Incidental Mutation 'R4678:Arhgef4'
| ID |
349709 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Arhgef4
|
| Ensembl Gene |
ENSMUSG00000037509 |
| Gene Name |
Rho guanine nucleotide exchange factor 4 |
| Synonyms |
Asef, 9330140K16Rik, C230030N03Rik |
| MMRRC Submission |
041931-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4678 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
34717263-34851819 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 34761749 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Glycine
at position 335
(E335G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124213
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000159747]
|
| AlphaFold |
Q7TNR9 |
| Predicted Effect |
unknown
Transcript: ENSMUST00000159747
AA Change: E335G
|
| SMART Domains |
Protein: ENSMUSP00000124213
Gene: ENSMUSG00000037509
AA Change: E335G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
15 |
28 |
N/A |
INTRINSIC |
|
low complexity region
|
573 |
584 |
N/A |
INTRINSIC |
|
low complexity region
|
686 |
712 |
N/A |
INTRINSIC |
|
low complexity region
|
915 |
926 |
N/A |
INTRINSIC |
|
low complexity region
|
1119 |
1137 |
N/A |
INTRINSIC |
|
low complexity region
|
1240 |
1254 |
N/A |
INTRINSIC |
|
SH3
|
1361 |
1416 |
3.73e-16 |
SMART |
|
RhoGEF
|
1453 |
1632 |
3.86e-56 |
SMART |
|
PH
|
1665 |
1773 |
2.33e-14 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 96.9%
- 20x: 94.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The protein encoded by this gene may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jun 2013]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased angiogenesis, vascular endothelial cell migration, tumor growth, and tumor vascularization. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(1) : Targeted, other(1) |
| Other mutations in this stock |
Total: 105 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110025L11Rik |
T |
C |
16: 88,860,873 (GRCm39) |
|
probably benign |
Het |
| Abcc4 |
A |
G |
14: 118,865,103 (GRCm39) |
S308P |
probably damaging |
Het |
| Agr3 |
G |
T |
12: 35,997,832 (GRCm39) |
V115L |
probably damaging |
Het |
| Ahr |
A |
T |
12: 35,557,463 (GRCm39) |
I319N |
probably damaging |
Het |
| Alpk1 |
A |
T |
3: 127,473,507 (GRCm39) |
V832D |
probably damaging |
Het |
| Ano1 |
T |
C |
7: 144,223,289 (GRCm39) |
T78A |
probably benign |
Het |
| Apob |
G |
A |
12: 8,045,585 (GRCm39) |
G897D |
probably damaging |
Het |
| Arfgef1 |
A |
G |
1: 10,212,891 (GRCm39) |
F1677L |
probably benign |
Het |
| Arhgap40 |
G |
T |
2: 158,374,226 (GRCm39) |
G217W |
probably benign |
Het |
| Calcoco2 |
T |
C |
11: 95,994,374 (GRCm39) |
T60A |
probably damaging |
Het |
| Catsperg1 |
A |
T |
7: 28,889,721 (GRCm39) |
S741T |
probably benign |
Het |
| Ccdc181 |
T |
G |
1: 164,105,846 (GRCm39) |
I27S |
probably damaging |
Het |
| Ceacam9 |
A |
T |
7: 16,459,334 (GRCm39) |
Y211F |
probably damaging |
Het |
| Cep41 |
T |
C |
6: 30,671,318 (GRCm39) |
|
probably null |
Het |
| Cercam |
T |
A |
2: 29,759,689 (GRCm39) |
L45Q |
probably damaging |
Het |
| Cnnm2 |
G |
A |
19: 46,751,685 (GRCm39) |
V492M |
possibly damaging |
Het |
| Cntn3 |
A |
G |
6: 102,180,981 (GRCm39) |
V738A |
probably damaging |
Het |
| Coq8a |
T |
C |
1: 179,997,646 (GRCm39) |
E351G |
probably damaging |
Het |
| Cyp3a57 |
T |
C |
5: 145,307,538 (GRCm39) |
|
probably null |
Het |
| Dbn1 |
T |
C |
13: 55,623,071 (GRCm39) |
I471V |
probably benign |
Het |
| Ddx21 |
G |
T |
10: 62,429,782 (GRCm39) |
Q321K |
probably benign |
Het |
| Dhx8 |
T |
C |
11: 101,630,634 (GRCm39) |
V347A |
probably damaging |
Het |
| Dkc1 |
A |
G |
X: 74,144,598 (GRCm39) |
I215V |
probably benign |
Homo |
| Dlg2 |
A |
G |
7: 92,077,788 (GRCm39) |
I685V |
possibly damaging |
Het |
| Dusp11 |
A |
C |
6: 85,930,363 (GRCm39) |
N140K |
probably damaging |
Het |
| Ece2 |
A |
G |
16: 20,459,468 (GRCm39) |
K454R |
probably damaging |
Het |
| Eno4 |
T |
A |
19: 58,935,181 (GRCm39) |
V131E |
probably damaging |
Het |
| Enpep |
A |
G |
3: 129,097,362 (GRCm39) |
|
probably null |
Het |
| Etv1 |
T |
C |
12: 38,885,219 (GRCm39) |
Y236H |
probably damaging |
Het |
| F2rl2 |
A |
G |
13: 95,837,140 (GRCm39) |
T62A |
probably benign |
Het |
| Fbxl21 |
T |
C |
13: 56,684,862 (GRCm39) |
V296A |
probably damaging |
Het |
| Fig4 |
T |
C |
10: 41,148,994 (GRCm39) |
I153V |
probably benign |
Het |
| Fis1 |
T |
A |
5: 136,991,951 (GRCm39) |
N41K |
possibly damaging |
Het |
| Fras1 |
T |
A |
5: 96,848,427 (GRCm39) |
M1814K |
probably benign |
Het |
| Frem2 |
T |
A |
3: 53,451,792 (GRCm39) |
I2266F |
probably benign |
Het |
| Gm10330 |
A |
T |
12: 23,829,843 (GRCm39) |
*113R |
probably null |
Het |
| Gm12185 |
T |
A |
11: 48,806,367 (GRCm39) |
I275F |
probably benign |
Het |
| Gsdme |
A |
T |
6: 50,206,304 (GRCm39) |
C180S |
possibly damaging |
Het |
| Herc1 |
A |
G |
9: 66,323,551 (GRCm39) |
E1355G |
probably benign |
Het |
| Hnrnpm |
A |
T |
17: 33,869,185 (GRCm39) |
I453N |
possibly damaging |
Het |
| Hspb9 |
T |
C |
11: 100,604,896 (GRCm39) |
L74P |
probably damaging |
Het |
| Ift46 |
C |
A |
9: 44,695,260 (GRCm39) |
Y85* |
probably null |
Het |
| Insyn2b |
T |
G |
11: 34,353,227 (GRCm39) |
L423R |
probably damaging |
Het |
| Ints3 |
T |
C |
3: 90,315,817 (GRCm39) |
T316A |
possibly damaging |
Het |
| Isg20 |
C |
T |
7: 78,564,076 (GRCm39) |
|
probably benign |
Het |
| Itga11 |
T |
A |
9: 62,642,639 (GRCm39) |
N187K |
probably damaging |
Het |
| Klhl9 |
G |
A |
4: 88,639,161 (GRCm39) |
T360I |
probably damaging |
Het |
| Krt39 |
T |
A |
11: 99,411,826 (GRCm39) |
I87F |
probably benign |
Het |
| Krtap19-4 |
G |
A |
16: 88,681,734 (GRCm39) |
S74F |
unknown |
Het |
| Lgi1 |
G |
A |
19: 38,289,737 (GRCm39) |
V268I |
probably damaging |
Het |
| Lrrc46 |
G |
A |
11: 96,925,719 (GRCm39) |
P248S |
probably benign |
Het |
| Lrrn4 |
C |
T |
2: 132,721,488 (GRCm39) |
V110I |
probably benign |
Het |
| Mamstr |
C |
A |
7: 45,294,116 (GRCm39) |
|
probably benign |
Het |
| Micu3 |
T |
A |
8: 40,833,718 (GRCm39) |
F451I |
probably damaging |
Het |
| Mid1 |
C |
A |
X: 168,768,044 (GRCm39) |
D130E |
possibly damaging |
Het |
| Mkks |
T |
C |
2: 136,722,201 (GRCm39) |
T319A |
probably benign |
Het |
| Mob3c |
A |
G |
4: 115,690,968 (GRCm39) |
|
probably null |
Het |
| Muc6 |
T |
C |
7: 141,230,554 (GRCm39) |
E1192G |
probably benign |
Het |
| Ndc80 |
A |
G |
17: 71,827,753 (GRCm39) |
|
probably null |
Het |
| Nfx1 |
A |
G |
4: 41,012,070 (GRCm39) |
K807E |
probably benign |
Het |
| Nrxn1 |
A |
T |
17: 90,930,850 (GRCm39) |
L181Q |
probably damaging |
Het |
| Nsun7 |
A |
G |
5: 66,418,407 (GRCm39) |
S46G |
probably benign |
Het |
| Nup98 |
A |
T |
7: 101,834,038 (GRCm39) |
L308H |
probably damaging |
Het |
| Or4c115 |
C |
A |
2: 88,927,860 (GRCm39) |
W137L |
probably benign |
Het |
| Or52j3 |
T |
C |
7: 102,836,098 (GRCm39) |
F97L |
probably damaging |
Het |
| Or6f2 |
T |
C |
7: 139,756,141 (GRCm39) |
V36A |
probably benign |
Het |
| Or8k32 |
T |
C |
2: 86,369,077 (GRCm39) |
M61V |
possibly damaging |
Het |
| Palb2 |
T |
C |
7: 121,726,589 (GRCm39) |
K427R |
probably damaging |
Het |
| Pcdha1 |
C |
A |
18: 37,063,965 (GRCm39) |
Q210K |
probably benign |
Het |
| Pcdhb2 |
T |
C |
18: 37,429,260 (GRCm39) |
L411P |
probably damaging |
Het |
| Pde4dip |
C |
A |
3: 97,602,321 (GRCm39) |
D2252Y |
probably damaging |
Het |
| Plekhg4 |
T |
A |
8: 106,107,003 (GRCm39) |
Y899* |
probably null |
Het |
| Plxnb2 |
G |
T |
15: 89,045,131 (GRCm39) |
T1105K |
probably benign |
Het |
| Psmd2 |
T |
C |
16: 20,478,719 (GRCm39) |
V606A |
probably damaging |
Het |
| Ptprq |
A |
T |
10: 107,521,043 (GRCm39) |
F710I |
probably benign |
Het |
| Rad51ap2 |
A |
G |
12: 11,506,552 (GRCm39) |
E158G |
probably damaging |
Het |
| Rasip1 |
T |
A |
7: 45,277,247 (GRCm39) |
H18Q |
possibly damaging |
Het |
| Rassf8 |
A |
G |
6: 145,760,808 (GRCm39) |
K45E |
probably damaging |
Het |
| Rrn3 |
T |
A |
16: 13,613,940 (GRCm39) |
M284K |
probably damaging |
Het |
| Rsf1 |
GGCG |
GGCGACGGCTGCG |
7: 97,229,113 (GRCm39) |
|
probably benign |
Het |
| Rtn2 |
C |
A |
7: 19,027,820 (GRCm39) |
N403K |
probably damaging |
Het |
| Rusc1 |
A |
G |
3: 88,997,027 (GRCm39) |
W462R |
probably damaging |
Het |
| Sdc3 |
T |
A |
4: 130,545,907 (GRCm39) |
|
probably benign |
Het |
| Secisbp2l |
C |
T |
2: 125,582,657 (GRCm39) |
G933D |
possibly damaging |
Het |
| Slc12a2 |
T |
A |
18: 58,039,032 (GRCm39) |
C537* |
probably null |
Het |
| Slc4a2 |
G |
A |
5: 24,639,238 (GRCm39) |
|
probably null |
Het |
| Spsb4 |
T |
A |
9: 96,877,744 (GRCm39) |
D193V |
probably damaging |
Het |
| Strn |
A |
C |
17: 78,984,780 (GRCm39) |
F288V |
probably damaging |
Het |
| Stx18 |
G |
A |
5: 38,293,712 (GRCm39) |
|
probably benign |
Het |
| Tfcp2l1 |
T |
A |
1: 118,596,378 (GRCm39) |
M371K |
probably benign |
Het |
| Thnsl1 |
A |
G |
2: 21,216,352 (GRCm39) |
|
probably null |
Het |
| Tlr11 |
C |
T |
14: 50,598,439 (GRCm39) |
H142Y |
possibly damaging |
Het |
| Tor1aip2 |
T |
A |
1: 155,940,780 (GRCm39) |
I362K |
probably damaging |
Het |
| Trmt13 |
T |
C |
3: 116,383,404 (GRCm39) |
K125E |
probably damaging |
Het |
| Trpm8 |
T |
C |
1: 88,264,851 (GRCm39) |
V320A |
probably benign |
Het |
| Ubr3 |
A |
T |
2: 69,766,263 (GRCm39) |
H377L |
probably damaging |
Het |
| Usp8 |
A |
G |
2: 126,567,349 (GRCm39) |
R123G |
probably null |
Het |
| Vim |
T |
A |
2: 13,579,775 (GRCm39) |
L178Q |
probably damaging |
Het |
| Vmn1r231 |
A |
C |
17: 21,110,489 (GRCm39) |
V142G |
possibly damaging |
Het |
| Vmn1r83 |
A |
G |
7: 12,055,697 (GRCm39) |
M120T |
possibly damaging |
Het |
| Vwce |
G |
T |
19: 10,642,012 (GRCm39) |
V913F |
possibly damaging |
Het |
| Zbtb18 |
C |
A |
1: 177,275,285 (GRCm39) |
T215K |
probably benign |
Het |
| Zeb2 |
A |
T |
2: 44,886,353 (GRCm39) |
D857E |
probably damaging |
Het |
| Zfp106 |
G |
A |
2: 120,364,221 (GRCm39) |
H729Y |
probably damaging |
Het |
| Zfp977 |
C |
A |
7: 42,229,437 (GRCm39) |
A363S |
probably benign |
Het |
|
| Other mutations in Arhgef4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00896:Arhgef4
|
APN |
1 |
34,850,777 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL02376:Arhgef4
|
APN |
1 |
34,845,140 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02604:Arhgef4
|
APN |
1 |
34,850,804 (GRCm39) |
nonsense |
probably null |
|
|
IGL03240:Arhgef4
|
APN |
1 |
34,845,107 (GRCm39) |
missense |
probably benign |
0.03 |
|
BB004:Arhgef4
|
UTSW |
1 |
34,846,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB014:Arhgef4
|
UTSW |
1 |
34,846,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0095:Arhgef4
|
UTSW |
1 |
34,771,451 (GRCm39) |
nonsense |
probably null |
|
|
R0157:Arhgef4
|
UTSW |
1 |
34,845,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0243:Arhgef4
|
UTSW |
1 |
34,846,080 (GRCm39) |
splice site |
probably null |
|
|
R0383:Arhgef4
|
UTSW |
1 |
34,849,614 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0440:Arhgef4
|
UTSW |
1 |
34,784,529 (GRCm39) |
splice site |
probably null |
|
|
R0452:Arhgef4
|
UTSW |
1 |
34,771,403 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0893:Arhgef4
|
UTSW |
1 |
34,846,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1429:Arhgef4
|
UTSW |
1 |
34,849,420 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1437:Arhgef4
|
UTSW |
1 |
34,763,026 (GRCm39) |
missense |
unknown |
|
|
R1669:Arhgef4
|
UTSW |
1 |
34,771,239 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1780:Arhgef4
|
UTSW |
1 |
34,763,241 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1809:Arhgef4
|
UTSW |
1 |
34,849,636 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1879:Arhgef4
|
UTSW |
1 |
34,761,521 (GRCm39) |
missense |
unknown |
|
|
R1908:Arhgef4
|
UTSW |
1 |
34,763,340 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1919:Arhgef4
|
UTSW |
1 |
34,850,221 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2020:Arhgef4
|
UTSW |
1 |
34,762,891 (GRCm39) |
missense |
unknown |
|
|
R2058:Arhgef4
|
UTSW |
1 |
34,761,458 (GRCm39) |
missense |
unknown |
|
|
R2213:Arhgef4
|
UTSW |
1 |
34,846,230 (GRCm39) |
splice site |
probably null |
|
|
R2851:Arhgef4
|
UTSW |
1 |
34,763,129 (GRCm39) |
missense |
unknown |
|
|
R2852:Arhgef4
|
UTSW |
1 |
34,763,129 (GRCm39) |
missense |
unknown |
|
|
R2853:Arhgef4
|
UTSW |
1 |
34,763,129 (GRCm39) |
missense |
unknown |
|
|
R3697:Arhgef4
|
UTSW |
1 |
34,761,521 (GRCm39) |
missense |
unknown |
|
|
R4012:Arhgef4
|
UTSW |
1 |
34,764,187 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4118:Arhgef4
|
UTSW |
1 |
34,771,428 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4133:Arhgef4
|
UTSW |
1 |
34,845,185 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4534:Arhgef4
|
UTSW |
1 |
34,762,162 (GRCm39) |
missense |
unknown |
|
|
R4535:Arhgef4
|
UTSW |
1 |
34,762,162 (GRCm39) |
missense |
unknown |
|
|
R4581:Arhgef4
|
UTSW |
1 |
34,771,205 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4665:Arhgef4
|
UTSW |
1 |
34,845,113 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4684:Arhgef4
|
UTSW |
1 |
34,850,866 (GRCm39) |
splice site |
probably null |
|
|
R4706:Arhgef4
|
UTSW |
1 |
34,771,298 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4745:Arhgef4
|
UTSW |
1 |
34,846,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4747:Arhgef4
|
UTSW |
1 |
34,762,355 (GRCm39) |
missense |
unknown |
|
|
R4988:Arhgef4
|
UTSW |
1 |
34,762,535 (GRCm39) |
missense |
unknown |
|
|
R5063:Arhgef4
|
UTSW |
1 |
34,763,296 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5154:Arhgef4
|
UTSW |
1 |
34,771,455 (GRCm39) |
missense |
probably benign |
0.43 |
|
R5156:Arhgef4
|
UTSW |
1 |
34,762,355 (GRCm39) |
missense |
unknown |
|
|
R5263:Arhgef4
|
UTSW |
1 |
34,764,078 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5450:Arhgef4
|
UTSW |
1 |
34,846,405 (GRCm39) |
intron |
probably benign |
|
|
R5807:Arhgef4
|
UTSW |
1 |
34,846,696 (GRCm39) |
intron |
probably benign |
|
|
R5863:Arhgef4
|
UTSW |
1 |
34,761,926 (GRCm39) |
missense |
unknown |
|
|
R6034:Arhgef4
|
UTSW |
1 |
34,760,984 (GRCm39) |
missense |
unknown |
|
|
R6034:Arhgef4
|
UTSW |
1 |
34,760,984 (GRCm39) |
missense |
unknown |
|
|
R6311:Arhgef4
|
UTSW |
1 |
34,763,062 (GRCm39) |
missense |
unknown |
|
|
R6315:Arhgef4
|
UTSW |
1 |
34,762,558 (GRCm39) |
missense |
unknown |
|
|
R6316:Arhgef4
|
UTSW |
1 |
34,762,558 (GRCm39) |
missense |
unknown |
|
|
R6318:Arhgef4
|
UTSW |
1 |
34,762,558 (GRCm39) |
missense |
unknown |
|
|
R6323:Arhgef4
|
UTSW |
1 |
34,762,558 (GRCm39) |
missense |
unknown |
|
|
R6324:Arhgef4
|
UTSW |
1 |
34,762,558 (GRCm39) |
missense |
unknown |
|
|
R6325:Arhgef4
|
UTSW |
1 |
34,762,558 (GRCm39) |
missense |
unknown |
|
|
R6340:Arhgef4
|
UTSW |
1 |
34,771,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6835:Arhgef4
|
UTSW |
1 |
34,845,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6981:Arhgef4
|
UTSW |
1 |
34,761,533 (GRCm39) |
missense |
unknown |
|
|
R7087:Arhgef4
|
UTSW |
1 |
34,850,767 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7297:Arhgef4
|
UTSW |
1 |
34,846,273 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7525:Arhgef4
|
UTSW |
1 |
34,848,785 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7614:Arhgef4
|
UTSW |
1 |
34,771,316 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7693:Arhgef4
|
UTSW |
1 |
34,763,222 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7892:Arhgef4
|
UTSW |
1 |
34,760,885 (GRCm39) |
missense |
unknown |
|
|
R7895:Arhgef4
|
UTSW |
1 |
34,845,478 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7927:Arhgef4
|
UTSW |
1 |
34,846,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7965:Arhgef4
|
UTSW |
1 |
34,850,762 (GRCm39) |
missense |
probably benign |
|
|
R7973:Arhgef4
|
UTSW |
1 |
34,763,518 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7979:Arhgef4
|
UTSW |
1 |
34,760,978 (GRCm39) |
missense |
unknown |
|
|
R8160:Arhgef4
|
UTSW |
1 |
34,762,655 (GRCm39) |
missense |
unknown |
|
|
R8175:Arhgef4
|
UTSW |
1 |
34,849,455 (GRCm39) |
missense |
probably benign |
|
|
R8178:Arhgef4
|
UTSW |
1 |
34,761,983 (GRCm39) |
missense |
unknown |
|
|
R9046:Arhgef4
|
UTSW |
1 |
34,850,846 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9077:Arhgef4
|
UTSW |
1 |
34,760,824 (GRCm39) |
missense |
unknown |
|
|
R9209:Arhgef4
|
UTSW |
1 |
34,849,576 (GRCm39) |
missense |
probably benign |
|
|
R9209:Arhgef4
|
UTSW |
1 |
34,764,241 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9355:Arhgef4
|
UTSW |
1 |
34,849,630 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9489:Arhgef4
|
UTSW |
1 |
34,761,745 (GRCm39) |
missense |
unknown |
|
|
R9509:Arhgef4
|
UTSW |
1 |
34,762,772 (GRCm39) |
missense |
unknown |
|
|
R9605:Arhgef4
|
UTSW |
1 |
34,761,745 (GRCm39) |
missense |
unknown |
|
|
R9665:Arhgef4
|
UTSW |
1 |
34,849,518 (GRCm39) |
missense |
probably benign |
|
|
R9675:Arhgef4
|
UTSW |
1 |
34,845,108 (GRCm39) |
missense |
probably benign |
|
|
R9790:Arhgef4
|
UTSW |
1 |
34,832,445 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9791:Arhgef4
|
UTSW |
1 |
34,832,445 (GRCm39) |
critical splice donor site |
probably null |
|
|
RF012:Arhgef4
|
UTSW |
1 |
34,763,565 (GRCm39) |
small deletion |
probably benign |
|
|
X0062:Arhgef4
|
UTSW |
1 |
34,763,308 (GRCm39) |
missense |
probably benign |
0.35 |
|
YA93:Arhgef4
|
UTSW |
1 |
34,771,298 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Arhgef4
|
UTSW |
1 |
34,844,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Arhgef4
|
UTSW |
1 |
34,762,810 (GRCm39) |
missense |
unknown |
|
|
Z1177:Arhgef4
|
UTSW |
1 |
34,763,340 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1177:Arhgef4
|
UTSW |
1 |
34,762,447 (GRCm39) |
missense |
unknown |
|
|
Z1177:Arhgef4
|
UTSW |
1 |
34,762,002 (GRCm39) |
missense |
unknown |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGTCAACCTCGATTGGGCAC -3'
(R):5'- TTTCCAGTGGAAGGCCTACAC -3'
Sequencing Primer
(F):5'- GATTGGGCACACCTTATCTCTTAGAC -3'
(R):5'- TGGAAGGCCTACACAGGGTG -3'
|
| Posted On |
2015-10-08 |
Incidental Mutation