211,743 (GRCm39) G91R probably damaging Het
Col5a3 A G 9: 20,726,192 (GRCm39) probably benign Het
Dcc C T 18: 71,682,069 (GRCm39) probably null Het
Deaf1 T A 7: 140,890,884 (GRCm39) T433S possibly damaging Het
Dnah8 T A 17: 30,903,211 (GRCm39) L950H probably damaging Het
Dnajc7 A T 11: 100,481,803 (GRCm39) Y228* probably null Het
Eno1b T C 18: 48,180,770 (GRCm39) V316A probably damaging Het
Exoc4 T C 6: 33,415,340 (GRCm39) M404T possibly damaging Het
Fignl1 A T 11: 11,751,268 (GRCm39) C596S probably benign Het
Fn1 A C 1: 71,663,337 (GRCm39) Y1050* probably null Het
Frem2 A G 3: 53,455,228 (GRCm39) L2116S possibly damaging Het
Gba2 T A 4: 43,568,092 (GRCm39) S732C probably damaging Het
Gcnt4 C A 13: 97,082,990 (GRCm39) S95R probably benign Het
Gpr37 A G 6: 25,669,623 (GRCm39) V407A probably benign Het
Gria2 A T 3: 80,599,799 (GRCm39) M695K probably damaging Het
Hoxa9 T C 6: 52,202,690 (GRCm39) K132R probably damaging Het
Ifi213 T A 1: 173,417,480 (GRCm39) T311S possibly damaging Het
Itgb2 T A 10: 77,385,884 (GRCm39) N282K probably damaging Het
Kcnh8 A T 17: 52,909,864 (GRCm39) Q11L probably benign Het
Klk14 T C 7: 43,343,781 (GRCm39) C163R probably damaging Het
Klk1b3 T A 7: 43,850,689 (GRCm39) W74R possibly damaging Het
Krtap13-1 G T 16: 88,526,142 (GRCm39) C122F possibly damaging Het
Luzp2 T C 7: 54,713,104 (GRCm39) probably null Het
Mbtps1 A T 8: 120,262,086 (GRCm39) D354E probably damaging Het
Mcpt9 C T 14: 56,266,049 (GRCm39) V60M probably damaging Het
Mical3 C A 6: 120,911,799 (GRCm39) E1083* probably null Het
Mrc2 G A 11: 105,239,257 (GRCm39) probably null Het
Mtor T A 4: 148,570,576 (GRCm39) V1211E probably benign Het
Myb T A 10: 21,021,223 (GRCm39) D402V probably damaging Het
Ncor2 G A 5: 125,107,923 (GRCm39) T1593I probably damaging Het
Ndst3 A G 3: 123,465,198 (GRCm39) I258T probably benign Het
Npy6r C A 18: 44,409,468 (GRCm39) H296Q probably damaging Het
Olfml2b T A 1: 170,472,516 (GRCm39) L9H probably damaging Het
Or10a3n A G 7: 108,493,324 (GRCm39) C97R probably damaging Het
Or1a1b A T 11: 74,097,361 (GRCm39) V227D possibly damaging Het
Or2w2 A T 13: 21,757,744 (GRCm39) V294D probably damaging Het
Or4k15 C A 14: 50,364,530 (GRCm39) N165K probably benign Het
Or5b119 C T 19: 13,457,376 (GRCm39) C62Y probably damaging Het
Or5b94 T A 19: 12,652,318 (GRCm39) Y250N probably damaging Het
Or6c207 G A 10: 129,104,274 (GRCm39) A306V probably benign Het
Or8b8 T A 9: 37,809,622 (GRCm39) S307R probably benign Het
Ovgp1 T C 3: 105,893,883 (GRCm39) probably benign Het
Parg G A 14: 31,996,821 (GRCm39) R304Q probably damaging Het
Pdf T G 8: 107,775,167 (GRCm39) S22R probably benign Het
Phlpp2 A T 8: 110,603,515 (GRCm39) R60S possibly damaging Het
Piwil2 C T 14: 70,639,646 (GRCm39) E401K probably benign Het
Pla2g4e T G 2: 120,016,863 (GRCm39) H226P possibly damaging Het
Polr3a T C 14: 24,502,576 (GRCm39) probably null Het
Ppp3cb T C 14: 20,570,714 (GRCm39) N339S possibly damaging Het
Ptch2 G A 4: 116,967,575 (GRCm39) D748N probably benign Het
Rai14 A C 15: 10,592,224 (GRCm39) Y224D probably damaging Het
Rft1 A G 14: 30,411,747 (GRCm39) I432V probably damaging Het
Rictor C T 15: 6,816,625 (GRCm39) A1299V possibly damaging Het
Sall2 A G 14: 52,551,210 (GRCm39) C662R probably damaging Het
Scn4b A G 9: 45,061,737 (GRCm39) N208D probably damaging Het
Sdhb G A 4: 140,700,226 (GRCm39) G109R probably damaging Het
Sec16a A G 2: 26,331,817 (GRCm39) V66A probably benign Het
Sema4g A G 19: 44,990,051 (GRCm39) Y710C probably damaging Het
Serpinb12 T A 1: 106,876,883 (GRCm39) D66E probably benign Het
Shc4 T A 2: 125,497,602 (GRCm39) D369V probably benign Het
Siglech T C 7: 55,421,441 (GRCm39) L285P probably damaging Het
Skint6 A G 4: 112,931,273 (GRCm39) M506T probably benign Het
Slco1a6 C A 6: 142,047,378 (GRCm39) C404F probably benign Het
Slfn14 T A 11: 83,174,140 (GRCm39) K284* probably null Het
Sox14 A G 9: 99,757,715 (GRCm39) I8T probably damaging Het
Srpk3 A G X: 72,818,547 (GRCm39) H79R possibly damaging Het
Tdpoz3 A T 3: 93,734,330 (GRCm39) H335L probably damaging Het
Tdrd5 T A 1: 156,111,944 (GRCm39) T479S probably benign Het
Tnik T C 3: 28,596,249 (GRCm39) probably null Het
Tnpo2 T C 8: 85,780,432 (GRCm39) S720P probably benign Het
Tpst1 A G 5: 130,130,547 (GRCm39) K6E probably damaging Het
Trank1 T A 9: 111,191,329 (GRCm39) I446N probably damaging Het
Trmt44 A T 5: 35,732,351 (GRCm39) D13E probably benign Het
Ubr4 T A 4: 139,126,890 (GRCm39) V471E possibly damaging Het
Ubtd1 A G 19: 42,022,030 (GRCm39) T101A probably benign Het
Ugt3a1 A T 15: 9,306,486 (GRCm39) K212* probably null Het
Zbtb7c C T 18: 76,269,918 (GRCm39) A2V possibly damaging Het
Zfp423 C T 8: 88,414,709 (GRCm39) G1182D possibly damaging Het
Zfp618 G A 4: 63,051,216 (GRCm39) V666M probably damaging Het
Zmat1 A T X: 133,873,694 (GRCm39) S566T probably damaging Homo
Zscan20 T C 4: 128,481,899 (GRCm39) T588A probably benign Het
Zscan25 G A 5: 145,227,926 (GRCm39) R530H probably damaging Het
Other mutations in Btnl10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02033:Btnl10 APN 11 58,810,141 (GRCm39) missense probably damaging 0.98
IGL03368:Btnl10 APN 11 58,810,212 (GRCm39) missense possibly damaging 0.61
FR4304:Btnl10 UTSW 11 58,814,756 (GRCm39) small insertion probably benign
FR4449:Btnl10 UTSW 11 58,814,754 (GRCm39) small insertion probably benign
FR4589:Btnl10 UTSW 11 58,814,755 (GRCm39) small insertion probably benign
FR4737:Btnl10 UTSW 11 58,814,757 (GRCm39) small insertion probably benign
FR4976:Btnl10 UTSW 11 58,814,755 (GRCm39) small insertion probably benign
R0420:Btnl10 UTSW 11 58,814,277 (GRCm39) missense probably damaging 1.00
R1875:Btnl10 UTSW 11 58,814,586 (GRCm39) missense probably damaging 0.97
R1908:Btnl10 UTSW 11 58,811,367 (GRCm39) missense possibly damaging 0.74
R3176:Btnl10 UTSW 11 58,813,216 (GRCm39) missense probably benign 0.00
R3177:Btnl10 UTSW 11 58,813,216 (GRCm39) missense probably benign 0.00
R3276:Btnl10 UTSW 11 58,813,216 (GRCm39) missense probably benign 0.00
R3277:Btnl10 UTSW 11 58,813,216 (GRCm39) missense probably benign 0.00
R4600:Btnl10 UTSW 11 58,814,426 (GRCm39) missense probably benign 0.01
R5447:Btnl10 UTSW 11 58,813,144 (GRCm39) missense probably benign 0.13
R5484:Btnl10 UTSW 11 58,814,651 (GRCm39) missense probably damaging 0.98
R5787:Btnl10 UTSW 11 58,811,169 (GRCm39) missense probably damaging 1.00
R5824:Btnl10 UTSW 11 58,814,266 (GRCm39) missense probably benign 0.05
R5859:Btnl10 UTSW 11 58,813,138 (GRCm39) missense probably benign 0.10
R6109:Btnl10 UTSW 11 58,811,130 (GRCm39) missense probably damaging 0.98
R6123:Btnl10 UTSW 11 58,811,130 (GRCm39) missense probably damaging 0.98
R6318:Btnl10 UTSW 11 58,817,691 (GRCm39) utr 3 prime probably benign
R7064:Btnl10 UTSW 11 58,810,134 (GRCm39) missense possibly damaging 0.74
R7083:Btnl10 UTSW 11 58,809,963 (GRCm39) missense probably damaging 1.00
R7152:Btnl10 UTSW 11 58,813,223 (GRCm39) missense probably benign
R7393:Btnl10 UTSW 11 58,814,532 (GRCm39) missense probably damaging 1.00
R7507:Btnl10 UTSW 11 58,811,384 (GRCm39) missense probably benign 0.05
R7893:Btnl10 UTSW 11 58,814,635 (GRCm39) missense probably benign 0.01
R8485:Btnl10 UTSW 11 58,811,142 (GRCm39) missense possibly damaging 0.92
R8529:Btnl10 UTSW 11 58,813,238 (GRCm39) missense probably benign 0.00
R8909:Btnl10 UTSW 11 58,813,198 (GRCm39) missense probably benign 0.00
R9205:Btnl10 UTSW 11 58,811,345 (GRCm39) missense probably damaging 1.00
R9564:Btnl10 UTSW 11 58,813,189 (GRCm39) missense probably benign 0.13
R9565:Btnl10 UTSW 11 58,813,189 (GRCm39) missense probably benign 0.13
R9675:Btnl10 UTSW 11 58,814,442 (GRCm39) missense probably damaging 1.00
RF018:Btnl10 UTSW 11 58,814,752 (GRCm39) small insertion probably benign
RF043:Btnl10 UTSW 11 58,814,752 (GRCm39) small insertion probably benign
X0064:Btnl10 UTSW 11 58,814,436 (GRCm39) missense probably damaging 1.00
Z1186:Btnl10 UTSW 11 58,817,650 (GRCm39) missense unknown
Z1186:Btnl10 UTSW 11 58,814,753 (GRCm39) small insertion probably benign
Z1186:Btnl10 UTSW 11 58,810,138 (GRCm39) missense probably benign
Z1187:Btnl10 UTSW 11 58,814,755 (GRCm39) small insertion probably benign
Z1187:Btnl10 UTSW 11 58,814,753 (GRCm39) small insertion probably benign
Z1187:Btnl10 UTSW 11 58,810,138 (GRCm39) missense probably benign
Z1187:Btnl10 UTSW 11 58,817,650 (GRCm39) missense unknown
Z1188:Btnl10 UTSW 11 58,814,753 (GRCm39) small insertion probably benign
Z1188:Btnl10 UTSW 11 58,810,138 (GRCm39) missense probably benign
Z1188:Btnl10 UTSW 11 58,817,650 (GRCm39) missense unknown
Z1189:Btnl10 UTSW 11 58,817,650 (GRCm39) missense unknown
Z1189:Btnl10 UTSW 11 58,814,753 (GRCm39) small insertion probably benign
Z1189:Btnl10 UTSW 11 58,810,138 (GRCm39) missense probably benign
Z1190:Btnl10 UTSW 11 58,817,650 (GRCm39) missense unknown
Z1190:Btnl10 UTSW 11 58,814,753 (GRCm39) small insertion probably benign
Z1190:Btnl10 UTSW 11 58,810,138 (GRCm39) missense probably benign
Z1191:Btnl10 UTSW 11 58,814,755 (GRCm39) small insertion probably benign
Z1191:Btnl10 UTSW 11 58,814,753 (GRCm39) small insertion probably benign
Z1191:Btnl10 UTSW 11 58,810,138 (GRCm39) missense probably benign
Z1191:Btnl10 UTSW 11 58,817,650 (GRCm39) missense unknown
Z1192:Btnl10 UTSW 11 58,814,754 (GRCm39) small insertion probably benign
Z1192:Btnl10 UTSW 11 58,814,753 (GRCm39) small insertion probably benign
Z1192:Btnl10 UTSW 11 58,810,138 (GRCm39) missense probably benign
Z1192:Btnl10 UTSW 11 58,817,650 (GRCm39) missense unknown
Z1192:Btnl10 UTSW 11 58,814,757 (GRCm39) small insertion probably benign
Predicted Primers PCR Primer
(F):5'- CAACCGTTTTATTTGGGATGAAGG -3'
(R):5'- CAGCAGGTAAGTCTCTGTCACC -3'

Sequencing Primer
(F):5'- GGGATGAAGGTATTGCATTAGTAATG -3'
(R):5'- TCACCTTCTCTGGGAGGAG -3'
Posted On 2015-09-25