Incidental Mutation 'R4630:Or6c212'
ID 349128
Institutional Source Beutler Lab
Gene Symbol Or6c212
Ensembl Gene ENSMUSG00000096858
Gene Name olfactory receptor family 6 subfamily C member 212
Synonyms Olfr805, GA_x6K02T2PULF-11402237-11401278, MOR110-4
MMRRC Submission 041895-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # R4630 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 129558452-129559411 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 129559350 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 21 (L21P)
Ref Sequence ENSEMBL: ENSMUSP00000149493 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078876] [ENSMUST00000204717] [ENSMUST00000216794] [ENSMUST00000217219]
AlphaFold Q8VFI4
Predicted Effect probably damaging
Transcript: ENSMUST00000078876
AA Change: L21P

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000092874
Gene: ENSMUSG00000096858
AA Change: L21P

DomainStartEndE-ValueType
Pfam:7tm_4 28 306 3.9e-52 PFAM
Pfam:7tm_1 39 288 5.1e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203573
AA Change: L21P
SMART Domains Protein: ENSMUSP00000144843
Gene: ENSMUSG00000096858
AA Change: L21P

DomainStartEndE-ValueType
Pfam:7tm_4 28 306 3.9e-52 PFAM
Pfam:7tm_1 39 288 5.1e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000204717
AA Change: L21P

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000216794
AA Change: L21P

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000217219
AA Change: L21P

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency 97% (74/76)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110070M22Rik A T 13: 119,624,622 (GRCm39) probably benign Het
Alkbh2 C T 5: 114,262,287 (GRCm39) E148K probably damaging Het
Aopep T C 13: 63,215,906 (GRCm39) S393P probably benign Het
BC024139 T G 15: 76,009,294 (GRCm39) Q240P probably benign Het
Bckdha A T 7: 25,330,884 (GRCm39) I44N probably damaging Het
Brpf1 T C 6: 113,286,867 (GRCm39) Y32H probably damaging Het
Catip A G 1: 74,408,072 (GRCm39) probably benign Het
Ccdc138 T C 10: 58,409,477 (GRCm39) L602P probably damaging Het
Cilp A T 9: 65,187,162 (GRCm39) T1086S probably benign Het
Comp A T 8: 70,827,032 (GRCm39) I58F possibly damaging Het
Crygs T C 16: 22,624,268 (GRCm39) E113G possibly damaging Het
Dnmt3b C T 2: 153,512,235 (GRCm39) R319* probably null Het
Eif3a A G 19: 60,758,366 (GRCm39) I804T unknown Het
Eif3a A T 19: 60,766,424 (GRCm39) H301Q probably benign Het
Elf3 A T 1: 135,184,478 (GRCm39) probably benign Het
Fads2b C A 2: 85,348,990 (GRCm39) G41* probably null Het
Gm10384 A G 15: 36,872,017 (GRCm39) noncoding transcript Het
Gm11627 T A 11: 102,469,657 (GRCm39) probably benign Het
Gpr183 A T 14: 122,192,261 (GRCm39) Y87N probably damaging Het
Gpr183 G C 14: 122,192,262 (GRCm39) Y86* probably null Het
Gpr26 T C 7: 131,568,709 (GRCm39) V18A probably damaging Het
Herc1 T A 9: 66,340,996 (GRCm39) probably null Het
Hint2 C T 4: 43,656,396 (GRCm39) probably benign Het
Jag1 A T 2: 136,927,899 (GRCm39) D837E probably damaging Het
Jmjd1c C A 10: 66,993,753 (GRCm39) S78* probably null Het
Kcnd3 C T 3: 105,566,082 (GRCm39) A421V probably damaging Het
Krt1 C T 15: 101,754,622 (GRCm39) G543S unknown Het
Lalba T C 15: 98,380,549 (GRCm39) M2V probably benign Het
Lama1 T A 17: 68,101,295 (GRCm39) D1929E probably benign Het
Macf1 T C 4: 123,367,432 (GRCm39) K878R possibly damaging Het
Mboat4 T C 8: 34,591,108 (GRCm39) S182P probably damaging Het
Muc5b A T 7: 141,411,721 (GRCm39) T1556S unknown Het
Myo1g T C 11: 6,469,047 (GRCm39) Y85C probably damaging Het
Ncapd2 C A 6: 125,156,196 (GRCm39) probably null Het
Nox3 T C 17: 3,744,257 (GRCm39) D96G possibly damaging Het
Or10a48 T C 7: 108,424,802 (GRCm39) M135V probably damaging Het
Or1e17 T C 11: 73,831,822 (GRCm39) L250P probably damaging Het
Pacs1 C T 19: 5,206,384 (GRCm39) probably null Het
Pgap4 C G 4: 49,586,254 (GRCm39) V305L probably benign Het
Pgm5 C A 19: 24,812,110 (GRCm39) G141* probably null Het
Pik3r4 A G 9: 105,532,098 (GRCm39) M557V probably benign Het
Pld4 T A 12: 112,731,498 (GRCm39) V217D probably damaging Het
Pphln1-ps1 T C 16: 13,495,278 (GRCm39) S126P probably damaging Het
Ppp1r3c T C 19: 36,710,915 (GRCm39) E285G probably benign Het
Pradc1 T A 6: 85,424,275 (GRCm39) M24L possibly damaging Het
Prepl T C 17: 85,390,659 (GRCm39) T100A probably benign Het
Rmi2 C T 16: 10,704,073 (GRCm39) T138I probably benign Het
Rtkn A T 6: 83,129,163 (GRCm39) K540* probably null Het
Sag C A 1: 87,762,340 (GRCm39) T335K probably damaging Het
Setd4 A G 16: 93,388,114 (GRCm39) L124P probably benign Het
Sh3gl2 A G 4: 85,297,646 (GRCm39) D208G probably damaging Het
Sult4a1 T C 15: 83,989,779 (GRCm39) T8A possibly damaging Het
Tert A G 13: 73,797,110 (GRCm39) D1116G probably damaging Het
Tlr4 A G 4: 66,757,477 (GRCm39) E90G probably benign Het
Tmem123 T C 9: 7,791,393 (GRCm39) L164P probably damaging Het
Top2b T G 14: 16,409,189 (GRCm38) I777M probably damaging Het
Trak1 G A 9: 121,283,491 (GRCm39) R419Q probably benign Het
Trp53bp1 G T 2: 121,038,368 (GRCm39) A1490D probably damaging Het
Ttc16 T C 2: 32,665,389 (GRCm39) probably benign Het
Tyw5 T A 1: 57,427,686 (GRCm39) Q306L probably damaging Het
Ube2j2 T A 4: 156,039,715 (GRCm39) I14N probably damaging Het
Vmn2r103 T C 17: 20,013,958 (GRCm39) I250T probably benign Het
Zar1 A G 5: 72,738,249 (GRCm39) V51A probably benign Het
Zbtb38 T G 9: 96,570,904 (GRCm39) N60T probably damaging Het
Zfp354a T C 11: 50,961,045 (GRCm39) S417P probably damaging Het
Zfp410 A T 12: 84,372,510 (GRCm39) D112V probably damaging Het
Zfp518a C T 19: 40,901,423 (GRCm39) Q451* probably null Het
Zfp64 T C 2: 168,768,463 (GRCm39) N383S possibly damaging Het
Zfp687 A T 3: 94,919,799 (GRCm39) probably null Het
Other mutations in Or6c212
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01141:Or6c212 APN 10 129,558,814 (GRCm39) missense probably benign
IGL01341:Or6c212 APN 10 129,558,747 (GRCm39) missense possibly damaging 0.87
IGL01960:Or6c212 APN 10 129,558,756 (GRCm39) missense probably damaging 1.00
IGL02729:Or6c212 APN 10 129,559,390 (GRCm39) missense probably benign 0.01
IGL02969:Or6c212 APN 10 129,559,065 (GRCm39) missense probably damaging 0.99
R0116:Or6c212 UTSW 10 129,558,846 (GRCm39) missense probably damaging 1.00
R1236:Or6c212 UTSW 10 129,558,675 (GRCm39) missense probably damaging 0.98
R1332:Or6c212 UTSW 10 129,559,116 (GRCm39) missense probably damaging 1.00
R2428:Or6c212 UTSW 10 129,558,652 (GRCm39) missense probably benign 0.05
R3725:Or6c212 UTSW 10 129,558,984 (GRCm39) missense probably damaging 1.00
R3726:Or6c212 UTSW 10 129,558,984 (GRCm39) missense probably damaging 1.00
R3804:Or6c212 UTSW 10 129,558,918 (GRCm39) missense possibly damaging 0.93
R4365:Or6c212 UTSW 10 129,559,281 (GRCm39) missense probably damaging 0.99
R4735:Or6c212 UTSW 10 129,558,792 (GRCm39) missense probably benign 0.06
R4923:Or6c212 UTSW 10 129,558,681 (GRCm39) missense probably benign 0.03
R4962:Or6c212 UTSW 10 129,558,592 (GRCm39) missense probably damaging 1.00
R5324:Or6c212 UTSW 10 129,558,814 (GRCm39) missense probably benign
R5406:Or6c212 UTSW 10 129,558,799 (GRCm39) missense probably damaging 1.00
R7705:Or6c212 UTSW 10 129,559,018 (GRCm39) missense probably benign 0.01
R8464:Or6c212 UTSW 10 129,558,783 (GRCm39) missense possibly damaging 0.88
R9368:Or6c212 UTSW 10 129,558,881 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CTCATCAAGAATCGTGGAATGC -3'
(R):5'- GAGGACAAGATTGTGAGTAAACTCT -3'

Sequencing Primer
(F):5'- GCAAGAAGATGTGAATGCCATTTCC -3'
(R):5'- TGAAGAACCAGTCAGTAGA -3'
Posted On 2015-10-08