Incidental Mutation 'R4673:Or13c7c'
ID 348603
Institutional Source Beutler Lab
Gene Symbol Or13c7c
Ensembl Gene ENSMUSG00000111611
Gene Name olfactory receptor family 13 subfamily C member 7C
Synonyms MOR262-12, Olfr157, mOR37c, Olfr37c, OR37C, GA_x6K02T2N78B-16110014-16110970
MMRRC Submission 041928-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.117) question?
Stock # R4673 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 43834752-43837643 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 43836430 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Arginine at position 20 (H20R)
Ref Sequence ENSEMBL: ENSMUSP00000150429 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079234] [ENSMUST00000214281] [ENSMUST00000215442]
AlphaFold Q9QZ20
Predicted Effect probably benign
Transcript: ENSMUST00000079234
AA Change: H20R

PolyPhen 2 Score 0.283 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000078226
Gene: ENSMUSG00000110970
AA Change: H20R

DomainStartEndE-ValueType
Pfam:7tm_4 31 314 4.8e-58 PFAM
Pfam:7tm_1 41 296 2.9e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214281
AA Change: H20R

PolyPhen 2 Score 0.283 (Sensitivity: 0.91; Specificity: 0.88)
Predicted Effect probably benign
Transcript: ENSMUST00000215442
AA Change: H20R

PolyPhen 2 Score 0.283 (Sensitivity: 0.91; Specificity: 0.88)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam32 T C 8: 25,374,471 (GRCm39) E507G probably damaging Het
Adam39 C T 8: 41,277,768 (GRCm39) T53I probably benign Het
Adam4 A T 12: 81,468,535 (GRCm39) S29T possibly damaging Het
Adamdec1 C A 14: 68,815,353 (GRCm39) E104* probably null Het
Alas1 G T 9: 106,113,676 (GRCm39) P523Q probably damaging Het
Aldh3a1 A G 11: 61,104,320 (GRCm39) D69G probably benign Het
Arhgap29 T A 3: 121,808,620 (GRCm39) V1266E probably damaging Het
Bcdin3d T C 15: 99,368,719 (GRCm39) D160G probably damaging Het
Btaf1 T A 19: 36,955,772 (GRCm39) F569I probably benign Het
Cacna1b A G 2: 24,521,956 (GRCm39) L1718S probably damaging Het
Casd1 A G 6: 4,629,975 (GRCm39) Y457C probably damaging Het
Creb3 T C 4: 43,563,192 (GRCm39) V97A probably benign Het
Cux2 G T 5: 122,025,539 (GRCm39) S43* probably null Het
Fhip1a A T 3: 85,638,020 (GRCm39) V93D probably damaging Het
Fsbp T G 4: 11,579,841 (GRCm39) N36K probably benign Het
Gm11565 A G 11: 99,806,040 (GRCm39) D144G probably benign Het
Gpn3 A G 5: 122,511,981 (GRCm39) Y19C probably damaging Het
Gstz1 A T 12: 87,208,837 (GRCm39) T148S probably benign Het
Gtf3c5 A G 2: 28,462,236 (GRCm39) I282T probably benign Het
Hspa2 T A 12: 76,452,514 (GRCm39) S403T possibly damaging Het
Il27 G A 7: 126,190,251 (GRCm39) T121I possibly damaging Het
Itpr2 A G 6: 146,274,671 (GRCm39) F837S probably damaging Het
Kctd1 T A 18: 15,196,284 (GRCm39) probably benign Het
Kynu A G 2: 43,569,815 (GRCm39) T366A probably damaging Het
Lama5 G A 2: 179,841,059 (GRCm39) T507I probably damaging Het
Myh11 C T 16: 14,087,105 (GRCm39) V124M probably damaging Het
Myh14 T A 7: 44,273,754 (GRCm39) H1331L probably damaging Het
Myh2 T A 11: 67,079,303 (GRCm39) L957Q probably damaging Het
Myh4 T C 11: 67,137,227 (GRCm39) F483L probably benign Het
Nbeal1 A C 1: 60,368,549 (GRCm39) K2631N probably damaging Het
Ofcc1 G A 13: 40,168,864 (GRCm39) T841I probably damaging Het
Ogg1 T C 6: 113,304,268 (GRCm39) C28R probably damaging Het
Or5b24 G A 19: 12,912,461 (GRCm39) A120T probably damaging Het
Or5k17 C T 16: 58,746,053 (GRCm39) V294I possibly damaging Het
Or6e1 C T 14: 54,519,789 (GRCm39) A188T possibly damaging Het
Or7g35 A G 9: 19,496,726 (GRCm39) K298E possibly damaging Het
Parp6 G C 9: 59,547,393 (GRCm39) R460P probably damaging Het
Phf14 A G 6: 11,992,056 (GRCm39) H744R probably damaging Het
Pibf1 A G 14: 99,370,787 (GRCm39) N263S possibly damaging Het
Plcb4 A G 2: 135,774,191 (GRCm39) T158A possibly damaging Het
Plce1 T C 19: 38,737,840 (GRCm39) S1615P possibly damaging Het
Plxna3 T G X: 73,382,554 (GRCm39) probably null Het
Rad54b T A 4: 11,609,449 (GRCm39) H633Q probably benign Het
Rgs22 T A 15: 36,100,079 (GRCm39) Y212F probably benign Het
Rnd3 G A 2: 51,022,553 (GRCm39) A163V probably benign Het
Rnf10 A T 5: 115,389,148 (GRCm39) V315E probably damaging Het
Robo2 C T 16: 73,701,266 (GRCm39) probably null Het
Rp1l1 T G 14: 64,268,719 (GRCm39) V1435G probably damaging Het
Scaf8 T A 17: 3,248,260 (GRCm39) D1194E probably benign Het
Septin12 T C 16: 4,809,807 (GRCm39) T198A probably damaging Het
Shisa2 A G 14: 59,867,629 (GRCm39) T294A probably damaging Het
Spta1 A G 1: 174,018,628 (GRCm39) probably null Het
Strbp A T 2: 37,535,691 (GRCm39) S6T probably damaging Het
Syf2 A G 4: 134,661,804 (GRCm39) E56G probably damaging Het
Thap4 T C 1: 93,642,588 (GRCm39) probably benign Het
Tnfaip3 T C 10: 18,887,580 (GRCm39) probably benign Het
Tnxb A G 17: 34,891,514 (GRCm39) E619G probably damaging Het
Tpr G A 1: 150,299,318 (GRCm39) A1173T probably benign Het
Tspan3 G A 9: 56,043,980 (GRCm39) R240W probably damaging Het
Tut7 G T 13: 59,944,659 (GRCm39) T658K probably damaging Het
Ubr4 C T 4: 139,138,027 (GRCm39) S1128L probably damaging Het
Ucp1 T C 8: 84,021,876 (GRCm39) V236A probably damaging Het
Usp34 TCACCACCACCACCACCACCACCACCAC TCACCACCACCACCACCACCACCAC 11: 23,314,480 (GRCm39) probably benign Het
Zfp940 T C 7: 29,544,863 (GRCm39) D348G probably benign Het
Zpld2 G A 4: 133,927,658 (GRCm39) A365V probably benign Het
Other mutations in Or13c7c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01138:Or13c7c APN 4 43,835,617 (GRCm39) missense probably damaging 1.00
R1406:Or13c7c UTSW 4 43,835,582 (GRCm39) missense possibly damaging 0.69
R1406:Or13c7c UTSW 4 43,835,582 (GRCm39) missense possibly damaging 0.69
R4386:Or13c7c UTSW 4 43,836,124 (GRCm39) missense probably benign 0.44
R5119:Or13c7c UTSW 4 43,836,433 (GRCm39) missense probably benign
R5150:Or13c7c UTSW 4 43,836,301 (GRCm39) missense probably damaging 1.00
R5379:Or13c7c UTSW 4 43,836,010 (GRCm39) missense probably benign
R6027:Or13c7c UTSW 4 43,835,842 (GRCm39) missense probably benign 0.03
R6542:Or13c7c UTSW 4 43,835,686 (GRCm39) missense probably benign 0.02
R8696:Or13c7c UTSW 4 43,836,193 (GRCm39) missense probably benign 0.00
R9360:Or13c7c UTSW 4 43,835,765 (GRCm39) missense probably benign 0.44
R9418:Or13c7c UTSW 4 43,835,879 (GRCm39) missense probably benign 0.21
Predicted Primers PCR Primer
(F):5'- AGGTGGTGTAGCAGATGTCC -3'
(R):5'- CAGTTGAACCTCAGAGGCTAAG -3'

Sequencing Primer
(F):5'- TCCAGGAAGGAGAGGTTCC -3'
(R):5'- CCAAGCTTGACGATGTAGCCTATG -3'
Posted On 2015-10-08