Incidental Mutation 'R4628:Vmn2r68'
ID 348950
Institutional Source Beutler Lab
Gene Symbol Vmn2r68
Ensembl Gene ENSMUSG00000096861
Gene Name vomeronasal 2, receptor 68
Synonyms EG620697, Vmn2r68-ps
MMRRC Submission 041893-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.085) question?
Stock # R4628 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 84870726-84886912 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 84883673 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 144 (V144A)
Ref Sequence ENSEMBL: ENSMUSP00000129411 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061074]
AlphaFold L7N2B3
Predicted Effect probably benign
Transcript: ENSMUST00000061074
AA Change: V144A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000129411
Gene: ENSMUSG00000096861
AA Change: V144A

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 77 463 4.5e-28 PFAM
Pfam:NCD3G 507 559 1.1e-18 PFAM
Pfam:7tm_3 589 827 3.7e-53 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 81 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca7 G T 10: 79,851,022 (GRCm39) probably null Het
Abcb4 A G 5: 8,957,399 (GRCm39) D176G probably benign Het
Adamts18 C T 8: 114,499,800 (GRCm39) W371* probably null Het
Akr1c13 G T 13: 4,247,869 (GRCm39) V214F probably damaging Het
Alkbh2 C T 5: 114,262,287 (GRCm39) E148K probably damaging Het
Ankrd12 T C 17: 66,292,989 (GRCm39) T815A probably benign Het
Arid3a T C 10: 79,766,992 (GRCm39) S89P possibly damaging Het
Ass1 A T 2: 31,371,000 (GRCm39) D63V probably damaging Het
Atxn3 T A 12: 101,889,337 (GRCm39) probably benign Het
Bcap29 C T 12: 31,676,806 (GRCm39) S88N probably benign Het
Bsn G T 9: 107,990,434 (GRCm39) P1773T probably damaging Het
Ccdc141 A G 2: 76,890,024 (GRCm39) S423P probably benign Het
Cfap46 A T 7: 139,260,843 (GRCm39) L85Q probably damaging Het
Chd8 T C 14: 52,444,372 (GRCm39) R438G probably benign Het
Chd9 T A 8: 91,710,091 (GRCm39) M289K probably benign Het
Col14a1 T A 15: 55,313,229 (GRCm39) Y26* probably null Het
Colec10 A G 15: 54,323,127 (GRCm39) T117A possibly damaging Het
Colq C A 14: 31,265,979 (GRCm39) G178V probably damaging Het
Defb3 A T 8: 19,345,156 (GRCm39) R37S probably benign Het
Duox1 A G 2: 122,176,733 (GRCm39) Y1418C probably damaging Het
Engase C T 11: 118,375,731 (GRCm39) S33F probably damaging Het
Erich3 A T 3: 154,469,324 (GRCm39) T1259S probably damaging Het
Fam98c T C 7: 28,854,693 (GRCm39) T49A possibly damaging Het
Fhod3 T A 18: 25,253,186 (GRCm39) F1379I possibly damaging Het
Fndc3b T C 3: 27,610,277 (GRCm39) I86V probably benign Het
Gm1123 A G 9: 98,896,289 (GRCm39) V197A probably damaging Het
Gm4847 A T 1: 166,457,964 (GRCm39) V463E probably damaging Het
Gm9772 T C 17: 22,226,188 (GRCm39) K32R probably damaging Het
Gm9804 T C 12: 49,448,540 (GRCm39) S161P unknown Het
Gpr162 C T 6: 124,838,405 (GRCm39) D82N probably benign Het
Grid2ip T C 5: 143,368,630 (GRCm39) V650A probably damaging Het
Hs1bp3 T C 12: 8,386,357 (GRCm39) V253A probably benign Het
Hsd3b6 T G 3: 98,713,895 (GRCm39) K135Q possibly damaging Het
Igfn1 T C 1: 135,887,468 (GRCm39) D2532G possibly damaging Het
Iqgap2 A G 13: 95,899,837 (GRCm39) Y74H probably benign Het
Itga2 A G 13: 115,014,229 (GRCm39) V233A probably benign Het
Kat14 A G 2: 144,246,140 (GRCm39) probably benign Het
Kctd21 A G 7: 96,996,782 (GRCm39) D85G probably damaging Het
Kera A G 10: 97,445,493 (GRCm39) N284S probably benign Het
Krt1 C T 15: 101,754,622 (GRCm39) G543S unknown Het
Lcmt1 T A 7: 123,010,035 (GRCm39) C183* probably null Het
Lcn5 A G 2: 25,548,075 (GRCm39) E28G possibly damaging Het
Leo1 A T 9: 75,352,979 (GRCm39) D174V probably damaging Het
Llgl1 A T 11: 60,600,811 (GRCm39) T636S probably damaging Het
Lrrc8e T A 8: 4,283,981 (GRCm39) C69S probably damaging Het
Maml3 A T 3: 51,703,891 (GRCm39) probably benign Het
Maz G T 7: 126,624,519 (GRCm39) H334N possibly damaging Het
Mcm6 T C 1: 128,279,285 (GRCm39) D167G probably benign Het
Mrpl24 A C 3: 87,829,436 (GRCm39) probably null Het
Myo18a G A 11: 77,714,962 (GRCm39) V834M probably damaging Het
Neb T A 2: 52,198,362 (GRCm39) R461* probably null Het
Notch4 C A 17: 34,789,159 (GRCm39) T486N probably damaging Het
Nphp3 A G 9: 103,880,257 (GRCm39) E93G probably damaging Het
Nup188 A G 2: 30,219,358 (GRCm39) Y858C probably damaging Het
Or13a17 T A 7: 140,271,291 (GRCm39) S158T probably benign Het
Or13a28 C T 7: 140,218,297 (GRCm39) R228C probably benign Het
Or1j11 T A 2: 36,311,869 (GRCm39) L153* probably null Het
Otud4 T A 8: 80,366,597 (GRCm39) D21E possibly damaging Het
Ovgp1 T A 3: 105,887,639 (GRCm39) probably null Het
Pdia3 A T 2: 121,244,620 (GRCm39) N11I possibly damaging Het
Pex5 T C 6: 124,380,079 (GRCm39) D286G possibly damaging Het
Pias3 T C 3: 96,607,136 (GRCm39) I133T probably damaging Het
Postn A G 3: 54,279,578 (GRCm39) D352G probably damaging Het
Prl7c1 T C 13: 27,962,065 (GRCm39) R81G probably benign Het
Rmi1 A G 13: 58,556,950 (GRCm39) R400G probably benign Het
Rtraf T A 14: 19,867,155 (GRCm39) N116I probably benign Het
Semp2l2a T A 8: 13,886,625 (GRCm39) R489W probably damaging Het
Slc6a12 T A 6: 121,328,951 (GRCm39) C50* probably null Het
Spring1 G C 5: 118,397,479 (GRCm39) A154P probably damaging Het
Srcin1 T A 11: 97,439,752 (GRCm39) H126L probably benign Het
Tmtc2 A T 10: 105,139,511 (GRCm39) S672T probably benign Het
Top2b T G 14: 16,409,189 (GRCm38) I777M probably damaging Het
Ube2c A G 2: 164,614,093 (GRCm39) N143S possibly damaging Het
Uroc1 A T 6: 90,332,310 (GRCm39) I556F probably damaging Het
Vmn1r124 T A 7: 20,994,302 (GRCm39) K81* probably null Het
Vmn1r57 T A 7: 5,223,972 (GRCm39) C166S probably damaging Het
Vmn2r114 ATTT ATT 17: 23,509,906 (GRCm39) probably null Het
Vmn2r85 C T 10: 130,261,235 (GRCm39) M367I probably benign Het
Vwa3a T A 7: 120,392,598 (GRCm39) N812K probably benign Het
Wdfy4 A T 14: 32,824,515 (GRCm39) N1301K probably damaging Het
Zfhx4 G A 3: 5,468,536 (GRCm39) R2898H probably damaging Het
Other mutations in Vmn2r68
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01391:Vmn2r68 APN 7 84,886,819 (GRCm39) missense probably benign
IGL01477:Vmn2r68 APN 7 84,882,691 (GRCm39) missense probably damaging 1.00
IGL01600:Vmn2r68 APN 7 84,871,468 (GRCm39) missense probably benign 0.39
IGL01979:Vmn2r68 APN 7 84,871,325 (GRCm39) missense probably benign
IGL01999:Vmn2r68 APN 7 84,871,439 (GRCm39) missense probably damaging 1.00
IGL02269:Vmn2r68 APN 7 84,870,947 (GRCm39) missense possibly damaging 0.84
IGL02517:Vmn2r68 APN 7 84,871,153 (GRCm39) nonsense probably null
IGL02827:Vmn2r68 APN 7 84,886,800 (GRCm39) missense probably damaging 1.00
IGL02852:Vmn2r68 APN 7 84,882,595 (GRCm39) missense probably damaging 1.00
IGL02982:Vmn2r68 APN 7 84,883,649 (GRCm39) missense probably benign 0.12
IGL03099:Vmn2r68 APN 7 84,871,448 (GRCm39) nonsense probably null
IGL03166:Vmn2r68 APN 7 84,871,331 (GRCm39) missense probably benign 0.01
IGL03168:Vmn2r68 APN 7 84,870,972 (GRCm39) missense probably damaging 1.00
IGL03243:Vmn2r68 APN 7 84,882,963 (GRCm39) missense possibly damaging 0.66
F5770:Vmn2r68 UTSW 7 84,871,088 (GRCm39) missense probably benign 0.01
R0280:Vmn2r68 UTSW 7 84,882,466 (GRCm39) critical splice donor site probably null
R0280:Vmn2r68 UTSW 7 84,882,457 (GRCm39) splice site probably benign
R0281:Vmn2r68 UTSW 7 84,882,466 (GRCm39) critical splice donor site probably null
R0281:Vmn2r68 UTSW 7 84,882,457 (GRCm39) splice site probably benign
R0348:Vmn2r68 UTSW 7 84,870,884 (GRCm39) missense possibly damaging 0.50
R0390:Vmn2r68 UTSW 7 84,882,466 (GRCm39) critical splice donor site probably null
R0390:Vmn2r68 UTSW 7 84,882,457 (GRCm39) splice site probably benign
R0722:Vmn2r68 UTSW 7 84,870,794 (GRCm39) missense possibly damaging 0.95
R1129:Vmn2r68 UTSW 7 84,886,712 (GRCm39) splice site probably null
R1136:Vmn2r68 UTSW 7 84,871,549 (GRCm39) missense possibly damaging 0.81
R1319:Vmn2r68 UTSW 7 84,881,700 (GRCm39) missense probably damaging 0.96
R1614:Vmn2r68 UTSW 7 84,870,946 (GRCm39) missense possibly damaging 0.93
R1682:Vmn2r68 UTSW 7 84,882,574 (GRCm39) missense possibly damaging 0.68
R1837:Vmn2r68 UTSW 7 84,882,886 (GRCm39) missense probably damaging 0.96
R1893:Vmn2r68 UTSW 7 84,883,867 (GRCm39) nonsense probably null
R1908:Vmn2r68 UTSW 7 84,883,260 (GRCm39) missense probably benign 0.09
R1909:Vmn2r68 UTSW 7 84,883,260 (GRCm39) missense probably benign 0.09
R1951:Vmn2r68 UTSW 7 84,883,102 (GRCm39) missense probably damaging 1.00
R2177:Vmn2r68 UTSW 7 84,871,123 (GRCm39) missense probably benign 0.01
R2178:Vmn2r68 UTSW 7 84,870,758 (GRCm39) frame shift probably null
R2185:Vmn2r68 UTSW 7 84,882,901 (GRCm39) nonsense probably null
R2188:Vmn2r68 UTSW 7 84,870,758 (GRCm39) frame shift probably null
R2282:Vmn2r68 UTSW 7 84,870,859 (GRCm39) missense possibly damaging 0.65
R2567:Vmn2r68 UTSW 7 84,883,803 (GRCm39) missense probably benign
R2869:Vmn2r68 UTSW 7 84,882,834 (GRCm39) missense probably benign 0.25
R2869:Vmn2r68 UTSW 7 84,882,834 (GRCm39) missense probably benign 0.25
R2870:Vmn2r68 UTSW 7 84,882,834 (GRCm39) missense probably benign 0.25
R2870:Vmn2r68 UTSW 7 84,882,834 (GRCm39) missense probably benign 0.25
R2871:Vmn2r68 UTSW 7 84,882,834 (GRCm39) missense probably benign 0.25
R2871:Vmn2r68 UTSW 7 84,882,834 (GRCm39) missense probably benign 0.25
R2873:Vmn2r68 UTSW 7 84,882,834 (GRCm39) missense probably benign 0.25
R2874:Vmn2r68 UTSW 7 84,882,834 (GRCm39) missense probably benign 0.25
R3149:Vmn2r68 UTSW 7 84,886,875 (GRCm39) missense probably benign 0.00
R3401:Vmn2r68 UTSW 7 84,870,758 (GRCm39) frame shift probably null
R3978:Vmn2r68 UTSW 7 84,881,670 (GRCm39) missense probably benign 0.00
R4399:Vmn2r68 UTSW 7 84,870,758 (GRCm39) frame shift probably null
R4401:Vmn2r68 UTSW 7 84,870,758 (GRCm39) frame shift probably null
R4421:Vmn2r68 UTSW 7 84,870,758 (GRCm39) frame shift probably null
R4478:Vmn2r68 UTSW 7 84,870,758 (GRCm39) frame shift probably null
R4479:Vmn2r68 UTSW 7 84,870,758 (GRCm39) frame shift probably null
R4495:Vmn2r68 UTSW 7 84,870,758 (GRCm39) frame shift probably null
R4649:Vmn2r68 UTSW 7 84,870,743 (GRCm39) missense probably benign
R4654:Vmn2r68 UTSW 7 84,882,769 (GRCm39) nonsense probably null
R4793:Vmn2r68 UTSW 7 84,883,648 (GRCm39) missense probably benign 0.01
R5007:Vmn2r68 UTSW 7 84,881,622 (GRCm39) missense probably benign
R5021:Vmn2r68 UTSW 7 84,882,942 (GRCm39) missense possibly damaging 0.62
R5082:Vmn2r68 UTSW 7 84,883,076 (GRCm39) missense probably benign 0.12
R5177:Vmn2r68 UTSW 7 84,871,199 (GRCm39) missense probably damaging 0.99
R5221:Vmn2r68 UTSW 7 84,871,085 (GRCm39) missense probably damaging 1.00
R5514:Vmn2r68 UTSW 7 84,886,767 (GRCm39) missense possibly damaging 0.92
R5521:Vmn2r68 UTSW 7 84,882,926 (GRCm39) missense probably benign 0.03
R5563:Vmn2r68 UTSW 7 84,871,283 (GRCm39) missense probably damaging 1.00
R5664:Vmn2r68 UTSW 7 84,882,978 (GRCm39) missense probably benign 0.02
R5829:Vmn2r68 UTSW 7 84,886,812 (GRCm39) missense probably benign 0.00
R6016:Vmn2r68 UTSW 7 84,871,453 (GRCm39) missense probably damaging 0.99
R6356:Vmn2r68 UTSW 7 84,883,048 (GRCm39) missense possibly damaging 0.85
R6413:Vmn2r68 UTSW 7 84,870,973 (GRCm39) missense probably damaging 1.00
R6418:Vmn2r68 UTSW 7 84,882,915 (GRCm39) missense probably benign
R6699:Vmn2r68 UTSW 7 84,881,583 (GRCm39) missense possibly damaging 0.58
R7287:Vmn2r68 UTSW 7 84,871,460 (GRCm39) missense probably benign 0.33
R7319:Vmn2r68 UTSW 7 84,883,042 (GRCm39) missense probably benign
R7374:Vmn2r68 UTSW 7 84,881,607 (GRCm39) missense possibly damaging 0.66
R7585:Vmn2r68 UTSW 7 84,881,587 (GRCm39) missense probably damaging 1.00
R7605:Vmn2r68 UTSW 7 84,883,116 (GRCm39) missense probably benign 0.01
R7892:Vmn2r68 UTSW 7 84,883,722 (GRCm39) missense probably benign
R7979:Vmn2r68 UTSW 7 84,883,625 (GRCm39) critical splice donor site probably null
R8177:Vmn2r68 UTSW 7 84,871,422 (GRCm39) nonsense probably null
R8349:Vmn2r68 UTSW 7 84,882,785 (GRCm39) missense probably damaging 1.00
R8378:Vmn2r68 UTSW 7 84,871,108 (GRCm39) missense probably benign 0.00
R8397:Vmn2r68 UTSW 7 84,886,722 (GRCm39) missense possibly damaging 0.71
R8449:Vmn2r68 UTSW 7 84,882,785 (GRCm39) missense probably damaging 1.00
R8543:Vmn2r68 UTSW 7 84,883,648 (GRCm39) missense probably benign 0.01
R8680:Vmn2r68 UTSW 7 84,871,321 (GRCm39) missense possibly damaging 0.68
R9056:Vmn2r68 UTSW 7 84,871,420 (GRCm39) missense possibly damaging 0.71
R9342:Vmn2r68 UTSW 7 84,882,993 (GRCm39) missense probably benign 0.39
R9734:Vmn2r68 UTSW 7 84,882,757 (GRCm39) missense possibly damaging 0.54
V7581:Vmn2r68 UTSW 7 84,871,088 (GRCm39) missense probably benign 0.01
Z1176:Vmn2r68 UTSW 7 84,871,289 (GRCm39) missense probably benign 0.27
Z1176:Vmn2r68 UTSW 7 84,870,941 (GRCm39) missense probably damaging 1.00
Z1176:Vmn2r68 UTSW 7 84,871,307 (GRCm39) missense possibly damaging 0.92
Predicted Primers PCR Primer
(F):5'- AATGCTGCTGCCTCCCATAC -3'
(R):5'- CCAAGACCAACCATTTGATTTTCTCTG -3'

Sequencing Primer
(F):5'- GCCTCCCATACCCATTTATGATAAAG -3'
(R):5'- CTCTGTTTATCTTGCCTTGGATG -3'
Posted On 2015-10-08