Incidental Mutation 'R4612:Kntc1'
| ID |
344811 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kntc1
|
| Ensembl Gene |
ENSMUSG00000029414 |
| Gene Name |
kinetochore associated 1 |
| Synonyms |
jgl |
| MMRRC Submission |
041823-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.948)
|
| Stock # |
R4612 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
123887779-123959656 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 123950706 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Glycine
at position 1995
(R1995G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000031366
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000031366]
|
| AlphaFold |
Q8C3Y4 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000031366
AA Change: R1995G
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000031366
Gene: ENSMUSG00000029414
AA Change: R1995G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
345 |
357 |
N/A |
INTRINSIC |
|
low complexity region
|
747 |
764 |
N/A |
INTRINSIC |
|
low complexity region
|
1033 |
1044 |
N/A |
INTRINSIC |
|
Pfam:Rod_C
|
1579 |
2128 |
3.2e-256 |
PFAM |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000197265
AA Change: R53G
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. Experimental evidence indicated that the encoded protein functioned in a similar manner to that of the Drosophila rough deal protein. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice have a kinked tail. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 109 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700019D03Rik |
T |
C |
1: 52,964,635 (GRCm39) |
D31G |
probably benign |
Het |
| 5730455P16Rik |
A |
T |
11: 80,268,806 (GRCm39) |
M1K |
probably null |
Het |
| Abca15 |
A |
G |
7: 119,934,384 (GRCm39) |
D120G |
probably benign |
Het |
| Adam26a |
A |
T |
8: 44,021,830 (GRCm39) |
N553K |
probably damaging |
Het |
| Adam32 |
A |
T |
8: 25,362,752 (GRCm39) |
C558S |
probably damaging |
Het |
| Adam34l |
A |
T |
8: 44,079,587 (GRCm39) |
F212L |
probably benign |
Het |
| Adam39 |
A |
T |
8: 41,278,958 (GRCm39) |
S450C |
probably damaging |
Het |
| Agap2 |
A |
T |
10: 126,915,965 (GRCm39) |
T159S |
unknown |
Het |
| Ahnak |
G |
A |
19: 8,981,088 (GRCm39) |
V791I |
probably benign |
Het |
| Ak7 |
T |
G |
12: 105,727,772 (GRCm39) |
L468R |
probably damaging |
Het |
| Akap12 |
A |
G |
10: 4,304,456 (GRCm39) |
D422G |
probably damaging |
Het |
| Antxr1 |
T |
A |
6: 87,265,155 (GRCm39) |
I129F |
probably damaging |
Het |
| Arhgap32 |
G |
A |
9: 32,170,775 (GRCm39) |
G1185D |
probably damaging |
Het |
| Atf7ip2 |
A |
T |
16: 10,059,427 (GRCm39) |
E322D |
probably benign |
Het |
| Atg4b |
T |
C |
1: 93,714,263 (GRCm39) |
F349L |
probably damaging |
Het |
| Atp6v1c1 |
A |
G |
15: 38,677,856 (GRCm39) |
K127R |
probably damaging |
Het |
| Atxn1l |
C |
T |
8: 110,458,736 (GRCm39) |
V509M |
possibly damaging |
Het |
| B3glct |
T |
A |
5: 149,663,022 (GRCm39) |
I260N |
probably damaging |
Het |
| Bcl2l12 |
G |
A |
7: 44,646,009 (GRCm39) |
P70L |
probably damaging |
Het |
| Bok |
T |
A |
1: 93,621,900 (GRCm39) |
F157L |
probably damaging |
Het |
| Bves |
G |
A |
10: 45,215,373 (GRCm39) |
G16D |
probably benign |
Het |
| Cacna1b |
T |
A |
2: 24,516,864 (GRCm39) |
K65* |
probably null |
Het |
| Casc3 |
A |
G |
11: 98,713,784 (GRCm39) |
T339A |
probably benign |
Het |
| Ccdc18 |
C |
T |
5: 108,283,307 (GRCm39) |
S6L |
probably benign |
Het |
| Cd86 |
A |
G |
16: 36,435,692 (GRCm39) |
Y242H |
probably benign |
Het |
| Chd3 |
A |
C |
11: 69,244,035 (GRCm39) |
Y1249* |
probably null |
Het |
| Chrne |
T |
C |
11: 70,507,848 (GRCm39) |
T284A |
probably damaging |
Het |
| Col12a1 |
T |
C |
9: 79,523,339 (GRCm39) |
D2746G |
probably damaging |
Het |
| Cryaa |
T |
A |
17: 31,897,448 (GRCm39) |
M72K |
probably benign |
Het |
| Csmd1 |
G |
T |
8: 15,971,908 (GRCm39) |
|
probably null |
Het |
| Det1 |
A |
T |
7: 78,493,454 (GRCm39) |
N183K |
probably damaging |
Het |
| Dis3 |
C |
A |
14: 99,328,871 (GRCm39) |
V294L |
probably benign |
Het |
| Dnah2 |
G |
A |
11: 69,374,193 (GRCm39) |
L1493F |
possibly damaging |
Het |
| Dsc2 |
A |
T |
18: 20,174,876 (GRCm39) |
D466E |
probably damaging |
Het |
| Dsg4 |
T |
A |
18: 20,595,470 (GRCm39) |
S558T |
probably benign |
Het |
| Dzip3 |
A |
T |
16: 48,772,403 (GRCm39) |
L422* |
probably null |
Het |
| Elp6 |
T |
C |
9: 110,143,087 (GRCm39) |
F100S |
probably damaging |
Het |
| Epg5 |
C |
T |
18: 78,025,629 (GRCm39) |
T1224I |
possibly damaging |
Het |
| Exoc1l |
A |
T |
5: 76,664,345 (GRCm39) |
N145Y |
probably damaging |
Het |
| F830016B08Rik |
T |
A |
18: 60,434,087 (GRCm39) |
I390N |
probably benign |
Het |
| Fam110c |
A |
G |
12: 31,124,655 (GRCm39) |
T206A |
unknown |
Het |
| Fam187b |
G |
A |
7: 30,676,518 (GRCm39) |
G9D |
possibly damaging |
Het |
| Fat1 |
A |
G |
8: 45,478,184 (GRCm39) |
D2410G |
probably damaging |
Het |
| Fbln1 |
T |
A |
15: 85,122,760 (GRCm39) |
F390Y |
probably benign |
Het |
| Fgg |
A |
G |
3: 82,917,397 (GRCm39) |
N142S |
probably damaging |
Het |
| Fhip1a |
G |
A |
3: 85,637,679 (GRCm39) |
R207* |
probably null |
Het |
| Flcn |
T |
C |
11: 59,683,513 (GRCm39) |
T555A |
probably damaging |
Het |
| Foxq1 |
G |
T |
13: 31,742,808 (GRCm39) |
|
probably benign |
Het |
| Gm3233 |
A |
T |
10: 77,595,498 (GRCm39) |
|
probably benign |
Het |
| Gprc5a |
G |
A |
6: 135,055,927 (GRCm39) |
V125I |
probably damaging |
Het |
| Gria2 |
T |
C |
3: 80,639,358 (GRCm39) |
D218G |
probably damaging |
Het |
| Gtf3c5 |
C |
T |
2: 28,469,596 (GRCm39) |
A103T |
probably benign |
Het |
| Hspg2 |
C |
T |
4: 137,246,251 (GRCm39) |
R1010C |
probably damaging |
Het |
| Hspg2 |
A |
G |
4: 137,266,886 (GRCm39) |
T1964A |
possibly damaging |
Het |
| Htatip2 |
G |
T |
7: 49,422,345 (GRCm39) |
E188* |
probably null |
Het |
| Ifna13 |
T |
G |
4: 88,562,113 (GRCm39) |
E170D |
probably damaging |
Het |
| Il4ra |
A |
G |
7: 125,175,255 (GRCm39) |
T488A |
probably benign |
Het |
| Jup |
G |
T |
11: 100,272,660 (GRCm39) |
H251N |
probably damaging |
Het |
| Kif21a |
A |
T |
15: 90,852,426 (GRCm39) |
|
probably null |
Het |
| Klhl28 |
T |
A |
12: 65,004,034 (GRCm39) |
I160L |
probably damaging |
Het |
| Klk1b5 |
A |
T |
7: 43,494,696 (GRCm39) |
T60S |
possibly damaging |
Het |
| Lrig2 |
A |
C |
3: 104,370,099 (GRCm39) |
I844M |
probably damaging |
Het |
| Lrp2 |
C |
T |
2: 69,288,771 (GRCm39) |
W3698* |
probably null |
Het |
| Lyar |
T |
A |
5: 38,382,053 (GRCm39) |
S12T |
possibly damaging |
Het |
| Map3k19 |
T |
C |
1: 127,743,037 (GRCm39) |
K1507E |
probably benign |
Het |
| Mre11a |
G |
A |
9: 14,714,199 (GRCm39) |
G267R |
probably damaging |
Het |
| Mthfd1l |
A |
G |
10: 3,980,717 (GRCm39) |
Q473R |
probably damaging |
Het |
| Ncald |
T |
A |
15: 37,397,593 (GRCm39) |
E29V |
probably benign |
Het |
| Neb |
T |
C |
2: 52,177,255 (GRCm39) |
D1362G |
probably damaging |
Het |
| Nme2 |
T |
C |
11: 93,846,428 (GRCm39) |
T7A |
possibly damaging |
Het |
| Nod2 |
T |
A |
8: 89,391,664 (GRCm39) |
L657Q |
possibly damaging |
Het |
| Nrm |
T |
A |
17: 36,174,421 (GRCm39) |
V75E |
probably benign |
Het |
| Ogfod1 |
A |
C |
8: 94,763,975 (GRCm39) |
K20T |
possibly damaging |
Het |
| Omp |
T |
C |
7: 97,794,348 (GRCm39) |
N93S |
probably damaging |
Het |
| Or10h28 |
T |
A |
17: 33,488,454 (GRCm39) |
V252E |
probably benign |
Het |
| Or14a256 |
T |
A |
7: 86,264,944 (GRCm39) |
Q303L |
probably benign |
Het |
| Or5h27 |
T |
C |
16: 59,006,674 (GRCm39) |
I57M |
probably damaging |
Het |
| Pcdhb15 |
A |
C |
18: 37,608,648 (GRCm39) |
T627P |
probably damaging |
Het |
| Pld1 |
A |
G |
3: 28,185,882 (GRCm39) |
T1036A |
possibly damaging |
Het |
| Pogk |
C |
A |
1: 166,226,334 (GRCm39) |
E606* |
probably null |
Het |
| Ppp1r10 |
T |
A |
17: 36,238,823 (GRCm39) |
L292Q |
probably damaging |
Het |
| Prpf6 |
T |
C |
2: 181,273,872 (GRCm39) |
C339R |
possibly damaging |
Het |
| Psd |
T |
A |
19: 46,301,778 (GRCm39) |
D937V |
probably benign |
Het |
| Rbak |
T |
C |
5: 143,160,222 (GRCm39) |
Q277R |
probably benign |
Het |
| Sbno1 |
T |
A |
5: 124,542,087 (GRCm39) |
Y355F |
probably damaging |
Het |
| Sec23ip |
C |
T |
7: 128,352,226 (GRCm39) |
Q201* |
probably null |
Het |
| Serpinb3a |
T |
C |
1: 106,975,337 (GRCm39) |
K157E |
probably damaging |
Het |
| Slc22a28 |
A |
T |
19: 8,078,770 (GRCm39) |
N306K |
probably damaging |
Het |
| Smarca2 |
C |
A |
19: 26,753,625 (GRCm39) |
D1584E |
possibly damaging |
Het |
| Snx29 |
C |
A |
16: 11,265,359 (GRCm39) |
Q530K |
probably damaging |
Het |
| Stard10 |
C |
A |
7: 100,994,877 (GRCm39) |
Q278K |
possibly damaging |
Het |
| Tgm2 |
C |
T |
2: 157,966,124 (GRCm39) |
C510Y |
probably benign |
Het |
| Tlr9 |
C |
T |
9: 106,101,006 (GRCm39) |
P99L |
probably damaging |
Het |
| Tmco4 |
T |
C |
4: 138,717,871 (GRCm39) |
W4R |
probably benign |
Het |
| Tmem151a |
T |
A |
19: 5,121,862 (GRCm39) |
|
probably benign |
Het |
| Tmem255b |
T |
C |
8: 13,504,228 (GRCm39) |
V140A |
probably benign |
Het |
| Trbj1-2 |
C |
T |
6: 41,510,950 (GRCm39) |
|
probably benign |
Het |
| Trpm2 |
T |
C |
10: 77,781,750 (GRCm39) |
T290A |
probably damaging |
Het |
| Tsc22d1 |
G |
A |
14: 76,656,445 (GRCm39) |
E120K |
possibly damaging |
Het |
| Ttc29 |
A |
G |
8: 79,052,175 (GRCm39) |
D352G |
probably benign |
Het |
| Usp25 |
A |
T |
16: 76,830,833 (GRCm39) |
I30F |
possibly damaging |
Het |
| Usp34 |
A |
C |
11: 23,382,268 (GRCm39) |
N1993T |
probably damaging |
Het |
| Vmn2r124 |
A |
C |
17: 18,283,284 (GRCm39) |
H326P |
probably benign |
Het |
| Vmn2r92 |
C |
A |
17: 18,387,132 (GRCm39) |
T157K |
probably benign |
Het |
| Vstm5 |
A |
T |
9: 15,168,789 (GRCm39) |
I118F |
probably benign |
Het |
| Vwa7 |
T |
C |
17: 35,242,426 (GRCm39) |
V510A |
probably damaging |
Het |
| Zfhx4 |
G |
A |
3: 5,462,123 (GRCm39) |
S1266N |
probably damaging |
Het |
| Zfp763 |
T |
A |
17: 33,237,922 (GRCm39) |
N408Y |
probably benign |
Het |
| Zswim5 |
C |
T |
4: 116,843,901 (GRCm39) |
H980Y |
probably damaging |
Het |
|
| Other mutations in Kntc1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00087:Kntc1
|
APN |
5 |
123,928,222 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL00514:Kntc1
|
APN |
5 |
123,929,590 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01103:Kntc1
|
APN |
5 |
123,902,283 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01106:Kntc1
|
APN |
5 |
123,900,666 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01357:Kntc1
|
APN |
5 |
123,895,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01367:Kntc1
|
APN |
5 |
123,896,546 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01538:Kntc1
|
APN |
5 |
123,919,721 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01546:Kntc1
|
APN |
5 |
123,903,068 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01595:Kntc1
|
APN |
5 |
123,941,758 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL01725:Kntc1
|
APN |
5 |
123,902,253 (GRCm39) |
missense |
probably benign |
|
|
IGL01916:Kntc1
|
APN |
5 |
123,939,976 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01936:Kntc1
|
APN |
5 |
123,949,439 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01942:Kntc1
|
APN |
5 |
123,916,330 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01973:Kntc1
|
APN |
5 |
123,904,021 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01982:Kntc1
|
APN |
5 |
123,947,159 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL02145:Kntc1
|
APN |
5 |
123,900,661 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL02510:Kntc1
|
APN |
5 |
123,957,125 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02611:Kntc1
|
APN |
5 |
123,950,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02669:Kntc1
|
APN |
5 |
123,893,727 (GRCm39) |
splice site |
probably benign |
|
|
IGL02737:Kntc1
|
APN |
5 |
123,957,183 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL02793:Kntc1
|
APN |
5 |
123,916,340 (GRCm39) |
splice site |
probably null |
|
|
IGL02809:Kntc1
|
APN |
5 |
123,914,645 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02860:Kntc1
|
APN |
5 |
123,907,936 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02875:Kntc1
|
APN |
5 |
123,916,340 (GRCm39) |
splice site |
probably null |
|
|
IGL02931:Kntc1
|
APN |
5 |
123,937,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03169:Kntc1
|
APN |
5 |
123,913,884 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL03267:Kntc1
|
APN |
5 |
123,896,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0006:Kntc1
|
UTSW |
5 |
123,927,201 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0006:Kntc1
|
UTSW |
5 |
123,927,201 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0017:Kntc1
|
UTSW |
5 |
123,919,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0125:Kntc1
|
UTSW |
5 |
123,903,120 (GRCm39) |
splice site |
probably benign |
|
|
R0324:Kntc1
|
UTSW |
5 |
123,916,175 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0580:Kntc1
|
UTSW |
5 |
123,941,732 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0608:Kntc1
|
UTSW |
5 |
123,924,137 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0725:Kntc1
|
UTSW |
5 |
123,907,767 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0733:Kntc1
|
UTSW |
5 |
123,928,979 (GRCm39) |
missense |
probably null |
|
|
R0781:Kntc1
|
UTSW |
5 |
123,937,965 (GRCm39) |
splice site |
probably benign |
|
|
R0787:Kntc1
|
UTSW |
5 |
123,934,167 (GRCm39) |
missense |
probably benign |
|
|
R1250:Kntc1
|
UTSW |
5 |
123,922,262 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1253:Kntc1
|
UTSW |
5 |
123,948,925 (GRCm39) |
frame shift |
probably null |
|
|
R1467:Kntc1
|
UTSW |
5 |
123,925,047 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1467:Kntc1
|
UTSW |
5 |
123,925,047 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1481:Kntc1
|
UTSW |
5 |
123,916,338 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1572:Kntc1
|
UTSW |
5 |
123,910,176 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1624:Kntc1
|
UTSW |
5 |
123,896,540 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R1749:Kntc1
|
UTSW |
5 |
123,927,162 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1993:Kntc1
|
UTSW |
5 |
123,948,874 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1993:Kntc1
|
UTSW |
5 |
123,897,162 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2071:Kntc1
|
UTSW |
5 |
123,932,340 (GRCm39) |
splice site |
probably null |
|
|
R2237:Kntc1
|
UTSW |
5 |
123,941,733 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R2239:Kntc1
|
UTSW |
5 |
123,941,733 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R2366:Kntc1
|
UTSW |
5 |
123,919,255 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2367:Kntc1
|
UTSW |
5 |
123,919,255 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2382:Kntc1
|
UTSW |
5 |
123,898,411 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2389:Kntc1
|
UTSW |
5 |
123,919,255 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2413:Kntc1
|
UTSW |
5 |
123,902,212 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2442:Kntc1
|
UTSW |
5 |
123,948,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2504:Kntc1
|
UTSW |
5 |
123,916,410 (GRCm39) |
nonsense |
probably null |
|
|
R2943:Kntc1
|
UTSW |
5 |
123,935,847 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R3116:Kntc1
|
UTSW |
5 |
123,940,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4107:Kntc1
|
UTSW |
5 |
123,900,661 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4176:Kntc1
|
UTSW |
5 |
123,914,680 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R4275:Kntc1
|
UTSW |
5 |
123,905,842 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4440:Kntc1
|
UTSW |
5 |
123,932,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4575:Kntc1
|
UTSW |
5 |
123,904,018 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4576:Kntc1
|
UTSW |
5 |
123,904,018 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4578:Kntc1
|
UTSW |
5 |
123,904,018 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4704:Kntc1
|
UTSW |
5 |
123,949,496 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4720:Kntc1
|
UTSW |
5 |
123,903,086 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R4784:Kntc1
|
UTSW |
5 |
123,954,825 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4785:Kntc1
|
UTSW |
5 |
123,954,825 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4824:Kntc1
|
UTSW |
5 |
123,928,196 (GRCm39) |
nonsense |
probably null |
|
|
R4847:Kntc1
|
UTSW |
5 |
123,940,337 (GRCm39) |
missense |
probably benign |
0.18 |
|
R4849:Kntc1
|
UTSW |
5 |
123,897,128 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4904:Kntc1
|
UTSW |
5 |
123,916,396 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R4922:Kntc1
|
UTSW |
5 |
123,940,309 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5080:Kntc1
|
UTSW |
5 |
123,900,649 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R5114:Kntc1
|
UTSW |
5 |
123,919,118 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5171:Kntc1
|
UTSW |
5 |
123,937,907 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5220:Kntc1
|
UTSW |
5 |
123,950,160 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5226:Kntc1
|
UTSW |
5 |
123,932,235 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5278:Kntc1
|
UTSW |
5 |
123,919,077 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5329:Kntc1
|
UTSW |
5 |
123,902,254 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5496:Kntc1
|
UTSW |
5 |
123,922,245 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5503:Kntc1
|
UTSW |
5 |
123,957,939 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5633:Kntc1
|
UTSW |
5 |
123,957,120 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5638:Kntc1
|
UTSW |
5 |
123,956,538 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R5697:Kntc1
|
UTSW |
5 |
123,903,070 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5757:Kntc1
|
UTSW |
5 |
123,945,372 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5773:Kntc1
|
UTSW |
5 |
123,932,220 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5940:Kntc1
|
UTSW |
5 |
123,924,258 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6019:Kntc1
|
UTSW |
5 |
123,900,579 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6230:Kntc1
|
UTSW |
5 |
123,927,072 (GRCm39) |
splice site |
probably null |
|
|
R6437:Kntc1
|
UTSW |
5 |
123,907,754 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6888:Kntc1
|
UTSW |
5 |
123,949,373 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6907:Kntc1
|
UTSW |
5 |
123,939,888 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7123:Kntc1
|
UTSW |
5 |
123,919,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7262:Kntc1
|
UTSW |
5 |
123,925,036 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7381:Kntc1
|
UTSW |
5 |
123,948,971 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7485:Kntc1
|
UTSW |
5 |
123,925,019 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R7512:Kntc1
|
UTSW |
5 |
123,929,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7581:Kntc1
|
UTSW |
5 |
123,954,818 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7687:Kntc1
|
UTSW |
5 |
123,897,152 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7798:Kntc1
|
UTSW |
5 |
123,957,180 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7798:Kntc1
|
UTSW |
5 |
123,924,357 (GRCm39) |
missense |
probably benign |
|
|
R7871:Kntc1
|
UTSW |
5 |
123,922,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7876:Kntc1
|
UTSW |
5 |
123,913,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7947:Kntc1
|
UTSW |
5 |
123,919,951 (GRCm39) |
missense |
unknown |
|
|
R7997:Kntc1
|
UTSW |
5 |
123,916,117 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8231:Kntc1
|
UTSW |
5 |
123,920,959 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R8257:Kntc1
|
UTSW |
5 |
123,896,586 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8345:Kntc1
|
UTSW |
5 |
123,924,993 (GRCm39) |
missense |
probably benign |
0.37 |
|
R8354:Kntc1
|
UTSW |
5 |
123,916,330 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8732:Kntc1
|
UTSW |
5 |
123,928,180 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8754:Kntc1
|
UTSW |
5 |
123,897,115 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8947:Kntc1
|
UTSW |
5 |
123,925,041 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9041:Kntc1
|
UTSW |
5 |
123,927,093 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9182:Kntc1
|
UTSW |
5 |
123,940,355 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9432:Kntc1
|
UTSW |
5 |
123,925,112 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9460:Kntc1
|
UTSW |
5 |
123,941,378 (GRCm39) |
nonsense |
probably null |
|
|
R9468:Kntc1
|
UTSW |
5 |
123,954,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9643:Kntc1
|
UTSW |
5 |
123,949,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9646:Kntc1
|
UTSW |
5 |
123,897,119 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9721:Kntc1
|
UTSW |
5 |
123,939,948 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9789:Kntc1
|
UTSW |
5 |
123,898,706 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
X0027:Kntc1
|
UTSW |
5 |
123,948,992 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0065:Kntc1
|
UTSW |
5 |
123,916,100 (GRCm39) |
nonsense |
probably null |
|
|
X0067:Kntc1
|
UTSW |
5 |
123,916,137 (GRCm39) |
unclassified |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AACATCTGCTCTTGGGCTCC -3'
(R):5'- GGCACTGTGACAAATGCTAGAG -3'
Sequencing Primer
(F):5'- TAGTTCAAAGCCATCCTGGG -3'
(R):5'- TAGAGCAGTGCCAGGTGACTC -3'
|
| Posted On |
2015-09-25 |
Incidental Mutation