Incidental Mutation 'R0255:Myo15b'
| ID |
34700 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Myo15b
|
| Ensembl Gene |
ENSMUSG00000034427 |
| Gene Name |
myosin XVB |
| Synonyms |
LOC217328, LOC380737, E330039G21Rik |
| MMRRC Submission |
038486-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.069)
|
| Stock # |
R0255 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
115749232-115783429 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 115777109 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Histidine
at position 912
(Y912H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000152405
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000040703]
[ENSMUST00000093911]
[ENSMUST00000125835]
[ENSMUST00000167507]
[ENSMUST00000222123]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000040703
AA Change: Y680H
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000048072
Gene: ENSMUSG00000034427
AA Change: Y680H
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
93 |
111 |
N/A |
INTRINSIC |
|
low complexity region
|
179 |
213 |
N/A |
INTRINSIC |
|
low complexity region
|
250 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
345 |
370 |
N/A |
INTRINSIC |
|
low complexity region
|
497 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
532 |
552 |
N/A |
INTRINSIC |
|
Blast:MYSc
|
587 |
775 |
3e-15 |
BLAST |
|
SH3
|
778 |
835 |
1.15e-7 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000093911
AA Change: Y2334H
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000091439
Gene: ENSMUSG00000034427
AA Change: Y2334H
| Domain | Start | End | E-Value | Type |
|---|
|
MYSc
|
1 |
640 |
2.4e-134 |
SMART |
|
IQ
|
660 |
682 |
1.03e1 |
SMART |
|
Pfam:MyTH4
|
837 |
945 |
2.1e-23 |
PFAM |
|
low complexity region
|
1050 |
1068 |
N/A |
INTRINSIC |
|
low complexity region
|
1136 |
1170 |
N/A |
INTRINSIC |
|
low complexity region
|
1207 |
1246 |
N/A |
INTRINSIC |
|
low complexity region
|
1302 |
1327 |
N/A |
INTRINSIC |
|
low complexity region
|
1454 |
1468 |
N/A |
INTRINSIC |
|
low complexity region
|
1489 |
1509 |
N/A |
INTRINSIC |
|
SH3
|
1735 |
1792 |
1.15e-7 |
SMART |
|
Pfam:MyTH4
|
1928 |
2029 |
8.3e-25 |
PFAM |
|
B41
|
2032 |
2235 |
6.99e-4 |
SMART |
|
low complexity region
|
2243 |
2253 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000125835
|
| SMART Domains |
Protein: ENSMUSP00000144423
Gene: ENSMUSG00000034427
| Domain | Start | End | E-Value | Type |
|---|
|
SH3
|
75 |
132 |
7e-10 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000132447
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000141947
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000167507
|
| SMART Domains |
Protein: ENSMUSP00000129226
Gene: ENSMUSG00000034427
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:MyTH4
|
100 |
205 |
3.1e-24 |
PFAM |
|
B41
|
207 |
410 |
6.99e-4 |
SMART |
|
low complexity region
|
418 |
428 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000222123
AA Change: Y912H
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Meta Mutation Damage Score |
0.2168 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.3%
- 20x: 95.6%
|
| Validation Efficiency |
93% (102/110) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 108 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700113H08Rik |
T |
C |
10: 87,061,907 (GRCm39) |
F119S |
probably damaging |
Het |
| Abca13 |
C |
A |
11: 9,531,545 (GRCm39) |
Q4591K |
probably damaging |
Het |
| Anapc1 |
A |
T |
2: 128,476,631 (GRCm39) |
M1329K |
probably damaging |
Het |
| Aoah |
A |
T |
13: 21,163,710 (GRCm39) |
K338* |
probably null |
Het |
| Ascc3 |
A |
T |
10: 50,521,154 (GRCm39) |
T416S |
probably benign |
Het |
| Baz2a |
A |
G |
10: 127,950,508 (GRCm39) |
T484A |
possibly damaging |
Het |
| Btnl6 |
T |
C |
17: 34,727,477 (GRCm39) |
N351S |
probably benign |
Het |
| Cacna1s |
T |
G |
1: 136,046,544 (GRCm39) |
I1772S |
possibly damaging |
Het |
| Ccdc8 |
A |
G |
7: 16,729,582 (GRCm39) |
D357G |
unknown |
Het |
| Ccna1 |
T |
C |
3: 54,958,049 (GRCm39) |
E152G |
probably damaging |
Het |
| Cct4 |
A |
G |
11: 22,949,073 (GRCm39) |
D273G |
probably damaging |
Het |
| Cd9 |
A |
G |
6: 125,440,703 (GRCm39) |
V96A |
probably damaging |
Het |
| Cdc5l |
G |
A |
17: 45,726,610 (GRCm39) |
R321W |
probably damaging |
Het |
| Cdh20 |
T |
C |
1: 109,922,036 (GRCm39) |
S43P |
probably benign |
Het |
| Cep95 |
G |
A |
11: 106,702,097 (GRCm39) |
V365M |
probably benign |
Het |
| Ces1c |
T |
C |
8: 93,854,152 (GRCm39) |
T128A |
probably benign |
Het |
| Chil5 |
A |
G |
3: 105,926,583 (GRCm39) |
V82A |
probably damaging |
Het |
| Clmn |
T |
C |
12: 104,748,023 (GRCm39) |
D508G |
probably benign |
Het |
| Cog8 |
A |
T |
8: 107,775,777 (GRCm39) |
|
probably benign |
Het |
| Cst3 |
A |
T |
2: 148,717,089 (GRCm39) |
V70E |
probably damaging |
Het |
| Ctcf |
A |
G |
8: 106,390,671 (GRCm39) |
T93A |
possibly damaging |
Het |
| Ctsk |
C |
A |
3: 95,416,188 (GRCm39) |
N315K |
probably benign |
Het |
| Cyp2j12 |
G |
T |
4: 96,029,262 (GRCm39) |
D6E |
probably benign |
Het |
| Dhx34 |
A |
G |
7: 15,939,917 (GRCm39) |
V655A |
probably benign |
Het |
| Dock10 |
T |
C |
1: 80,583,593 (GRCm39) |
Y203C |
probably damaging |
Het |
| Dok7 |
A |
T |
5: 35,221,678 (GRCm39) |
D26V |
probably damaging |
Het |
| Epha8 |
G |
A |
4: 136,667,597 (GRCm39) |
H295Y |
probably damaging |
Het |
| Esf1 |
A |
G |
2: 139,990,843 (GRCm39) |
|
probably benign |
Het |
| Fam83c |
A |
G |
2: 155,671,672 (GRCm39) |
S588P |
probably benign |
Het |
| Fat3 |
G |
A |
9: 15,881,002 (GRCm39) |
|
probably benign |
Het |
| Fhdc1 |
T |
C |
3: 84,360,817 (GRCm39) |
|
probably benign |
Het |
| Frmd4b |
A |
G |
6: 97,285,047 (GRCm39) |
V338A |
probably damaging |
Het |
| Fsd1l |
A |
G |
4: 53,694,727 (GRCm39) |
T394A |
probably damaging |
Het |
| Gbf1 |
A |
G |
19: 46,242,549 (GRCm39) |
|
probably benign |
Het |
| Glg1 |
G |
T |
8: 111,886,490 (GRCm39) |
Q1101K |
possibly damaging |
Het |
| Glt8d2 |
T |
A |
10: 82,487,361 (GRCm39) |
|
probably null |
Het |
| Gm19345 |
T |
C |
7: 19,588,855 (GRCm39) |
|
probably benign |
Het |
| Gpr179 |
A |
T |
11: 97,226,892 (GRCm39) |
D1754E |
probably benign |
Het |
| Hydin |
A |
G |
8: 111,291,650 (GRCm39) |
T3381A |
probably benign |
Het |
| Igkv12-41 |
G |
A |
6: 69,835,822 (GRCm39) |
T16I |
possibly damaging |
Het |
| Insl5 |
A |
G |
4: 102,875,313 (GRCm39) |
*146Q |
probably null |
Het |
| Iqce |
A |
T |
5: 140,651,957 (GRCm39) |
I655N |
possibly damaging |
Het |
| Irf2bp1 |
G |
A |
7: 18,738,927 (GRCm39) |
R189H |
possibly damaging |
Het |
| Itprid2 |
T |
A |
2: 79,490,810 (GRCm39) |
L976Q |
probably damaging |
Het |
| Itsn1 |
C |
T |
16: 91,602,978 (GRCm39) |
|
probably benign |
Het |
| Kansl3 |
A |
T |
1: 36,384,050 (GRCm39) |
I724N |
probably benign |
Het |
| Kcna4 |
T |
C |
2: 107,126,907 (GRCm39) |
I547T |
probably damaging |
Het |
| Klk1b4 |
A |
T |
7: 43,860,158 (GRCm39) |
I91F |
probably benign |
Het |
| Lmbr1 |
A |
G |
5: 29,457,753 (GRCm39) |
S282P |
probably damaging |
Het |
| Lrrc17 |
G |
A |
5: 21,765,967 (GRCm39) |
A150T |
probably benign |
Het |
| Lrrc2 |
A |
G |
9: 110,809,966 (GRCm39) |
E334G |
possibly damaging |
Het |
| Lrrc7 |
G |
A |
3: 157,866,475 (GRCm39) |
Q1077* |
probably null |
Het |
| Mapk8 |
A |
T |
14: 33,109,264 (GRCm39) |
|
probably benign |
Het |
| Mast1 |
T |
A |
8: 85,638,650 (GRCm39) |
T1560S |
probably benign |
Het |
| Mdh1b |
C |
A |
1: 63,758,777 (GRCm39) |
A272S |
probably damaging |
Het |
| Nf1 |
T |
G |
11: 79,299,525 (GRCm39) |
|
probably null |
Het |
| Nme7 |
T |
A |
1: 164,172,944 (GRCm39) |
D218E |
probably damaging |
Het |
| Nsun7 |
T |
A |
5: 66,446,751 (GRCm39) |
|
probably benign |
Het |
| Nxpe2 |
A |
G |
9: 48,251,870 (GRCm39) |
|
probably null |
Het |
| Or1e34 |
A |
G |
11: 73,778,655 (GRCm39) |
V181A |
probably benign |
Het |
| Or2ag16 |
G |
A |
7: 106,352,196 (GRCm39) |
T133I |
probably benign |
Het |
| Or2n1c |
T |
G |
17: 38,519,286 (GRCm39) |
I50R |
probably benign |
Het |
| Or5p53 |
T |
A |
7: 107,533,375 (GRCm39) |
V216D |
probably damaging |
Het |
| P2ry1 |
T |
C |
3: 60,910,951 (GRCm39) |
V30A |
probably benign |
Het |
| Pgm2 |
T |
A |
5: 64,269,386 (GRCm39) |
I491N |
possibly damaging |
Het |
| Pkd1l3 |
A |
T |
8: 110,365,386 (GRCm39) |
D1169V |
probably damaging |
Het |
| Poldip2 |
T |
A |
11: 78,403,189 (GRCm39) |
S18T |
probably benign |
Het |
| Prg4 |
C |
T |
1: 150,331,558 (GRCm39) |
|
probably benign |
Het |
| Prkab2 |
T |
A |
3: 97,574,728 (GRCm39) |
Y241* |
probably null |
Het |
| Prmt7 |
A |
G |
8: 106,953,839 (GRCm39) |
|
probably benign |
Het |
| Proser3 |
T |
A |
7: 30,245,842 (GRCm39) |
R80W |
probably damaging |
Het |
| Prr12 |
A |
G |
7: 44,699,415 (GRCm39) |
|
probably benign |
Het |
| Psmd1 |
A |
T |
1: 86,006,304 (GRCm39) |
L223F |
probably damaging |
Het |
| Rab13 |
A |
G |
3: 90,131,088 (GRCm39) |
|
probably benign |
Het |
| Rgl1 |
C |
T |
1: 152,428,347 (GRCm39) |
C294Y |
probably damaging |
Het |
| Rpl21-ps4 |
C |
A |
14: 11,227,556 (GRCm38) |
|
noncoding transcript |
Het |
| Rusc2 |
T |
C |
4: 43,423,954 (GRCm39) |
V1036A |
probably damaging |
Het |
| Sae1 |
T |
A |
7: 16,104,247 (GRCm39) |
K121* |
probably null |
Het |
| Sap130 |
C |
T |
18: 31,813,559 (GRCm39) |
P539S |
probably damaging |
Het |
| Saxo4 |
C |
T |
19: 10,452,418 (GRCm39) |
R364Q |
probably damaging |
Het |
| Scube2 |
A |
G |
7: 109,424,079 (GRCm39) |
L475P |
probably damaging |
Het |
| Sec16a |
T |
C |
2: 26,321,198 (GRCm39) |
D1298G |
probably damaging |
Het |
| Serpinb9b |
T |
C |
13: 33,222,003 (GRCm39) |
F206L |
probably benign |
Het |
| Sh3bp1 |
T |
A |
15: 78,788,534 (GRCm39) |
Y202* |
probably null |
Het |
| Shprh |
T |
A |
10: 11,062,135 (GRCm39) |
C1177S |
possibly damaging |
Het |
| Slc27a6 |
T |
C |
18: 58,742,937 (GRCm39) |
Y542H |
possibly damaging |
Het |
| Slc41a1 |
T |
C |
1: 131,771,650 (GRCm39) |
|
probably benign |
Het |
| Slc46a1 |
T |
C |
11: 78,361,625 (GRCm39) |
F424L |
probably damaging |
Het |
| Slc66a2 |
C |
T |
18: 80,306,733 (GRCm39) |
A101V |
probably benign |
Het |
| Slc6a12 |
G |
A |
6: 121,333,877 (GRCm39) |
V238I |
probably damaging |
Het |
| Slc6a20a |
A |
G |
9: 123,493,686 (GRCm39) |
V65A |
probably damaging |
Het |
| Slc9c1 |
T |
A |
16: 45,374,663 (GRCm39) |
S343T |
probably benign |
Het |
| Spcs3 |
C |
A |
8: 54,981,415 (GRCm39) |
R60I |
probably benign |
Het |
| Tbc1d16 |
C |
A |
11: 119,038,401 (GRCm39) |
R764L |
possibly damaging |
Het |
| Tcaf2 |
A |
T |
6: 42,619,838 (GRCm39) |
V63E |
possibly damaging |
Het |
| Tmc1 |
G |
T |
19: 20,766,951 (GRCm39) |
A750E |
possibly damaging |
Het |
| Tmem273 |
A |
G |
14: 32,530,320 (GRCm39) |
K83E |
possibly damaging |
Het |
| Tmem81 |
C |
G |
1: 132,435,567 (GRCm39) |
I124M |
probably damaging |
Het |
| Tmx3 |
T |
C |
18: 90,558,130 (GRCm39) |
I394T |
probably damaging |
Het |
| Trank1 |
G |
A |
9: 111,195,092 (GRCm39) |
E1039K |
possibly damaging |
Het |
| Trpc4ap |
A |
G |
2: 155,499,866 (GRCm39) |
|
probably benign |
Het |
| Tsen54 |
T |
C |
11: 115,706,234 (GRCm39) |
C123R |
probably damaging |
Het |
| Ubtd1 |
A |
G |
19: 42,020,373 (GRCm39) |
D39G |
possibly damaging |
Het |
| Vmn1r181 |
A |
T |
7: 23,683,759 (GRCm39) |
M75L |
probably benign |
Het |
| Zc3h7a |
T |
C |
16: 10,958,601 (GRCm39) |
T847A |
probably damaging |
Het |
| Zc3hav1 |
A |
G |
6: 38,313,485 (GRCm39) |
C187R |
probably damaging |
Het |
| Zfp692 |
G |
A |
11: 58,201,229 (GRCm39) |
|
probably benign |
Het |
| Zmiz1 |
G |
A |
14: 25,654,919 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Myo15b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00556:Myo15b
|
APN |
11 |
115,782,742 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL01409:Myo15b
|
APN |
11 |
115,760,330 (GRCm39) |
nonsense |
probably null |
|
|
IGL01539:Myo15b
|
APN |
11 |
115,754,299 (GRCm39) |
missense |
probably benign |
0.43 |
|
IGL01895:Myo15b
|
APN |
11 |
115,774,324 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
IGL02254:Myo15b
|
APN |
11 |
115,777,109 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02343:Myo15b
|
APN |
11 |
115,764,226 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02349:Myo15b
|
APN |
11 |
115,753,931 (GRCm39) |
splice site |
probably benign |
|
|
IGL02368:Myo15b
|
APN |
11 |
115,767,828 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL02576:Myo15b
|
APN |
11 |
115,780,879 (GRCm39) |
missense |
probably null |
0.97 |
|
IGL02650:Myo15b
|
APN |
11 |
115,777,337 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02661:Myo15b
|
APN |
11 |
115,774,895 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02716:Myo15b
|
APN |
11 |
115,774,535 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL02733:Myo15b
|
APN |
11 |
115,775,076 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02951:Myo15b
|
APN |
11 |
115,772,127 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03017:Myo15b
|
APN |
11 |
115,778,743 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL03029:Myo15b
|
APN |
11 |
115,762,469 (GRCm39) |
missense |
probably benign |
0.08 |
|
ANU74:Myo15b
|
UTSW |
11 |
115,769,239 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0092:Myo15b
|
UTSW |
11 |
115,753,812 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0325:Myo15b
|
UTSW |
11 |
115,775,091 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0614:Myo15b
|
UTSW |
11 |
115,773,739 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0652:Myo15b
|
UTSW |
11 |
115,755,468 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0711:Myo15b
|
UTSW |
11 |
115,774,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0815:Myo15b
|
UTSW |
11 |
115,757,162 (GRCm39) |
splice site |
probably benign |
|
|
R0961:Myo15b
|
UTSW |
11 |
115,773,280 (GRCm39) |
missense |
probably benign |
0.15 |
|
R1066:Myo15b
|
UTSW |
11 |
115,770,577 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1221:Myo15b
|
UTSW |
11 |
115,777,546 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R1240:Myo15b
|
UTSW |
11 |
115,771,327 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R1275:Myo15b
|
UTSW |
11 |
115,774,318 (GRCm39) |
small deletion |
probably benign |
|
|
R1313:Myo15b
|
UTSW |
11 |
115,775,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1313:Myo15b
|
UTSW |
11 |
115,775,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1317:Myo15b
|
UTSW |
11 |
115,774,460 (GRCm39) |
missense |
probably null |
0.14 |
|
R1491:Myo15b
|
UTSW |
11 |
115,777,683 (GRCm39) |
splice site |
probably null |
|
|
R1552:Myo15b
|
UTSW |
11 |
115,757,461 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1731:Myo15b
|
UTSW |
11 |
115,782,386 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R1800:Myo15b
|
UTSW |
11 |
115,771,335 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1843:Myo15b
|
UTSW |
11 |
115,760,412 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1888:Myo15b
|
UTSW |
11 |
115,777,899 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1888:Myo15b
|
UTSW |
11 |
115,777,899 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1894:Myo15b
|
UTSW |
11 |
115,777,899 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1917:Myo15b
|
UTSW |
11 |
115,773,080 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R1934:Myo15b
|
UTSW |
11 |
115,754,310 (GRCm39) |
missense |
probably benign |
0.30 |
|
R1939:Myo15b
|
UTSW |
11 |
115,778,529 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1945:Myo15b
|
UTSW |
11 |
115,769,224 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1986:Myo15b
|
UTSW |
11 |
115,773,701 (GRCm39) |
missense |
probably benign |
0.31 |
|
R2130:Myo15b
|
UTSW |
11 |
115,762,469 (GRCm39) |
missense |
probably benign |
0.08 |
|
R2138:Myo15b
|
UTSW |
11 |
115,774,633 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2176:Myo15b
|
UTSW |
11 |
115,757,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2415:Myo15b
|
UTSW |
11 |
115,770,390 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2483:Myo15b
|
UTSW |
11 |
115,755,565 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3620:Myo15b
|
UTSW |
11 |
115,762,013 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R3716:Myo15b
|
UTSW |
11 |
115,754,239 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4013:Myo15b
|
UTSW |
11 |
115,762,282 (GRCm39) |
nonsense |
probably null |
|
|
R4021:Myo15b
|
UTSW |
11 |
115,764,331 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4119:Myo15b
|
UTSW |
11 |
115,764,318 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4120:Myo15b
|
UTSW |
11 |
115,764,318 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4499:Myo15b
|
UTSW |
11 |
115,781,778 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4653:Myo15b
|
UTSW |
11 |
115,770,813 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4655:Myo15b
|
UTSW |
11 |
115,781,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4700:Myo15b
|
UTSW |
11 |
115,752,761 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4702:Myo15b
|
UTSW |
11 |
115,774,834 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4777:Myo15b
|
UTSW |
11 |
115,770,478 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4833:Myo15b
|
UTSW |
11 |
115,778,428 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R5083:Myo15b
|
UTSW |
11 |
115,757,482 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5121:Myo15b
|
UTSW |
11 |
115,776,880 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5146:Myo15b
|
UTSW |
11 |
115,782,024 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5535:Myo15b
|
UTSW |
11 |
115,772,127 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5647:Myo15b
|
UTSW |
11 |
115,762,337 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5849:Myo15b
|
UTSW |
11 |
115,772,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5882:Myo15b
|
UTSW |
11 |
115,760,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5956:Myo15b
|
UTSW |
11 |
115,764,583 (GRCm39) |
missense |
probably benign |
0.34 |
|
R6273:Myo15b
|
UTSW |
11 |
115,753,625 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R6302:Myo15b
|
UTSW |
11 |
115,777,065 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6318:Myo15b
|
UTSW |
11 |
115,781,657 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6462:Myo15b
|
UTSW |
11 |
115,750,268 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6792:Myo15b
|
UTSW |
11 |
115,775,923 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6963:Myo15b
|
UTSW |
11 |
115,781,540 (GRCm39) |
splice site |
probably null |
|
|
R7015:Myo15b
|
UTSW |
11 |
115,762,670 (GRCm39) |
missense |
|
|
|
R7020:Myo15b
|
UTSW |
11 |
115,757,493 (GRCm39) |
nonsense |
probably null |
|
|
R7096:Myo15b
|
UTSW |
11 |
115,782,324 (GRCm39) |
splice site |
probably null |
|
|
R7219:Myo15b
|
UTSW |
11 |
115,767,921 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7400:Myo15b
|
UTSW |
11 |
115,750,939 (GRCm39) |
missense |
|
|
|
R7413:Myo15b
|
UTSW |
11 |
115,768,970 (GRCm39) |
missense |
|
|
|
R7483:Myo15b
|
UTSW |
11 |
115,749,570 (GRCm39) |
missense |
|
|
|
R7523:Myo15b
|
UTSW |
11 |
115,781,684 (GRCm39) |
missense |
unknown |
|
|
R7737:Myo15b
|
UTSW |
11 |
115,778,749 (GRCm39) |
missense |
unknown |
|
|
R7784:Myo15b
|
UTSW |
11 |
115,752,166 (GRCm39) |
missense |
|
|
|
R7842:Myo15b
|
UTSW |
11 |
115,762,321 (GRCm39) |
missense |
|
|
|
R7921:Myo15b
|
UTSW |
11 |
115,778,004 (GRCm39) |
nonsense |
probably null |
|
|
R8065:Myo15b
|
UTSW |
11 |
115,778,769 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8183:Myo15b
|
UTSW |
11 |
115,773,843 (GRCm39) |
splice site |
probably null |
|
|
R8193:Myo15b
|
UTSW |
11 |
115,775,973 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8237:Myo15b
|
UTSW |
11 |
115,767,827 (GRCm39) |
missense |
|
|
|
R8430:Myo15b
|
UTSW |
11 |
115,773,049 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8482:Myo15b
|
UTSW |
11 |
115,774,083 (GRCm39) |
nonsense |
probably null |
|
|
R8515:Myo15b
|
UTSW |
11 |
115,749,610 (GRCm39) |
missense |
|
|
|
R8798:Myo15b
|
UTSW |
11 |
115,754,232 (GRCm39) |
missense |
|
|
|
R8937:Myo15b
|
UTSW |
11 |
115,773,127 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8975:Myo15b
|
UTSW |
11 |
115,781,780 (GRCm39) |
missense |
unknown |
|
|
R9045:Myo15b
|
UTSW |
11 |
115,783,178 (GRCm39) |
makesense |
probably null |
|
|
R9117:Myo15b
|
UTSW |
11 |
115,778,743 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9185:Myo15b
|
UTSW |
11 |
115,771,255 (GRCm39) |
missense |
unknown |
|
|
R9226:Myo15b
|
UTSW |
11 |
115,750,924 (GRCm39) |
missense |
|
|
|
R9302:Myo15b
|
UTSW |
11 |
115,776,238 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9318:Myo15b
|
UTSW |
11 |
115,775,965 (GRCm39) |
missense |
probably benign |
0.26 |
|
R9336:Myo15b
|
UTSW |
11 |
115,771,064 (GRCm39) |
missense |
|
|
|
R9337:Myo15b
|
UTSW |
11 |
115,749,861 (GRCm39) |
missense |
|
|
|
R9338:Myo15b
|
UTSW |
11 |
115,762,238 (GRCm39) |
missense |
|
|
|
R9498:Myo15b
|
UTSW |
11 |
115,770,784 (GRCm39) |
missense |
|
|
|
R9500:Myo15b
|
UTSW |
11 |
115,777,466 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9602:Myo15b
|
UTSW |
11 |
115,769,269 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9642:Myo15b
|
UTSW |
11 |
115,772,335 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
X0020:Myo15b
|
UTSW |
11 |
115,762,625 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1176:Myo15b
|
UTSW |
11 |
115,778,751 (GRCm39) |
missense |
unknown |
|
|
Z1176:Myo15b
|
UTSW |
11 |
115,774,278 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCTGGGTAATATATGCACTGCCAC -3'
(R):5'- CATTCTTCAAGGACAGCTCCAGGG -3'
Sequencing Primer
(F):5'- GGACACCTTCACAGAGTCCTG -3'
(R):5'- CTGTAGGAACAGAGTGTCTTCAGC -3'
|
| Posted On |
2013-05-09 |
Incidental Mutation