Incidental Mutation 'R4621:Rexo5'
ID 346148
Institutional Source Beutler Lab
Gene Symbol Rexo5
Ensembl Gene ENSMUSG00000030924
Gene Name RNA exonuclease 5
Synonyms 2610020H08Rik
MMRRC Submission 041886-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.132) question?
Stock # R4621 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 119393229-119448166 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 119418722 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Arginine at position 254 (I254R)
Ref Sequence ENSEMBL: ENSMUSP00000033218 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033218] [ENSMUST00000084644] [ENSMUST00000106520] [ENSMUST00000133758]
AlphaFold D3YW29
Predicted Effect probably benign
Transcript: ENSMUST00000033218
AA Change: I254R

PolyPhen 2 Score 0.186 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000033218
Gene: ENSMUSG00000030924
AA Change: I254R

DomainStartEndE-ValueType
low complexity region 105 116 N/A INTRINSIC
low complexity region 123 134 N/A INTRINSIC
Pfam:RNase_T 225 330 1.4e-12 PFAM
Blast:RRM 424 463 5e-17 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000084644
AA Change: I62R

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000081694
Gene: ENSMUSG00000030924
AA Change: I62R

DomainStartEndE-ValueType
EXOIII 31 189 2.72e-29 SMART
RRM 298 367 3.23e-9 SMART
Blast:RRM 393 437 2e-22 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000106520
AA Change: I254R

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000102130
Gene: ENSMUSG00000030924
AA Change: I254R

DomainStartEndE-ValueType
low complexity region 105 116 N/A INTRINSIC
low complexity region 123 134 N/A INTRINSIC
EXOIII 223 381 2.72e-29 SMART
RRM 491 560 3.23e-9 SMART
RRM 586 661 3.28e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000133758
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137015
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149132
Predicted Effect probably benign
Transcript: ENSMUST00000207042
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.9%
Validation Efficiency 100% (90/90)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal fertility. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 77 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd2 T C 7: 78,975,235 (GRCm39) Y142H probably damaging Het
Abra C T 15: 41,732,620 (GRCm39) D149N probably benign Het
Acin1 A T 14: 54,890,900 (GRCm39) probably benign Het
Adap2 T A 11: 80,064,899 (GRCm39) probably null Het
Afdn A G 17: 14,109,082 (GRCm39) E1535G probably damaging Het
Ajm1 G A 2: 25,468,412 (GRCm39) P500S probably damaging Het
Ak9 A G 10: 41,282,887 (GRCm39) N1218D possibly damaging Het
Angptl1 G A 1: 156,672,494 (GRCm39) V107M probably damaging Het
Arhgap26 G A 18: 39,032,894 (GRCm39) probably benign Het
Cage1 A C 13: 38,209,477 (GRCm39) S61A possibly damaging Het
Cdadc1 T C 14: 59,824,004 (GRCm39) T163A probably benign Het
Celsr2 A T 3: 108,302,532 (GRCm39) V2568D possibly damaging Het
Cep44 G A 8: 56,995,951 (GRCm39) T166M probably damaging Het
Cnksr3 T C 10: 7,076,182 (GRCm39) K187E possibly damaging Het
Cyp20a1 A G 1: 60,415,258 (GRCm39) T295A probably benign Het
Dus2 T A 8: 106,757,074 (GRCm39) M88K probably damaging Het
E330034G19Rik A T 14: 24,346,070 (GRCm39) probably benign Het
Ecrg4 G A 1: 43,776,412 (GRCm39) probably null Het
Efna5 T C 17: 62,958,040 (GRCm39) D72G probably benign Het
Epb41l2 T C 10: 25,378,038 (GRCm39) probably null Het
Espn A G 4: 152,215,709 (GRCm39) S408P probably damaging Het
Evi5l T C 8: 4,252,909 (GRCm39) probably benign Het
F830016B08Rik G A 18: 60,433,939 (GRCm39) V341I probably benign Het
Flii A G 11: 60,606,937 (GRCm39) L1013P possibly damaging Het
Fndc10 G A 4: 155,779,264 (GRCm39) V103M probably damaging Het
Frem3 T A 8: 81,395,820 (GRCm39) probably null Het
Gltp C T 5: 114,812,188 (GRCm39) R106Q probably damaging Het
Gtf3c3 A G 1: 54,458,575 (GRCm39) Y449H probably damaging Het
H1f9 G A 11: 94,858,986 (GRCm39) V94M probably damaging Het
Hmga1b T C 11: 120,653,866 (GRCm39) V51A probably damaging Het
Hsph1 A G 5: 149,542,308 (GRCm39) V705A probably benign Het
Igkv13-84 T C 6: 68,916,783 (GRCm39) S27P possibly damaging Het
Il15ra A G 2: 11,723,140 (GRCm39) N55D possibly damaging Het
Kctd19 T G 8: 106,123,103 (GRCm39) N104H probably damaging Het
Kif27 T G 13: 58,478,827 (GRCm39) D572A probably benign Het
Larp1b G A 3: 40,918,424 (GRCm39) G22R possibly damaging Het
Lcn2 A T 2: 32,274,655 (GRCm39) probably benign Het
Lmtk2 T A 5: 144,111,752 (GRCm39) I824N probably benign Het
Ltbp2 A G 12: 84,856,122 (GRCm39) I707T probably damaging Het
Macf1 A G 4: 123,266,141 (GRCm39) probably null Het
Magel2 A T 7: 62,027,486 (GRCm39) H130L unknown Het
Mcoln1 A G 8: 3,555,923 (GRCm39) I73V probably damaging Het
Mplkipl1 C T 19: 61,164,364 (GRCm39) G24R unknown Het
Mycbp2 G T 14: 103,457,415 (GRCm39) T1627K probably benign Het
Myh8 A G 11: 67,177,084 (GRCm39) E412G probably damaging Het
Myo9a T A 9: 59,778,355 (GRCm39) D1370E probably benign Het
Ndufaf5 A G 2: 140,025,845 (GRCm39) T135A probably benign Het
Neb G A 2: 52,161,051 (GRCm39) Q2207* probably null Het
Nek3 T C 8: 22,647,055 (GRCm39) Y160C probably damaging Het
Or2y6 G C 11: 52,104,706 (GRCm39) L37V probably benign Het
Or5k8 A T 16: 58,644,469 (GRCm39) I201N possibly damaging Het
Osbpl8 A G 10: 111,105,279 (GRCm39) I245V probably benign Het
Pcdh9 T C 14: 94,125,079 (GRCm39) I241V probably benign Het
Pcdhb12 A G 18: 37,570,213 (GRCm39) Q453R probably benign Het
Pcdhb2 A G 18: 37,428,980 (GRCm39) T318A probably benign Het
Prlr T A 15: 10,319,462 (GRCm39) probably benign Het
Ptprz1 C T 6: 23,001,453 (GRCm39) A1181V possibly damaging Het
Racgap1 C A 15: 99,524,087 (GRCm39) S440I probably benign Het
Rap1gap2 A G 11: 74,326,525 (GRCm39) probably null Het
Rbm5 A G 9: 107,631,345 (GRCm39) V244A probably damaging Het
Robo2 A T 16: 73,782,821 (GRCm39) S316T probably benign Het
Satb2 A T 1: 56,884,778 (GRCm39) V382E probably damaging Het
Scg2 C T 1: 79,414,381 (GRCm39) R114Q probably benign Het
Scube2 T C 7: 109,399,857 (GRCm39) D893G possibly damaging Het
Snrpn T C 7: 59,637,274 (GRCm39) D14G possibly damaging Het
Spag17 A G 3: 100,010,559 (GRCm39) T2018A probably benign Het
Spata9 T G 13: 76,116,001 (GRCm39) F17V possibly damaging Het
Supt6 A G 11: 78,103,572 (GRCm39) Y1378H possibly damaging Het
Thsd7b T C 1: 129,358,652 (GRCm39) S29P possibly damaging Het
Tmem59 A T 4: 107,047,915 (GRCm39) probably benign Het
Tmem87a A G 2: 120,227,905 (GRCm39) S81P probably benign Het
Togaram1 A T 12: 65,029,224 (GRCm39) E882D possibly damaging Het
Trbj2-4 T A 6: 41,520,308 (GRCm39) probably benign Het
Trim42 T A 9: 97,245,201 (GRCm39) Y533F probably benign Het
Tssk5 C T 15: 76,256,668 (GRCm39) R280Q probably benign Het
Vmn1r82 A G 7: 12,039,263 (GRCm39) T179A possibly damaging Het
Yipf7 T A 5: 69,676,704 (GRCm39) Q145L possibly damaging Het
Other mutations in Rexo5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01308:Rexo5 APN 7 119,433,499 (GRCm39) missense probably damaging 1.00
R0347:Rexo5 UTSW 7 119,423,119 (GRCm39) critical splice donor site probably null
R0442:Rexo5 UTSW 7 119,442,508 (GRCm39) missense probably damaging 1.00
R0589:Rexo5 UTSW 7 119,444,606 (GRCm39) missense probably benign 0.00
R0980:Rexo5 UTSW 7 119,423,035 (GRCm39) missense probably damaging 1.00
R1465:Rexo5 UTSW 7 119,400,581 (GRCm39) critical splice donor site probably null
R1465:Rexo5 UTSW 7 119,400,581 (GRCm39) critical splice donor site probably null
R1505:Rexo5 UTSW 7 119,398,826 (GRCm39) nonsense probably null
R1775:Rexo5 UTSW 7 119,444,634 (GRCm39) missense probably benign 0.00
R1911:Rexo5 UTSW 7 119,398,867 (GRCm39) missense probably damaging 1.00
R1996:Rexo5 UTSW 7 119,423,080 (GRCm39) missense probably damaging 1.00
R4168:Rexo5 UTSW 7 119,426,621 (GRCm39) intron probably benign
R4169:Rexo5 UTSW 7 119,426,621 (GRCm39) intron probably benign
R4402:Rexo5 UTSW 7 119,433,599 (GRCm39) missense possibly damaging 0.82
R4486:Rexo5 UTSW 7 119,424,800 (GRCm39) missense probably benign 0.00
R4620:Rexo5 UTSW 7 119,426,526 (GRCm39) missense probably benign 0.37
R4865:Rexo5 UTSW 7 119,400,553 (GRCm39) nonsense probably null
R4884:Rexo5 UTSW 7 119,424,774 (GRCm39) nonsense probably null
R5171:Rexo5 UTSW 7 119,423,002 (GRCm39) missense probably damaging 1.00
R5209:Rexo5 UTSW 7 119,433,522 (GRCm39) nonsense probably null
R5266:Rexo5 UTSW 7 119,443,660 (GRCm39) missense probably benign 0.00
R5463:Rexo5 UTSW 7 119,433,526 (GRCm39) missense probably damaging 1.00
R5579:Rexo5 UTSW 7 119,433,626 (GRCm39) critical splice donor site probably null
R6163:Rexo5 UTSW 7 119,404,470 (GRCm39) missense probably damaging 1.00
R6305:Rexo5 UTSW 7 119,427,348 (GRCm39) missense probably damaging 1.00
R7144:Rexo5 UTSW 7 119,404,414 (GRCm39) missense probably damaging 1.00
R7282:Rexo5 UTSW 7 119,417,636 (GRCm39) missense probably damaging 0.97
R8143:Rexo5 UTSW 7 119,433,484 (GRCm39) splice site probably null
R8379:Rexo5 UTSW 7 119,433,508 (GRCm39) missense probably benign 0.03
R8550:Rexo5 UTSW 7 119,400,568 (GRCm39) missense probably benign 0.01
R8841:Rexo5 UTSW 7 119,448,011 (GRCm39) missense probably benign 0.00
R9133:Rexo5 UTSW 7 119,444,667 (GRCm39) missense probably damaging 1.00
R9287:Rexo5 UTSW 7 119,402,025 (GRCm39) missense probably damaging 1.00
R9404:Rexo5 UTSW 7 119,400,542 (GRCm39) missense probably damaging 1.00
R9499:Rexo5 UTSW 7 119,404,480 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AATCCATGTGGCTGAGGGTAGG -3'
(R):5'- TGACAGTACAACTTCAGCAGC -3'

Sequencing Primer
(F):5'- AGGGTAGGTGGTAGCTGGTAC -3'
(R):5'- GGCATACTCTGCTCTAGA -3'
Posted On 2015-09-25