Mutagenetix > Incidental Mutation

Incidental Mutation 'R4678:Herc1'

349776

Institutional Source

Beutler Lab

Gene Symbol

Herc1

Ensembl Gene

ENSMUSG00000038664

Gene Name

HECT and RLD domain containing E3 ubiquitin protein ligase family member 1

Synonyms

tbl, D130015N03Rik, 2810449H11Rik

MMRRC Submission

041931-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R4678 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

66257732-66416057 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 66323551 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 1355 (E1355G)

Ref Sequence

ENSEMBL: ENSMUSP00000044801 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000042824]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000042824
AA Change: E1355G

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000044801
Gene: ENSMUSG00000038664
AA Change: E1355G

Domain	Start	End	E-Value	Type
low complexity region	79	90	N/A	INTRINSIC
low complexity region	136	147	N/A	INTRINSIC
Pfam:RCC1	476	526	5.4e-15	PFAM
Pfam:RCC1_2	513	542	1.3e-9	PFAM
Pfam:RCC1	529	576	5.5e-16	PFAM
Pfam:RCC1	579	629	1.5e-10	PFAM
Pfam:RCC1	632	680	3.6e-9	PFAM
Pfam:RCC1_2	667	696	2.2e-11	PFAM
Pfam:RCC1	683	733	1.2e-14	PFAM
low complexity region	787	807	N/A	INTRINSIC
low complexity region	852	864	N/A	INTRINSIC
low complexity region	1014	1025	N/A	INTRINSIC
low complexity region	1080	1100	N/A	INTRINSIC
low complexity region	1348	1378	N/A	INTRINSIC
low complexity region	1659	1676	N/A	INTRINSIC
low complexity region	1865	1874	N/A	INTRINSIC
low complexity region	2002	2030	N/A	INTRINSIC
SPRY	2067	2188	1.8e-30	SMART
coiled coil region	2251	2280	N/A	INTRINSIC
low complexity region	2410	2423	N/A	INTRINSIC
low complexity region	2613	2629	N/A	INTRINSIC
low complexity region	2633	2648	N/A	INTRINSIC
low complexity region	2650	2667	N/A	INTRINSIC
low complexity region	2736	2749	N/A	INTRINSIC
low complexity region	2882	2896	N/A	INTRINSIC
low complexity region	2924	2935	N/A	INTRINSIC
low complexity region	2971	2987	N/A	INTRINSIC
low complexity region	3045	3051	N/A	INTRINSIC
low complexity region	3168	3186	N/A	INTRINSIC
low complexity region	3191	3213	N/A	INTRINSIC
low complexity region	3364	3379	N/A	INTRINSIC
WD40	3415	3454	1.68e-6	SMART
WD40	3570	3608	3.68e1	SMART
WD40	3613	3652	4.3e-1	SMART
WD40	3657	3702	3.17e-2	SMART
WD40	3734	3773	8.29e-6	SMART
low complexity region	3950	3964	N/A	INTRINSIC
Pfam:RCC1_2	4079	4111	7.3e-9	PFAM
Pfam:RCC1	4098	4147	3.4e-16	PFAM
Pfam:RCC1_2	4134	4163	1.8e-7	PFAM
Pfam:RCC1	4150	4199	7.2e-16	PFAM
Pfam:RCC1	4204	4252	6.1e-12	PFAM
Pfam:RCC1	4255	4304	2.4e-7	PFAM
Pfam:RCC1_2	4291	4320	5.8e-12	PFAM
Pfam:RCC1	4307	4356	8.9e-16	PFAM
Blast:HECTc	4389	4423	2e-11	BLAST
HECTc	4497	4846	8.2e-148	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000186450

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000187676

Coding Region Coverage

1x: 99.3%
3x: 98.6%
10x: 96.9%
20x: 94.1%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gen encodes a member of the HERC protein family. This protein stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein may be involved in membrane transport processes. [provided by RefSeq, Mar 2012]
PHENOTYPE: Homozygotes for this spontaneous mutation exhibit an abnormal cerebellar Purkinje cell layer and Purkinje cell degeneration. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 105 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110025L11Rik	T	C	16: 88,860,873 (GRCm39)		probably benign	Het
Abcc4	A	G	14: 118,865,103 (GRCm39)	S308P	probably damaging	Het
Agr3	G	T	12: 35,997,832 (GRCm39)	V115L	probably damaging	Het
Ahr	A	T	12: 35,557,463 (GRCm39)	I319N	probably damaging	Het
Alpk1	A	T	3: 127,473,507 (GRCm39)	V832D	probably damaging	Het
Ano1	T	C	7: 144,223,289 (GRCm39)	T78A	probably benign	Het
Apob	G	A	12: 8,045,585 (GRCm39)	G897D	probably damaging	Het
Arfgef1	A	G	1: 10,212,891 (GRCm39)	F1677L	probably benign	Het
Arhgap40	G	T	2: 158,374,226 (GRCm39)	G217W	probably benign	Het
Arhgef4	A	G	1: 34,761,749 (GRCm39)	E335G	unknown	Het
Calcoco2	T	C	11: 95,994,374 (GRCm39)	T60A	probably damaging	Het
Catsperg1	A	T	7: 28,889,721 (GRCm39)	S741T	probably benign	Het
Ccdc181	T	G	1: 164,105,846 (GRCm39)	I27S	probably damaging	Het
Ceacam9	A	T	7: 16,459,334 (GRCm39)	Y211F	probably damaging	Het
Cep41	T	C	6: 30,671,318 (GRCm39)		probably null	Het
Cercam	T	A	2: 29,759,689 (GRCm39)	L45Q	probably damaging	Het
Cnnm2	G	A	19: 46,751,685 (GRCm39)	V492M	possibly damaging	Het
Cntn3	A	G	6: 102,180,981 (GRCm39)	V738A	probably damaging	Het
Coq8a	T	C	1: 179,997,646 (GRCm39)	E351G	probably damaging	Het
Cyp3a57	T	C	5: 145,307,538 (GRCm39)		probably null	Het
Dbn1	T	C	13: 55,623,071 (GRCm39)	I471V	probably benign	Het
Ddx21	G	T	10: 62,429,782 (GRCm39)	Q321K	probably benign	Het
Dhx8	T	C	11: 101,630,634 (GRCm39)	V347A	probably damaging	Het
Dkc1	A	G	X: 74,144,598 (GRCm39)	I215V	probably benign	Homo
Dlg2	A	G	7: 92,077,788 (GRCm39)	I685V	possibly damaging	Het
Dusp11	A	C	6: 85,930,363 (GRCm39)	N140K	probably damaging	Het
Ece2	A	G	16: 20,459,468 (GRCm39)	K454R	probably damaging	Het
Eno4	T	A	19: 58,935,181 (GRCm39)	V131E	probably damaging	Het
Enpep	A	G	3: 129,097,362 (GRCm39)		probably null	Het
Etv1	T	C	12: 38,885,219 (GRCm39)	Y236H	probably damaging	Het
F2rl2	A	G	13: 95,837,140 (GRCm39)	T62A	probably benign	Het
Fbxl21	T	C	13: 56,684,862 (GRCm39)	V296A	probably damaging	Het
Fig4	T	C	10: 41,148,994 (GRCm39)	I153V	probably benign	Het
Fis1	T	A	5: 136,991,951 (GRCm39)	N41K	possibly damaging	Het
Fras1	T	A	5: 96,848,427 (GRCm39)	M1814K	probably benign	Het
Frem2	T	A	3: 53,451,792 (GRCm39)	I2266F	probably benign	Het
Gm10330	A	T	12: 23,829,843 (GRCm39)	*113R	probably null	Het
Gm12185	T	A	11: 48,806,367 (GRCm39)	I275F	probably benign	Het
Gsdme	A	T	6: 50,206,304 (GRCm39)	C180S	possibly damaging	Het
Hnrnpm	A	T	17: 33,869,185 (GRCm39)	I453N	possibly damaging	Het
Hspb9	T	C	11: 100,604,896 (GRCm39)	L74P	probably damaging	Het
Ift46	C	A	9: 44,695,260 (GRCm39)	Y85*	probably null	Het
Insyn2b	T	G	11: 34,353,227 (GRCm39)	L423R	probably damaging	Het
Ints3	T	C	3: 90,315,817 (GRCm39)	T316A	possibly damaging	Het
Isg20	C	T	7: 78,564,076 (GRCm39)		probably benign	Het
Itga11	T	A	9: 62,642,639 (GRCm39)	N187K	probably damaging	Het
Klhl9	G	A	4: 88,639,161 (GRCm39)	T360I	probably damaging	Het
Krt39	T	A	11: 99,411,826 (GRCm39)	I87F	probably benign	Het
Krtap19-4	G	A	16: 88,681,734 (GRCm39)	S74F	unknown	Het
Lgi1	G	A	19: 38,289,737 (GRCm39)	V268I	probably damaging	Het
Lrrc46	G	A	11: 96,925,719 (GRCm39)	P248S	probably benign	Het
Lrrn4	C	T	2: 132,721,488 (GRCm39)	V110I	probably benign	Het
Mamstr	C	A	7: 45,294,116 (GRCm39)		probably benign	Het
Micu3	T	A	8: 40,833,718 (GRCm39)	F451I	probably damaging	Het
Mid1	C	A	X: 168,768,044 (GRCm39)	D130E	possibly damaging	Het
Mkks	T	C	2: 136,722,201 (GRCm39)	T319A	probably benign	Het
Mob3c	A	G	4: 115,690,968 (GRCm39)		probably null	Het
Muc6	T	C	7: 141,230,554 (GRCm39)	E1192G	probably benign	Het
Ndc80	A	G	17: 71,827,753 (GRCm39)		probably null	Het
Nfx1	A	G	4: 41,012,070 (GRCm39)	K807E	probably benign	Het
Nrxn1	A	T	17: 90,930,850 (GRCm39)	L181Q	probably damaging	Het
Nsun7	A	G	5: 66,418,407 (GRCm39)	S46G	probably benign	Het
Nup98	A	T	7: 101,834,038 (GRCm39)	L308H	probably damaging	Het
Or4c115	C	A	2: 88,927,860 (GRCm39)	W137L	probably benign	Het
Or52j3	T	C	7: 102,836,098 (GRCm39)	F97L	probably damaging	Het
Or6f2	T	C	7: 139,756,141 (GRCm39)	V36A	probably benign	Het
Or8k32	T	C	2: 86,369,077 (GRCm39)	M61V	possibly damaging	Het
Palb2	T	C	7: 121,726,589 (GRCm39)	K427R	probably damaging	Het
Pcdha1	C	A	18: 37,063,965 (GRCm39)	Q210K	probably benign	Het
Pcdhb2	T	C	18: 37,429,260 (GRCm39)	L411P	probably damaging	Het
Pde4dip	C	A	3: 97,602,321 (GRCm39)	D2252Y	probably damaging	Het
Plekhg4	T	A	8: 106,107,003 (GRCm39)	Y899*	probably null	Het
Plxnb2	G	T	15: 89,045,131 (GRCm39)	T1105K	probably benign	Het
Psmd2	T	C	16: 20,478,719 (GRCm39)	V606A	probably damaging	Het
Ptprq	A	T	10: 107,521,043 (GRCm39)	F710I	probably benign	Het
Rad51ap2	A	G	12: 11,506,552 (GRCm39)	E158G	probably damaging	Het
Rasip1	T	A	7: 45,277,247 (GRCm39)	H18Q	possibly damaging	Het
Rassf8	A	G	6: 145,760,808 (GRCm39)	K45E	probably damaging	Het
Rrn3	T	A	16: 13,613,940 (GRCm39)	M284K	probably damaging	Het
Rsf1	GGCG	GGCGACGGCTGCG	7: 97,229,113 (GRCm39)		probably benign	Het
Rtn2	C	A	7: 19,027,820 (GRCm39)	N403K	probably damaging	Het
Rusc1	A	G	3: 88,997,027 (GRCm39)	W462R	probably damaging	Het
Sdc3	T	A	4: 130,545,907 (GRCm39)		probably benign	Het
Secisbp2l	C	T	2: 125,582,657 (GRCm39)	G933D	possibly damaging	Het
Slc12a2	T	A	18: 58,039,032 (GRCm39)	C537*	probably null	Het
Slc4a2	G	A	5: 24,639,238 (GRCm39)		probably null	Het
Spsb4	T	A	9: 96,877,744 (GRCm39)	D193V	probably damaging	Het
Strn	A	C	17: 78,984,780 (GRCm39)	F288V	probably damaging	Het
Stx18	G	A	5: 38,293,712 (GRCm39)		probably benign	Het
Tfcp2l1	T	A	1: 118,596,378 (GRCm39)	M371K	probably benign	Het
Thnsl1	A	G	2: 21,216,352 (GRCm39)		probably null	Het
Tlr11	C	T	14: 50,598,439 (GRCm39)	H142Y	possibly damaging	Het
Tor1aip2	T	A	1: 155,940,780 (GRCm39)	I362K	probably damaging	Het
Trmt13	T	C	3: 116,383,404 (GRCm39)	K125E	probably damaging	Het
Trpm8	T	C	1: 88,264,851 (GRCm39)	V320A	probably benign	Het
Ubr3	A	T	2: 69,766,263 (GRCm39)	H377L	probably damaging	Het
Usp8	A	G	2: 126,567,349 (GRCm39)	R123G	probably null	Het
Vim	T	A	2: 13,579,775 (GRCm39)	L178Q	probably damaging	Het
Vmn1r231	A	C	17: 21,110,489 (GRCm39)	V142G	possibly damaging	Het
Vmn1r83	A	G	7: 12,055,697 (GRCm39)	M120T	possibly damaging	Het
Vwce	G	T	19: 10,642,012 (GRCm39)	V913F	possibly damaging	Het
Zbtb18	C	A	1: 177,275,285 (GRCm39)	T215K	probably benign	Het
Zeb2	A	T	2: 44,886,353 (GRCm39)	D857E	probably damaging	Het
Zfp106	G	A	2: 120,364,221 (GRCm39)	H729Y	probably damaging	Het
Zfp977	C	A	7: 42,229,437 (GRCm39)	A363S	probably benign	Het

Other mutations in Herc1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00092:Herc1	APN	9	66,391,248 (GRCm39)	missense	probably benign	0.02
IGL00159:Herc1	APN	9	66,344,964 (GRCm39)	missense	possibly damaging	0.94
IGL00486:Herc1	APN	9	66,383,402 (GRCm39)	missense	probably benign
IGL00717:Herc1	APN	9	66,392,284 (GRCm39)	missense	probably damaging	1.00
IGL00766:Herc1	APN	9	66,358,023 (GRCm39)	missense	probably damaging	1.00
IGL00776:Herc1	APN	9	66,328,320 (GRCm39)	missense	probably benign
IGL00987:Herc1	APN	9	66,315,334 (GRCm39)	missense	probably benign	0.07
IGL01090:Herc1	APN	9	66,376,457 (GRCm39)	nonsense	probably null
IGL01098:Herc1	APN	9	66,369,204 (GRCm39)	critical splice donor site	probably null
IGL01106:Herc1	APN	9	66,383,720 (GRCm39)	splice site	probably benign
IGL01120:Herc1	APN	9	66,336,162 (GRCm39)	missense	probably benign
IGL01359:Herc1	APN	9	66,346,550 (GRCm39)	missense	probably benign	0.01
IGL01360:Herc1	APN	9	66,390,981 (GRCm39)	missense	probably benign
IGL01364:Herc1	APN	9	66,306,643 (GRCm39)	missense	probably benign	0.00
IGL01470:Herc1	APN	9	66,404,918 (GRCm39)	missense	possibly damaging	0.94
IGL01670:Herc1	APN	9	66,394,342 (GRCm39)	missense	probably damaging	1.00
IGL01825:Herc1	APN	9	66,307,089 (GRCm39)	missense	probably benign	0.00
IGL01903:Herc1	APN	9	66,294,154 (GRCm39)	nonsense	probably null
IGL01988:Herc1	APN	9	66,395,357 (GRCm39)	splice site	probably benign
IGL02074:Herc1	APN	9	66,358,265 (GRCm39)	missense	probably benign
IGL02089:Herc1	APN	9	66,388,151 (GRCm39)	missense	probably damaging	1.00
IGL02177:Herc1	APN	9	66,341,793 (GRCm39)	missense	probably benign
IGL02300:Herc1	APN	9	66,383,645 (GRCm39)	missense	probably benign	0.01
IGL02304:Herc1	APN	9	66,383,696 (GRCm39)	missense	probably benign	0.06
IGL02369:Herc1	APN	9	66,399,293 (GRCm39)	nonsense	probably null
IGL02445:Herc1	APN	9	66,340,764 (GRCm39)	missense	possibly damaging	0.95
IGL02447:Herc1	APN	9	66,404,610 (GRCm39)	missense	possibly damaging	0.59
IGL02549:Herc1	APN	9	66,307,183 (GRCm39)	missense	probably damaging	0.98
IGL02571:Herc1	APN	9	66,341,887 (GRCm39)	splice site	probably benign
IGL02709:Herc1	APN	9	66,404,962 (GRCm39)	missense	probably damaging	0.97
IGL02717:Herc1	APN	9	66,279,203 (GRCm39)	nonsense	probably null
IGL02726:Herc1	APN	9	66,349,270 (GRCm39)	missense	probably benign	0.37
IGL02733:Herc1	APN	9	66,358,274 (GRCm39)	missense	probably benign
IGL02963:Herc1	APN	9	66,296,105 (GRCm39)	missense	probably damaging	0.99
IGL03101:Herc1	APN	9	66,395,279 (GRCm39)	missense	probably benign
IGL03193:Herc1	APN	9	66,309,962 (GRCm39)	missense	probably benign
IGL03203:Herc1	APN	9	66,296,182 (GRCm39)	critical splice donor site	probably null
IGL03216:Herc1	APN	9	66,386,228 (GRCm39)	missense	probably benign	0.06
IGL03282:Herc1	APN	9	66,358,741 (GRCm39)	missense	probably benign	0.05
IGL03295:Herc1	APN	9	66,303,985 (GRCm39)	missense	possibly damaging	0.56
cradle	UTSW	9	66,391,148 (GRCm39)	splice site	probably null
miracles	UTSW	9	66,370,119 (GRCm39)	nonsense	probably null
newton	UTSW	9	66,375,085 (GRCm39)	missense	probably damaging	1.00
R0907_Herc1_362	UTSW	9	66,340,710 (GRCm39)	missense	possibly damaging	0.94
R4427_Herc1_231	UTSW	9	66,403,287 (GRCm39)	missense	probably damaging	1.00
R5026_Herc1_363	UTSW	9	66,393,408 (GRCm39)	missense	probably benign	0.03
stables	UTSW	9	66,386,735 (GRCm39)	missense	probably benign	0.13
strangle	UTSW	9	66,408,470 (GRCm39)	frame shift	probably null
IGL03134:Herc1	UTSW	9	66,341,345 (GRCm39)	critical splice acceptor site	probably benign
PIT4243001:Herc1	UTSW	9	66,279,489 (GRCm39)	missense	probably benign	0.00
PIT4486001:Herc1	UTSW	9	66,279,671 (GRCm39)	missense	probably damaging	1.00
PIT4696001:Herc1	UTSW	9	66,386,291 (GRCm39)	missense	probably damaging	1.00
R0044:Herc1	UTSW	9	66,355,457 (GRCm39)	missense	probably benign	0.04
R0044:Herc1	UTSW	9	66,355,457 (GRCm39)	missense	probably benign	0.04
R0052:Herc1	UTSW	9	66,307,438 (GRCm39)	missense	probably damaging	0.99
R0114:Herc1	UTSW	9	66,369,128 (GRCm39)	missense	probably damaging	0.99
R0129:Herc1	UTSW	9	66,355,357 (GRCm39)	missense	probably damaging	1.00
R0131:Herc1	UTSW	9	66,388,192 (GRCm39)	missense	probably benign	0.00
R0131:Herc1	UTSW	9	66,388,192 (GRCm39)	missense	probably benign	0.00
R0132:Herc1	UTSW	9	66,388,192 (GRCm39)	missense	probably benign	0.00
R0158:Herc1	UTSW	9	66,403,203 (GRCm39)	nonsense	probably null
R0333:Herc1	UTSW	9	66,371,981 (GRCm39)	splice site	probably null
R0384:Herc1	UTSW	9	66,388,332 (GRCm39)	splice site	probably benign
R0419:Herc1	UTSW	9	66,353,356 (GRCm39)	splice site	probably benign
R0453:Herc1	UTSW	9	66,307,054 (GRCm39)	missense	probably benign	0.20
R0458:Herc1	UTSW	9	66,383,663 (GRCm39)	missense	probably benign	0.12
R0490:Herc1	UTSW	9	66,392,281 (GRCm39)	missense	probably damaging	1.00
R0506:Herc1	UTSW	9	66,355,441 (GRCm39)	missense	probably damaging	0.99
R0513:Herc1	UTSW	9	66,352,927 (GRCm39)	missense	possibly damaging	0.96
R0628:Herc1	UTSW	9	66,358,163 (GRCm39)	missense	probably benign	0.35
R0666:Herc1	UTSW	9	66,392,170 (GRCm39)	splice site	probably benign
R0674:Herc1	UTSW	9	66,408,474 (GRCm39)	missense	probably damaging	0.99
R0682:Herc1	UTSW	9	66,389,263 (GRCm39)	missense	possibly damaging	0.95
R0690:Herc1	UTSW	9	66,294,120 (GRCm39)	nonsense	probably null
R0701:Herc1	UTSW	9	66,395,232 (GRCm39)	missense	probably damaging	1.00
R0766:Herc1	UTSW	9	66,412,122 (GRCm39)	missense	probably damaging	1.00
R0850:Herc1	UTSW	9	66,373,952 (GRCm39)	missense	probably damaging	1.00
R0907:Herc1	UTSW	9	66,340,710 (GRCm39)	missense	possibly damaging	0.94
R0972:Herc1	UTSW	9	66,279,427 (GRCm39)	missense	probably damaging	1.00
R0976:Herc1	UTSW	9	66,347,160 (GRCm39)	missense	possibly damaging	0.74
R1027:Herc1	UTSW	9	66,363,250 (GRCm39)	missense	probably benign
R1200:Herc1	UTSW	9	66,393,406 (GRCm39)	missense	probably damaging	1.00
R1226:Herc1	UTSW	9	66,323,545 (GRCm39)	missense	probably benign	0.00
R1364:Herc1	UTSW	9	66,307,375 (GRCm39)	missense	probably damaging	1.00
R1395:Herc1	UTSW	9	66,346,463 (GRCm39)	missense	probably benign	0.13
R1432:Herc1	UTSW	9	66,372,751 (GRCm39)	missense	probably benign	0.13
R1440:Herc1	UTSW	9	66,375,085 (GRCm39)	missense	probably damaging	1.00
R1476:Herc1	UTSW	9	66,415,548 (GRCm39)	missense	probably damaging	1.00
R1590:Herc1	UTSW	9	66,399,235 (GRCm39)	splice site	probably benign
R1634:Herc1	UTSW	9	66,380,820 (GRCm39)	missense	possibly damaging	0.51
R1700:Herc1	UTSW	9	66,357,960 (GRCm39)	splice site	probably null
R1753:Herc1	UTSW	9	66,409,366 (GRCm39)	critical splice donor site	probably null
R1753:Herc1	UTSW	9	66,376,292 (GRCm39)	missense	probably damaging	1.00
R1796:Herc1	UTSW	9	66,296,138 (GRCm39)	nonsense	probably null
R1830:Herc1	UTSW	9	66,404,881 (GRCm39)	missense	possibly damaging	0.95
R1855:Herc1	UTSW	9	66,298,708 (GRCm39)	missense	possibly damaging	0.95
R1866:Herc1	UTSW	9	66,358,073 (GRCm39)	missense	probably damaging	1.00
R1894:Herc1	UTSW	9	66,386,743 (GRCm39)	missense	probably damaging	1.00
R1918:Herc1	UTSW	9	66,383,408 (GRCm39)	splice site	probably null
R1999:Herc1	UTSW	9	66,393,360 (GRCm39)	missense	probably benign	0.07
R2034:Herc1	UTSW	9	66,349,254 (GRCm39)	missense	probably benign	0.01
R2138:Herc1	UTSW	9	66,377,589 (GRCm39)	missense	possibly damaging	0.94
R2186:Herc1	UTSW	9	66,347,183 (GRCm39)	missense	probably benign	0.45
R2192:Herc1	UTSW	9	66,372,688 (GRCm39)	missense	probably damaging	0.99
R2312:Herc1	UTSW	9	66,415,563 (GRCm39)	nonsense	probably null
R2338:Herc1	UTSW	9	66,336,251 (GRCm39)	missense	possibly damaging	0.69
R3035:Herc1	UTSW	9	66,391,217 (GRCm39)	missense	possibly damaging	0.89
R3732:Herc1	UTSW	9	66,352,922 (GRCm39)	missense	probably damaging	1.00
R3732:Herc1	UTSW	9	66,352,922 (GRCm39)	missense	probably damaging	1.00
R3733:Herc1	UTSW	9	66,352,922 (GRCm39)	missense	probably damaging	1.00
R3917:Herc1	UTSW	9	66,341,748 (GRCm39)	missense	possibly damaging	0.94
R3953:Herc1	UTSW	9	66,341,075 (GRCm39)	nonsense	probably null
R4073:Herc1	UTSW	9	66,325,774 (GRCm39)	missense	probably benign	0.12
R4075:Herc1	UTSW	9	66,325,774 (GRCm39)	missense	probably benign	0.12
R4241:Herc1	UTSW	9	66,355,630 (GRCm39)	frame shift	probably null
R4260:Herc1	UTSW	9	66,355,630 (GRCm39)	frame shift	probably null
R4261:Herc1	UTSW	9	66,355,630 (GRCm39)	frame shift	probably null
R4300:Herc1	UTSW	9	66,396,688 (GRCm39)	missense	probably damaging	1.00
R4398:Herc1	UTSW	9	66,386,735 (GRCm39)	missense	probably benign	0.13
R4426:Herc1	UTSW	9	66,403,287 (GRCm39)	missense	probably damaging	1.00
R4427:Herc1	UTSW	9	66,403,287 (GRCm39)	missense	probably damaging	1.00
R4590:Herc1	UTSW	9	66,344,946 (GRCm39)	missense	probably damaging	0.97
R4630:Herc1	UTSW	9	66,340,996 (GRCm39)	splice site	probably null
R4656:Herc1	UTSW	9	66,301,993 (GRCm39)	missense	probably damaging	0.97
R4658:Herc1	UTSW	9	66,386,773 (GRCm39)	missense	possibly damaging	0.50
R4663:Herc1	UTSW	9	66,340,660 (GRCm39)	missense	probably damaging	0.98
R4675:Herc1	UTSW	9	66,298,740 (GRCm39)	missense	probably damaging	1.00
R4754:Herc1	UTSW	9	66,408,488 (GRCm39)	missense	probably benign	0.00
R4766:Herc1	UTSW	9	66,349,211 (GRCm39)	missense	probably benign	0.00
R4792:Herc1	UTSW	9	66,403,266 (GRCm39)	missense	possibly damaging	0.67
R4828:Herc1	UTSW	9	66,404,625 (GRCm39)	splice site	probably null
R4832:Herc1	UTSW	9	66,403,253 (GRCm39)	missense	probably benign	0.11
R4879:Herc1	UTSW	9	66,370,119 (GRCm39)	nonsense	probably null
R4948:Herc1	UTSW	9	66,392,184 (GRCm39)	missense	probably benign
R5021:Herc1	UTSW	9	66,377,608 (GRCm39)	missense	possibly damaging	0.48
R5022:Herc1	UTSW	9	66,377,608 (GRCm39)	missense	possibly damaging	0.48
R5023:Herc1	UTSW	9	66,377,608 (GRCm39)	missense	possibly damaging	0.48
R5024:Herc1	UTSW	9	66,377,608 (GRCm39)	missense	possibly damaging	0.48
R5025:Herc1	UTSW	9	66,377,608 (GRCm39)	missense	possibly damaging	0.48
R5026:Herc1	UTSW	9	66,393,408 (GRCm39)	missense	probably benign	0.03
R5027:Herc1	UTSW	9	66,380,811 (GRCm39)	missense	probably benign	0.01
R5027:Herc1	UTSW	9	66,411,900 (GRCm39)	missense	probably damaging	0.98
R5038:Herc1	UTSW	9	66,383,742 (GRCm39)	intron	probably benign
R5041:Herc1	UTSW	9	66,336,327 (GRCm39)	missense	possibly damaging	0.86
R5053:Herc1	UTSW	9	66,377,608 (GRCm39)	missense	possibly damaging	0.48
R5137:Herc1	UTSW	9	66,355,505 (GRCm39)	missense	probably benign
R5197:Herc1	UTSW	9	66,355,786 (GRCm39)	missense	probably damaging	0.99
R5207:Herc1	UTSW	9	66,307,151 (GRCm39)	nonsense	probably null
R5247:Herc1	UTSW	9	66,341,833 (GRCm39)	missense	probably benign	0.01
R5267:Herc1	UTSW	9	66,369,091 (GRCm39)	missense	probably damaging	1.00
R5274:Herc1	UTSW	9	66,306,691 (GRCm39)	missense	probably benign
R5375:Herc1	UTSW	9	66,375,169 (GRCm39)	missense	probably damaging	0.99
R5401:Herc1	UTSW	9	66,409,338 (GRCm39)	missense	probably damaging	1.00
R5560:Herc1	UTSW	9	66,358,401 (GRCm39)	missense	probably benign	0.02
R5566:Herc1	UTSW	9	66,372,819 (GRCm39)	missense	possibly damaging	0.95
R5577:Herc1	UTSW	9	66,389,263 (GRCm39)	missense	probably damaging	0.99
R5596:Herc1	UTSW	9	66,341,345 (GRCm39)	critical splice acceptor site	probably benign
R5665:Herc1	UTSW	9	66,372,717 (GRCm39)	missense	probably damaging	1.00
R5744:Herc1	UTSW	9	66,415,475 (GRCm39)	missense	probably damaging	1.00
R5802:Herc1	UTSW	9	66,370,160 (GRCm39)	missense	probably damaging	1.00
R5822:Herc1	UTSW	9	66,352,894 (GRCm39)	missense	probably benign	0.00
R5954:Herc1	UTSW	9	66,358,774 (GRCm39)	splice site	probably benign
R5977:Herc1	UTSW	9	66,340,604 (GRCm39)	missense	possibly damaging	0.77
R6022:Herc1	UTSW	9	66,390,967 (GRCm39)	missense	probably damaging	1.00
R6043:Herc1	UTSW	9	66,315,436 (GRCm39)	missense	probably benign
R6046:Herc1	UTSW	9	66,352,831 (GRCm39)	missense	probably damaging	0.99
R6089:Herc1	UTSW	9	66,352,814 (GRCm39)	missense	probably damaging	1.00
R6123:Herc1	UTSW	9	66,404,532 (GRCm39)	missense	probably damaging	0.97
R6155:Herc1	UTSW	9	66,340,705 (GRCm39)	missense	possibly damaging	0.95
R6190:Herc1	UTSW	9	66,283,663 (GRCm39)	missense	possibly damaging	0.56
R6220:Herc1	UTSW	9	66,341,070 (GRCm39)	missense	probably damaging	1.00
R6265:Herc1	UTSW	9	66,279,298 (GRCm39)	missense	probably benign	0.05
R6348:Herc1	UTSW	9	66,395,258 (GRCm39)	missense	possibly damaging	0.77
R6362:Herc1	UTSW	9	66,379,190 (GRCm39)	missense	probably damaging	1.00
R6394:Herc1	UTSW	9	66,302,341 (GRCm39)	missense	probably damaging	0.99
R6434:Herc1	UTSW	9	66,393,464 (GRCm39)	missense	probably damaging	0.99
R6483:Herc1	UTSW	9	66,355,811 (GRCm39)	missense	possibly damaging	0.64
R6607:Herc1	UTSW	9	66,325,849 (GRCm39)	missense	probably benign	0.02
R6633:Herc1	UTSW	9	66,346,534 (GRCm39)	nonsense	probably null
R6634:Herc1	UTSW	9	66,345,026 (GRCm39)	missense	probably benign
R6693:Herc1	UTSW	9	66,386,258 (GRCm39)	missense	probably damaging	0.99
R6695:Herc1	UTSW	9	66,391,148 (GRCm39)	splice site	probably null
R6748:Herc1	UTSW	9	66,408,470 (GRCm39)	frame shift	probably null
R6750:Herc1	UTSW	9	66,408,470 (GRCm39)	frame shift	probably null
R6751:Herc1	UTSW	9	66,408,470 (GRCm39)	frame shift	probably null
R6774:Herc1	UTSW	9	66,408,470 (GRCm39)	frame shift	probably null
R6785:Herc1	UTSW	9	66,408,470 (GRCm39)	frame shift	probably null
R6786:Herc1	UTSW	9	66,408,470 (GRCm39)	frame shift	probably null
R6856:Herc1	UTSW	9	66,305,180 (GRCm39)	missense	probably benign	0.05
R6966:Herc1	UTSW	9	66,318,347 (GRCm39)	missense	probably benign	0.07
R7020:Herc1	UTSW	9	66,393,360 (GRCm39)	missense	probably benign	0.07
R7109:Herc1	UTSW	9	66,389,171 (GRCm39)	missense	probably benign	0.03
R7122:Herc1	UTSW	9	66,307,056 (GRCm39)	missense	possibly damaging	0.69
R7209:Herc1	UTSW	9	66,292,314 (GRCm39)	missense	possibly damaging	0.95
R7222:Herc1	UTSW	9	66,374,781 (GRCm39)	missense	probably damaging	0.98
R7303:Herc1	UTSW	9	66,358,098 (GRCm39)	missense	possibly damaging	0.93
R7305:Herc1	UTSW	9	66,369,150 (GRCm39)	missense
R7438:Herc1	UTSW	9	66,302,038 (GRCm39)	missense	probably benign	0.00
R7535:Herc1	UTSW	9	66,382,135 (GRCm39)	missense	probably damaging	1.00
R7585:Herc1	UTSW	9	66,352,829 (GRCm39)	missense	probably damaging	1.00
R7603:Herc1	UTSW	9	66,358,665 (GRCm39)	nonsense	probably null
R7670:Herc1	UTSW	9	66,323,629 (GRCm39)	missense	probably damaging	0.99
R7705:Herc1	UTSW	9	66,347,116 (GRCm39)	missense	possibly damaging	0.86
R7723:Herc1	UTSW	9	66,279,158 (GRCm39)	missense	probably benign	0.24
R7730:Herc1	UTSW	9	66,400,472 (GRCm39)	small deletion	probably benign
R7880:Herc1	UTSW	9	66,415,506 (GRCm39)	missense	probably damaging	0.99
R7958:Herc1	UTSW	9	66,393,475 (GRCm39)	missense	probably damaging	1.00
R7976:Herc1	UTSW	9	66,341,552 (GRCm39)	missense	possibly damaging	0.94
R8006:Herc1	UTSW	9	66,352,842 (GRCm39)	nonsense	probably null
R8084:Herc1	UTSW	9	66,383,217 (GRCm39)	missense	probably benign	0.45
R8094:Herc1	UTSW	9	66,400,462 (GRCm39)	missense	probably damaging	0.98
R8099:Herc1	UTSW	9	66,279,422 (GRCm39)	missense	probably damaging	1.00
R8151:Herc1	UTSW	9	66,341,073 (GRCm39)	missense	probably damaging	0.98
R8159:Herc1	UTSW	9	66,369,003 (GRCm39)	missense	probably null
R8190:Herc1	UTSW	9	66,325,733 (GRCm39)	missense	probably benign	0.00
R8213:Herc1	UTSW	9	66,358,170 (GRCm39)	missense	probably damaging	0.99
R8230:Herc1	UTSW	9	66,377,598 (GRCm39)	missense	probably damaging	0.99
R8265:Herc1	UTSW	9	66,293,986 (GRCm39)	nonsense	probably null
R8270:Herc1	UTSW	9	66,395,232 (GRCm39)	missense	probably damaging	1.00
R8353:Herc1	UTSW	9	66,415,571 (GRCm39)	missense	possibly damaging	0.88
R8423:Herc1	UTSW	9	66,415,442 (GRCm39)	missense	probably damaging	0.99
R8506:Herc1	UTSW	9	66,380,863 (GRCm39)	missense	possibly damaging	0.52
R8523:Herc1	UTSW	9	66,358,224 (GRCm39)	missense	probably benign
R8530:Herc1	UTSW	9	66,325,910 (GRCm39)	missense	probably benign
R8545:Herc1	UTSW	9	66,279,257 (GRCm39)	nonsense	probably null
R8682:Herc1	UTSW	9	66,370,130 (GRCm39)	missense
R8720:Herc1	UTSW	9	66,389,105 (GRCm39)	missense	probably benign	0.38
R8792:Herc1	UTSW	9	66,372,768 (GRCm39)	missense	probably damaging	1.00
R8915:Herc1	UTSW	9	66,318,456 (GRCm39)	missense	probably damaging	1.00
R8964:Herc1	UTSW	9	66,352,872 (GRCm39)	missense	probably damaging	1.00
R9056:Herc1	UTSW	9	66,380,782 (GRCm39)	missense	probably benign	0.10
R9158:Herc1	UTSW	9	66,376,400 (GRCm39)	missense	probably benign	0.00
R9167:Herc1	UTSW	9	66,411,900 (GRCm39)	missense	possibly damaging	0.75
R9192:Herc1	UTSW	9	66,321,413 (GRCm39)	missense	probably benign	0.35
R9252:Herc1	UTSW	9	66,309,834 (GRCm39)	missense	probably damaging	1.00
R9260:Herc1	UTSW	9	66,325,691 (GRCm39)	nonsense	probably null
R9261:Herc1	UTSW	9	66,412,129 (GRCm39)	missense	probably damaging	0.98
R9430:Herc1	UTSW	9	66,325,785 (GRCm39)	nonsense	probably null
R9519:Herc1	UTSW	9	66,307,356 (GRCm39)	missense	probably damaging	0.97
R9563:Herc1	UTSW	9	66,294,193 (GRCm39)	critical splice donor site	probably null
R9589:Herc1	UTSW	9	66,372,840 (GRCm39)	missense	possibly damaging	0.95
R9600:Herc1	UTSW	9	66,304,594 (GRCm39)	missense	possibly damaging	0.95
R9659:Herc1	UTSW	9	66,307,185 (GRCm39)	missense	probably benign	0.03
R9740:Herc1	UTSW	9	66,355,796 (GRCm39)	missense	probably damaging	1.00
R9774:Herc1	UTSW	9	66,372,032 (GRCm39)	missense	probably null
R9781:Herc1	UTSW	9	66,280,004 (GRCm39)	missense	probably benign
R9788:Herc1	UTSW	9	66,307,185 (GRCm39)	missense	probably benign	0.03
RF023:Herc1	UTSW	9	66,365,616 (GRCm39)	missense
X0011:Herc1	UTSW	9	66,307,441 (GRCm39)	missense	probably benign	0.28
X0067:Herc1	UTSW	9	66,355,806 (GRCm39)	missense	probably benign	0.03
Z1176:Herc1	UTSW	9	66,341,858 (GRCm39)	missense	probably benign
Z1177:Herc1	UTSW	9	66,379,193 (GRCm39)	missense	probably damaging	0.99
Z1177:Herc1	UTSW	9	66,365,707 (GRCm39)	missense	probably null

Predicted Primers

PCR Primer
(F):5'- TGATAGCAGCAGTATTTTCTAAGGC -3'
(R):5'- CCCCTGTAATGTTGGCTAATGC -3'

Sequencing Primer
(F):5'- GATCACAGATAACCAAGACT -3'
(R):5'- ATCCCTGGTAAAGTGTCAGATGC -3'

Posted On

2015-10-08