Mutagenetix > Incidental Mutation

Incidental Mutation 'R4677:Ccpg1'

349675

Institutional Source

Beutler Lab

Gene Symbol

Ccpg1

Ensembl Gene

ENSMUSG00000034563

Gene Name

cell cycle progression 1

Synonyms

9430028F23Rik, 1810073J13Rik, 1700030B06Rik, D9Ertd392e

MMRRC Submission

042014-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R4677 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

72892711-72923622 bp(+) (GRCm39)

Type of Mutation

intron

DNA Base Change (assembly)

A to G at 72923197 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000139076 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000037977] [ENSMUST00000085350] [ENSMUST00000093819] [ENSMUST00000098566] [ENSMUST00000124008] [ENSMUST00000184389] [ENSMUST00000184035] [ENSMUST00000183746] [ENSMUST00000140675] [ENSMUST00000149692] [ENSMUST00000150826]

AlphaFold

Q640L3

Predicted Effect

probably benign
Transcript: ENSMUST00000037977

SMART Domains

Protein: ENSMUSP00000045669
Gene: ENSMUSG00000034563

Domain	Start	End	E-Value	Type
low complexity region	2	11	N/A	INTRINSIC
low complexity region	83	94	N/A	INTRINSIC
low complexity region	155	174	N/A	INTRINSIC
low complexity region	187	209	N/A	INTRINSIC
transmembrane domain	219	241	N/A	INTRINSIC
coiled coil region	296	450	N/A	INTRINSIC
low complexity region	566	572	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000085350

SMART Domains

Protein: ENSMUSP00000082458
Gene: ENSMUSG00000034563

Domain	Start	End	E-Value	Type
low complexity region	2	11	N/A	INTRINSIC
low complexity region	83	94	N/A	INTRINSIC
low complexity region	155	174	N/A	INTRINSIC
low complexity region	187	209	N/A	INTRINSIC
transmembrane domain	219	241	N/A	INTRINSIC
coiled coil region	296	450	N/A	INTRINSIC
low complexity region	566	572	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000093819

Predicted Effect

probably benign
Transcript: ENSMUST00000098566

SMART Domains

Protein: ENSMUSP00000096165
Gene: ENSMUSG00000079469

Domain	Start	End	E-Value	Type
Pfam:Glyco_transf_22	51	438	4.7e-122	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000124008

SMART Domains

Protein: ENSMUSP00000121059
Gene: ENSMUSG00000034563

Domain	Start	End	E-Value	Type
low complexity region	2	11	N/A	INTRINSIC
low complexity region	83	94	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000131924

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000138466

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000184776

Predicted Effect

probably benign
Transcript: ENSMUST00000184389

SMART Domains

Protein: ENSMUSP00000139076
Gene: ENSMUSG00000079469

Domain	Start	End	E-Value	Type
Pfam:Glyco_transf_22	51	438	3.9e-122	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000184035

SMART Domains

Protein: ENSMUSP00000139269
Gene: ENSMUSG00000079469

Domain	Start	End	E-Value	Type
Pfam:Glyco_transf_22	51	438	3.9e-122	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000183746

SMART Domains

Protein: ENSMUSP00000138885
Gene: ENSMUSG00000079469

Domain	Start	End	E-Value	Type
Pfam:Glyco_transf_22	51	438	3.9e-122	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000140675

SMART Domains

Protein: ENSMUSP00000116976
Gene: ENSMUSG00000034563

Domain	Start	End	E-Value	Type
low complexity region	2	11	N/A	INTRINSIC
low complexity region	83	94	N/A	INTRINSIC
low complexity region	155	174	N/A	INTRINSIC
low complexity region	187	209	N/A	INTRINSIC
transmembrane domain	219	241	N/A	INTRINSIC
coiled coil region	296	450	N/A	INTRINSIC
low complexity region	566	572	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000149692

SMART Domains

Protein: ENSMUSP00000120629
Gene: ENSMUSG00000089865

Domain	Start	End	E-Value	Type
Pfam:CS	6	77	2.1e-9	PFAM
coiled coil region	101	161	N/A	INTRINSIC
Pfam:TPR_11	286	352	2e-14	PFAM
Pfam:TPR_1	322	352	5.6e-6	PFAM
Blast:TPR	364	386	1e-5	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000150826

SMART Domains

Protein: ENSMUSP00000122966
Gene: ENSMUSG00000034563

Domain	Start	End	E-Value	Type
low complexity region	2	11	N/A	INTRINSIC
low complexity region	83	94	N/A	INTRINSIC
low complexity region	155	174	N/A	INTRINSIC
low complexity region	187	209	N/A	INTRINSIC
transmembrane domain	219	241	N/A	INTRINSIC
coiled coil region	296	450	N/A	INTRINSIC
low complexity region	566	572	N/A	INTRINSIC

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.9%
20x: 94.2%

Validation Efficiency

100% (85/85)

Allele List at MGI

Other mutations in this stock

Total: 74 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts9	T	C	6: 92,793,587 (GRCm39)	M1T	probably null	Het
Akap3	T	C	6: 126,842,226 (GRCm39)	S282P	probably damaging	Het
Anxa10	A	G	8: 62,516,054 (GRCm39)	I206T	probably damaging	Het
Apobec3	A	G	15: 79,779,713 (GRCm39)	D52G	probably damaging	Het
Arl6	A	T	16: 59,439,228 (GRCm39)		probably null	Het
Calcoco1	T	C	15: 102,626,329 (GRCm39)	E87G	probably damaging	Het
Ccdc88b	C	A	19: 6,825,636 (GRCm39)	A1206S	probably damaging	Het
Cdon	A	G	9: 35,389,901 (GRCm39)	N852D	probably damaging	Het
Cobl	T	A	11: 12,336,665 (GRCm39)	Q41L	possibly damaging	Het
Cspg4b	A	G	13: 113,516,020 (GRCm39)	T145A	unknown	Het
Dcdc2b	T	C	4: 129,507,936 (GRCm39)	T39A	probably damaging	Het
Ddx55	A	T	5: 124,705,997 (GRCm39)	D474V	probably benign	Het
Dipk2a	A	T	9: 94,402,457 (GRCm39)	C402S	probably damaging	Het
Dnah17	A	G	11: 118,010,640 (GRCm39)	L521P	probably damaging	Het
Exoc1	A	G	5: 76,707,010 (GRCm39)	D497G	probably null	Het
Fam151a	A	G	4: 106,605,456 (GRCm39)	E606G	possibly damaging	Het
Fbxw11	T	A	11: 32,692,535 (GRCm39)	L502*	probably null	Het
Fcrl1	A	G	3: 87,297,563 (GRCm39)	S337G	possibly damaging	Het
G6pc1	C	A	11: 101,267,439 (GRCm39)	F296L	probably benign	Het
Gm17472	C	A	6: 42,957,809 (GRCm39)	T26N	probably damaging	Het
Grin2b	A	G	6: 135,751,870 (GRCm39)	V564A	probably benign	Het
H2-Ob	T	C	17: 34,461,618 (GRCm39)	I119T	probably benign	Het
Hhip	A	G	8: 80,771,726 (GRCm39)	Y195H	probably damaging	Het
Igkc	A	T	6: 70,703,662 (GRCm39)		probably benign	Het
Islr	A	T	9: 58,064,642 (GRCm39)	D288E	probably damaging	Het
Kdelr1	A	G	7: 45,523,197 (GRCm39)	S36G	probably benign	Het
Lama5	G	T	2: 179,821,159 (GRCm39)	H3134Q	possibly damaging	Het
Loricrin	A	G	3: 91,989,050 (GRCm39)	Y79H	unknown	Het
Lrp1b	A	G	2: 40,691,496 (GRCm39)	F3327S	probably damaging	Het
Lrrc41	C	T	4: 115,952,332 (GRCm39)	H637Y	probably benign	Het
Map2k6	C	T	11: 110,290,220 (GRCm39)		probably benign	Het
Mcm3ap	T	G	10: 76,306,404 (GRCm39)	F172L	probably damaging	Het
Muc19	G	A	15: 91,772,411 (GRCm39)		noncoding transcript	Het
Muc21	T	A	17: 35,930,599 (GRCm39)		probably benign	Het
Muc6	T	A	7: 141,224,212 (GRCm39)		probably benign	Het
Nek1	A	T	8: 61,481,840 (GRCm39)	I252L	probably damaging	Het
Nrg2	A	T	18: 36,154,152 (GRCm39)	H588Q	possibly damaging	Het
Nt5dc2	T	C	14: 30,860,878 (GRCm39)	V351A	possibly damaging	Het
Or1j12	A	G	2: 36,343,062 (GRCm39)	N155S	probably benign	Het
Or51b17	T	C	7: 103,542,615 (GRCm39)	E109G	probably damaging	Het
Or5m5	A	G	2: 85,814,315 (GRCm39)	T44A	possibly damaging	Het
Or8k1	A	T	2: 86,048,032 (GRCm39)	S7R	probably benign	Het
Pde3a	A	G	6: 141,411,865 (GRCm39)	N480D	probably benign	Het
Pde6c	A	G	19: 38,145,833 (GRCm39)	K374E	probably damaging	Het
Pdhx	G	A	2: 102,903,811 (GRCm39)		probably null	Het
Pi4ka	A	G	16: 17,100,237 (GRCm39)	Y1888H	probably damaging	Het
Pnpla2	T	A	7: 141,038,356 (GRCm39)	M203K	probably damaging	Het
Prrc2c	C	T	1: 162,532,748 (GRCm39)		probably benign	Het
Ptcd3	G	T	6: 71,870,498 (GRCm39)	H321N	probably benign	Het
Ptprt	A	G	2: 161,743,366 (GRCm39)		probably null	Het
Ptx4	A	G	17: 25,342,100 (GRCm39)	T192A	probably benign	Het
Qars1	A	G	9: 108,386,889 (GRCm39)		probably benign	Het
Ralgapa2	G	A	2: 146,187,387 (GRCm39)	P1372S	possibly damaging	Het
Rps6ka4	G	T	19: 6,816,854 (GRCm39)	T107K	probably damaging	Het
Rsf1	A	G	7: 97,329,980 (GRCm39)	T1169A	possibly damaging	Het
Ryr2	C	A	13: 11,721,553 (GRCm39)	W2626L	probably damaging	Het
Scn4a	C	T	11: 106,214,788 (GRCm39)	V1270I	probably damaging	Het
Serpinb9b	T	C	13: 33,223,806 (GRCm39)	S333P	probably damaging	Het
Sned1	A	G	1: 93,224,019 (GRCm39)		probably benign	Het
Sult1c2	C	T	17: 54,137,137 (GRCm39)	V262M	possibly damaging	Het
Tll1	A	T	8: 64,504,411 (GRCm39)	F662I	probably benign	Het
Tmem161a	A	T	8: 70,633,597 (GRCm39)		probably null	Het
Top1mt	A	C	15: 75,535,907 (GRCm39)	V465G	possibly damaging	Het
Trcg1	A	G	9: 57,153,144 (GRCm39)	K596E	possibly damaging	Het
Trim27	T	A	13: 21,365,086 (GRCm39)		probably null	Het
Trpm3	A	G	19: 22,964,752 (GRCm39)	I1406V	possibly damaging	Het
Tssc4	T	A	7: 142,624,246 (GRCm39)	S254T	probably damaging	Het
Ttc7	C	A	17: 87,678,163 (GRCm39)		probably benign	Het
Usp30	A	G	5: 114,257,705 (GRCm39)	T288A	probably damaging	Het
Usp48	C	A	4: 137,343,692 (GRCm39)	R441S	probably benign	Het
Vmn1r29	T	C	6: 58,284,285 (GRCm39)	S2P	probably benign	Het
Vmn2r65	T	A	7: 84,613,082 (GRCm39)	I46L	possibly damaging	Het
Zeb1	A	T	18: 5,766,775 (GRCm39)	I429F	probably damaging	Het
Zfp943	A	G	17: 22,212,176 (GRCm39)	R421G	probably benign	Het

Other mutations in Ccpg1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01665:Ccpg1	APN	9	72,913,159 (GRCm39)	missense	probably damaging	1.00
IGL01710:Ccpg1	APN	9	72,904,723 (GRCm39)	utr 3 prime	probably benign
IGL01818:Ccpg1	APN	9	72,904,735 (GRCm39)	missense	probably damaging	1.00
K7894:Ccpg1	UTSW	9	72,909,159 (GRCm39)	critical splice donor site	probably null
R0586:Ccpg1	UTSW	9	72,909,103 (GRCm39)	missense	probably benign	0.00
R1188:Ccpg1	UTSW	9	72,919,788 (GRCm39)	missense	possibly damaging	0.55
R1503:Ccpg1	UTSW	9	72,906,760 (GRCm39)	missense	probably benign	0.00
R1599:Ccpg1	UTSW	9	72,906,407 (GRCm39)	nonsense	probably null
R2130:Ccpg1	UTSW	9	72,920,440 (GRCm39)	missense	probably damaging	0.98
R2188:Ccpg1	UTSW	9	72,920,388 (GRCm39)	missense	probably benign	0.00
R3052:Ccpg1	UTSW	9	72,913,150 (GRCm39)	missense	probably damaging	1.00
R4155:Ccpg1	UTSW	9	72,919,449 (GRCm39)	missense	probably benign	0.38
R4156:Ccpg1	UTSW	9	72,919,449 (GRCm39)	missense	probably benign	0.38
R4157:Ccpg1	UTSW	9	72,919,449 (GRCm39)	missense	probably benign	0.38
R4257:Ccpg1	UTSW	9	72,919,909 (GRCm39)	missense	probably damaging	1.00
R5081:Ccpg1	UTSW	9	72,906,360 (GRCm39)	missense	possibly damaging	0.94
R5227:Ccpg1	UTSW	9	72,919,354 (GRCm39)	nonsense	probably null
R5288:Ccpg1	UTSW	9	72,920,326 (GRCm39)	missense	probably benign
R5385:Ccpg1	UTSW	9	72,920,326 (GRCm39)	missense	probably benign
R5386:Ccpg1	UTSW	9	72,920,326 (GRCm39)	missense	probably benign
R5412:Ccpg1	UTSW	9	72,917,588 (GRCm39)	missense	probably damaging	1.00
R5754:Ccpg1	UTSW	9	72,920,526 (GRCm39)	missense	possibly damaging	0.78
R6230:Ccpg1	UTSW	9	72,919,638 (GRCm39)	missense	probably benign	0.00
R7269:Ccpg1	UTSW	9	72,920,609 (GRCm39)	missense	probably benign	0.06
R7287:Ccpg1	UTSW	9	72,922,688 (GRCm39)	missense	probably benign	0.05
R7542:Ccpg1	UTSW	9	72,919,741 (GRCm39)	missense	probably damaging	1.00
R7882:Ccpg1	UTSW	9	72,922,787 (GRCm39)	missense	probably damaging	1.00
R8266:Ccpg1	UTSW	9	72,913,001 (GRCm39)	missense	probably damaging	1.00
R8268:Ccpg1	UTSW	9	72,913,001 (GRCm39)	missense	probably damaging	1.00
R8269:Ccpg1	UTSW	9	72,913,001 (GRCm39)	missense	probably damaging	1.00
R8345:Ccpg1	UTSW	9	72,913,001 (GRCm39)	missense	probably damaging	1.00
R8829:Ccpg1	UTSW	9	72,917,633 (GRCm39)	missense	probably benign	0.00
R9450:Ccpg1	UTSW	9	72,904,703 (GRCm39)	missense	unknown
R9648:Ccpg1	UTSW	9	72,919,312 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ATGAAACAGGGCTTGGTTTGAG -3'
(R):5'- AAGGACTTCTGCAGAGACGTTG -3'

Sequencing Primer
(F):5'- CTTGGTTTGAGGAGCTGAGC -3'
(R):5'- CTTCTGCAGAGACGTTGGCATAAC -3'

Posted On

2015-10-08