Incidental Mutation 'R0255:Shprh'
| ID |
34685 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Shprh
|
| Ensembl Gene |
ENSMUSG00000090112 |
| Gene Name |
SNF2 histone linker PHD RING helicase |
| Synonyms |
2610103K11Rik, D230017O13Rik |
| MMRRC Submission |
038486-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0255 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
11025171-11093339 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 11062135 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Serine
at position 1177
(C1177S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132870
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044053]
[ENSMUST00000054814]
[ENSMUST00000159541]
[ENSMUST00000159810]
|
| AlphaFold |
Q7TPQ3 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000044053
AA Change: C1177S
PolyPhen 2
Score 0.922 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000039422
Gene: ENSMUSG00000090112
AA Change: C1177S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
195 |
250 |
3e-12 |
BLAST |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
DEXDc
|
295 |
866 |
4.02e-17 |
SMART |
|
H15
|
431 |
497 |
3.76e-5 |
SMART |
|
PHD
|
651 |
698 |
2.33e-5 |
SMART |
|
low complexity region
|
1393 |
1404 |
N/A |
INTRINSIC |
|
RING
|
1423 |
1469 |
9.68e-3 |
SMART |
|
Pfam:Helicase_C
|
1500 |
1613 |
1.6e-8 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000054814
AA Change: C1177S
PolyPhen 2
Score 0.922 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000125849
Gene: ENSMUSG00000090112
AA Change: C1177S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
195 |
250 |
3e-12 |
BLAST |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
DEXDc
|
295 |
866 |
4.02e-17 |
SMART |
|
H15
|
431 |
497 |
3.76e-5 |
SMART |
|
PHD
|
651 |
698 |
2.33e-5 |
SMART |
|
low complexity region
|
1393 |
1404 |
N/A |
INTRINSIC |
|
RING
|
1423 |
1469 |
9.68e-3 |
SMART |
|
SCOP:d1fuka_
|
1504 |
1616 |
6e-8 |
SMART |
|
Blast:HELICc
|
1533 |
1613 |
4e-46 |
BLAST |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000159541
AA Change: C1177S
PolyPhen 2
Score 0.922 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000132870
Gene: ENSMUSG00000090112
AA Change: C1177S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
195 |
250 |
3e-12 |
BLAST |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
DEXDc
|
295 |
866 |
4.02e-17 |
SMART |
|
H15
|
431 |
497 |
3.76e-5 |
SMART |
|
PHD
|
651 |
698 |
2.33e-5 |
SMART |
|
low complexity region
|
1393 |
1404 |
N/A |
INTRINSIC |
|
RING
|
1423 |
1469 |
9.68e-3 |
SMART |
|
SCOP:d1fuka_
|
1504 |
1619 |
4e-8 |
SMART |
|
Blast:HELICc
|
1533 |
1613 |
6e-46 |
BLAST |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159553
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159810
|
| SMART Domains |
Protein: ENSMUSP00000125457
Gene: ENSMUSG00000090112
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
195 |
250 |
2e-12 |
BLAST |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
DEXDc
|
295 |
866 |
4.02e-17 |
SMART |
|
H15
|
431 |
497 |
3.76e-5 |
SMART |
|
PHD
|
651 |
698 |
2.33e-5 |
SMART |
|
Blast:DEXDc
|
948 |
1026 |
2e-9 |
BLAST |
|
| Meta Mutation Damage Score |
0.3017 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.3%
- 20x: 95.6%
|
| Validation Efficiency |
93% (102/110) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).[supplied by OMIM, Mar 2008]
PHENOTYPE: The gene product is an E3 ligase involved in poly-ubiquitination of Pcna. Neither homozygous truncation nor KO affect B cell somatic hypermutation or class switching. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 108 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700113H08Rik |
T |
C |
10: 87,061,907 (GRCm39) |
F119S |
probably damaging |
Het |
| Abca13 |
C |
A |
11: 9,531,545 (GRCm39) |
Q4591K |
probably damaging |
Het |
| Anapc1 |
A |
T |
2: 128,476,631 (GRCm39) |
M1329K |
probably damaging |
Het |
| Aoah |
A |
T |
13: 21,163,710 (GRCm39) |
K338* |
probably null |
Het |
| Ascc3 |
A |
T |
10: 50,521,154 (GRCm39) |
T416S |
probably benign |
Het |
| Baz2a |
A |
G |
10: 127,950,508 (GRCm39) |
T484A |
possibly damaging |
Het |
| Btnl6 |
T |
C |
17: 34,727,477 (GRCm39) |
N351S |
probably benign |
Het |
| Cacna1s |
T |
G |
1: 136,046,544 (GRCm39) |
I1772S |
possibly damaging |
Het |
| Ccdc8 |
A |
G |
7: 16,729,582 (GRCm39) |
D357G |
unknown |
Het |
| Ccna1 |
T |
C |
3: 54,958,049 (GRCm39) |
E152G |
probably damaging |
Het |
| Cct4 |
A |
G |
11: 22,949,073 (GRCm39) |
D273G |
probably damaging |
Het |
| Cd9 |
A |
G |
6: 125,440,703 (GRCm39) |
V96A |
probably damaging |
Het |
| Cdc5l |
G |
A |
17: 45,726,610 (GRCm39) |
R321W |
probably damaging |
Het |
| Cdh20 |
T |
C |
1: 109,922,036 (GRCm39) |
S43P |
probably benign |
Het |
| Cep95 |
G |
A |
11: 106,702,097 (GRCm39) |
V365M |
probably benign |
Het |
| Ces1c |
T |
C |
8: 93,854,152 (GRCm39) |
T128A |
probably benign |
Het |
| Chil5 |
A |
G |
3: 105,926,583 (GRCm39) |
V82A |
probably damaging |
Het |
| Clmn |
T |
C |
12: 104,748,023 (GRCm39) |
D508G |
probably benign |
Het |
| Cog8 |
A |
T |
8: 107,775,777 (GRCm39) |
|
probably benign |
Het |
| Cst3 |
A |
T |
2: 148,717,089 (GRCm39) |
V70E |
probably damaging |
Het |
| Ctcf |
A |
G |
8: 106,390,671 (GRCm39) |
T93A |
possibly damaging |
Het |
| Ctsk |
C |
A |
3: 95,416,188 (GRCm39) |
N315K |
probably benign |
Het |
| Cyp2j12 |
G |
T |
4: 96,029,262 (GRCm39) |
D6E |
probably benign |
Het |
| Dhx34 |
A |
G |
7: 15,939,917 (GRCm39) |
V655A |
probably benign |
Het |
| Dock10 |
T |
C |
1: 80,583,593 (GRCm39) |
Y203C |
probably damaging |
Het |
| Dok7 |
A |
T |
5: 35,221,678 (GRCm39) |
D26V |
probably damaging |
Het |
| Epha8 |
G |
A |
4: 136,667,597 (GRCm39) |
H295Y |
probably damaging |
Het |
| Esf1 |
A |
G |
2: 139,990,843 (GRCm39) |
|
probably benign |
Het |
| Fam83c |
A |
G |
2: 155,671,672 (GRCm39) |
S588P |
probably benign |
Het |
| Fat3 |
G |
A |
9: 15,881,002 (GRCm39) |
|
probably benign |
Het |
| Fhdc1 |
T |
C |
3: 84,360,817 (GRCm39) |
|
probably benign |
Het |
| Frmd4b |
A |
G |
6: 97,285,047 (GRCm39) |
V338A |
probably damaging |
Het |
| Fsd1l |
A |
G |
4: 53,694,727 (GRCm39) |
T394A |
probably damaging |
Het |
| Gbf1 |
A |
G |
19: 46,242,549 (GRCm39) |
|
probably benign |
Het |
| Glg1 |
G |
T |
8: 111,886,490 (GRCm39) |
Q1101K |
possibly damaging |
Het |
| Glt8d2 |
T |
A |
10: 82,487,361 (GRCm39) |
|
probably null |
Het |
| Gm19345 |
T |
C |
7: 19,588,855 (GRCm39) |
|
probably benign |
Het |
| Gpr179 |
A |
T |
11: 97,226,892 (GRCm39) |
D1754E |
probably benign |
Het |
| Hydin |
A |
G |
8: 111,291,650 (GRCm39) |
T3381A |
probably benign |
Het |
| Igkv12-41 |
G |
A |
6: 69,835,822 (GRCm39) |
T16I |
possibly damaging |
Het |
| Insl5 |
A |
G |
4: 102,875,313 (GRCm39) |
*146Q |
probably null |
Het |
| Iqce |
A |
T |
5: 140,651,957 (GRCm39) |
I655N |
possibly damaging |
Het |
| Irf2bp1 |
G |
A |
7: 18,738,927 (GRCm39) |
R189H |
possibly damaging |
Het |
| Itprid2 |
T |
A |
2: 79,490,810 (GRCm39) |
L976Q |
probably damaging |
Het |
| Itsn1 |
C |
T |
16: 91,602,978 (GRCm39) |
|
probably benign |
Het |
| Kansl3 |
A |
T |
1: 36,384,050 (GRCm39) |
I724N |
probably benign |
Het |
| Kcna4 |
T |
C |
2: 107,126,907 (GRCm39) |
I547T |
probably damaging |
Het |
| Klk1b4 |
A |
T |
7: 43,860,158 (GRCm39) |
I91F |
probably benign |
Het |
| Lmbr1 |
A |
G |
5: 29,457,753 (GRCm39) |
S282P |
probably damaging |
Het |
| Lrrc17 |
G |
A |
5: 21,765,967 (GRCm39) |
A150T |
probably benign |
Het |
| Lrrc2 |
A |
G |
9: 110,809,966 (GRCm39) |
E334G |
possibly damaging |
Het |
| Lrrc7 |
G |
A |
3: 157,866,475 (GRCm39) |
Q1077* |
probably null |
Het |
| Mapk8 |
A |
T |
14: 33,109,264 (GRCm39) |
|
probably benign |
Het |
| Mast1 |
T |
A |
8: 85,638,650 (GRCm39) |
T1560S |
probably benign |
Het |
| Mdh1b |
C |
A |
1: 63,758,777 (GRCm39) |
A272S |
probably damaging |
Het |
| Myo15b |
T |
C |
11: 115,777,109 (GRCm39) |
Y912H |
probably damaging |
Het |
| Nf1 |
T |
G |
11: 79,299,525 (GRCm39) |
|
probably null |
Het |
| Nme7 |
T |
A |
1: 164,172,944 (GRCm39) |
D218E |
probably damaging |
Het |
| Nsun7 |
T |
A |
5: 66,446,751 (GRCm39) |
|
probably benign |
Het |
| Nxpe2 |
A |
G |
9: 48,251,870 (GRCm39) |
|
probably null |
Het |
| Or1e34 |
A |
G |
11: 73,778,655 (GRCm39) |
V181A |
probably benign |
Het |
| Or2ag16 |
G |
A |
7: 106,352,196 (GRCm39) |
T133I |
probably benign |
Het |
| Or2n1c |
T |
G |
17: 38,519,286 (GRCm39) |
I50R |
probably benign |
Het |
| Or5p53 |
T |
A |
7: 107,533,375 (GRCm39) |
V216D |
probably damaging |
Het |
| P2ry1 |
T |
C |
3: 60,910,951 (GRCm39) |
V30A |
probably benign |
Het |
| Pgm2 |
T |
A |
5: 64,269,386 (GRCm39) |
I491N |
possibly damaging |
Het |
| Pkd1l3 |
A |
T |
8: 110,365,386 (GRCm39) |
D1169V |
probably damaging |
Het |
| Poldip2 |
T |
A |
11: 78,403,189 (GRCm39) |
S18T |
probably benign |
Het |
| Prg4 |
C |
T |
1: 150,331,558 (GRCm39) |
|
probably benign |
Het |
| Prkab2 |
T |
A |
3: 97,574,728 (GRCm39) |
Y241* |
probably null |
Het |
| Prmt7 |
A |
G |
8: 106,953,839 (GRCm39) |
|
probably benign |
Het |
| Proser3 |
T |
A |
7: 30,245,842 (GRCm39) |
R80W |
probably damaging |
Het |
| Prr12 |
A |
G |
7: 44,699,415 (GRCm39) |
|
probably benign |
Het |
| Psmd1 |
A |
T |
1: 86,006,304 (GRCm39) |
L223F |
probably damaging |
Het |
| Rab13 |
A |
G |
3: 90,131,088 (GRCm39) |
|
probably benign |
Het |
| Rgl1 |
C |
T |
1: 152,428,347 (GRCm39) |
C294Y |
probably damaging |
Het |
| Rpl21-ps4 |
C |
A |
14: 11,227,556 (GRCm38) |
|
noncoding transcript |
Het |
| Rusc2 |
T |
C |
4: 43,423,954 (GRCm39) |
V1036A |
probably damaging |
Het |
| Sae1 |
T |
A |
7: 16,104,247 (GRCm39) |
K121* |
probably null |
Het |
| Sap130 |
C |
T |
18: 31,813,559 (GRCm39) |
P539S |
probably damaging |
Het |
| Saxo4 |
C |
T |
19: 10,452,418 (GRCm39) |
R364Q |
probably damaging |
Het |
| Scube2 |
A |
G |
7: 109,424,079 (GRCm39) |
L475P |
probably damaging |
Het |
| Sec16a |
T |
C |
2: 26,321,198 (GRCm39) |
D1298G |
probably damaging |
Het |
| Serpinb9b |
T |
C |
13: 33,222,003 (GRCm39) |
F206L |
probably benign |
Het |
| Sh3bp1 |
T |
A |
15: 78,788,534 (GRCm39) |
Y202* |
probably null |
Het |
| Slc27a6 |
T |
C |
18: 58,742,937 (GRCm39) |
Y542H |
possibly damaging |
Het |
| Slc41a1 |
T |
C |
1: 131,771,650 (GRCm39) |
|
probably benign |
Het |
| Slc46a1 |
T |
C |
11: 78,361,625 (GRCm39) |
F424L |
probably damaging |
Het |
| Slc66a2 |
C |
T |
18: 80,306,733 (GRCm39) |
A101V |
probably benign |
Het |
| Slc6a12 |
G |
A |
6: 121,333,877 (GRCm39) |
V238I |
probably damaging |
Het |
| Slc6a20a |
A |
G |
9: 123,493,686 (GRCm39) |
V65A |
probably damaging |
Het |
| Slc9c1 |
T |
A |
16: 45,374,663 (GRCm39) |
S343T |
probably benign |
Het |
| Spcs3 |
C |
A |
8: 54,981,415 (GRCm39) |
R60I |
probably benign |
Het |
| Tbc1d16 |
C |
A |
11: 119,038,401 (GRCm39) |
R764L |
possibly damaging |
Het |
| Tcaf2 |
A |
T |
6: 42,619,838 (GRCm39) |
V63E |
possibly damaging |
Het |
| Tmc1 |
G |
T |
19: 20,766,951 (GRCm39) |
A750E |
possibly damaging |
Het |
| Tmem273 |
A |
G |
14: 32,530,320 (GRCm39) |
K83E |
possibly damaging |
Het |
| Tmem81 |
C |
G |
1: 132,435,567 (GRCm39) |
I124M |
probably damaging |
Het |
| Tmx3 |
T |
C |
18: 90,558,130 (GRCm39) |
I394T |
probably damaging |
Het |
| Trank1 |
G |
A |
9: 111,195,092 (GRCm39) |
E1039K |
possibly damaging |
Het |
| Trpc4ap |
A |
G |
2: 155,499,866 (GRCm39) |
|
probably benign |
Het |
| Tsen54 |
T |
C |
11: 115,706,234 (GRCm39) |
C123R |
probably damaging |
Het |
| Ubtd1 |
A |
G |
19: 42,020,373 (GRCm39) |
D39G |
possibly damaging |
Het |
| Vmn1r181 |
A |
T |
7: 23,683,759 (GRCm39) |
M75L |
probably benign |
Het |
| Zc3h7a |
T |
C |
16: 10,958,601 (GRCm39) |
T847A |
probably damaging |
Het |
| Zc3hav1 |
A |
G |
6: 38,313,485 (GRCm39) |
C187R |
probably damaging |
Het |
| Zfp692 |
G |
A |
11: 58,201,229 (GRCm39) |
|
probably benign |
Het |
| Zmiz1 |
G |
A |
14: 25,654,919 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Shprh |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00492:Shprh
|
APN |
10 |
11,063,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00583:Shprh
|
APN |
10 |
11,063,764 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL00684:Shprh
|
APN |
10 |
11,038,781 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL01295:Shprh
|
APN |
10 |
11,059,612 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01387:Shprh
|
APN |
10 |
11,045,998 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01635:Shprh
|
APN |
10 |
11,045,763 (GRCm39) |
nonsense |
probably null |
|
|
IGL01833:Shprh
|
APN |
10 |
11,066,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02013:Shprh
|
APN |
10 |
11,057,246 (GRCm39) |
splice site |
probably benign |
|
|
IGL02502:Shprh
|
APN |
10 |
11,070,101 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
IGL02819:Shprh
|
APN |
10 |
11,030,509 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
PIT4581001:Shprh
|
UTSW |
10 |
11,068,238 (GRCm39) |
frame shift |
probably null |
|
|
R0010:Shprh
|
UTSW |
10 |
11,027,675 (GRCm39) |
missense |
probably benign |
|
|
R0010:Shprh
|
UTSW |
10 |
11,027,675 (GRCm39) |
missense |
probably benign |
|
|
R0053:Shprh
|
UTSW |
10 |
11,070,116 (GRCm39) |
splice site |
probably null |
|
|
R0053:Shprh
|
UTSW |
10 |
11,070,116 (GRCm39) |
splice site |
probably null |
|
|
R0325:Shprh
|
UTSW |
10 |
11,045,853 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0331:Shprh
|
UTSW |
10 |
11,069,914 (GRCm39) |
splice site |
probably benign |
|
|
R0494:Shprh
|
UTSW |
10 |
11,032,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0532:Shprh
|
UTSW |
10 |
11,038,556 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0546:Shprh
|
UTSW |
10 |
11,059,631 (GRCm39) |
splice site |
probably benign |
|
|
R0574:Shprh
|
UTSW |
10 |
11,038,821 (GRCm39) |
unclassified |
probably benign |
|
|
R0605:Shprh
|
UTSW |
10 |
11,082,856 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0662:Shprh
|
UTSW |
10 |
11,062,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1148:Shprh
|
UTSW |
10 |
11,089,226 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1148:Shprh
|
UTSW |
10 |
11,089,226 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1263:Shprh
|
UTSW |
10 |
11,035,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1588:Shprh
|
UTSW |
10 |
11,040,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1638:Shprh
|
UTSW |
10 |
11,032,822 (GRCm39) |
missense |
probably benign |
|
|
R1830:Shprh
|
UTSW |
10 |
11,062,655 (GRCm39) |
splice site |
probably null |
|
|
R1898:Shprh
|
UTSW |
10 |
11,062,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1903:Shprh
|
UTSW |
10 |
11,059,541 (GRCm39) |
nonsense |
probably null |
|
|
R2060:Shprh
|
UTSW |
10 |
11,027,864 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2225:Shprh
|
UTSW |
10 |
11,037,979 (GRCm39) |
unclassified |
probably benign |
|
|
R2363:Shprh
|
UTSW |
10 |
11,047,697 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2509:Shprh
|
UTSW |
10 |
11,042,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2891:Shprh
|
UTSW |
10 |
11,040,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3077:Shprh
|
UTSW |
10 |
11,046,157 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3150:Shprh
|
UTSW |
10 |
11,045,774 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3796:Shprh
|
UTSW |
10 |
11,054,501 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4196:Shprh
|
UTSW |
10 |
11,083,604 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R4423:Shprh
|
UTSW |
10 |
11,062,262 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4488:Shprh
|
UTSW |
10 |
11,036,215 (GRCm39) |
missense |
probably benign |
0.17 |
|
R4748:Shprh
|
UTSW |
10 |
11,046,220 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4768:Shprh
|
UTSW |
10 |
11,057,284 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4867:Shprh
|
UTSW |
10 |
11,040,301 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4937:Shprh
|
UTSW |
10 |
11,032,863 (GRCm39) |
missense |
probably benign |
|
|
R5140:Shprh
|
UTSW |
10 |
11,030,449 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5318:Shprh
|
UTSW |
10 |
11,042,301 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5323:Shprh
|
UTSW |
10 |
11,046,041 (GRCm39) |
splice site |
probably null |
|
|
R5450:Shprh
|
UTSW |
10 |
11,088,074 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R5872:Shprh
|
UTSW |
10 |
11,063,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6030:Shprh
|
UTSW |
10 |
11,027,735 (GRCm39) |
missense |
probably benign |
0.37 |
|
R6030:Shprh
|
UTSW |
10 |
11,027,735 (GRCm39) |
missense |
probably benign |
0.37 |
|
R6392:Shprh
|
UTSW |
10 |
11,054,485 (GRCm39) |
nonsense |
probably null |
|
|
R6416:Shprh
|
UTSW |
10 |
11,043,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6470:Shprh
|
UTSW |
10 |
11,047,681 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6513:Shprh
|
UTSW |
10 |
11,062,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6530:Shprh
|
UTSW |
10 |
11,070,011 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6678:Shprh
|
UTSW |
10 |
11,042,289 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6757:Shprh
|
UTSW |
10 |
11,057,252 (GRCm39) |
splice site |
probably null |
|
|
R6971:Shprh
|
UTSW |
10 |
11,042,437 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7158:Shprh
|
UTSW |
10 |
11,042,474 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7582:Shprh
|
UTSW |
10 |
11,040,449 (GRCm39) |
missense |
probably benign |
|
|
R7757:Shprh
|
UTSW |
10 |
11,037,924 (GRCm39) |
missense |
probably benign |
0.30 |
|
R7812:Shprh
|
UTSW |
10 |
11,027,735 (GRCm39) |
missense |
probably benign |
|
|
R7998:Shprh
|
UTSW |
10 |
11,061,085 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8061:Shprh
|
UTSW |
10 |
11,088,077 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8082:Shprh
|
UTSW |
10 |
11,027,555 (GRCm39) |
missense |
probably benign |
0.22 |
|
R8116:Shprh
|
UTSW |
10 |
11,089,205 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8390:Shprh
|
UTSW |
10 |
11,063,727 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8445:Shprh
|
UTSW |
10 |
11,057,313 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8530:Shprh
|
UTSW |
10 |
11,027,678 (GRCm39) |
missense |
probably benign |
0.37 |
|
R8759:Shprh
|
UTSW |
10 |
11,032,908 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8937:Shprh
|
UTSW |
10 |
11,061,181 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R8995:Shprh
|
UTSW |
10 |
11,040,574 (GRCm39) |
nonsense |
probably null |
|
|
R9053:Shprh
|
UTSW |
10 |
11,030,446 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9131:Shprh
|
UTSW |
10 |
11,038,589 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R9176:Shprh
|
UTSW |
10 |
11,036,320 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9391:Shprh
|
UTSW |
10 |
11,038,633 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9423:Shprh
|
UTSW |
10 |
11,081,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9563:Shprh
|
UTSW |
10 |
11,042,235 (GRCm39) |
nonsense |
probably null |
|
|
R9668:Shprh
|
UTSW |
10 |
11,082,076 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9709:Shprh
|
UTSW |
10 |
11,038,574 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9718:Shprh
|
UTSW |
10 |
11,089,248 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9750:Shprh
|
UTSW |
10 |
11,040,204 (GRCm39) |
missense |
probably damaging |
0.98 |
|
RF012:Shprh
|
UTSW |
10 |
11,040,585 (GRCm39) |
missense |
probably benign |
0.02 |
|
V8831:Shprh
|
UTSW |
10 |
11,062,606 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Shprh
|
UTSW |
10 |
11,062,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Shprh
|
UTSW |
10 |
11,040,297 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Shprh
|
UTSW |
10 |
11,027,506 (GRCm39) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ACTGTATCCTCTCTGTTAGGTCCCAAG -3'
(R):5'- TTCATCAGCTTTACAAAAGACGCAGC -3'
Sequencing Primer
(F):5'- GTTAGGTCCCAAGAATAGAATTACC -3'
(R):5'- CAACCATTTCTGAGATCATGCGG -3'
|
| Posted On |
2013-05-09 |
Incidental Mutation