Incidental Mutation 'R4614:Wnk4'
| ID |
344966 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Wnk4
|
| Ensembl Gene |
ENSMUSG00000035112 |
| Gene Name |
WNK lysine deficient protein kinase 4 |
| Synonyms |
2010002J11Rik, Prkwnk4 |
| MMRRC Submission |
041825-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.318)
|
| Stock # |
R4614 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
101151393-101168235 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 101164937 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Aspartic acid
at position 755
(E755D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000099397
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000017332]
[ENSMUST00000103107]
[ENSMUST00000103108]
[ENSMUST00000139487]
[ENSMUST00000147741]
[ENSMUST00000168089]
[ENSMUST00000170056]
|
| AlphaFold |
Q80UE6 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000017332
|
| SMART Domains |
Protein: ENSMUSP00000017332
Gene: ENSMUSG00000017188
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Coiled-coil_56
|
1 |
106 |
1.8e-56 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000103107
|
| SMART Domains |
Protein: ENSMUSP00000099396
Gene: ENSMUSG00000078653
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Cyclin_N
|
111 |
180 |
1.8e-6 |
PFAM |
|
low complexity region
|
212 |
221 |
N/A |
INTRINSIC |
|
low complexity region
|
319 |
330 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000103108
AA Change: E755D
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
| SMART Domains |
Protein: ENSMUSP00000099397
Gene: ENSMUSG00000035112
AA Change: E755D
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
31 |
45 |
N/A |
INTRINSIC |
|
low complexity region
|
52 |
64 |
N/A |
INTRINSIC |
|
low complexity region
|
76 |
92 |
N/A |
INTRINSIC |
|
low complexity region
|
95 |
105 |
N/A |
INTRINSIC |
|
low complexity region
|
126 |
155 |
N/A |
INTRINSIC |
|
Pfam:Pkinase_Tyr
|
171 |
427 |
4.7e-42 |
PFAM |
|
Pfam:Pkinase
|
171 |
429 |
9e-55 |
PFAM |
|
Pfam:OSR1_C
|
450 |
486 |
3e-18 |
PFAM |
|
low complexity region
|
503 |
513 |
N/A |
INTRINSIC |
|
low complexity region
|
516 |
530 |
N/A |
INTRINSIC |
|
low complexity region
|
544 |
560 |
N/A |
INTRINSIC |
|
low complexity region
|
627 |
638 |
N/A |
INTRINSIC |
|
low complexity region
|
660 |
678 |
N/A |
INTRINSIC |
|
low complexity region
|
757 |
778 |
N/A |
INTRINSIC |
|
low complexity region
|
793 |
808 |
N/A |
INTRINSIC |
|
low complexity region
|
841 |
877 |
N/A |
INTRINSIC |
|
low complexity region
|
882 |
915 |
N/A |
INTRINSIC |
|
low complexity region
|
921 |
951 |
N/A |
INTRINSIC |
|
low complexity region
|
1014 |
1033 |
N/A |
INTRINSIC |
|
low complexity region
|
1093 |
1112 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000128735
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000139487
|
| SMART Domains |
Protein: ENSMUSP00000129666
Gene: ENSMUSG00000035112
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
31 |
45 |
N/A |
INTRINSIC |
|
low complexity region
|
52 |
64 |
N/A |
INTRINSIC |
|
low complexity region
|
76 |
92 |
N/A |
INTRINSIC |
|
low complexity region
|
95 |
105 |
N/A |
INTRINSIC |
|
low complexity region
|
126 |
155 |
N/A |
INTRINSIC |
|
Pfam:Pkinase_Tyr
|
171 |
242 |
4e-8 |
PFAM |
|
Pfam:Pkinase
|
171 |
252 |
1.9e-10 |
PFAM |
|
low complexity region
|
269 |
283 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000147741
|
| SMART Domains |
Protein: ENSMUSP00000131298
Gene: ENSMUSG00000035112
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
31 |
45 |
N/A |
INTRINSIC |
|
low complexity region
|
52 |
64 |
N/A |
INTRINSIC |
|
low complexity region
|
76 |
92 |
N/A |
INTRINSIC |
|
low complexity region
|
95 |
105 |
N/A |
INTRINSIC |
|
low complexity region
|
126 |
155 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
171 |
394 |
9.3e-50 |
PFAM |
|
Pfam:Pkinase_Tyr
|
171 |
399 |
3.7e-38 |
PFAM |
|
low complexity region
|
401 |
413 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168089
|
| SMART Domains |
Protein: ENSMUSP00000130367
Gene: ENSMUSG00000017188
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Coiled-coil_56
|
1 |
74 |
2.7e-35 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170372
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170056
|
| SMART Domains |
Protein: ENSMUSP00000132123
Gene: ENSMUSG00000035112
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:OSR1_C
|
13 |
49 |
8.6e-20 |
PFAM |
|
low complexity region
|
66 |
76 |
N/A |
INTRINSIC |
|
low complexity region
|
79 |
93 |
N/A |
INTRINSIC |
|
low complexity region
|
107 |
123 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.0653 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.2%
|
| Validation Efficiency |
98% (95/97) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009]
PHENOTYPE: Mice homozygous for a null allele display increased Na+, K+ and Cl- urinary excretion, alkalosis and decreased plasma Cl-, K+, Mg2+ and renin levels. Mice homozygous for a point mutation exhibit acidosis, hypertension, increased circulating potassium levels and decreased potassium excretion. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 88 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2210408I21Rik |
T |
G |
13: 77,402,375 (GRCm39) |
|
probably null |
Het |
| 4932414N04Rik |
C |
A |
2: 68,575,804 (GRCm39) |
T701K |
probably benign |
Het |
| Abcb11 |
A |
T |
2: 69,115,025 (GRCm39) |
H640Q |
possibly damaging |
Het |
| Ago2 |
C |
T |
15: 73,002,816 (GRCm39) |
V139M |
probably damaging |
Het |
| Apol11a |
A |
T |
15: 77,400,772 (GRCm39) |
K86N |
probably benign |
Het |
| Ass1 |
T |
C |
2: 31,404,795 (GRCm39) |
Y359H |
probably damaging |
Het |
| Bpifa3 |
A |
T |
2: 153,978,200 (GRCm39) |
N34I |
probably damaging |
Het |
| Brwd1 |
A |
T |
16: 95,848,559 (GRCm39) |
L540H |
probably damaging |
Het |
| C3ar1 |
G |
A |
6: 122,827,680 (GRCm39) |
S179F |
probably benign |
Het |
| Ccnb1ip1 |
T |
C |
14: 51,029,652 (GRCm39) |
T137A |
probably benign |
Het |
| Cd5l |
A |
G |
3: 87,275,926 (GRCm39) |
T299A |
probably benign |
Het |
| Cdk12 |
T |
A |
11: 98,140,603 (GRCm39) |
|
probably benign |
Het |
| Cep290 |
T |
C |
10: 100,344,602 (GRCm39) |
M480T |
probably benign |
Het |
| Cep290 |
G |
A |
10: 100,395,549 (GRCm39) |
R2112K |
possibly damaging |
Het |
| Chn2 |
G |
A |
6: 54,267,388 (GRCm39) |
M292I |
probably damaging |
Het |
| Cic |
TCCCCC |
TCCCCCCC |
7: 24,991,095 (GRCm39) |
|
probably null |
Het |
| Cpeb1 |
A |
T |
7: 81,086,018 (GRCm39) |
D41E |
possibly damaging |
Het |
| Csf2rb2 |
C |
G |
15: 78,175,902 (GRCm39) |
C184S |
probably damaging |
Het |
| Ctsc |
G |
A |
7: 87,927,583 (GRCm39) |
|
probably null |
Het |
| Cyp2c40 |
G |
A |
19: 39,792,300 (GRCm39) |
S191L |
probably damaging |
Het |
| Dagla |
T |
C |
19: 10,225,641 (GRCm39) |
E841G |
probably damaging |
Het |
| Dld |
A |
T |
12: 31,383,944 (GRCm39) |
Y386* |
probably null |
Het |
| Dpp8 |
G |
A |
9: 64,973,678 (GRCm39) |
S634N |
probably benign |
Het |
| Duox2 |
A |
T |
2: 122,120,038 (GRCm39) |
V824E |
probably damaging |
Het |
| Dync2h1 |
A |
C |
9: 7,011,290 (GRCm39) |
S3634R |
probably benign |
Het |
| Eef1d |
T |
C |
15: 75,775,425 (GRCm39) |
N78S |
probably benign |
Het |
| Fcrl5 |
T |
A |
3: 87,355,733 (GRCm39) |
I482N |
probably damaging |
Het |
| Fezf1 |
A |
T |
6: 23,247,857 (GRCm39) |
C73S |
possibly damaging |
Het |
| Fgfr1 |
A |
G |
8: 26,047,813 (GRCm39) |
D53G |
probably benign |
Het |
| Fmn1 |
T |
C |
2: 113,195,494 (GRCm39) |
L398S |
unknown |
Het |
| Gm17175 |
T |
C |
14: 51,809,042 (GRCm39) |
Q108R |
probably benign |
Het |
| Gm28042 |
G |
A |
2: 119,871,639 (GRCm39) |
G669D |
probably damaging |
Het |
| Gm6185 |
A |
G |
1: 161,050,669 (GRCm39) |
|
noncoding transcript |
Het |
| Gucy2g |
A |
T |
19: 55,190,579 (GRCm39) |
C1018* |
probably null |
Het |
| H2-Q10 |
A |
T |
17: 35,784,917 (GRCm39) |
|
probably benign |
Het |
| H2-T22 |
T |
G |
17: 36,351,429 (GRCm39) |
Q267P |
probably benign |
Het |
| Hibadh |
A |
G |
6: 52,523,915 (GRCm39) |
Y328H |
possibly damaging |
Het |
| Hsd3b3 |
T |
A |
3: 98,649,396 (GRCm39) |
Y309F |
probably benign |
Het |
| Ighv1-37 |
C |
T |
12: 114,859,863 (GRCm39) |
A116T |
probably benign |
Het |
| Ighv1-82 |
T |
C |
12: 115,916,280 (GRCm39) |
T77A |
probably benign |
Het |
| Igkv8-21 |
A |
T |
6: 70,292,141 (GRCm39) |
S34T |
probably benign |
Het |
| Insyn1 |
AGAGGAGGAGGAGGAGG |
AGAGGAGGAGGAGG |
9: 58,406,715 (GRCm39) |
|
probably benign |
Het |
| Iqch |
A |
G |
9: 63,389,863 (GRCm39) |
M733T |
probably benign |
Het |
| Jakmip2 |
T |
A |
18: 43,695,657 (GRCm39) |
D539V |
probably damaging |
Het |
| Lgi2 |
A |
G |
5: 52,695,775 (GRCm39) |
S395P |
probably damaging |
Het |
| Lrrc40 |
A |
T |
3: 157,760,271 (GRCm39) |
N344I |
probably damaging |
Het |
| Ltbp1 |
G |
A |
17: 75,596,989 (GRCm39) |
|
probably benign |
Het |
| Metap1d |
C |
T |
2: 71,355,292 (GRCm39) |
P332L |
probably benign |
Het |
| Mfap4 |
C |
A |
11: 61,376,335 (GRCm39) |
|
probably benign |
Het |
| Mis18bp1 |
T |
A |
12: 65,200,303 (GRCm39) |
|
probably benign |
Het |
| Mta2 |
T |
C |
19: 8,925,492 (GRCm39) |
|
probably null |
Het |
| Mtmr4 |
T |
C |
11: 87,501,761 (GRCm39) |
L548S |
probably damaging |
Het |
| Muc4 |
A |
G |
16: 32,577,432 (GRCm39) |
K241E |
probably benign |
Het |
| Mup18 |
T |
A |
4: 61,590,154 (GRCm39) |
I125F |
possibly damaging |
Het |
| Nfs1 |
A |
G |
2: 155,985,970 (GRCm39) |
S31P |
probably benign |
Het |
| Or10g6 |
T |
A |
9: 39,934,255 (GRCm39) |
C189S |
probably damaging |
Het |
| Or10z1 |
A |
G |
1: 174,078,188 (GRCm39) |
F102L |
possibly damaging |
Het |
| Or2f1b |
G |
T |
6: 42,739,352 (GRCm39) |
R122L |
probably benign |
Het |
| Otogl |
A |
T |
10: 107,727,985 (GRCm39) |
C245* |
probably null |
Het |
| Pcdhb16 |
G |
A |
18: 37,613,398 (GRCm39) |
G786D |
probably benign |
Het |
| Pdcd5 |
C |
T |
7: 35,346,472 (GRCm39) |
|
probably benign |
Het |
| Phkg2 |
C |
T |
7: 127,176,792 (GRCm39) |
R61W |
probably damaging |
Het |
| Piezo1 |
A |
T |
8: 123,213,150 (GRCm39) |
I1871N |
probably benign |
Het |
| Pkd2l1 |
C |
A |
19: 44,142,573 (GRCm39) |
A490S |
probably damaging |
Het |
| Plxnd1 |
T |
C |
6: 115,949,486 (GRCm39) |
T767A |
possibly damaging |
Het |
| Polr3c |
T |
G |
3: 96,623,787 (GRCm39) |
I322L |
probably benign |
Het |
| Ppp1r26 |
C |
A |
2: 28,340,860 (GRCm39) |
H163Q |
probably benign |
Het |
| Prox1 |
T |
G |
1: 189,894,205 (GRCm39) |
Y80S |
probably damaging |
Het |
| Pygl |
T |
C |
12: 70,257,753 (GRCm39) |
|
probably null |
Het |
| Rab23 |
T |
C |
1: 33,778,466 (GRCm39) |
V236A |
probably benign |
Het |
| Setd2 |
T |
C |
9: 110,398,881 (GRCm39) |
|
probably null |
Het |
| Slc5a7 |
A |
G |
17: 54,583,587 (GRCm39) |
S568P |
probably benign |
Het |
| Smpd3 |
A |
G |
8: 106,986,371 (GRCm39) |
L477P |
probably damaging |
Het |
| Spg21 |
A |
G |
9: 65,387,671 (GRCm39) |
|
probably null |
Het |
| Spta1 |
A |
T |
1: 174,020,543 (GRCm39) |
I551F |
probably damaging |
Het |
| Supt5 |
A |
T |
7: 28,025,397 (GRCm39) |
I135N |
possibly damaging |
Het |
| Tacstd2 |
A |
G |
6: 67,512,170 (GRCm39) |
F174S |
probably damaging |
Het |
| Tas1r2 |
A |
T |
4: 139,387,098 (GRCm39) |
T186S |
probably damaging |
Het |
| Tie1 |
A |
G |
4: 118,336,248 (GRCm39) |
Y673H |
probably damaging |
Het |
| Tom1l1 |
A |
T |
11: 90,561,952 (GRCm39) |
N190K |
probably damaging |
Het |
| Tox2 |
T |
C |
2: 163,162,567 (GRCm39) |
L479P |
probably damaging |
Het |
| Tox4 |
C |
T |
14: 52,524,924 (GRCm39) |
T249I |
probably damaging |
Het |
| Trmt1l |
C |
T |
1: 151,329,799 (GRCm39) |
Q581* |
probably null |
Het |
| Vmn1r49 |
A |
G |
6: 90,049,534 (GRCm39) |
V156A |
probably benign |
Het |
| Vmn2r13 |
A |
T |
5: 109,323,065 (GRCm39) |
F75I |
probably benign |
Het |
| Washc2 |
T |
A |
6: 116,215,135 (GRCm39) |
S502T |
possibly damaging |
Het |
| Zfp207 |
T |
A |
11: 80,286,016 (GRCm39) |
|
probably benign |
Het |
| Zfp352 |
A |
G |
4: 90,113,318 (GRCm39) |
K486R |
probably benign |
Het |
|
| Other mutations in Wnk4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00231:Wnk4
|
APN |
11 |
101,159,574 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
IGL00535:Wnk4
|
APN |
11 |
101,155,175 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01401:Wnk4
|
APN |
11 |
101,167,509 (GRCm39) |
splice site |
probably benign |
|
|
IGL01931:Wnk4
|
APN |
11 |
101,159,310 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01977:Wnk4
|
APN |
11 |
101,156,240 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02165:Wnk4
|
APN |
11 |
101,166,117 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02197:Wnk4
|
APN |
11 |
101,154,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02457:Wnk4
|
APN |
11 |
101,160,389 (GRCm39) |
splice site |
probably benign |
|
|
IGL02963:Wnk4
|
APN |
11 |
101,167,039 (GRCm39) |
unclassified |
probably benign |
|
|
ashamed
|
UTSW |
11 |
101,156,257 (GRCm39) |
missense |
probably damaging |
1.00 |
|
blushing
|
UTSW |
11 |
101,156,203 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Caught_dead
|
UTSW |
11 |
101,155,156 (GRCm39) |
missense |
probably damaging |
1.00 |
|
lowered
|
UTSW |
11 |
101,159,318 (GRCm39) |
critical splice donor site |
probably null |
|
|
mortification
|
UTSW |
11 |
101,154,720 (GRCm39) |
makesense |
probably null |
|
|
shame
|
UTSW |
11 |
101,153,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0066:Wnk4
|
UTSW |
11 |
101,156,261 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0317:Wnk4
|
UTSW |
11 |
101,159,630 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0628:Wnk4
|
UTSW |
11 |
101,165,849 (GRCm39) |
missense |
probably benign |
0.10 |
|
R0630:Wnk4
|
UTSW |
11 |
101,156,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0710:Wnk4
|
UTSW |
11 |
101,164,932 (GRCm39) |
missense |
probably benign |
0.22 |
|
R1290:Wnk4
|
UTSW |
11 |
101,167,166 (GRCm39) |
unclassified |
probably benign |
|
|
R1482:Wnk4
|
UTSW |
11 |
101,160,462 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1775:Wnk4
|
UTSW |
11 |
101,167,166 (GRCm39) |
unclassified |
probably benign |
|
|
R2005:Wnk4
|
UTSW |
11 |
101,154,716 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2229:Wnk4
|
UTSW |
11 |
101,166,467 (GRCm39) |
unclassified |
probably benign |
|
|
R2258:Wnk4
|
UTSW |
11 |
101,165,861 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2323:Wnk4
|
UTSW |
11 |
101,159,307 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3081:Wnk4
|
UTSW |
11 |
101,167,717 (GRCm39) |
splice site |
probably benign |
|
|
R3763:Wnk4
|
UTSW |
11 |
101,160,114 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4196:Wnk4
|
UTSW |
11 |
101,160,457 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4447:Wnk4
|
UTSW |
11 |
101,159,277 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R4751:Wnk4
|
UTSW |
11 |
101,167,188 (GRCm39) |
unclassified |
probably benign |
|
|
R4948:Wnk4
|
UTSW |
11 |
101,159,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5067:Wnk4
|
UTSW |
11 |
101,153,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5073:Wnk4
|
UTSW |
11 |
101,152,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5107:Wnk4
|
UTSW |
11 |
101,166,364 (GRCm39) |
unclassified |
probably benign |
|
|
R5181:Wnk4
|
UTSW |
11 |
101,156,203 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5205:Wnk4
|
UTSW |
11 |
101,155,964 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5252:Wnk4
|
UTSW |
11 |
101,159,574 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R5273:Wnk4
|
UTSW |
11 |
101,154,695 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5293:Wnk4
|
UTSW |
11 |
101,166,023 (GRCm39) |
unclassified |
probably benign |
|
|
R5609:Wnk4
|
UTSW |
11 |
101,166,462 (GRCm39) |
unclassified |
probably benign |
|
|
R5915:Wnk4
|
UTSW |
11 |
101,154,720 (GRCm39) |
makesense |
probably null |
|
|
R5931:Wnk4
|
UTSW |
11 |
101,152,047 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6126:Wnk4
|
UTSW |
11 |
101,167,174 (GRCm39) |
unclassified |
probably benign |
|
|
R6164:Wnk4
|
UTSW |
11 |
101,165,894 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R6191:Wnk4
|
UTSW |
11 |
101,155,156 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6267:Wnk4
|
UTSW |
11 |
101,164,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6274:Wnk4
|
UTSW |
11 |
101,156,257 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6296:Wnk4
|
UTSW |
11 |
101,164,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7132:Wnk4
|
UTSW |
11 |
101,152,026 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7251:Wnk4
|
UTSW |
11 |
101,155,979 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R7352:Wnk4
|
UTSW |
11 |
101,155,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7404:Wnk4
|
UTSW |
11 |
101,159,318 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7624:Wnk4
|
UTSW |
11 |
101,155,180 (GRCm39) |
nonsense |
probably null |
|
|
R7634:Wnk4
|
UTSW |
11 |
101,153,721 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7780:Wnk4
|
UTSW |
11 |
101,160,403 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8006:Wnk4
|
UTSW |
11 |
101,159,182 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8046:Wnk4
|
UTSW |
11 |
101,164,918 (GRCm39) |
missense |
probably benign |
0.20 |
|
R8143:Wnk4
|
UTSW |
11 |
101,153,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8458:Wnk4
|
UTSW |
11 |
101,166,147 (GRCm39) |
nonsense |
probably null |
|
|
R8735:Wnk4
|
UTSW |
11 |
101,167,092 (GRCm39) |
missense |
unknown |
|
|
R9025:Wnk4
|
UTSW |
11 |
101,153,641 (GRCm39) |
nonsense |
probably null |
|
|
R9206:Wnk4
|
UTSW |
11 |
101,164,882 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9295:Wnk4
|
UTSW |
11 |
101,160,078 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9610:Wnk4
|
UTSW |
11 |
101,159,250 (GRCm39) |
nonsense |
probably null |
|
|
R9611:Wnk4
|
UTSW |
11 |
101,159,250 (GRCm39) |
nonsense |
probably null |
|
|
R9674:Wnk4
|
UTSW |
11 |
101,166,874 (GRCm39) |
missense |
unknown |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CAGTCAGGGTGGGATGATATC -3'
(R):5'- TGGGCTTCTGAGGATTCAAAAG -3'
Sequencing Primer
(F):5'- GGATGATATCCTCCTCTCACCC -3'
(R):5'- CATGTTCTCAAGCGGTTCAAAGG -3'
|
| Posted On |
2015-09-25 |
Incidental Mutation