Incidental Mutation 'R0266:Ccng2'
ID 34920
Institutional Source Beutler Lab
Gene Symbol Ccng2
Ensembl Gene ENSMUSG00000029385
Gene Name cyclin G2
Synonyms
MMRRC Submission 038492-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0266 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 93415432-93424090 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 93419148 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000113278 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031331] [ENSMUST00000121127]
AlphaFold O08918
Predicted Effect probably benign
Transcript: ENSMUST00000031331
SMART Domains Protein: ENSMUSP00000031331
Gene: ENSMUSG00000029385

DomainStartEndE-ValueType
CYCLIN 61 147 3.06e-15 SMART
low complexity region 218 237 N/A INTRINSIC
low complexity region 295 317 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000121127
SMART Domains Protein: ENSMUSP00000113278
Gene: ENSMUSG00000029385

DomainStartEndE-ValueType
CYCLIN 61 147 3.06e-15 SMART
low complexity region 218 237 N/A INTRINSIC
low complexity region 295 317 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130183
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149329
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152097
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153260
Coding Region Coverage
  • 1x: 98.3%
  • 3x: 97.2%
  • 10x: 94.9%
  • 20x: 89.8%
Validation Efficiency 100% (79/79)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 77 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700001K19Rik A G 12: 110,635,188 (GRCm39) S117P possibly damaging Het
Aars2 T C 17: 45,818,436 (GRCm39) probably benign Het
Acot11 T C 4: 106,607,185 (GRCm39) D466G probably damaging Het
Adgrd1 G A 5: 129,216,658 (GRCm39) A342T probably benign Het
Apbb2 A T 5: 66,459,954 (GRCm39) N714K probably benign Het
Aqp12 C A 1: 92,934,572 (GRCm39) H150N possibly damaging Het
Brinp3 T A 1: 146,558,418 (GRCm39) L114* probably null Het
Cd36 T A 5: 18,003,250 (GRCm39) R265S probably benign Het
Ces4a T C 8: 105,868,598 (GRCm39) L104S probably benign Het
Clca4b T C 3: 144,628,547 (GRCm39) I387V probably damaging Het
Cul7 T A 17: 46,965,521 (GRCm39) H566Q probably benign Het
Ddx60 A T 8: 62,486,527 (GRCm39) H1646L possibly damaging Het
Dntt T C 19: 41,047,566 (GRCm39) I503T probably damaging Het
Dynlt1a T G 17: 6,367,670 (GRCm39) E2D probably benign Het
Efemp2 G T 19: 5,528,027 (GRCm39) C78F probably damaging Het
Esco1 T C 18: 10,594,605 (GRCm39) E227G probably benign Het
Fezf2 T A 14: 12,342,607 (GRCm38) K419N probably damaging Het
Gm17541 A T 12: 4,739,487 (GRCm39) probably benign Het
Gm2381 G A 7: 42,469,372 (GRCm39) Q251* probably null Het
Gm4782 T G 6: 50,587,674 (GRCm39) S686R probably damaging Het
Grin3a G A 4: 49,665,501 (GRCm39) R1045* probably null Het
Grm8 T C 6: 27,285,895 (GRCm39) Y839C probably damaging Het
Gtf3c1 G A 7: 125,243,306 (GRCm39) P1766L possibly damaging Het
Herc2 T A 7: 55,856,326 (GRCm39) H3921Q probably damaging Het
Hes6 A T 1: 91,340,026 (GRCm39) D143E possibly damaging Het
Hmcn2 A G 2: 31,284,839 (GRCm39) E2055G probably benign Het
Hmcn2 G A 2: 31,335,365 (GRCm39) probably benign Het
Ikzf3 A G 11: 98,358,143 (GRCm39) L398P probably benign Het
Il10ra A T 9: 45,176,950 (GRCm39) I125N probably benign Het
Kcnb2 G A 1: 15,783,137 (GRCm39) probably benign Het
Krt77 T C 15: 101,777,813 (GRCm39) R81G possibly damaging Het
Lrrc40 T A 3: 157,747,298 (GRCm39) probably null Het
Man1a2 C T 3: 100,489,350 (GRCm39) R543Q probably damaging Het
Mansc1 T C 6: 134,587,670 (GRCm39) D169G probably benign Het
Mdn1 T A 4: 32,741,835 (GRCm39) S3869T probably damaging Het
Mettl14 A T 3: 123,176,475 (GRCm39) S58T probably benign Het
Mrpl4 T C 9: 20,914,610 (GRCm39) V62A probably benign Het
Myh3 A G 11: 66,984,498 (GRCm39) D1085G possibly damaging Het
Myo5c C A 9: 75,191,498 (GRCm39) probably benign Het
Naalad2 G T 9: 18,262,239 (GRCm39) probably benign Het
Nat3 A G 8: 68,000,432 (GRCm39) T104A probably benign Het
Nek4 A G 14: 30,679,253 (GRCm39) E198G probably damaging Het
Olfm1 A G 2: 28,119,619 (GRCm39) Y403C probably damaging Het
Or5w11 C A 2: 87,459,626 (GRCm39) T273K possibly damaging Het
Or7e177 A T 9: 20,212,454 (GRCm39) R320S probably benign Het
Osbpl1a T A 18: 13,004,220 (GRCm39) probably null Het
Pax7 G A 4: 139,507,047 (GRCm39) S330L possibly damaging Het
Pcdhb15 C A 18: 37,608,329 (GRCm39) D520E probably damaging Het
Pgm3 T C 9: 86,449,586 (GRCm39) T145A probably benign Het
Phox2b G A 5: 67,253,968 (GRCm39) probably null Het
Pik3r6 A T 11: 68,417,234 (GRCm39) R59* probably null Het
Pold1 A G 7: 44,190,449 (GRCm39) probably benign Het
Ppp1r21 T C 17: 88,876,500 (GRCm39) probably benign Het
Prl5a1 A G 13: 28,333,970 (GRCm39) K158E possibly damaging Het
Rag2 T G 2: 101,460,948 (GRCm39) C419W probably damaging Het
Reln A G 5: 22,193,774 (GRCm39) S1395P probably damaging Het
Retnlb T G 16: 48,639,022 (GRCm39) Y74* probably null Het
Robo3 A G 9: 37,333,936 (GRCm39) S633P probably damaging Het
Ryr1 A G 7: 28,740,104 (GRCm39) S3941P probably damaging Het
Scnn1b A G 7: 121,511,698 (GRCm39) N370S probably damaging Het
Slc6a5 C A 7: 49,588,156 (GRCm39) probably benign Het
Sort1 T A 3: 108,252,247 (GRCm39) N481K probably benign Het
Sptlc3 T A 2: 139,437,957 (GRCm39) I417K possibly damaging Het
Svil T A 18: 5,099,063 (GRCm39) probably benign Het
Taf4b T C 18: 14,946,134 (GRCm39) probably benign Het
Tchp T C 5: 114,847,394 (GRCm39) M71T possibly damaging Het
Thsd4 T A 9: 59,904,417 (GRCm39) H233L probably benign Het
Tmem217 G T 17: 29,745,573 (GRCm39) N52K possibly damaging Het
Tmem38b T C 4: 53,840,765 (GRCm39) L60S probably damaging Het
Uqcrfs1 A C 13: 30,725,146 (GRCm39) N131K probably benign Het
Vars1 T A 17: 35,232,845 (GRCm39) S896R probably benign Het
Vmn1r170 A T 7: 23,305,906 (GRCm39) M103L probably benign Het
Vmn2r22 T C 6: 123,614,363 (GRCm39) Y409C probably damaging Het
Vmn2r92 C T 17: 18,388,219 (GRCm39) A408V probably damaging Het
Wdr49 A T 3: 75,359,103 (GRCm39) I8N possibly damaging Het
Zfp648 T A 1: 154,080,632 (GRCm39) Y264N probably damaging Het
Zmym1 A C 4: 126,941,818 (GRCm39) F857V possibly damaging Het
Other mutations in Ccng2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01148:Ccng2 APN 5 93,418,746 (GRCm39) missense probably damaging 0.99
IGL01289:Ccng2 APN 5 93,421,276 (GRCm39) missense probably null 0.88
R0133:Ccng2 UTSW 5 93,421,240 (GRCm39) missense probably benign 0.15
R0346:Ccng2 UTSW 5 93,418,753 (GRCm39) missense probably damaging 1.00
R0401:Ccng2 UTSW 5 93,421,272 (GRCm39) missense possibly damaging 0.52
R1087:Ccng2 UTSW 5 93,421,303 (GRCm39) missense probably benign 0.17
R1373:Ccng2 UTSW 5 93,418,914 (GRCm39) splice site probably benign
R1696:Ccng2 UTSW 5 93,421,241 (GRCm39) missense possibly damaging 0.90
R3727:Ccng2 UTSW 5 93,422,810 (GRCm39) missense probably damaging 1.00
R5395:Ccng2 UTSW 5 93,417,257 (GRCm39) missense possibly damaging 0.84
R6337:Ccng2 UTSW 5 93,418,780 (GRCm39) missense probably benign
R6611:Ccng2 UTSW 5 93,421,202 (GRCm39) missense probably benign 0.00
R7077:Ccng2 UTSW 5 93,417,199 (GRCm39) missense possibly damaging 0.91
R7140:Ccng2 UTSW 5 93,416,614 (GRCm39) missense probably benign 0.00
R7161:Ccng2 UTSW 5 93,421,202 (GRCm39) missense probably benign 0.00
R7193:Ccng2 UTSW 5 93,421,202 (GRCm39) missense probably benign 0.00
R7233:Ccng2 UTSW 5 93,421,202 (GRCm39) missense probably benign 0.00
R7235:Ccng2 UTSW 5 93,421,202 (GRCm39) missense probably benign 0.00
R7269:Ccng2 UTSW 5 93,421,202 (GRCm39) missense probably benign 0.00
R7270:Ccng2 UTSW 5 93,421,202 (GRCm39) missense probably benign 0.00
R7271:Ccng2 UTSW 5 93,421,202 (GRCm39) missense probably benign 0.00
R7449:Ccng2 UTSW 5 93,421,202 (GRCm39) missense probably benign 0.00
R7451:Ccng2 UTSW 5 93,421,202 (GRCm39) missense probably benign 0.00
R7567:Ccng2 UTSW 5 93,418,731 (GRCm39) missense probably benign 0.01
R7614:Ccng2 UTSW 5 93,421,202 (GRCm39) missense probably benign 0.00
R7657:Ccng2 UTSW 5 93,421,202 (GRCm39) missense probably benign 0.00
R7658:Ccng2 UTSW 5 93,421,202 (GRCm39) missense probably benign 0.00
R7743:Ccng2 UTSW 5 93,421,202 (GRCm39) missense probably benign 0.00
R7744:Ccng2 UTSW 5 93,421,202 (GRCm39) missense probably benign 0.00
R7745:Ccng2 UTSW 5 93,421,202 (GRCm39) missense probably benign 0.00
R7874:Ccng2 UTSW 5 93,421,202 (GRCm39) missense probably benign 0.00
R7875:Ccng2 UTSW 5 93,421,202 (GRCm39) missense probably benign 0.00
R7876:Ccng2 UTSW 5 93,421,202 (GRCm39) missense probably benign 0.00
R7877:Ccng2 UTSW 5 93,421,202 (GRCm39) missense probably benign 0.00
R7884:Ccng2 UTSW 5 93,421,202 (GRCm39) missense probably benign 0.00
R8053:Ccng2 UTSW 5 93,421,202 (GRCm39) missense probably benign 0.00
R8279:Ccng2 UTSW 5 93,421,202 (GRCm39) missense probably benign 0.00
R8282:Ccng2 UTSW 5 93,421,202 (GRCm39) missense probably benign 0.00
R8492:Ccng2 UTSW 5 93,419,313 (GRCm39) missense probably damaging 1.00
R8503:Ccng2 UTSW 5 93,421,202 (GRCm39) missense probably benign 0.00
R8504:Ccng2 UTSW 5 93,421,202 (GRCm39) missense probably benign 0.00
R8528:Ccng2 UTSW 5 93,417,164 (GRCm39) missense possibly damaging 0.60
R9010:Ccng2 UTSW 5 93,416,616 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TCAGTCAGTGTAAATGCACAGCGTC -3'
(R):5'- AGAGAATTTCCAGCAGTTCCACGG -3'

Sequencing Primer
(F):5'- CTATGAGCTGGAAGCTACCACTG -3'
(R):5'- AGCAGTTCCACGGATTTTATCG -3'
Posted On 2013-05-09