Incidental Mutation 'R4611:Mrc2'
| ID |
344748 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mrc2
|
| Ensembl Gene |
ENSMUSG00000020695 |
| Gene Name |
mannose receptor, C type 2 |
| Synonyms |
Endo180, uPARAP, novel lectin |
| MMRRC Submission |
041822-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4611 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
105183469-105241965 bp(+) (GRCm39) |
| Type of Mutation |
splice site (5 bp from exon) |
| DNA Base Change (assembly) |
G to A
at 105239257 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000097909
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021038]
[ENSMUST00000100335]
|
| AlphaFold |
Q64449 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000021038
|
| SMART Domains |
Protein: ENSMUSP00000021038
Gene: ENSMUSG00000020695
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
30 |
N/A |
INTRINSIC |
|
RICIN
|
40 |
160 |
8.49e-12 |
SMART |
|
FN2
|
179 |
227 |
4.83e-27 |
SMART |
|
CLECT
|
234 |
359 |
1.15e-33 |
SMART |
|
CLECT
|
381 |
504 |
1.47e-40 |
SMART |
|
CLECT
|
520 |
644 |
6.82e-27 |
SMART |
|
CLECT
|
668 |
808 |
2.71e-30 |
SMART |
|
CLECT
|
824 |
950 |
6.77e-31 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000100335
|
| SMART Domains |
Protein: ENSMUSP00000097909
Gene: ENSMUSG00000020695
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
30 |
N/A |
INTRINSIC |
|
RICIN
|
40 |
160 |
8.49e-12 |
SMART |
|
FN2
|
179 |
227 |
4.83e-27 |
SMART |
|
CLECT
|
234 |
359 |
1.15e-33 |
SMART |
|
CLECT
|
381 |
504 |
1.47e-40 |
SMART |
|
CLECT
|
520 |
644 |
6.82e-27 |
SMART |
|
CLECT
|
668 |
808 |
2.71e-30 |
SMART |
|
CLECT
|
824 |
950 |
6.77e-31 |
SMART |
|
CLECT
|
971 |
1107 |
3.91e-36 |
SMART |
|
CLECT
|
1124 |
1243 |
1.04e-17 |
SMART |
|
CLECT
|
1259 |
1392 |
9.08e-23 |
SMART |
|
transmembrane domain
|
1412 |
1434 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]
PHENOTYPE: Homozygous mice are visibly normal, viable and have no reproductive defects. Mouse embryonic fibroblasts derived from null mice exhibit decreased migration while bone marrow-derived macrophages exhibit increased migration. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 100 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930522L14Rik |
G |
A |
5: 109,885,259 (GRCm39) |
R200C |
probably benign |
Het |
| Ak7 |
G |
A |
12: 105,679,834 (GRCm39) |
V123M |
probably benign |
Het |
| Aoc1l1 |
A |
T |
6: 48,952,090 (GRCm39) |
Q5L |
probably benign |
Het |
| Apc |
T |
C |
18: 34,451,618 (GRCm39) |
L2804P |
probably damaging |
Het |
| Apob |
C |
A |
12: 8,061,331 (GRCm39) |
A3271E |
probably damaging |
Het |
| Asl |
G |
T |
5: 130,047,157 (GRCm39) |
A147E |
probably damaging |
Het |
| Atp1a1 |
A |
G |
3: 101,494,259 (GRCm39) |
V447A |
probably benign |
Het |
| AY358078 |
T |
A |
14: 52,063,532 (GRCm39) |
C393S |
possibly damaging |
Het |
| Bcl11b |
T |
C |
12: 107,882,789 (GRCm39) |
K509E |
probably damaging |
Het |
| Btnl1 |
T |
C |
17: 34,598,699 (GRCm39) |
I105T |
probably damaging |
Het |
| Btnl10 |
A |
G |
11: 58,811,183 (GRCm39) |
T169A |
probably damaging |
Het |
| C8b |
T |
C |
4: 104,647,841 (GRCm39) |
I278T |
probably damaging |
Het |
| Ccdc66 |
T |
C |
14: 27,222,377 (GRCm39) |
N122S |
probably damaging |
Het |
| Cd8b1 |
T |
C |
6: 71,309,459 (GRCm39) |
V181A |
probably benign |
Het |
| Cdan1 |
A |
T |
2: 120,561,201 (GRCm39) |
V189D |
probably damaging |
Het |
| Celf2 |
G |
T |
2: 6,590,831 (GRCm39) |
N279K |
possibly damaging |
Het |
| Cfap52 |
T |
C |
11: 67,817,247 (GRCm39) |
N549D |
probably damaging |
Het |
| Cmklr1 |
C |
T |
5: 113,752,930 (GRCm39) |
V24M |
probably benign |
Het |
| Cntnap4 |
G |
T |
8: 113,500,371 (GRCm39) |
|
probably null |
Het |
| Col27a1 |
G |
A |
4: 63,211,743 (GRCm39) |
G91R |
probably damaging |
Het |
| Col5a3 |
A |
G |
9: 20,726,192 (GRCm39) |
|
probably benign |
Het |
| Dcc |
C |
T |
18: 71,682,069 (GRCm39) |
|
probably null |
Het |
| Deaf1 |
T |
A |
7: 140,890,884 (GRCm39) |
T433S |
possibly damaging |
Het |
| Dnah8 |
T |
A |
17: 30,903,211 (GRCm39) |
L950H |
probably damaging |
Het |
| Dnajc7 |
A |
T |
11: 100,481,803 (GRCm39) |
Y228* |
probably null |
Het |
| Eno1b |
T |
C |
18: 48,180,770 (GRCm39) |
V316A |
probably damaging |
Het |
| Exoc4 |
T |
C |
6: 33,415,340 (GRCm39) |
M404T |
possibly damaging |
Het |
| Fignl1 |
A |
T |
11: 11,751,268 (GRCm39) |
C596S |
probably benign |
Het |
| Fn1 |
A |
C |
1: 71,663,337 (GRCm39) |
Y1050* |
probably null |
Het |
| Frem2 |
A |
G |
3: 53,455,228 (GRCm39) |
L2116S |
possibly damaging |
Het |
| Gba2 |
T |
A |
4: 43,568,092 (GRCm39) |
S732C |
probably damaging |
Het |
| Gcnt4 |
C |
A |
13: 97,082,990 (GRCm39) |
S95R |
probably benign |
Het |
| Gpr37 |
A |
G |
6: 25,669,623 (GRCm39) |
V407A |
probably benign |
Het |
| Gria2 |
A |
T |
3: 80,599,799 (GRCm39) |
M695K |
probably damaging |
Het |
| Hoxa9 |
T |
C |
6: 52,202,690 (GRCm39) |
K132R |
probably damaging |
Het |
| Ifi213 |
T |
A |
1: 173,417,480 (GRCm39) |
T311S |
possibly damaging |
Het |
| Itgb2 |
T |
A |
10: 77,385,884 (GRCm39) |
N282K |
probably damaging |
Het |
| Kcnh8 |
A |
T |
17: 52,909,864 (GRCm39) |
Q11L |
probably benign |
Het |
| Klk14 |
T |
C |
7: 43,343,781 (GRCm39) |
C163R |
probably damaging |
Het |
| Klk1b3 |
T |
A |
7: 43,850,689 (GRCm39) |
W74R |
possibly damaging |
Het |
| Krtap13-1 |
G |
T |
16: 88,526,142 (GRCm39) |
C122F |
possibly damaging |
Het |
| Luzp2 |
T |
C |
7: 54,713,104 (GRCm39) |
|
probably null |
Het |
| Mbtps1 |
A |
T |
8: 120,262,086 (GRCm39) |
D354E |
probably damaging |
Het |
| Mcpt9 |
C |
T |
14: 56,266,049 (GRCm39) |
V60M |
probably damaging |
Het |
| Mical3 |
C |
A |
6: 120,911,799 (GRCm39) |
E1083* |
probably null |
Het |
| Mtor |
T |
A |
4: 148,570,576 (GRCm39) |
V1211E |
probably benign |
Het |
| Myb |
T |
A |
10: 21,021,223 (GRCm39) |
D402V |
probably damaging |
Het |
| Ncor2 |
G |
A |
5: 125,107,923 (GRCm39) |
T1593I |
probably damaging |
Het |
| Ndst3 |
A |
G |
3: 123,465,198 (GRCm39) |
I258T |
probably benign |
Het |
| Npy6r |
C |
A |
18: 44,409,468 (GRCm39) |
H296Q |
probably damaging |
Het |
| Olfml2b |
T |
A |
1: 170,472,516 (GRCm39) |
L9H |
probably damaging |
Het |
| Or10a3n |
A |
G |
7: 108,493,324 (GRCm39) |
C97R |
probably damaging |
Het |
| Or1a1b |
A |
T |
11: 74,097,361 (GRCm39) |
V227D |
possibly damaging |
Het |
| Or2w2 |
A |
T |
13: 21,757,744 (GRCm39) |
V294D |
probably damaging |
Het |
| Or4k15 |
C |
A |
14: 50,364,530 (GRCm39) |
N165K |
probably benign |
Het |
| Or5b119 |
C |
T |
19: 13,457,376 (GRCm39) |
C62Y |
probably damaging |
Het |
| Or5b94 |
T |
A |
19: 12,652,318 (GRCm39) |
Y250N |
probably damaging |
Het |
| Or6c207 |
G |
A |
10: 129,104,274 (GRCm39) |
A306V |
probably benign |
Het |
| Or8b8 |
T |
A |
9: 37,809,622 (GRCm39) |
S307R |
probably benign |
Het |
| Ovgp1 |
T |
C |
3: 105,893,883 (GRCm39) |
|
probably benign |
Het |
| Parg |
G |
A |
14: 31,996,821 (GRCm39) |
R304Q |
probably damaging |
Het |
| Pdf |
T |
G |
8: 107,775,167 (GRCm39) |
S22R |
probably benign |
Het |
| Phlpp2 |
A |
T |
8: 110,603,515 (GRCm39) |
R60S |
possibly damaging |
Het |
| Piwil2 |
C |
T |
14: 70,639,646 (GRCm39) |
E401K |
probably benign |
Het |
| Pla2g4e |
T |
G |
2: 120,016,863 (GRCm39) |
H226P |
possibly damaging |
Het |
| Polr3a |
T |
C |
14: 24,502,576 (GRCm39) |
|
probably null |
Het |
| Ppp3cb |
T |
C |
14: 20,570,714 (GRCm39) |
N339S |
possibly damaging |
Het |
| Ptch2 |
G |
A |
4: 116,967,575 (GRCm39) |
D748N |
probably benign |
Het |
| Rai14 |
A |
C |
15: 10,592,224 (GRCm39) |
Y224D |
probably damaging |
Het |
| Rft1 |
A |
G |
14: 30,411,747 (GRCm39) |
I432V |
probably damaging |
Het |
| Rictor |
C |
T |
15: 6,816,625 (GRCm39) |
A1299V |
possibly damaging |
Het |
| Sall2 |
A |
G |
14: 52,551,210 (GRCm39) |
C662R |
probably damaging |
Het |
| Scn4b |
A |
G |
9: 45,061,737 (GRCm39) |
N208D |
probably damaging |
Het |
| Sdhb |
G |
A |
4: 140,700,226 (GRCm39) |
G109R |
probably damaging |
Het |
| Sec16a |
A |
G |
2: 26,331,817 (GRCm39) |
V66A |
probably benign |
Het |
| Sema4g |
A |
G |
19: 44,990,051 (GRCm39) |
Y710C |
probably damaging |
Het |
| Serpinb12 |
T |
A |
1: 106,876,883 (GRCm39) |
D66E |
probably benign |
Het |
| Shc4 |
T |
A |
2: 125,497,602 (GRCm39) |
D369V |
probably benign |
Het |
| Siglech |
T |
C |
7: 55,421,441 (GRCm39) |
L285P |
probably damaging |
Het |
| Skint6 |
A |
G |
4: 112,931,273 (GRCm39) |
M506T |
probably benign |
Het |
| Slco1a6 |
C |
A |
6: 142,047,378 (GRCm39) |
C404F |
probably benign |
Het |
| Slfn14 |
T |
A |
11: 83,174,140 (GRCm39) |
K284* |
probably null |
Het |
| Sox14 |
A |
G |
9: 99,757,715 (GRCm39) |
I8T |
probably damaging |
Het |
| Srpk3 |
A |
G |
X: 72,818,547 (GRCm39) |
H79R |
possibly damaging |
Het |
| Tdpoz3 |
A |
T |
3: 93,734,330 (GRCm39) |
H335L |
probably damaging |
Het |
| Tdrd5 |
T |
A |
1: 156,111,944 (GRCm39) |
T479S |
probably benign |
Het |
| Tnik |
T |
C |
3: 28,596,249 (GRCm39) |
|
probably null |
Het |
| Tnpo2 |
T |
C |
8: 85,780,432 (GRCm39) |
S720P |
probably benign |
Het |
| Tpst1 |
A |
G |
5: 130,130,547 (GRCm39) |
K6E |
probably damaging |
Het |
| Trank1 |
T |
A |
9: 111,191,329 (GRCm39) |
I446N |
probably damaging |
Het |
| Trmt44 |
A |
T |
5: 35,732,351 (GRCm39) |
D13E |
probably benign |
Het |
| Ubr4 |
T |
A |
4: 139,126,890 (GRCm39) |
V471E |
possibly damaging |
Het |
| Ubtd1 |
A |
G |
19: 42,022,030 (GRCm39) |
T101A |
probably benign |
Het |
| Ugt3a1 |
A |
T |
15: 9,306,486 (GRCm39) |
K212* |
probably null |
Het |
| Zbtb7c |
C |
T |
18: 76,269,918 (GRCm39) |
A2V |
possibly damaging |
Het |
| Zfp423 |
C |
T |
8: 88,414,709 (GRCm39) |
G1182D |
possibly damaging |
Het |
| Zfp618 |
G |
A |
4: 63,051,216 (GRCm39) |
V666M |
probably damaging |
Het |
| Zmat1 |
A |
T |
X: 133,873,694 (GRCm39) |
S566T |
probably damaging |
Homo |
| Zscan20 |
T |
C |
4: 128,481,899 (GRCm39) |
T588A |
probably benign |
Het |
| Zscan25 |
G |
A |
5: 145,227,926 (GRCm39) |
R530H |
probably damaging |
Het |
|
| Other mutations in Mrc2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01105:Mrc2
|
APN |
11 |
105,219,567 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01374:Mrc2
|
APN |
11 |
105,238,469 (GRCm39) |
nonsense |
probably null |
|
|
IGL01751:Mrc2
|
APN |
11 |
105,216,560 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01780:Mrc2
|
APN |
11 |
105,216,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01835:Mrc2
|
APN |
11 |
105,227,503 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02350:Mrc2
|
APN |
11 |
105,216,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02357:Mrc2
|
APN |
11 |
105,216,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02829:Mrc2
|
APN |
11 |
105,227,533 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL02863:Mrc2
|
APN |
11 |
105,224,446 (GRCm39) |
splice site |
probably benign |
|
|
IGL02940:Mrc2
|
APN |
11 |
105,231,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02988:Mrc2
|
UTSW |
11 |
105,216,397 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0254:Mrc2
|
UTSW |
11 |
105,238,692 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0634:Mrc2
|
UTSW |
11 |
105,238,518 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1102:Mrc2
|
UTSW |
11 |
105,231,647 (GRCm39) |
missense |
probably benign |
|
|
R1233:Mrc2
|
UTSW |
11 |
105,239,241 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1244:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R1458:Mrc2
|
UTSW |
11 |
105,228,598 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1500:Mrc2
|
UTSW |
11 |
105,238,551 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1573:Mrc2
|
UTSW |
11 |
105,227,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1770:Mrc2
|
UTSW |
11 |
105,229,619 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1842:Mrc2
|
UTSW |
11 |
105,228,546 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2156:Mrc2
|
UTSW |
11 |
105,238,682 (GRCm39) |
splice site |
probably null |
|
|
R2165:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2265:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2266:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2267:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2268:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2269:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2270:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2271:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2272:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2296:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2298:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2300:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2326:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2518:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2519:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2520:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2895:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3029:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3030:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3079:Mrc2
|
UTSW |
11 |
105,227,539 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3122:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3149:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3150:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3420:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3422:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3441:Mrc2
|
UTSW |
11 |
105,238,542 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R3726:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3731:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3800:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3820:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3821:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3837:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3838:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3849:Mrc2
|
UTSW |
11 |
105,183,729 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3850:Mrc2
|
UTSW |
11 |
105,183,729 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3914:Mrc2
|
UTSW |
11 |
105,238,058 (GRCm39) |
splice site |
probably benign |
|
|
R3932:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3933:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3971:Mrc2
|
UTSW |
11 |
105,218,857 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R4105:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4107:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4113:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4274:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4399:Mrc2
|
UTSW |
11 |
105,227,484 (GRCm39) |
nonsense |
probably null |
|
|
R4477:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4478:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4493:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4494:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4495:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4547:Mrc2
|
UTSW |
11 |
105,227,467 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4600:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4601:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4602:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4603:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4610:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4637:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4672:Mrc2
|
UTSW |
11 |
105,233,923 (GRCm39) |
missense |
probably benign |
0.22 |
|
R4674:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4675:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4693:Mrc2
|
UTSW |
11 |
105,234,528 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4706:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4707:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4791:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4792:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4888:Mrc2
|
UTSW |
11 |
105,232,034 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5523:Mrc2
|
UTSW |
11 |
105,234,408 (GRCm39) |
missense |
probably benign |
|
|
R5600:Mrc2
|
UTSW |
11 |
105,224,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5634:Mrc2
|
UTSW |
11 |
105,227,040 (GRCm39) |
nonsense |
probably null |
|
|
R5692:Mrc2
|
UTSW |
11 |
105,227,468 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5706:Mrc2
|
UTSW |
11 |
105,223,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5775:Mrc2
|
UTSW |
11 |
105,228,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6140:Mrc2
|
UTSW |
11 |
105,237,615 (GRCm39) |
missense |
probably benign |
|
|
R6146:Mrc2
|
UTSW |
11 |
105,216,470 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6225:Mrc2
|
UTSW |
11 |
105,237,646 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6437:Mrc2
|
UTSW |
11 |
105,240,669 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6618:Mrc2
|
UTSW |
11 |
105,240,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6675:Mrc2
|
UTSW |
11 |
105,233,906 (GRCm39) |
splice site |
probably null |
|
|
R6680:Mrc2
|
UTSW |
11 |
105,216,579 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6868:Mrc2
|
UTSW |
11 |
105,219,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6979:Mrc2
|
UTSW |
11 |
105,239,461 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7038:Mrc2
|
UTSW |
11 |
105,223,062 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7303:Mrc2
|
UTSW |
11 |
105,216,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7320:Mrc2
|
UTSW |
11 |
105,220,061 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7422:Mrc2
|
UTSW |
11 |
105,183,609 (GRCm39) |
start gained |
probably benign |
|
|
R7537:Mrc2
|
UTSW |
11 |
105,183,623 (GRCm39) |
missense |
probably benign |
|
|
R7640:Mrc2
|
UTSW |
11 |
105,223,121 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R7709:Mrc2
|
UTSW |
11 |
105,237,285 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7885:Mrc2
|
UTSW |
11 |
105,223,092 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7976:Mrc2
|
UTSW |
11 |
105,238,829 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R8042:Mrc2
|
UTSW |
11 |
105,239,181 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8096:Mrc2
|
UTSW |
11 |
105,234,333 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8353:Mrc2
|
UTSW |
11 |
105,223,137 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8453:Mrc2
|
UTSW |
11 |
105,223,137 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8519:Mrc2
|
UTSW |
11 |
105,238,132 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R8771:Mrc2
|
UTSW |
11 |
105,240,596 (GRCm39) |
missense |
probably benign |
|
|
R8787:Mrc2
|
UTSW |
11 |
105,238,465 (GRCm39) |
missense |
probably benign |
|
|
R8925:Mrc2
|
UTSW |
11 |
105,216,334 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8927:Mrc2
|
UTSW |
11 |
105,216,334 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8991:Mrc2
|
UTSW |
11 |
105,229,740 (GRCm39) |
missense |
probably benign |
|
|
R9017:Mrc2
|
UTSW |
11 |
105,216,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9096:Mrc2
|
UTSW |
11 |
105,231,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9097:Mrc2
|
UTSW |
11 |
105,231,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9223:Mrc2
|
UTSW |
11 |
105,220,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9471:Mrc2
|
UTSW |
11 |
105,234,559 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9531:Mrc2
|
UTSW |
11 |
105,240,731 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
T0970:Mrc2
|
UTSW |
11 |
105,238,453 (GRCm39) |
missense |
probably benign |
0.41 |
|
X0004:Mrc2
|
UTSW |
11 |
105,238,453 (GRCm39) |
missense |
probably benign |
0.41 |
|
X0062:Mrc2
|
UTSW |
11 |
105,238,301 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1176:Mrc2
|
UTSW |
11 |
105,238,186 (GRCm39) |
nonsense |
probably null |
|
|
Z1176:Mrc2
|
UTSW |
11 |
105,232,202 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTTGCACTTGAGCTGCCAG -3'
(R):5'- TGTGGAAGGAACCCATTGG -3'
Sequencing Primer
(F):5'- GGTCTATCACCATAAGGAGAATCTGC -3'
(R):5'- CCATTGGGAAGGTGTGGGAATG -3'
|
| Posted On |
2015-09-25 |
Incidental Mutation