Incidental Mutation 'R4670:Cyp4f37'
ID 348392
Institutional Source Beutler Lab
Gene Symbol Cyp4f37
Ensembl Gene ENSMUSG00000062464
Gene Name cytochrome P450, family 4, subfamily f, polypeptide 37
Synonyms Gm9705
MMRRC Submission 041926-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.222) question?
Stock # R4670 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 32840283-32855158 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 32844126 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 77 (M77L)
Ref Sequence ENSEMBL: ENSMUSP00000076827 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077639]
AlphaFold Q3V1F1
Predicted Effect probably benign
Transcript: ENSMUST00000077639
AA Change: M77L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000076827
Gene: ENSMUSG00000062464
AA Change: M77L

DomainStartEndE-ValueType
Pfam:p450 52 515 1.1e-136 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.8%
Validation Efficiency 97% (69/71)
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsm5 T A 7: 119,130,983 (GRCm39) probably null Het
Alb T A 5: 90,610,665 (GRCm39) S82T probably benign Het
Arf4 A G 14: 26,374,248 (GRCm39) probably benign Het
Arhgap22 T C 14: 33,084,500 (GRCm39) C260R probably damaging Het
Arhgap32 A G 9: 32,081,441 (GRCm39) E153G probably benign Het
Arhgef18 T A 8: 3,484,897 (GRCm39) M200K probably damaging Het
Atp1a4 T A 1: 172,062,567 (GRCm39) N647Y probably benign Het
Atp5f1c A T 2: 10,064,428 (GRCm39) L226Q probably damaging Het
Bcas1 T C 2: 170,226,245 (GRCm39) K310R probably damaging Het
Cadm3 T A 1: 173,174,013 (GRCm39) T67S probably damaging Het
Cartpt C T 13: 100,036,588 (GRCm39) probably null Het
Cenpj A T 14: 56,790,840 (GRCm39) V403E possibly damaging Het
Chst7 C A X: 19,927,110 (GRCm39) R386S probably damaging Het
Dnah7b A T 1: 46,117,684 (GRCm39) D50V probably damaging Het
Galnt4 A G 10: 98,945,160 (GRCm39) D295G possibly damaging Het
Gin1 C T 1: 97,712,565 (GRCm39) P154S probably damaging Het
Gm6471 G A 7: 142,385,360 (GRCm39) noncoding transcript Het
Gm6818 T A 7: 38,101,981 (GRCm39) noncoding transcript Het
Gm9271 T A 7: 39,013,734 (GRCm39) noncoding transcript Het
Gpam A G 19: 55,084,551 (GRCm39) probably null Het
Gpr183 T C 14: 122,192,149 (GRCm39) D124G probably damaging Het
Ift140 C A 17: 25,317,935 (GRCm39) probably benign Het
Itih5 A C 2: 10,195,180 (GRCm39) I191L probably benign Het
Jcad A G 18: 4,674,175 (GRCm39) T646A probably benign Het
Kank1 T C 19: 25,387,944 (GRCm39) M511T probably benign Het
Krt74 A T 15: 101,667,304 (GRCm39) noncoding transcript Het
Lrrc37a A G 11: 103,395,363 (GRCm39) S21P probably benign Het
Lrrc8c G A 5: 105,756,240 (GRCm39) V672I probably benign Het
Lypd4 T C 7: 24,566,151 (GRCm39) R58G probably benign Het
Magi1 A T 6: 93,663,624 (GRCm39) probably null Het
Mefv T A 16: 3,526,071 (GRCm39) L745F possibly damaging Het
Myh13 A T 11: 67,255,564 (GRCm39) K1645* probably null Het
Naip6 A G 13: 100,431,239 (GRCm39) probably null Het
Nlrp1c-ps T C 11: 71,171,382 (GRCm39) noncoding transcript Het
Nsmce3 A T 7: 64,522,530 (GRCm39) L46Q probably benign Het
Or51aa2 A G 7: 103,188,393 (GRCm39) V16A possibly damaging Het
Or6k6 T A 1: 173,945,427 (GRCm39) M52L probably benign Het
Or8k37 T C 2: 86,469,512 (GRCm39) D180G possibly damaging Het
P2ry12 T C 3: 59,125,325 (GRCm39) probably null Het
Pcx T A 19: 4,669,916 (GRCm39) V861E probably damaging Het
Pkp3 C T 7: 140,662,612 (GRCm39) P75S probably benign Het
Plscr4 T C 9: 92,364,920 (GRCm39) probably null Het
Pole A G 5: 110,454,253 (GRCm39) T923A probably benign Het
Ptgir A G 7: 16,640,794 (GRCm39) M29V possibly damaging Het
Rhot2 A C 17: 26,060,305 (GRCm39) probably benign Het
Rsrp1 A G 4: 134,651,488 (GRCm39) Y84C unknown Het
Sbf2 T C 7: 109,934,606 (GRCm39) K1348E probably damaging Het
Sgip1 A T 4: 102,726,951 (GRCm39) N53Y probably damaging Het
Snapc2 A G 8: 4,304,998 (GRCm39) T127A possibly damaging Het
Snx8 A G 5: 140,341,713 (GRCm39) probably null Het
Spag8 A G 4: 43,653,378 (GRCm39) probably benign Het
Srebf2 T C 15: 82,076,503 (GRCm39) F718L probably damaging Het
Szt2 C G 4: 118,233,026 (GRCm39) probably benign Het
Traf3ip2 C T 10: 39,515,256 (GRCm39) P345S possibly damaging Het
Tubgcp4 T A 2: 121,004,146 (GRCm39) Y62* probably null Het
Usp29 T A 7: 6,965,914 (GRCm39) S586T possibly damaging Het
Vasp T C 7: 18,998,350 (GRCm39) N108S probably benign Het
Vmn1r214 A G 13: 23,219,141 (GRCm39) M212V probably benign Het
Wipi2 G C 5: 142,645,345 (GRCm39) A194P probably benign Het
Zbtb4 T A 11: 69,667,355 (GRCm39) I220N probably damaging Het
Zcchc2 A T 1: 105,917,996 (GRCm39) probably benign Het
Zfp729a T A 13: 67,769,534 (GRCm39) K232* probably null Het
Zfp995 A T 17: 22,106,320 (GRCm39) M1K probably null Het
Other mutations in Cyp4f37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01140:Cyp4f37 APN 17 32,848,027 (GRCm39) missense probably benign 0.20
IGL01994:Cyp4f37 APN 17 32,844,150 (GRCm39) nonsense probably null
IGL02073:Cyp4f37 APN 17 32,846,825 (GRCm39) missense possibly damaging 0.59
IGL02145:Cyp4f37 APN 17 32,849,009 (GRCm39) missense probably benign 0.43
IGL02814:Cyp4f37 APN 17 32,853,645 (GRCm39) missense probably benign 0.01
IGL02873:Cyp4f37 APN 17 32,844,142 (GRCm39) missense probably benign 0.00
IGL02937:Cyp4f37 APN 17 32,844,163 (GRCm39) missense probably benign 0.00
IGL03170:Cyp4f37 APN 17 32,844,093 (GRCm39) splice site probably benign
R0625:Cyp4f37 UTSW 17 32,853,652 (GRCm39) missense probably damaging 1.00
R1774:Cyp4f37 UTSW 17 32,848,864 (GRCm39) missense possibly damaging 0.59
R1871:Cyp4f37 UTSW 17 32,853,639 (GRCm39) missense probably damaging 1.00
R2232:Cyp4f37 UTSW 17 32,853,244 (GRCm39) missense probably benign 0.23
R2847:Cyp4f37 UTSW 17 32,848,099 (GRCm39) missense probably damaging 1.00
R2848:Cyp4f37 UTSW 17 32,848,099 (GRCm39) missense probably damaging 1.00
R4027:Cyp4f37 UTSW 17 32,850,646 (GRCm39) missense probably benign 0.00
R4463:Cyp4f37 UTSW 17 32,846,710 (GRCm39) critical splice acceptor site probably null
R4517:Cyp4f37 UTSW 17 32,850,566 (GRCm39) missense probably benign 0.00
R4573:Cyp4f37 UTSW 17 32,848,061 (GRCm39) missense probably benign 0.23
R5752:Cyp4f37 UTSW 17 32,850,306 (GRCm39) missense probably damaging 1.00
R5930:Cyp4f37 UTSW 17 32,848,957 (GRCm39) missense possibly damaging 0.79
R6248:Cyp4f37 UTSW 17 32,848,864 (GRCm39) missense possibly damaging 0.59
R7412:Cyp4f37 UTSW 17 32,848,818 (GRCm39) missense possibly damaging 0.87
R7969:Cyp4f37 UTSW 17 32,844,181 (GRCm39) missense probably benign 0.00
R8066:Cyp4f37 UTSW 17 32,854,047 (GRCm39) missense probably benign 0.21
R8187:Cyp4f37 UTSW 17 32,854,171 (GRCm39) missense probably benign
R8303:Cyp4f37 UTSW 17 32,853,152 (GRCm39) critical splice acceptor site probably null
R8309:Cyp4f37 UTSW 17 32,853,952 (GRCm39) missense probably damaging 1.00
R8407:Cyp4f37 UTSW 17 32,853,158 (GRCm39) missense probably damaging 1.00
R8869:Cyp4f37 UTSW 17 32,844,096 (GRCm39) missense probably benign 0.01
R9054:Cyp4f37 UTSW 17 32,853,253 (GRCm39) missense probably benign 0.25
R9565:Cyp4f37 UTSW 17 32,844,205 (GRCm39) missense possibly damaging 0.79
R9674:Cyp4f37 UTSW 17 32,846,841 (GRCm39) critical splice donor site probably null
X0057:Cyp4f37 UTSW 17 32,844,198 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CTCATGTGTACAGGAAGGGG -3'
(R):5'- CTGACAGATTCAGCCCCATC -3'

Sequencing Primer
(F):5'- GGCACATGTAGTTGAAGTATTGACTC -3'
(R):5'- CTGGTCAATCCCGGGATAGAGTG -3'
Posted On 2015-10-08