Incidental Mutation 'R4605:Ankra2'
ID 345976
Institutional Source Beutler Lab
Gene Symbol Ankra2
Ensembl Gene ENSMUSG00000021661
Gene Name ankyrin repeat family A member 2
Synonyms
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.275) question?
Stock # R4605 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 98399584-98411262 bp(+) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) A to G at 98402742 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000153417 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022164] [ENSMUST00000040972] [ENSMUST00000091356] [ENSMUST00000123924] [ENSMUST00000150352] [ENSMUST00000150916] [ENSMUST00000226100]
AlphaFold Q99PE2
Predicted Effect probably benign
Transcript: ENSMUST00000022164
SMART Domains Protein: ENSMUSP00000022164
Gene: ENSMUSG00000021661

DomainStartEndE-ValueType
ANK 180 209 1.45e-6 SMART
ANK 213 242 1.05e-3 SMART
ANK 246 275 1.76e-5 SMART
Blast:ANK 279 308 1e-7 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000040972
SMART Domains Protein: ENSMUSP00000048204
Gene: ENSMUSG00000041747

DomainStartEndE-ValueType
WD40 31 66 6.85e1 SMART
WD40 69 108 1.66e-5 SMART
WD40 111 150 2.82e-8 SMART
WD40 153 193 7.33e-7 SMART
WD40 196 233 3.9e-2 SMART
WD40 237 276 1.39e-7 SMART
WD40 279 317 1.7e2 SMART
Pfam:UTP15_C 343 490 3.5e-50 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000091356
SMART Domains Protein: ENSMUSP00000088915
Gene: ENSMUSG00000021661

DomainStartEndE-ValueType
ANK 20 49 1.45e-6 SMART
ANK 53 82 1.05e-3 SMART
ANK 86 115 1.76e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000123924
SMART Domains Protein: ENSMUSP00000122701
Gene: ENSMUSG00000021661

DomainStartEndE-ValueType
ANK 180 209 1.45e-6 SMART
ANK 213 242 1.05e-3 SMART
ANK 246 275 1.76e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000150352
SMART Domains Protein: ENSMUSP00000117508
Gene: ENSMUSG00000021661

DomainStartEndE-ValueType
ANK 180 209 1.45e-6 SMART
ANK 213 242 1.05e-3 SMART
ANK 246 275 1.76e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000150916
SMART Domains Protein: ENSMUSP00000116590
Gene: ENSMUSG00000021661

DomainStartEndE-ValueType
ANK 20 49 1.45e-6 SMART
ANK 53 82 1.05e-3 SMART
ANK 86 115 1.76e-5 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155629
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224842
Predicted Effect probably benign
Transcript: ENSMUST00000226100
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223606
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency
Allele List at MGI

All alleles(3) : Targeted(2) Gene trapped(1)

Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp9b T A 18: 80,796,364 (GRCm39) probably null Het
Birc6 G A 17: 74,946,929 (GRCm39) D2885N probably damaging Het
Chaf1b A T 16: 93,684,977 (GRCm39) N142I possibly damaging Het
Ckap5 G A 2: 91,406,559 (GRCm39) G787S probably damaging Het
Ctc1 G T 11: 68,920,552 (GRCm39) C372F possibly damaging Het
Dip2b A G 15: 100,107,517 (GRCm39) T1176A probably benign Het
Epha10 A G 4: 124,779,550 (GRCm39) E132G probably damaging Het
Extl1 A G 4: 134,087,145 (GRCm39) V471A probably benign Het
Fgd6 T C 10: 93,880,217 (GRCm39) L357P probably benign Het
Gapvd1 A T 2: 34,618,549 (GRCm39) C275S probably damaging Het
Kcnj2 G A 11: 110,963,676 (GRCm39) C356Y probably damaging Het
Kcnk10 T C 12: 98,456,219 (GRCm39) D204G probably damaging Het
Krtap9-1 A C 11: 99,764,579 (GRCm39) E105A unknown Het
Loxhd1 G A 18: 77,493,642 (GRCm39) V668I probably benign Het
Ly86 T C 13: 37,558,987 (GRCm39) I62T possibly damaging Het
Maip1 A G 1: 57,450,891 (GRCm39) I178V probably benign Het
Mical3 G A 6: 121,011,041 (GRCm39) Q386* probably null Het
Or5an11 T C 19: 12,246,532 (GRCm39) *313Q probably null Het
Or5b107 T A 19: 13,142,612 (GRCm39) V78D probably damaging Het
Or5p52 A C 7: 107,502,445 (GRCm39) I174L probably benign Het
Or8j3b G A 2: 86,205,141 (GRCm39) T205I probably benign Het
Pcdha12 T C 18: 37,154,576 (GRCm39) S432P probably damaging Het
Prex1 A T 2: 166,555,464 (GRCm39) Y59N probably benign Het
Sbf1 A G 15: 89,187,684 (GRCm39) F654L probably damaging Het
Sh2d5 T A 4: 137,984,566 (GRCm39) Y187* probably null Het
Slc9a4 T C 1: 40,640,195 (GRCm39) probably null Het
Smyd2 A G 1: 189,629,623 (GRCm39) S136P probably damaging Het
Spata31e2 T C 1: 26,722,267 (GRCm39) K971R probably benign Het
Srsf11 A T 3: 157,728,560 (GRCm39) L115* probably null Het
Tbx19 C T 1: 164,981,153 (GRCm39) V114I possibly damaging Het
Unc5b A G 10: 60,610,182 (GRCm39) V545A probably benign Het
Ush2a A G 1: 188,642,998 (GRCm39) Y4120C probably damaging Het
Vps13a T C 19: 16,617,403 (GRCm39) T3002A probably damaging Het
Zkscan2 A T 7: 123,097,947 (GRCm39) W150R probably damaging Het
Other mutations in Ankra2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02168:Ankra2 APN 13 98,409,882 (GRCm39) splice site probably benign
IGL02807:Ankra2 APN 13 98,408,250 (GRCm39) missense probably damaging 1.00
IGL03030:Ankra2 APN 13 98,409,881 (GRCm39) splice site probably benign
R0068:Ankra2 UTSW 13 98,409,891 (GRCm39) nonsense probably null
R0068:Ankra2 UTSW 13 98,409,891 (GRCm39) nonsense probably null
R0302:Ankra2 UTSW 13 98,408,200 (GRCm39) missense probably damaging 1.00
R0499:Ankra2 UTSW 13 98,402,962 (GRCm39) missense probably damaging 1.00
R0729:Ankra2 UTSW 13 98,408,235 (GRCm39) missense probably damaging 1.00
R1848:Ankra2 UTSW 13 98,407,632 (GRCm39) missense probably damaging 1.00
R2185:Ankra2 UTSW 13 98,402,912 (GRCm39) missense probably damaging 0.99
R2230:Ankra2 UTSW 13 98,407,646 (GRCm39) missense probably damaging 0.99
R2232:Ankra2 UTSW 13 98,407,646 (GRCm39) missense probably damaging 0.99
R3898:Ankra2 UTSW 13 98,410,317 (GRCm39) missense probably benign 0.13
R4855:Ankra2 UTSW 13 98,409,919 (GRCm39) missense probably damaging 1.00
R5806:Ankra2 UTSW 13 98,405,005 (GRCm39) critical splice donor site probably null
R5901:Ankra2 UTSW 13 98,407,644 (GRCm39) missense probably damaging 0.99
R6478:Ankra2 UTSW 13 98,404,950 (GRCm39) missense probably damaging 1.00
R7469:Ankra2 UTSW 13 98,402,882 (GRCm39) missense probably benign 0.01
Z1177:Ankra2 UTSW 13 98,408,785 (GRCm39) missense possibly damaging 0.73
Predicted Primers
Posted On 2015-09-25