Incidental Mutation 'R4627:Ralgapa2'
| ID |
348836 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ralgapa2
|
| Ensembl Gene |
ENSMUSG00000037110 |
| Gene Name |
Ral GTPase activating protein, alpha subunit 2 (catalytic) |
| Synonyms |
AS250, A230067G21Rik, RGC2 |
| MMRRC Submission |
041892-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.209)
|
| Stock # |
R4627 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
146081799-146354264 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 146203373 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 1159
(S1159P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153734
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000109986]
[ENSMUST00000131824]
[ENSMUST00000228797]
|
| AlphaFold |
A3KGS3 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000109986
AA Change: S1112P
PolyPhen 2
Score 0.698 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000105613
Gene: ENSMUSG00000037110
AA Change: S1112P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
469 |
480 |
N/A |
INTRINSIC |
|
low complexity region
|
1017 |
1028 |
N/A |
INTRINSIC |
|
low complexity region
|
1296 |
1301 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
1701 |
1877 |
6.8e-48 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000131824
AA Change: S1074P
PolyPhen 2
Score 0.698 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000122039
Gene: ENSMUSG00000037110
AA Change: S1074P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
469 |
480 |
N/A |
INTRINSIC |
|
low complexity region
|
979 |
990 |
N/A |
INTRINSIC |
|
low complexity region
|
1258 |
1263 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
1663 |
1842 |
1.3e-66 |
PFAM |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000146307
AA Change: S100P
|
| SMART Domains |
Protein: ENSMUSP00000114547
Gene: ENSMUSG00000037110
AA Change: S100P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
6 |
17 |
N/A |
INTRINSIC |
|
low complexity region
|
285 |
290 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
690 |
830 |
4.9e-39 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000148784
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000149499
AA Change: S744P
|
| SMART Domains |
Protein: ENSMUSP00000122017
Gene: ENSMUSG00000037110
AA Change: S744P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
140 |
151 |
N/A |
INTRINSIC |
|
low complexity region
|
650 |
661 |
N/A |
INTRINSIC |
|
low complexity region
|
929 |
934 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
1334 |
1511 |
2.4e-48 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000228797
AA Change: S1159P
PolyPhen 2
Score 0.881 (Sensitivity: 0.82; Specificity: 0.94)
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.3%
- 20x: 95.4%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased incidence and severity of induced urothelial bladder tumors. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 92 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam6a |
A |
T |
12: 113,508,569 (GRCm39) |
D314V |
probably benign |
Het |
| Adamts18 |
C |
T |
8: 114,499,800 (GRCm39) |
W371* |
probably null |
Het |
| Adamtsl2 |
T |
A |
2: 26,983,597 (GRCm39) |
L331Q |
probably damaging |
Het |
| Akr1c13 |
G |
T |
13: 4,247,869 (GRCm39) |
V214F |
probably damaging |
Het |
| Aldoart1 |
T |
C |
4: 72,770,680 (GRCm39) |
T43A |
probably benign |
Het |
| Alkbh2 |
C |
T |
5: 114,262,287 (GRCm39) |
E148K |
probably damaging |
Het |
| Ano7 |
T |
C |
1: 93,302,907 (GRCm39) |
I15T |
probably benign |
Het |
| Aopep |
T |
C |
13: 63,215,906 (GRCm39) |
S393P |
probably benign |
Het |
| Aox3 |
A |
T |
1: 58,164,194 (GRCm39) |
T155S |
probably damaging |
Het |
| Ap2a1 |
C |
T |
7: 44,553,843 (GRCm39) |
V535M |
probably damaging |
Het |
| Apbb2 |
C |
T |
5: 66,557,419 (GRCm39) |
|
probably null |
Het |
| Astn1 |
C |
A |
1: 158,329,821 (GRCm39) |
H225Q |
possibly damaging |
Het |
| Atm |
A |
G |
9: 53,367,806 (GRCm39) |
I2439T |
possibly damaging |
Het |
| Atp1b2 |
T |
A |
11: 69,492,160 (GRCm39) |
I263F |
probably damaging |
Het |
| Ccdc184 |
A |
T |
15: 98,066,638 (GRCm39) |
N148Y |
probably benign |
Het |
| Cdca7 |
TGAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGA |
TGAAGAAGAAGAAGAAGAAGAAGAAGAAGA |
2: 72,312,205 (GRCm39) |
|
probably benign |
Het |
| Cep192 |
C |
G |
18: 67,945,440 (GRCm39) |
P180R |
probably benign |
Het |
| Cfap46 |
T |
C |
7: 139,237,197 (GRCm39) |
Y571C |
probably damaging |
Het |
| Cfap46 |
A |
T |
7: 139,260,843 (GRCm39) |
L85Q |
probably damaging |
Het |
| Chchd6 |
G |
A |
6: 89,361,642 (GRCm39) |
L226F |
probably damaging |
Het |
| Cnot6l |
A |
G |
5: 96,225,070 (GRCm39) |
V541A |
probably benign |
Het |
| Cobl |
T |
C |
11: 12,201,093 (GRCm39) |
E1214G |
probably damaging |
Het |
| Cpsf2 |
G |
A |
12: 101,956,154 (GRCm39) |
R319Q |
probably benign |
Het |
| Csdc2 |
T |
C |
15: 81,833,324 (GRCm39) |
V107A |
probably benign |
Het |
| Csmd1 |
A |
G |
8: 16,747,933 (GRCm39) |
W273R |
probably benign |
Het |
| Dnah2 |
T |
A |
11: 69,356,202 (GRCm39) |
N2156I |
probably damaging |
Het |
| Dsp |
A |
G |
13: 38,352,617 (GRCm39) |
Y165C |
probably benign |
Het |
| Exoc1 |
T |
C |
5: 76,690,075 (GRCm39) |
V205A |
probably benign |
Het |
| Fam98c |
T |
C |
7: 28,854,693 (GRCm39) |
T49A |
possibly damaging |
Het |
| Fbln2 |
G |
T |
6: 91,236,749 (GRCm39) |
V755L |
probably damaging |
Het |
| Fhad1 |
A |
T |
4: 141,623,779 (GRCm39) |
V1371D |
possibly damaging |
Het |
| Folh1 |
A |
T |
7: 86,422,460 (GRCm39) |
M59K |
probably benign |
Het |
| Foxf2 |
A |
T |
13: 31,810,871 (GRCm39) |
H270L |
probably benign |
Het |
| Gm14401 |
G |
A |
2: 176,778,109 (GRCm39) |
R65H |
probably benign |
Het |
| Gpn1 |
C |
A |
5: 31,655,737 (GRCm39) |
Y592* |
probably null |
Het |
| Hmcn1 |
T |
G |
1: 150,471,645 (GRCm39) |
D4903A |
probably benign |
Het |
| Hnf1a |
T |
C |
5: 115,093,930 (GRCm39) |
R220G |
probably damaging |
Het |
| Hoxd10 |
G |
A |
2: 74,522,636 (GRCm39) |
A105T |
probably benign |
Het |
| Kcnd3 |
C |
T |
3: 105,566,082 (GRCm39) |
A421V |
probably damaging |
Het |
| Kidins220 |
C |
T |
12: 25,107,041 (GRCm39) |
T1498I |
possibly damaging |
Het |
| Klhl2 |
G |
T |
8: 65,211,225 (GRCm39) |
Y274* |
probably null |
Het |
| Lmbrd1 |
A |
G |
1: 24,745,080 (GRCm39) |
Y140C |
probably damaging |
Het |
| Mapk8ip3 |
G |
A |
17: 25,122,267 (GRCm39) |
T706I |
probably benign |
Het |
| Mast4 |
A |
C |
13: 103,470,529 (GRCm39) |
S58A |
possibly damaging |
Het |
| Mcm6 |
T |
C |
1: 128,279,285 (GRCm39) |
D167G |
probably benign |
Het |
| Mmachc |
A |
T |
4: 116,560,668 (GRCm39) |
S276T |
probably damaging |
Het |
| Nfat5 |
A |
T |
8: 108,095,908 (GRCm39) |
Q1289L |
probably damaging |
Het |
| Nlrc4 |
G |
T |
17: 74,753,623 (GRCm39) |
F253L |
probably damaging |
Het |
| Nr1i3 |
C |
A |
1: 171,044,014 (GRCm39) |
A112E |
probably benign |
Het |
| Or10ac1 |
T |
A |
6: 42,515,375 (GRCm39) |
T194S |
possibly damaging |
Het |
| Or13a17 |
T |
A |
7: 140,271,291 (GRCm39) |
S158T |
probably benign |
Het |
| Or2b28 |
T |
C |
13: 21,531,634 (GRCm39) |
F179L |
probably damaging |
Het |
| Or7g33 |
G |
T |
9: 19,448,969 (GRCm39) |
Q86K |
possibly damaging |
Het |
| Orc5 |
G |
T |
5: 22,753,003 (GRCm39) |
F10L |
probably benign |
Het |
| Pde10a |
A |
C |
17: 9,200,484 (GRCm39) |
D779A |
probably damaging |
Het |
| Pde4b |
T |
C |
4: 102,458,802 (GRCm39) |
L486S |
probably damaging |
Het |
| Pex2 |
A |
T |
3: 5,626,341 (GRCm39) |
I156N |
probably damaging |
Het |
| Phtf2 |
C |
T |
5: 20,978,738 (GRCm39) |
R63Q |
probably damaging |
Het |
| Prag1 |
A |
G |
8: 36,570,446 (GRCm39) |
Y343C |
probably damaging |
Het |
| Prdm16 |
A |
T |
4: 154,451,697 (GRCm39) |
Y170N |
probably damaging |
Het |
| Prpf6 |
A |
C |
2: 181,243,267 (GRCm39) |
K5T |
probably damaging |
Het |
| Ptpn1 |
A |
G |
2: 167,809,701 (GRCm39) |
K103R |
probably benign |
Het |
| Rapgef3 |
G |
T |
15: 97,656,810 (GRCm39) |
D318E |
probably damaging |
Het |
| Ripk4 |
A |
T |
16: 97,545,226 (GRCm39) |
S474T |
probably damaging |
Het |
| Rmi1 |
A |
G |
13: 58,556,950 (GRCm39) |
R400G |
probably benign |
Het |
| Sec16a |
A |
G |
2: 26,319,405 (GRCm39) |
V1491A |
probably damaging |
Het |
| Sec16a |
C |
T |
2: 26,321,080 (GRCm39) |
|
probably null |
Het |
| Setd7 |
G |
T |
3: 51,450,086 (GRCm39) |
N113K |
probably damaging |
Het |
| Shank2 |
C |
T |
7: 143,965,161 (GRCm39) |
T1502M |
probably damaging |
Het |
| Skor1 |
A |
T |
9: 63,052,758 (GRCm39) |
C376S |
probably damaging |
Het |
| Slc12a3 |
A |
T |
8: 95,056,012 (GRCm39) |
L49F |
probably benign |
Het |
| Slc35d3 |
C |
T |
10: 19,725,077 (GRCm39) |
V260M |
probably damaging |
Het |
| Slc46a1 |
T |
A |
11: 78,357,715 (GRCm39) |
V256E |
probably benign |
Het |
| Slc6a1 |
T |
C |
6: 114,285,067 (GRCm39) |
S127P |
probably benign |
Het |
| Syngr4 |
A |
G |
7: 45,536,452 (GRCm39) |
L190P |
probably damaging |
Het |
| Tagap |
G |
A |
17: 8,145,773 (GRCm39) |
|
probably null |
Het |
| Tamm41 |
A |
T |
6: 115,011,963 (GRCm39) |
N89K |
probably benign |
Het |
| Tbc1d31 |
T |
A |
15: 57,831,308 (GRCm39) |
M922K |
probably benign |
Het |
| Tbk1 |
T |
C |
10: 121,403,985 (GRCm39) |
N254S |
possibly damaging |
Het |
| Tfec |
A |
G |
6: 16,840,478 (GRCm39) |
S140P |
probably damaging |
Het |
| Tnrc18 |
T |
C |
5: 142,725,883 (GRCm39) |
E1802G |
unknown |
Het |
| Tom1l2 |
C |
T |
11: 60,133,533 (GRCm39) |
|
probably null |
Het |
| Tonsl |
T |
G |
15: 76,521,424 (GRCm39) |
K323Q |
probably damaging |
Het |
| Tsnaxip1 |
A |
T |
8: 106,568,039 (GRCm39) |
E268D |
probably damaging |
Het |
| Ttf1 |
C |
A |
2: 28,955,172 (GRCm39) |
H179N |
possibly damaging |
Het |
| Ttn |
T |
C |
2: 76,556,517 (GRCm39) |
S30163G |
probably damaging |
Het |
| Ube2c |
A |
G |
2: 164,614,093 (GRCm39) |
N143S |
possibly damaging |
Het |
| Ugt1a10 |
G |
A |
1: 88,146,112 (GRCm39) |
R519Q |
probably damaging |
Het |
| Utp25 |
T |
C |
1: 192,790,003 (GRCm39) |
T719A |
probably benign |
Het |
| Vmn2r9 |
T |
C |
5: 108,995,463 (GRCm39) |
Y395C |
probably damaging |
Het |
| Vwa8 |
G |
A |
14: 79,341,137 (GRCm39) |
|
probably null |
Het |
| Zfp9 |
A |
G |
6: 118,441,937 (GRCm39) |
Y242H |
probably damaging |
Het |
|
| Other mutations in Ralgapa2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00666:Ralgapa2
|
APN |
2 |
146,327,056 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
IGL00915:Ralgapa2
|
APN |
2 |
146,184,442 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01012:Ralgapa2
|
APN |
2 |
146,263,659 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL01018:Ralgapa2
|
APN |
2 |
146,252,112 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01018:Ralgapa2
|
APN |
2 |
146,252,113 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01902:Ralgapa2
|
APN |
2 |
146,156,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02160:Ralgapa2
|
APN |
2 |
146,190,360 (GRCm39) |
splice site |
probably benign |
|
|
IGL02321:Ralgapa2
|
APN |
2 |
146,254,736 (GRCm39) |
nonsense |
probably null |
|
|
IGL02412:Ralgapa2
|
APN |
2 |
146,254,052 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL03026:Ralgapa2
|
APN |
2 |
146,302,695 (GRCm39) |
splice site |
probably benign |
|
|
IGL03115:Ralgapa2
|
APN |
2 |
146,266,734 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03256:Ralgapa2
|
APN |
2 |
146,302,632 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03379:Ralgapa2
|
APN |
2 |
146,199,907 (GRCm39) |
missense |
probably benign |
0.01 |
|
Chow
|
UTSW |
2 |
146,188,638 (GRCm39) |
nonsense |
probably null |
|
|
purina
|
UTSW |
2 |
146,175,406 (GRCm39) |
missense |
probably damaging |
1.00 |
|
P4748:Ralgapa2
|
UTSW |
2 |
146,188,731 (GRCm39) |
nonsense |
probably null |
|
|
R0012:Ralgapa2
|
UTSW |
2 |
146,254,672 (GRCm39) |
missense |
probably benign |
|
|
R0012:Ralgapa2
|
UTSW |
2 |
146,254,672 (GRCm39) |
missense |
probably benign |
|
|
R0165:Ralgapa2
|
UTSW |
2 |
146,230,407 (GRCm39) |
splice site |
probably benign |
|
|
R0344:Ralgapa2
|
UTSW |
2 |
146,188,714 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R0402:Ralgapa2
|
UTSW |
2 |
146,276,729 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0419:Ralgapa2
|
UTSW |
2 |
146,270,592 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R0638:Ralgapa2
|
UTSW |
2 |
146,184,112 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0704:Ralgapa2
|
UTSW |
2 |
146,293,704 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0722:Ralgapa2
|
UTSW |
2 |
146,230,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0866:Ralgapa2
|
UTSW |
2 |
146,277,923 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1065:Ralgapa2
|
UTSW |
2 |
146,292,478 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1212:Ralgapa2
|
UTSW |
2 |
146,199,902 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1395:Ralgapa2
|
UTSW |
2 |
146,230,420 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1614:Ralgapa2
|
UTSW |
2 |
146,230,532 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1686:Ralgapa2
|
UTSW |
2 |
146,199,920 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1799:Ralgapa2
|
UTSW |
2 |
146,184,648 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1905:Ralgapa2
|
UTSW |
2 |
146,229,621 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1956:Ralgapa2
|
UTSW |
2 |
146,302,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2144:Ralgapa2
|
UTSW |
2 |
146,230,524 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2148:Ralgapa2
|
UTSW |
2 |
146,273,807 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2219:Ralgapa2
|
UTSW |
2 |
146,263,599 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2220:Ralgapa2
|
UTSW |
2 |
146,263,599 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2261:Ralgapa2
|
UTSW |
2 |
146,184,603 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2402:Ralgapa2
|
UTSW |
2 |
146,195,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2495:Ralgapa2
|
UTSW |
2 |
146,203,320 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R3752:Ralgapa2
|
UTSW |
2 |
146,263,551 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3953:Ralgapa2
|
UTSW |
2 |
146,277,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3956:Ralgapa2
|
UTSW |
2 |
146,277,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4177:Ralgapa2
|
UTSW |
2 |
146,327,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4182:Ralgapa2
|
UTSW |
2 |
146,277,914 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4193:Ralgapa2
|
UTSW |
2 |
146,184,493 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4332:Ralgapa2
|
UTSW |
2 |
146,102,288 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4507:Ralgapa2
|
UTSW |
2 |
146,195,168 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4574:Ralgapa2
|
UTSW |
2 |
146,277,919 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4585:Ralgapa2
|
UTSW |
2 |
146,156,944 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4647:Ralgapa2
|
UTSW |
2 |
146,229,549 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R4677:Ralgapa2
|
UTSW |
2 |
146,187,387 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4724:Ralgapa2
|
UTSW |
2 |
146,187,453 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4760:Ralgapa2
|
UTSW |
2 |
146,188,669 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4831:Ralgapa2
|
UTSW |
2 |
146,246,987 (GRCm39) |
intron |
probably benign |
|
|
R4962:Ralgapa2
|
UTSW |
2 |
146,276,754 (GRCm39) |
nonsense |
probably null |
|
|
R4993:Ralgapa2
|
UTSW |
2 |
146,289,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5041:Ralgapa2
|
UTSW |
2 |
146,327,071 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5120:Ralgapa2
|
UTSW |
2 |
146,254,004 (GRCm39) |
missense |
probably benign |
0.26 |
|
R5185:Ralgapa2
|
UTSW |
2 |
146,230,406 (GRCm39) |
splice site |
probably null |
|
|
R5393:Ralgapa2
|
UTSW |
2 |
146,187,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5428:Ralgapa2
|
UTSW |
2 |
146,176,414 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5439:Ralgapa2
|
UTSW |
2 |
146,184,430 (GRCm39) |
missense |
probably benign |
0.08 |
|
R5476:Ralgapa2
|
UTSW |
2 |
146,289,356 (GRCm39) |
missense |
probably benign |
|
|
R5695:Ralgapa2
|
UTSW |
2 |
146,175,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5705:Ralgapa2
|
UTSW |
2 |
146,291,193 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5718:Ralgapa2
|
UTSW |
2 |
146,295,326 (GRCm39) |
splice site |
probably null |
|
|
R5817:Ralgapa2
|
UTSW |
2 |
146,175,406 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5877:Ralgapa2
|
UTSW |
2 |
146,230,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5994:Ralgapa2
|
UTSW |
2 |
146,203,373 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6048:Ralgapa2
|
UTSW |
2 |
146,276,765 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6158:Ralgapa2
|
UTSW |
2 |
146,266,596 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6169:Ralgapa2
|
UTSW |
2 |
146,292,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6280:Ralgapa2
|
UTSW |
2 |
146,184,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6301:Ralgapa2
|
UTSW |
2 |
146,169,331 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6650:Ralgapa2
|
UTSW |
2 |
146,230,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6959:Ralgapa2
|
UTSW |
2 |
146,184,621 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7020:Ralgapa2
|
UTSW |
2 |
146,188,638 (GRCm39) |
nonsense |
probably null |
|
|
R7035:Ralgapa2
|
UTSW |
2 |
146,353,777 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7167:Ralgapa2
|
UTSW |
2 |
146,190,374 (GRCm39) |
missense |
probably benign |
|
|
R7186:Ralgapa2
|
UTSW |
2 |
146,230,406 (GRCm39) |
splice site |
probably null |
|
|
R7252:Ralgapa2
|
UTSW |
2 |
146,184,671 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7266:Ralgapa2
|
UTSW |
2 |
146,176,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7371:Ralgapa2
|
UTSW |
2 |
146,189,046 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7432:Ralgapa2
|
UTSW |
2 |
146,276,776 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7470:Ralgapa2
|
UTSW |
2 |
146,266,587 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7663:Ralgapa2
|
UTSW |
2 |
146,260,335 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7780:Ralgapa2
|
UTSW |
2 |
146,184,334 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7973:Ralgapa2
|
UTSW |
2 |
146,230,481 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8018:Ralgapa2
|
UTSW |
2 |
146,182,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8063:Ralgapa2
|
UTSW |
2 |
146,285,775 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8070:Ralgapa2
|
UTSW |
2 |
146,195,199 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8264:Ralgapa2
|
UTSW |
2 |
146,175,370 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8309:Ralgapa2
|
UTSW |
2 |
146,246,786 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8409:Ralgapa2
|
UTSW |
2 |
146,086,897 (GRCm39) |
missense |
|
|
|
R8474:Ralgapa2
|
UTSW |
2 |
146,266,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8487:Ralgapa2
|
UTSW |
2 |
146,230,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8492:Ralgapa2
|
UTSW |
2 |
146,184,524 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R8733:Ralgapa2
|
UTSW |
2 |
146,266,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8856:Ralgapa2
|
UTSW |
2 |
146,184,139 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8858:Ralgapa2
|
UTSW |
2 |
146,102,285 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8862:Ralgapa2
|
UTSW |
2 |
146,266,731 (GRCm39) |
missense |
probably benign |
0.41 |
|
R9146:Ralgapa2
|
UTSW |
2 |
146,184,252 (GRCm39) |
missense |
probably benign |
|
|
R9324:Ralgapa2
|
UTSW |
2 |
146,302,645 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9439:Ralgapa2
|
UTSW |
2 |
146,254,058 (GRCm39) |
missense |
probably benign |
|
|
R9457:Ralgapa2
|
UTSW |
2 |
146,176,474 (GRCm39) |
missense |
probably damaging |
0.99 |
|
RF019:Ralgapa2
|
UTSW |
2 |
146,203,423 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
X0019:Ralgapa2
|
UTSW |
2 |
146,230,572 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
Z1088:Ralgapa2
|
UTSW |
2 |
146,276,825 (GRCm39) |
missense |
probably benign |
0.20 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGCCCAGTTTCACATCGCAC -3'
(R):5'- ACCATTGGAATTATGCATCCCC -3'
Sequencing Primer
(F):5'- CAGTTTCACATCGCACTAATGAGTC -3'
(R):5'- GGAATTATGCATCCCCCGTAC -3'
|
| Posted On |
2015-10-08 |
Incidental Mutation