Incidental Mutation 'R4622:Cdc42bpa'
| ID |
346204 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cdc42bpa
|
| Ensembl Gene |
ENSMUSG00000026490 |
| Gene Name |
CDC42 binding protein kinase alpha |
| Synonyms |
DMPK-like, A930014J19Rik |
| MMRRC Submission |
041887-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.834)
|
| Stock # |
R4622 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
179788037-179993168 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 179902223 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Asparagine
at position 493
(K493N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000106746
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000076687]
[ENSMUST00000097450]
[ENSMUST00000097453]
[ENSMUST00000111117]
[ENSMUST00000134959]
[ENSMUST00000212756]
|
| AlphaFold |
Q3UU96 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000076687
AA Change: K493N
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000075980
Gene: ENSMUSG00000026490
AA Change: K493N
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
77 |
343 |
1.06e-86 |
SMART |
|
S_TK_X
|
344 |
406 |
1.18e-15 |
SMART |
|
coiled coil region
|
435 |
588 |
N/A |
INTRINSIC |
|
coiled coil region
|
632 |
735 |
N/A |
INTRINSIC |
|
Pfam:DMPK_coil
|
800 |
860 |
2.7e-29 |
PFAM |
|
C1
|
919 |
968 |
4.09e-7 |
SMART |
|
PH
|
989 |
1109 |
6.02e-8 |
SMART |
|
CNH
|
1134 |
1411 |
3.37e-17 |
SMART |
|
low complexity region
|
1456 |
1468 |
N/A |
INTRINSIC |
|
PBD
|
1477 |
1512 |
2.05e-10 |
SMART |
|
low complexity region
|
1531 |
1546 |
N/A |
INTRINSIC |
|
low complexity region
|
1567 |
1580 |
N/A |
INTRINSIC |
|
low complexity region
|
1606 |
1620 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000097450
AA Change: K493N
PolyPhen 2
Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000095059
Gene: ENSMUSG00000026490
AA Change: K493N
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
77 |
343 |
1.06e-86 |
SMART |
|
S_TK_X
|
344 |
406 |
1.18e-15 |
SMART |
|
coiled coil region
|
435 |
669 |
N/A |
INTRINSIC |
|
coiled coil region
|
713 |
816 |
N/A |
INTRINSIC |
|
Pfam:DMPK_coil
|
881 |
941 |
2.2e-29 |
PFAM |
|
C1
|
1000 |
1049 |
4.09e-7 |
SMART |
|
PH
|
1070 |
1190 |
6.02e-8 |
SMART |
|
CNH
|
1215 |
1492 |
3.37e-17 |
SMART |
|
low complexity region
|
1537 |
1549 |
N/A |
INTRINSIC |
|
PBD
|
1558 |
1593 |
2.05e-10 |
SMART |
|
low complexity region
|
1612 |
1627 |
N/A |
INTRINSIC |
|
low complexity region
|
1648 |
1661 |
N/A |
INTRINSIC |
|
low complexity region
|
1687 |
1701 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000097453
AA Change: K493N
PolyPhen 2
Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000095062
Gene: ENSMUSG00000026490
AA Change: K493N
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
77 |
343 |
1.06e-86 |
SMART |
|
S_TK_X
|
344 |
406 |
1.18e-15 |
SMART |
|
coiled coil region
|
435 |
669 |
N/A |
INTRINSIC |
|
coiled coil region
|
713 |
816 |
N/A |
INTRINSIC |
|
Pfam:DMPK_coil
|
881 |
941 |
2.5e-29 |
PFAM |
|
C1
|
972 |
1021 |
4.09e-7 |
SMART |
|
PH
|
1042 |
1162 |
6.02e-8 |
SMART |
|
CNH
|
1187 |
1464 |
3.37e-17 |
SMART |
|
low complexity region
|
1509 |
1521 |
N/A |
INTRINSIC |
|
PBD
|
1530 |
1565 |
2.05e-10 |
SMART |
|
low complexity region
|
1584 |
1599 |
N/A |
INTRINSIC |
|
low complexity region
|
1620 |
1633 |
N/A |
INTRINSIC |
|
low complexity region
|
1659 |
1673 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000111117
AA Change: K493N
PolyPhen 2
Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000106746
Gene: ENSMUSG00000026490
AA Change: K493N
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
77 |
343 |
1.06e-86 |
SMART |
|
S_TK_X
|
344 |
406 |
1.18e-15 |
SMART |
|
low complexity region
|
484 |
499 |
N/A |
INTRINSIC |
|
Pfam:KELK
|
529 |
608 |
1.1e-32 |
PFAM |
|
coiled coil region
|
713 |
816 |
N/A |
INTRINSIC |
|
Pfam:DMPK_coil
|
881 |
941 |
2.6e-29 |
PFAM |
|
C1
|
1013 |
1062 |
4.09e-7 |
SMART |
|
PH
|
1083 |
1203 |
6.02e-8 |
SMART |
|
CNH
|
1228 |
1505 |
3.37e-17 |
SMART |
|
low complexity region
|
1550 |
1562 |
N/A |
INTRINSIC |
|
PBD
|
1571 |
1606 |
2.05e-10 |
SMART |
|
low complexity region
|
1625 |
1640 |
N/A |
INTRINSIC |
|
low complexity region
|
1661 |
1674 |
N/A |
INTRINSIC |
|
low complexity region
|
1700 |
1714 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000134959
|
| SMART Domains |
Protein: ENSMUSP00000142018
Gene: ENSMUSG00000026490
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:4AW2|A
|
2 |
90 |
1e-58 |
PDB |
|
SCOP:d1koba_
|
50 |
90 |
7e-5 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000212756
AA Change: K493N
PolyPhen 2
Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
|
| Meta Mutation Damage Score |
0.0600 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.3%
|
| Validation Efficiency |
98% (107/109) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 99 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aadacl2 |
A |
T |
3: 59,914,474 (GRCm39) |
N26Y |
probably damaging |
Het |
| Aass |
C |
T |
6: 23,092,329 (GRCm39) |
D194N |
probably damaging |
Het |
| Acp7 |
T |
C |
7: 28,313,822 (GRCm39) |
Y404C |
probably damaging |
Het |
| Acsl1 |
A |
T |
8: 46,979,410 (GRCm39) |
I421L |
probably benign |
Het |
| Adgrb3 |
A |
T |
1: 25,865,569 (GRCm39) |
D91E |
probably damaging |
Het |
| Adgrg3 |
T |
C |
8: 95,767,153 (GRCm39) |
S503P |
probably damaging |
Het |
| Adgrg6 |
A |
T |
10: 14,317,243 (GRCm39) |
C526S |
probably damaging |
Het |
| Arhgap32 |
A |
T |
9: 32,150,644 (GRCm39) |
I15F |
possibly damaging |
Het |
| Arid1b |
G |
T |
17: 5,045,325 (GRCm39) |
|
probably benign |
Het |
| Asnsd1 |
A |
G |
1: 53,387,378 (GRCm39) |
V83A |
probably benign |
Het |
| Atg101 |
A |
G |
15: 101,191,213 (GRCm39) |
|
probably benign |
Het |
| Atp8a1 |
T |
C |
5: 67,840,056 (GRCm39) |
|
probably benign |
Het |
| Aurkb |
T |
A |
11: 68,939,188 (GRCm39) |
L137Q |
probably damaging |
Het |
| AY702103 |
A |
T |
17: 50,547,029 (GRCm39) |
|
noncoding transcript |
Het |
| B3gnt9 |
A |
G |
8: 105,980,477 (GRCm39) |
S304P |
probably benign |
Het |
| Babam2 |
T |
C |
5: 32,164,656 (GRCm39) |
V310A |
probably damaging |
Het |
| Batf |
A |
G |
12: 85,755,327 (GRCm39) |
D60G |
possibly damaging |
Het |
| Baz1a |
A |
T |
12: 54,988,300 (GRCm39) |
I283K |
probably benign |
Het |
| Bmerb1 |
A |
C |
16: 13,911,786 (GRCm39) |
E44A |
possibly damaging |
Het |
| Bst1 |
T |
G |
5: 43,976,261 (GRCm39) |
|
probably benign |
Het |
| C2 |
C |
A |
17: 35,082,650 (GRCm39) |
V490L |
probably damaging |
Het |
| Cacna1e |
T |
C |
1: 154,347,311 (GRCm39) |
E952G |
possibly damaging |
Het |
| Ccnyl1 |
A |
G |
1: 64,757,417 (GRCm39) |
D262G |
probably damaging |
Het |
| Cenpe |
A |
G |
3: 134,949,469 (GRCm39) |
T85A |
probably benign |
Het |
| Ces2e |
T |
A |
8: 105,655,341 (GRCm39) |
|
probably null |
Het |
| Chd3 |
T |
A |
11: 69,239,834 (GRCm39) |
R1665W |
probably damaging |
Het |
| Cpm |
A |
G |
10: 117,506,202 (GRCm39) |
N188D |
possibly damaging |
Het |
| Cspg4b |
A |
G |
13: 113,456,615 (GRCm39) |
D887G |
probably benign |
Het |
| Ctnnd2 |
A |
T |
15: 30,887,315 (GRCm39) |
M781L |
probably benign |
Het |
| Ctnnd2 |
A |
G |
15: 31,009,259 (GRCm39) |
T1094A |
probably benign |
Het |
| Cux1 |
T |
C |
5: 136,337,154 (GRCm39) |
K657R |
probably damaging |
Het |
| Ddx54 |
G |
A |
5: 120,764,488 (GRCm39) |
V732M |
probably damaging |
Het |
| Ecrg4 |
G |
T |
1: 43,781,481 (GRCm39) |
R121L |
possibly damaging |
Het |
| Efna5 |
T |
C |
17: 62,958,040 (GRCm39) |
D72G |
probably benign |
Het |
| Eva1c |
T |
A |
16: 90,694,343 (GRCm39) |
|
probably null |
Het |
| Evi5l |
T |
C |
8: 4,252,909 (GRCm39) |
|
probably benign |
Het |
| Fasl |
A |
G |
1: 161,614,703 (GRCm39) |
L120P |
probably benign |
Het |
| H2-M9 |
A |
T |
17: 36,952,716 (GRCm39) |
|
probably null |
Het |
| Hdgf |
C |
A |
3: 87,821,884 (GRCm39) |
N198K |
possibly damaging |
Het |
| Hspa9 |
A |
T |
18: 35,082,090 (GRCm39) |
M172K |
possibly damaging |
Het |
| Il1r1 |
A |
C |
1: 40,351,580 (GRCm39) |
L406F |
probably damaging |
Het |
| Il31 |
T |
C |
5: 123,618,498 (GRCm39) |
D96G |
probably damaging |
Het |
| Inhbc |
A |
G |
10: 127,193,146 (GRCm39) |
I290T |
probably benign |
Het |
| Lrp2 |
A |
T |
2: 69,290,693 (GRCm39) |
V3589D |
possibly damaging |
Het |
| Lrrc14 |
A |
T |
15: 76,600,540 (GRCm39) |
|
probably benign |
Het |
| Lyst |
G |
A |
13: 13,848,983 (GRCm39) |
A2057T |
probably benign |
Het |
| Macf1 |
A |
G |
4: 123,266,141 (GRCm39) |
|
probably null |
Het |
| Mapk10 |
C |
A |
5: 103,137,590 (GRCm39) |
G209V |
probably damaging |
Het |
| Mcoln1 |
A |
G |
8: 3,555,923 (GRCm39) |
I73V |
probably damaging |
Het |
| Met |
G |
T |
6: 17,513,383 (GRCm39) |
R411L |
probably benign |
Het |
| Mplkipl1 |
C |
T |
19: 61,164,364 (GRCm39) |
G24R |
unknown |
Het |
| Mrpl4 |
G |
A |
9: 20,918,793 (GRCm39) |
R176Q |
probably damaging |
Het |
| Mrtfb |
G |
A |
16: 13,150,570 (GRCm39) |
G102D |
probably damaging |
Het |
| Mtmr3 |
T |
C |
11: 4,441,067 (GRCm39) |
T528A |
possibly damaging |
Het |
| Mtmr7 |
A |
T |
8: 41,034,583 (GRCm39) |
N246K |
probably damaging |
Het |
| Mycbp2 |
G |
T |
14: 103,457,415 (GRCm39) |
T1627K |
probably benign |
Het |
| Necab3 |
A |
G |
2: 154,397,502 (GRCm39) |
|
probably null |
Het |
| Nr1d1 |
C |
T |
11: 98,660,710 (GRCm39) |
C419Y |
probably damaging |
Het |
| Nwd1 |
C |
A |
8: 73,393,928 (GRCm39) |
A397E |
probably damaging |
Het |
| Oas1f |
A |
T |
5: 120,986,390 (GRCm39) |
K114N |
probably damaging |
Het |
| Or13a18 |
T |
A |
7: 140,190,611 (GRCm39) |
C169* |
probably null |
Het |
| Or1e35 |
C |
A |
11: 73,797,737 (GRCm39) |
V194F |
possibly damaging |
Het |
| Or51ab3 |
G |
T |
7: 103,201,361 (GRCm39) |
R123L |
probably benign |
Het |
| Or5k8 |
A |
T |
16: 58,644,469 (GRCm39) |
I201N |
possibly damaging |
Het |
| Or5w13 |
T |
A |
2: 87,523,987 (GRCm39) |
K80* |
probably null |
Het |
| Osbpl8 |
T |
C |
10: 111,127,357 (GRCm39) |
S814P |
probably benign |
Het |
| Pcdhgb7 |
A |
T |
18: 37,886,183 (GRCm39) |
Q451L |
probably benign |
Het |
| Pde7b |
C |
T |
10: 20,294,538 (GRCm39) |
R300Q |
probably damaging |
Het |
| Pgghg |
A |
G |
7: 140,521,409 (GRCm39) |
|
probably null |
Het |
| Plcg1 |
A |
G |
2: 160,589,688 (GRCm39) |
|
probably benign |
Het |
| Plxna2 |
A |
T |
1: 194,494,458 (GRCm39) |
I1892L |
probably benign |
Het |
| Ppt2 |
A |
G |
17: 34,844,875 (GRCm39) |
V123A |
probably benign |
Het |
| Prdx5 |
G |
T |
19: 6,884,341 (GRCm39) |
|
probably benign |
Het |
| Prpf40b |
A |
G |
15: 99,214,197 (GRCm39) |
D819G |
probably benign |
Het |
| Prss3l |
A |
T |
6: 41,422,246 (GRCm39) |
I53N |
probably damaging |
Het |
| Psap |
T |
G |
10: 60,136,630 (GRCm39) |
C536W |
probably damaging |
Het |
| Rab3gap1 |
T |
C |
1: 127,870,156 (GRCm39) |
C919R |
probably benign |
Het |
| Racgap1 |
C |
A |
15: 99,524,087 (GRCm39) |
S440I |
probably benign |
Het |
| Rec8 |
C |
T |
14: 55,862,215 (GRCm39) |
R480C |
probably damaging |
Het |
| Reg3d |
A |
G |
6: 78,354,442 (GRCm39) |
L53S |
probably benign |
Het |
| Rnft2 |
T |
A |
5: 118,370,471 (GRCm39) |
S244C |
probably damaging |
Het |
| Scn2a |
T |
C |
2: 65,582,371 (GRCm39) |
V1573A |
probably benign |
Het |
| Selenoo |
G |
T |
15: 88,979,910 (GRCm39) |
G353* |
probably null |
Het |
| Siva1 |
A |
G |
12: 112,611,501 (GRCm39) |
Y34C |
probably damaging |
Het |
| Slc2a4 |
C |
T |
11: 69,835,600 (GRCm39) |
|
probably benign |
Het |
| Slc39a12 |
A |
T |
2: 14,405,136 (GRCm39) |
T243S |
probably benign |
Het |
| Slc9b2 |
T |
C |
3: 135,038,279 (GRCm39) |
I453T |
probably damaging |
Het |
| Spag17 |
A |
G |
3: 100,010,559 (GRCm39) |
T2018A |
probably benign |
Het |
| Tbc1d24 |
A |
T |
17: 24,427,865 (GRCm39) |
D32E |
probably benign |
Het |
| Tet1 |
T |
A |
10: 62,655,253 (GRCm39) |
H1556L |
possibly damaging |
Het |
| Tmem59 |
A |
T |
4: 107,047,915 (GRCm39) |
|
probably benign |
Het |
| Ttn |
A |
T |
2: 76,731,296 (GRCm39) |
|
probably benign |
Het |
| Uimc1 |
A |
T |
13: 55,225,307 (GRCm39) |
L89H |
probably damaging |
Het |
| Vipas39 |
A |
G |
12: 87,291,317 (GRCm39) |
I343T |
probably damaging |
Het |
| Vmn2r71 |
G |
T |
7: 85,269,817 (GRCm39) |
V443L |
probably benign |
Het |
| Zbtb14 |
G |
A |
17: 69,695,342 (GRCm39) |
D347N |
possibly damaging |
Het |
| Zfp980 |
G |
T |
4: 145,428,627 (GRCm39) |
C452F |
probably damaging |
Het |
| Zmym5 |
T |
A |
14: 57,049,693 (GRCm39) |
|
probably benign |
Het |
| Znfx1 |
T |
C |
2: 166,883,673 (GRCm39) |
T145A |
possibly damaging |
Het |
|
| Other mutations in Cdc42bpa |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00498:Cdc42bpa
|
APN |
1 |
179,933,686 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00807:Cdc42bpa
|
APN |
1 |
179,969,018 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL00972:Cdc42bpa
|
APN |
1 |
179,902,249 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01084:Cdc42bpa
|
APN |
1 |
179,969,839 (GRCm39) |
splice site |
probably benign |
|
|
IGL01149:Cdc42bpa
|
APN |
1 |
179,902,137 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01377:Cdc42bpa
|
APN |
1 |
179,892,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01541:Cdc42bpa
|
APN |
1 |
179,978,723 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL01657:Cdc42bpa
|
APN |
1 |
179,939,431 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01720:Cdc42bpa
|
APN |
1 |
179,938,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02227:Cdc42bpa
|
APN |
1 |
179,921,989 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL02234:Cdc42bpa
|
APN |
1 |
179,978,756 (GRCm39) |
nonsense |
probably null |
|
|
IGL02253:Cdc42bpa
|
APN |
1 |
179,859,161 (GRCm39) |
splice site |
probably benign |
|
|
IGL02587:Cdc42bpa
|
APN |
1 |
179,921,510 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02671:Cdc42bpa
|
APN |
1 |
179,889,387 (GRCm39) |
missense |
probably benign |
|
|
IGL02746:Cdc42bpa
|
APN |
1 |
179,939,312 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02756:Cdc42bpa
|
APN |
1 |
179,936,824 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
IGL02994:Cdc42bpa
|
APN |
1 |
179,827,002 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03073:Cdc42bpa
|
APN |
1 |
179,921,941 (GRCm39) |
splice site |
probably benign |
|
|
IGL03295:Cdc42bpa
|
APN |
1 |
179,977,769 (GRCm39) |
missense |
probably benign |
0.00 |
|
P0022:Cdc42bpa
|
UTSW |
1 |
179,788,841 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4142001:Cdc42bpa
|
UTSW |
1 |
179,859,125 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0125:Cdc42bpa
|
UTSW |
1 |
179,788,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0268:Cdc42bpa
|
UTSW |
1 |
179,983,347 (GRCm39) |
intron |
probably benign |
|
|
R0472:Cdc42bpa
|
UTSW |
1 |
179,867,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0492:Cdc42bpa
|
UTSW |
1 |
179,928,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0609:Cdc42bpa
|
UTSW |
1 |
179,867,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0691:Cdc42bpa
|
UTSW |
1 |
179,972,400 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0738:Cdc42bpa
|
UTSW |
1 |
179,827,027 (GRCm39) |
splice site |
probably benign |
|
|
R1547:Cdc42bpa
|
UTSW |
1 |
179,902,209 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1553:Cdc42bpa
|
UTSW |
1 |
179,921,540 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1601:Cdc42bpa
|
UTSW |
1 |
179,892,566 (GRCm39) |
nonsense |
probably null |
|
|
R1709:Cdc42bpa
|
UTSW |
1 |
179,894,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2101:Cdc42bpa
|
UTSW |
1 |
179,974,533 (GRCm39) |
missense |
probably benign |
0.39 |
|
R2279:Cdc42bpa
|
UTSW |
1 |
179,864,484 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2357:Cdc42bpa
|
UTSW |
1 |
179,894,792 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R2373:Cdc42bpa
|
UTSW |
1 |
179,939,349 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R2570:Cdc42bpa
|
UTSW |
1 |
179,977,742 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R3709:Cdc42bpa
|
UTSW |
1 |
179,892,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3710:Cdc42bpa
|
UTSW |
1 |
179,892,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3816:Cdc42bpa
|
UTSW |
1 |
179,972,451 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3854:Cdc42bpa
|
UTSW |
1 |
179,983,543 (GRCm39) |
intron |
probably benign |
|
|
R3855:Cdc42bpa
|
UTSW |
1 |
179,983,543 (GRCm39) |
intron |
probably benign |
|
|
R3917:Cdc42bpa
|
UTSW |
1 |
179,933,719 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4604:Cdc42bpa
|
UTSW |
1 |
179,936,759 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4664:Cdc42bpa
|
UTSW |
1 |
179,972,130 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4665:Cdc42bpa
|
UTSW |
1 |
179,972,130 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4887:Cdc42bpa
|
UTSW |
1 |
179,972,200 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R4989:Cdc42bpa
|
UTSW |
1 |
179,965,366 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5033:Cdc42bpa
|
UTSW |
1 |
179,892,580 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5050:Cdc42bpa
|
UTSW |
1 |
179,900,018 (GRCm39) |
nonsense |
probably null |
|
|
R5077:Cdc42bpa
|
UTSW |
1 |
179,922,098 (GRCm39) |
intron |
probably benign |
|
|
R5196:Cdc42bpa
|
UTSW |
1 |
179,899,978 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5276:Cdc42bpa
|
UTSW |
1 |
179,965,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5313:Cdc42bpa
|
UTSW |
1 |
179,911,998 (GRCm39) |
missense |
probably benign |
|
|
R5364:Cdc42bpa
|
UTSW |
1 |
179,894,747 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5372:Cdc42bpa
|
UTSW |
1 |
179,892,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5405:Cdc42bpa
|
UTSW |
1 |
179,966,085 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5405:Cdc42bpa
|
UTSW |
1 |
179,894,894 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5646:Cdc42bpa
|
UTSW |
1 |
179,933,659 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5713:Cdc42bpa
|
UTSW |
1 |
179,911,975 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6012:Cdc42bpa
|
UTSW |
1 |
179,892,655 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6029:Cdc42bpa
|
UTSW |
1 |
179,939,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6378:Cdc42bpa
|
UTSW |
1 |
179,921,561 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6609:Cdc42bpa
|
UTSW |
1 |
179,928,839 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7122:Cdc42bpa
|
UTSW |
1 |
179,892,583 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7289:Cdc42bpa
|
UTSW |
1 |
179,889,362 (GRCm39) |
nonsense |
probably null |
|
|
R7670:Cdc42bpa
|
UTSW |
1 |
179,892,646 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7912:Cdc42bpa
|
UTSW |
1 |
179,921,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8139:Cdc42bpa
|
UTSW |
1 |
179,896,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8362:Cdc42bpa
|
UTSW |
1 |
179,989,690 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8378:Cdc42bpa
|
UTSW |
1 |
179,989,709 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8794:Cdc42bpa
|
UTSW |
1 |
179,894,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8835:Cdc42bpa
|
UTSW |
1 |
179,896,916 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8896:Cdc42bpa
|
UTSW |
1 |
179,958,373 (GRCm39) |
intron |
probably benign |
|
|
R9012:Cdc42bpa
|
UTSW |
1 |
179,859,077 (GRCm39) |
missense |
|
|
|
R9110:Cdc42bpa
|
UTSW |
1 |
179,945,258 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9178:Cdc42bpa
|
UTSW |
1 |
179,958,401 (GRCm39) |
missense |
|
|
|
R9184:Cdc42bpa
|
UTSW |
1 |
179,972,301 (GRCm39) |
missense |
probably benign |
0.13 |
|
R9204:Cdc42bpa
|
UTSW |
1 |
179,939,460 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9227:Cdc42bpa
|
UTSW |
1 |
179,933,638 (GRCm39) |
missense |
probably benign |
|
|
R9230:Cdc42bpa
|
UTSW |
1 |
179,933,638 (GRCm39) |
missense |
probably benign |
|
|
R9299:Cdc42bpa
|
UTSW |
1 |
179,972,073 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9366:Cdc42bpa
|
UTSW |
1 |
179,921,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9381:Cdc42bpa
|
UTSW |
1 |
179,969,048 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9461:Cdc42bpa
|
UTSW |
1 |
179,969,861 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9559:Cdc42bpa
|
UTSW |
1 |
179,939,459 (GRCm39) |
critical splice donor site |
probably null |
|
|
X0026:Cdc42bpa
|
UTSW |
1 |
179,788,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Cdc42bpa
|
UTSW |
1 |
179,892,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTCCTGTTCCATTTCATTACAAATGA -3'
(R):5'- TTTCCAGATCAAATTATGAAACCAGA -3'
Sequencing Primer
(F):5'- CAAAACCAAGAGCTAGTTCTTTGAG -3'
(R):5'- TGAAACCAGAACTAATTTTATTTGCC -3'
|
| Posted On |
2015-09-25 |
Incidental Mutation