Incidental Mutation 'R4602:Gm4922'
ID 345725
Institutional Source Beutler Lab
Gene Symbol Gm4922
Ensembl Gene ENSMUSG00000044624
Gene Name predicted gene 4922
Synonyms
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4602 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 18655475-18662541 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 18660007 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 238 (Y238*)
Ref Sequence ENSEMBL: ENSMUSP00000149756 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055107] [ENSMUST00000216654]
AlphaFold Q8C0N0
Predicted Effect probably null
Transcript: ENSMUST00000055107
AA Change: Y238*
SMART Domains Protein: ENSMUSP00000055273
Gene: ENSMUSG00000044624
AA Change: Y238*

DomainStartEndE-ValueType
low complexity region 3 13 N/A INTRINSIC
S_TKc 28 275 1.92e-75 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215162
Predicted Effect probably null
Transcript: ENSMUST00000216654
AA Change: Y238*
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahnak A G 19: 8,988,189 (GRCm39) K3158E possibly damaging Het
Ak7 G A 12: 105,679,834 (GRCm39) V123M probably benign Het
Ankmy1 A T 1: 92,816,372 (GRCm39) N247K probably benign Het
Atp1a1 A G 3: 101,494,259 (GRCm39) V447A probably benign Het
Atp1a4 A C 1: 172,067,332 (GRCm39) M600R probably damaging Het
Baat A G 4: 49,502,727 (GRCm39) Y132H probably damaging Het
Ceacam15 A G 7: 16,405,906 (GRCm39) V215A probably damaging Het
Celf2 G T 2: 6,590,831 (GRCm39) N279K possibly damaging Het
Cfap96 A T 8: 46,423,505 (GRCm39) I69N probably damaging Het
Clec14a C T 12: 58,314,767 (GRCm39) R285H probably benign Het
Ctnna1 T G 18: 35,312,880 (GRCm39) I244R possibly damaging Het
Dcxr T A 11: 120,617,130 (GRCm39) N105Y possibly damaging Het
Dnajc6 T C 4: 101,468,461 (GRCm39) F166L probably damaging Het
Ercc3 G A 18: 32,378,624 (GRCm39) A202T probably benign Het
Faf1 A G 4: 109,584,625 (GRCm39) D67G probably benign Het
Fancm G A 12: 65,171,718 (GRCm39) R1786H probably benign Het
Fnbp1 A G 2: 30,926,552 (GRCm39) probably null Het
Frem2 A G 3: 53,455,228 (GRCm39) L2116S possibly damaging Het
Gbp5 A G 3: 142,209,546 (GRCm39) E164G probably benign Het
Gm8257 A G 14: 44,893,774 (GRCm39) Y62H probably damaging Het
Grin2b A G 6: 135,755,739 (GRCm39) F525S probably damaging Het
Hjv T G 3: 96,434,869 (GRCm39) S203A probably benign Het
Hsd17b3 C A 13: 64,210,984 (GRCm39) probably null Het
Ighv1-23 T A 12: 114,728,179 (GRCm39) Q81L probably benign Het
Inpp4b T C 8: 82,696,164 (GRCm39) V366A probably damaging Het
Jak1 G T 4: 101,036,791 (GRCm39) A283D possibly damaging Het
Kmt2d G T 15: 98,748,140 (GRCm39) probably benign Het
Mbtps1 A T 8: 120,262,086 (GRCm39) D354E probably damaging Het
Mettl17 T C 14: 52,126,246 (GRCm39) V218A probably damaging Het
Mrc2 G A 11: 105,239,257 (GRCm39) probably null Het
Nfat5 C T 8: 108,093,855 (GRCm39) Q699* probably null Het
Or4s2b G A 2: 88,508,240 (GRCm39) V14I probably benign Het
Or4s2b T G 2: 88,508,523 (GRCm39) V101G probably benign Het
Or7e174 C A 9: 20,012,540 (GRCm39) H162N probably benign Het
Osbpl7 C A 11: 96,947,095 (GRCm39) S265R possibly damaging Het
Pcdh15 A G 10: 74,430,046 (GRCm39) T1258A probably damaging Het
Pcdh20 A T 14: 88,705,866 (GRCm39) L478Q probably damaging Het
Pde11a A G 2: 75,988,677 (GRCm39) V488A probably benign Het
Phactr1 A T 13: 43,248,441 (GRCm39) E463D probably benign Het
Phaf1 C A 8: 105,973,520 (GRCm39) N282K possibly damaging Het
Samd9l A T 6: 3,373,935 (GRCm39) Y1109N probably damaging Het
Samd9l GAA GAAA 6: 3,373,937 (GRCm39) probably null Het
Secisbp2l C T 2: 125,582,657 (GRCm39) G933D possibly damaging Het
Serpinb12 T A 1: 106,876,883 (GRCm39) D66E probably benign Het
Sgk2 G A 2: 162,836,674 (GRCm39) probably null Het
Slco1a6 C A 6: 142,047,378 (GRCm39) C404F probably benign Het
Spaca6 C T 17: 18,051,387 (GRCm39) A21V probably damaging Het
Sphkap G T 1: 83,256,782 (GRCm39) Y322* probably null Het
Sptlc3 G A 2: 139,478,600 (GRCm39) V520I probably benign Het
Stox2 A G 8: 47,645,970 (GRCm39) S497P probably damaging Het
Syt9 A T 7: 107,035,594 (GRCm39) K204* probably null Het
Taf3 A G 2: 9,957,468 (GRCm39) V233A probably damaging Het
Tbccd1 T C 16: 22,637,285 (GRCm39) probably null Het
Tdrd5 T A 1: 156,111,944 (GRCm39) T479S probably benign Het
Tex10 T C 4: 48,452,946 (GRCm39) D671G probably benign Het
Tgtp2 T C 11: 48,949,811 (GRCm39) T254A probably damaging Het
Tmtc2 T C 10: 105,249,391 (GRCm39) Y114C probably benign Het
Tns2 C T 15: 102,017,369 (GRCm39) R281C probably damaging Het
Ubac1 A T 2: 25,888,989 (GRCm39) I402N probably damaging Het
Zmat1 A T X: 133,873,694 (GRCm39) S566T probably damaging Homo
Other mutations in Gm4922
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01810:Gm4922 APN 10 18,659,795 (GRCm39) missense probably benign 0.20
IGL01818:Gm4922 APN 10 18,660,701 (GRCm39) missense unknown
IGL01931:Gm4922 APN 10 18,660,042 (GRCm39) missense probably benign 0.01
IGL02021:Gm4922 APN 10 18,660,225 (GRCm39) missense probably damaging 1.00
IGL02573:Gm4922 APN 10 18,659,423 (GRCm39) missense probably benign 0.05
IGL03305:Gm4922 APN 10 18,659,232 (GRCm39) nonsense probably null
R0149:Gm4922 UTSW 10 18,659,289 (GRCm39) missense probably benign 0.10
R0361:Gm4922 UTSW 10 18,659,289 (GRCm39) missense probably benign 0.10
R0564:Gm4922 UTSW 10 18,659,813 (GRCm39) missense possibly damaging 0.66
R1079:Gm4922 UTSW 10 18,660,086 (GRCm39) missense probably damaging 0.97
R1163:Gm4922 UTSW 10 18,659,469 (GRCm39) missense possibly damaging 0.83
R1164:Gm4922 UTSW 10 18,659,469 (GRCm39) missense possibly damaging 0.83
R1398:Gm4922 UTSW 10 18,659,496 (GRCm39) missense possibly damaging 0.65
R1458:Gm4922 UTSW 10 18,659,640 (GRCm39) nonsense probably null
R1867:Gm4922 UTSW 10 18,660,211 (GRCm39) missense possibly damaging 0.73
R1994:Gm4922 UTSW 10 18,659,388 (GRCm39) missense probably benign 0.10
R2146:Gm4922 UTSW 10 18,659,264 (GRCm39) missense probably benign
R2437:Gm4922 UTSW 10 18,659,829 (GRCm39) missense probably benign 0.00
R3551:Gm4922 UTSW 10 18,660,244 (GRCm39) missense probably benign 0.01
R3939:Gm4922 UTSW 10 18,660,362 (GRCm39) missense probably damaging 1.00
R4580:Gm4922 UTSW 10 18,659,432 (GRCm39) missense probably benign 0.00
R4704:Gm4922 UTSW 10 18,660,567 (GRCm39) missense probably benign 0.20
R4790:Gm4922 UTSW 10 18,659,916 (GRCm39) missense possibly damaging 0.58
R5478:Gm4922 UTSW 10 18,659,885 (GRCm39) missense probably benign
R5510:Gm4922 UTSW 10 18,659,745 (GRCm39) missense probably benign 0.00
R5694:Gm4922 UTSW 10 18,660,035 (GRCm39) missense possibly damaging 0.76
R6080:Gm4922 UTSW 10 18,660,500 (GRCm39) missense probably damaging 1.00
R6869:Gm4922 UTSW 10 18,660,263 (GRCm39) missense probably damaging 1.00
R6923:Gm4922 UTSW 10 18,659,616 (GRCm39) missense probably damaging 1.00
R7667:Gm4922 UTSW 10 18,660,096 (GRCm39) missense probably damaging 1.00
R8198:Gm4922 UTSW 10 18,659,340 (GRCm39) missense probably benign 0.00
R8270:Gm4922 UTSW 10 18,659,760 (GRCm39) missense probably benign 0.00
R8310:Gm4922 UTSW 10 18,659,536 (GRCm39) missense probably benign 0.09
R9454:Gm4922 UTSW 10 18,660,329 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTGCCATTATGTCAGGGTCTG -3'
(R):5'- CTAGGTGCCAGATTCATGCCTG -3'

Sequencing Primer
(F):5'- CCATTATGTCAGGGTCTGGAAAGC -3'
(R):5'- ATTGGAAAGGCTGTGTGGAGC -3'
Posted On 2015-09-25