Incidental Mutation 'R4672:Adamdec1'
ID 348567
Institutional Source Beutler Lab
Gene Symbol Adamdec1
Ensembl Gene ENSMUSG00000022057
Gene Name ADAM-like, decysin 1
Synonyms Dcsn, 2210414L24Rik
MMRRC Submission 041927-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # R4672 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 68800829-68819535 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 68815353 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Stop codon at position 104 (E104*)
Ref Sequence ENSEMBL: ENSMUSP00000022641 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022641]
AlphaFold Q9R0X2
Predicted Effect probably null
Transcript: ENSMUST00000022641
AA Change: E104*
SMART Domains Protein: ENSMUSP00000022641
Gene: ENSMUSG00000022057
AA Change: E104*

DomainStartEndE-ValueType
signal peptide 1 33 N/A INTRINSIC
Pfam:Pep_M12B_propep 37 175 3.9e-29 PFAM
Pfam:Reprolysin_5 215 389 9.8e-17 PFAM
Pfam:Reprolysin_4 216 407 7.3e-12 PFAM
Pfam:Reprolysin 217 411 1.5e-57 PFAM
Pfam:Reprolysin_3 242 360 1e-11 PFAM
DISIN 427 465 1.12e-3 SMART
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.8%
Validation Efficiency 98% (113/115)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This encoded protein is thought to be a secreted protein belonging to the disintegrin metalloproteinase family. Its expression is upregulated during dendritic cells maturation. This protein may play an important role in dendritic cell function and their interactions with germinal center T cells. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 105 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8a G A 11: 109,962,702 (GRCm39) L483F possibly damaging Het
Abca8b A G 11: 109,827,274 (GRCm39) F1507L possibly damaging Het
Adamts16 G A 13: 70,927,637 (GRCm39) probably benign Het
Alppl2 T C 1: 87,017,187 (GRCm39) probably benign Het
Aplnr A G 2: 84,967,524 (GRCm39) Y183C probably damaging Het
Atm G A 9: 53,433,501 (GRCm39) R250W probably damaging Het
B4galt7 T C 13: 55,757,132 (GRCm39) L275P probably damaging Het
Bltp1 A G 3: 36,944,139 (GRCm39) *330W probably null Het
Ccdc178 G A 18: 22,283,501 (GRCm39) Q10* probably null Het
Ccr9 T C 9: 123,608,752 (GRCm39) Y145H probably damaging Het
Cd209f C T 8: 4,153,685 (GRCm39) G188D probably damaging Het
Cep70 T A 9: 99,136,365 (GRCm39) S23T possibly damaging Het
Cpped1 C A 16: 11,623,238 (GRCm39) E294* probably null Het
Crisp1 T A 17: 40,605,404 (GRCm39) probably null Het
Disp1 T C 1: 182,880,215 (GRCm39) probably null Het
Dlg2 A T 7: 91,935,743 (GRCm39) M624L probably damaging Het
Elf2 A G 3: 51,163,855 (GRCm39) V558A probably damaging Het
Eno2 T C 6: 124,743,109 (GRCm39) D209G probably damaging Het
Fam187b G A 7: 30,676,968 (GRCm39) R159H probably damaging Het
Fh1 G A 1: 175,431,617 (GRCm39) A423V probably benign Het
Frg1 C T 8: 41,853,846 (GRCm39) D164N probably benign Het
Fsbp T G 4: 11,579,841 (GRCm39) N36K probably benign Het
Gcn1 A G 5: 115,744,579 (GRCm39) T1592A probably damaging Het
Gimap3 A G 6: 48,742,687 (GRCm39) I81T probably damaging Het
Gjb6 C T 14: 57,362,235 (GRCm39) V9I probably benign Het
Gkap1 T C 13: 58,411,770 (GRCm39) S68G possibly damaging Het
Gpatch8 A T 11: 102,369,784 (GRCm39) S1251R probably damaging Het
Gria4 A G 9: 4,664,981 (GRCm39) F92L possibly damaging Het
H2-Q1 C A 17: 35,539,906 (GRCm39) D58E probably damaging Het
Hs1bp3 G T 12: 8,391,983 (GRCm39) G362* probably null Het
Igfn1 T A 1: 135,893,107 (GRCm39) H2114L possibly damaging Het
Igkv12-98 A G 6: 68,547,940 (GRCm39) Q22R probably benign Het
Ing3 A G 6: 21,965,729 (GRCm39) probably null Het
Insr C T 8: 3,217,501 (GRCm39) probably null Het
Kdm3b T C 18: 34,941,630 (GRCm39) S374P probably benign Het
Kif14 A C 1: 136,449,016 (GRCm39) Q1472P probably benign Het
Kif14 G T 1: 136,449,017 (GRCm39) Q1472H probably benign Het
Knstrn A G 2: 118,664,512 (GRCm39) E202G probably damaging Het
Knstrn G T 2: 118,664,513 (GRCm39) E202D possibly damaging Het
Krt12 A G 11: 99,309,509 (GRCm39) probably benign Het
Lgi3 A T 14: 70,771,897 (GRCm39) I195F possibly damaging Het
Lima1 T C 15: 99,741,590 (GRCm39) N29D probably damaging Het
Liph T C 16: 21,802,806 (GRCm39) I88V probably benign Het
Lrrk1 A G 7: 65,929,120 (GRCm39) S86P probably benign Het
Lsamp A G 16: 41,775,697 (GRCm39) R166G probably damaging Het
Mamdc2 T A 19: 23,328,148 (GRCm39) N407Y probably damaging Het
Mast3 CATA CA 8: 71,237,441 (GRCm39) probably null Het
Megf6 T A 4: 154,333,909 (GRCm39) N212K probably damaging Het
Met A C 6: 17,571,803 (GRCm39) D1374A probably benign Het
Mrc2 A G 11: 105,233,923 (GRCm39) T902A probably benign Het
Mroh3 T A 1: 136,118,713 (GRCm39) T535S probably benign Het
Muc1 G T 3: 89,139,384 (GRCm39) V595L probably damaging Het
Myh2 T A 11: 67,079,303 (GRCm39) L957Q probably damaging Het
Myorg T A 4: 41,499,061 (GRCm39) M190L probably benign Het
Ncl A T 1: 86,284,324 (GRCm39) D257E probably benign Het
Nipbl T A 15: 8,332,468 (GRCm39) D2263V probably damaging Het
Optc C A 1: 133,825,555 (GRCm39) V324L possibly damaging Het
Or4k15 A G 14: 50,364,714 (GRCm39) N227D probably benign Het
Or4k42 A T 2: 111,319,902 (GRCm39) N200K possibly damaging Het
Or7g35 A G 9: 19,496,726 (GRCm39) K298E possibly damaging Het
Osbpl9 A G 4: 108,921,806 (GRCm39) I604T possibly damaging Het
Otog C A 7: 45,939,210 (GRCm39) A2080D probably damaging Het
Parp6 G C 9: 59,547,393 (GRCm39) R460P probably damaging Het
Phactr4 G T 4: 132,098,017 (GRCm39) P417Q probably damaging Het
Pigt T C 2: 164,339,498 (GRCm39) probably benign Het
Plekha5 A G 6: 140,470,655 (GRCm39) I99V probably damaging Het
Plxna3 T G X: 73,382,554 (GRCm39) probably null Het
Ppp2r1b G A 9: 50,779,019 (GRCm39) M362I probably damaging Het
Pramel34 T A 5: 93,784,182 (GRCm39) R230S probably damaging Het
Rad51 A G 2: 118,954,327 (GRCm39) I136V probably benign Het
Rad54b T A 4: 11,609,449 (GRCm39) H633Q probably benign Het
Rasal2 A G 1: 157,071,231 (GRCm39) F41S probably benign Het
Reep3 T A 10: 66,857,629 (GRCm39) H154L probably benign Het
Rp1l1 T G 14: 64,268,719 (GRCm39) V1435G probably damaging Het
Rps6ka5 C A 12: 100,620,546 (GRCm39) K125N possibly damaging Het
Rsad1 A T 11: 94,434,444 (GRCm39) M330K probably damaging Het
Scand1 A G 2: 156,153,850 (GRCm39) probably null Het
Setd6 A G 8: 96,444,640 (GRCm39) H111R probably null Het
Slc27a3 T C 3: 90,294,953 (GRCm39) N368S possibly damaging Het
Slc38a2 T C 15: 96,596,518 (GRCm39) T32A probably benign Het
Smg7 A G 1: 152,721,164 (GRCm39) S683P probably damaging Het
Smyd2 A T 1: 189,642,101 (GRCm39) L62M probably damaging Het
Sox5 T C 6: 143,779,075 (GRCm39) Y687C probably damaging Het
Spaca6 T A 17: 18,057,005 (GRCm39) C53* probably null Het
Spata31e4 T C 13: 50,857,208 (GRCm39) Y949H probably benign Het
Spire2 T C 8: 124,084,850 (GRCm39) V230A probably benign Het
Sptbn2 G T 19: 4,782,524 (GRCm39) V487L probably benign Het
Stk3 T A 15: 35,099,603 (GRCm39) I110L probably benign Het
Stox2 T A 8: 47,645,141 (GRCm39) Y773F probably damaging Het
Tbrg1 C A 9: 37,562,632 (GRCm39) A259S probably damaging Het
Tnfsf18 C A 1: 161,331,307 (GRCm39) D152E probably benign Het
Tpr G A 1: 150,299,318 (GRCm39) A1173T probably benign Het
Trrap T C 5: 144,722,290 (GRCm39) L271P probably damaging Het
Ttn G T 2: 76,657,419 (GRCm39) probably benign Het
U2surp A G 9: 95,375,198 (GRCm39) S192P possibly damaging Het
Ubr4 C T 4: 139,138,027 (GRCm39) S1128L probably damaging Het
Ucma G A 2: 4,981,465 (GRCm39) probably null Het
Urb1 A T 16: 90,569,522 (GRCm39) D1401E probably benign Het
Usp54 A T 14: 20,631,597 (GRCm39) probably benign Het
Vmn1r31 A G 6: 58,449,056 (GRCm39) Y270H probably damaging Het
Vmn1r90 T A 7: 14,295,493 (GRCm39) T202S probably benign Het
Vmn2r88 A G 14: 51,655,612 (GRCm39) Y616C probably damaging Het
Vmn2r95 T A 17: 18,672,413 (GRCm39) W717R probably damaging Het
Zcchc4 C A 5: 52,953,947 (GRCm39) T209K probably benign Het
Zfp955b T A 17: 33,524,233 (GRCm39) probably benign Het
Other mutations in Adamdec1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01691:Adamdec1 APN 14 68,810,556 (GRCm39) missense probably damaging 1.00
IGL02026:Adamdec1 APN 14 68,809,251 (GRCm39) missense possibly damaging 0.81
IGL02068:Adamdec1 APN 14 68,814,558 (GRCm39) missense probably benign 0.21
IGL02416:Adamdec1 APN 14 68,810,282 (GRCm39) missense probably null 0.99
IGL02739:Adamdec1 APN 14 68,807,605 (GRCm39) nonsense probably null
IGL03078:Adamdec1 APN 14 68,806,299 (GRCm39) missense possibly damaging 0.53
IGL03115:Adamdec1 APN 14 68,808,802 (GRCm39) missense probably damaging 1.00
R0201:Adamdec1 UTSW 14 68,819,406 (GRCm39) critical splice donor site probably null
R0243:Adamdec1 UTSW 14 68,819,407 (GRCm39) critical splice donor site probably null
R0244:Adamdec1 UTSW 14 68,806,172 (GRCm39) nonsense probably null
R0416:Adamdec1 UTSW 14 68,806,161 (GRCm39) missense possibly damaging 0.79
R1373:Adamdec1 UTSW 14 68,808,400 (GRCm39) missense probably damaging 1.00
R1856:Adamdec1 UTSW 14 68,808,397 (GRCm39) missense probably damaging 1.00
R2570:Adamdec1 UTSW 14 68,816,657 (GRCm39) missense probably damaging 0.98
R3684:Adamdec1 UTSW 14 68,819,447 (GRCm39) missense probably benign 0.04
R3755:Adamdec1 UTSW 14 68,814,587 (GRCm39) missense probably damaging 1.00
R4450:Adamdec1 UTSW 14 68,810,568 (GRCm39) missense probably benign 0.00
R4661:Adamdec1 UTSW 14 68,807,562 (GRCm39) missense probably damaging 1.00
R4673:Adamdec1 UTSW 14 68,815,353 (GRCm39) nonsense probably null
R4902:Adamdec1 UTSW 14 68,809,215 (GRCm39) missense probably damaging 0.99
R5017:Adamdec1 UTSW 14 68,810,694 (GRCm39) missense probably benign 0.01
R5018:Adamdec1 UTSW 14 68,809,228 (GRCm39) missense probably damaging 1.00
R5141:Adamdec1 UTSW 14 68,810,577 (GRCm39) missense probably benign 0.00
R5329:Adamdec1 UTSW 14 68,807,612 (GRCm39) missense probably damaging 1.00
R5395:Adamdec1 UTSW 14 68,808,352 (GRCm39) missense probably benign 0.04
R5864:Adamdec1 UTSW 14 68,807,551 (GRCm39) missense probably damaging 1.00
R6032:Adamdec1 UTSW 14 68,816,633 (GRCm39) missense probably damaging 1.00
R6032:Adamdec1 UTSW 14 68,816,633 (GRCm39) missense probably damaging 1.00
R6114:Adamdec1 UTSW 14 68,809,252 (GRCm39) missense probably benign 0.00
R6633:Adamdec1 UTSW 14 68,810,601 (GRCm39) missense probably benign 0.03
R7243:Adamdec1 UTSW 14 68,809,203 (GRCm39) missense probably benign 0.06
R7580:Adamdec1 UTSW 14 68,802,980 (GRCm39) missense probably benign 0.00
R8388:Adamdec1 UTSW 14 68,810,684 (GRCm39) nonsense probably null
R9133:Adamdec1 UTSW 14 68,814,547 (GRCm39) nonsense probably null
X0025:Adamdec1 UTSW 14 68,807,607 (GRCm39) missense probably damaging 1.00
X0050:Adamdec1 UTSW 14 68,807,607 (GRCm39) missense probably damaging 1.00
X0062:Adamdec1 UTSW 14 68,810,701 (GRCm39) missense probably benign 0.12
Z1177:Adamdec1 UTSW 14 68,818,092 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- CCACTCCTATCTTTGAAAAGTTTGCTG -3'
(R):5'- GAATTAGGCTTAAGCTAGCTGGC -3'

Sequencing Primer
(F):5'- GAAAAGTTTGCTGTGATTTCTGACC -3'
(R):5'- GTGTGTGTGTGTAAAAATGCAC -3'
Posted On 2015-10-08